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Resultados de la búsqueda125 resultados
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Dlk1 dosage regulates hippocampal neurogenesis and cognition
Raquel Montalbán-Loro, Glenda Lassi, Anna Lozano-Ureña, Ana Perez-Villalba, Esteban Jiménez-Villalba, Marika Charalambous, Giorgio Vallortigara, Alexa E. Horner, Lisa M. Saksida, Timothy J. Bussey, José Luis Trejo, Valter Tucci, Anne C. Ferguson-Smith and Sacri R. Ferrón
(2021). ArticlePNAS.
https://doi.org/10.1073/pnas.2015505118
DOI: https://doi.org/10.1073/pnas.2015505118 -
Aberrations of Genomic Imprinting in Glioblastoma Formation
Anna Lozano-Ureña, Esteban Jiménez-Villalba, Alejandro Pinedo-Serrano, Antonio Jordán-Pla, Martina Kirstein and Sacri R. Ferrón
(2021). ArticleFront. Oncol..
https://doi.org/10.3389/fonc.2021.630482
DOI: https://doi.org/10.3389/fonc.2021.630482 -
Priming maritime pine megagametophytes during somatic embryogenesis improved plant adaptation to heat stress
Pérez-Oliver MA; Haro JG; Pavlovi´c I; Novák O; Segura J; Sales E; Arrillaga
(2021). Article919156 - Plants-Basel.
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Scutellospora deformata (Scutellosporaceae), a new species of Gigasporales from the Mediterranean sand dunes of Spain
Guillén, A., Serrano-Tamay, F., Peris, J.B., Arrillaga, I.
(2021). Article916710 - Phytotaxa.
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Phosphoglycerate dehydrogenase genes differentially affect Arabidopsis metabolism and development
Casatejada-Anchel, R., Muñoz-Bertomeu, J., Rosa-Téllez, S., Anoman, A.D., González-Nebauer, S., Torres-Moncho, A., Fernie, A.R., Ros, R
(2021). ArticlePlant Science.
110863
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Structural analysis and biochemical properties of laccase enzymes from two Pediococcus species
Isidoro Olmeda; Patricia Casino; Robert E. Collins; Ramón Sendra; Sara Callejón; Juanjo Huesa; Alexei S. Soares; Sergi Ferrer; Isabel Pardo
(2021). ArticleMicrobial Biotechnology.
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Piriform cortex alterations in the Ts65Dn model for down syndrome.
Carbonell J, Blasco-Ibáñez JM, Crespo C, Nácher J, Varea E
(2020). Article1747:147031
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Enhanced activity of glycolytic enzymes in Drosophila and human cell models of Parkinson’s disease based on DJ-1 deficiency
Solana-Manrique C., Sanz F.J., Ripollés E., Bañó M.C., Torres J., Muñoz-Soriano V., Paricio N
(2020). Article158, 137-148
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Rabphilin involvement in filtration and molecular uptake in Drosophila nephrocytes suggests a similar role in human podocytes
Selma-Soriano E, Llamusi B, Fernández-Costa JM, Ozimski LL, Artero R, Redón J - 2020 - Dis Model Mech
(2020). ArticleDrosophila nephrocytes share functional, structural and molecular similarities with human podocytes. It is known that podocytes express the rabphilin 3A (RPH3A)-RAB3A complex, and its expression is altered in mouse and human proteinuric disease. Furthermore, we previously identified a polymorphism that suggested a role for RPH3A protein in the development of urinary albumin excretion. As endocytosis and vesicle trafficking are fundamental pathways for nephrocytes, the objective of this study was to assess the role of the RPH3A orthologue in Drosophila, Rabphilin (Rph), in the structure and function of nephrocytes. We confirmed that Rph is required for the correct function of the endocytic...
Drosophila nephrocytes share functional, structural and molecular similarities with human podocytes. It is known that podocytes express the rabphilin 3A (RPH3A)-RAB3A complex, and its expression is altered in mouse and human proteinuric disease. Furthermore, we previously identified a polymorphism that suggested a role for RPH3A protein in the development of urinary albumin excretion. As endocytosis and vesicle trafficking are fundamental pathways for nephrocytes, the objective of this study was to assess the role of the RPH3A orthologue in Drosophila, Rabphilin (Rph), in the structure and function of nephrocytes. We confirmed that Rph is required for the correct function of the endocytic pathway in pericardial Drosophila nephrocytes. Knockdown of Rph reduced the expression of the cubilin and stick and stones genes, which encode proteins that are involved in protein uptake and filtration. We also found that reduced Rph expression resulted in a disappearance of the labyrinthine channel structure and a reduction in the number of endosomes, which ultimately leads to changes in the number and volume of nephrocytes. Finally, we demonstrated that the administration of retinoic acid to IR-Rph nephrocytes rescued some altered aspects, such as filtration and molecular uptake, as well as the maintenance of cell fate. According to our data, Rph is crucial for nephrocyte filtration and reabsorption, and it is required for the maintenance of the ultrastructure, integrity and differentiation of the nephrocyte.
Leer más Ocultar DOI: 10.1242/dmm.041509 -
Therapeutic Potential of AntagomiR-23b for Treating Myotonic Dystrophy
Cerro-Herreros E, González-Martínez I, Moreno-Cervera N, Overby S, Pérez-Alonso M, Llamusí B, Artero R - 2020 - Mol Ther Nucleic Acids
(2020). ArticleMyotonic dystrophy type 1 (DM1) is a chronically debilitating, rare genetic disease that originates from an expansion of a noncoding CTG repeat in the dystrophia myotonica protein kinase (DMPK) gene. The expansion becomes pathogenic when DMPK transcripts contain 50 or more repetitions due to the sequestration of the muscleblind-like (MBNL) family of proteins. Depletion of MBNLs causes alterations in splicing patterns in transcripts that contribute to clinical symptoms such as myotonia and muscle weakness and wasting. We previously found that microRNA (miR)-23b directly regulates MBNL1 in DM1 myoblasts and mice and that antisense technology ("antagomiRs") blocking this microRNA (miRNA)...
Myotonic dystrophy type 1 (DM1) is a chronically debilitating, rare genetic disease that originates from an expansion of a noncoding CTG repeat in the dystrophia myotonica protein kinase (DMPK) gene. The expansion becomes pathogenic when DMPK transcripts contain 50 or more repetitions due to the sequestration of the muscleblind-like (MBNL) family of proteins. Depletion of MBNLs causes alterations in splicing patterns in transcripts that contribute to clinical symptoms such as myotonia and muscle weakness and wasting. We previously found that microRNA (miR)-23b directly regulates MBNL1 in DM1 myoblasts and mice and that antisense technology ("antagomiRs") blocking this microRNA (miRNA) boosts MBNL1 protein levels. Here, we show the therapeutic effect over time in response to administration of antagomiR-23b as a treatment in human skeletal actin long repeat (HSALR) mice. Subcutaneous administration of antagomiR-23b upregulated the expression of MBNL1 protein and rescued splicing alterations, grip strength, and myotonia in a dose-dependent manner with long-lasting effects. Additionally, the effects of the treatment on grip strength and myotonia were still slightly notable after 45 days. The pharmacokinetic data obtained provide further evidence that miR-23b could be a valid therapeutic target for DM1.
Leer más Ocultar DOI: 10.1016/j.omtn.2020.07.021
