CV Paula Alepuz 

I studied Chemistry at the Universities of Alicante and Valencia, Spain, where I graduated with a distinction. In 1997, I obtained a Doctorate in Chemistry with Cum Laude from the University of Valencia. In my thesis, under the supervision of Dr Francisco Estruch, I characterised a new gene from the yeast Saccharomyces cerevisiae, which encodes a protein involved in the genetic response to different environmental signals. During my PhD, I spent 5 months at Johns Hopkins University in Baltimore (USA) in the laboratory of Dr Kyle Cunningham, where I completed part of my studies. From 1998 to 2001 I was a postdoctoral fellow at the University of Vienna (Austria) in the laboratory of Dr Gustav Ammerer, funded by a long-term EMBO fellowship. During this time we discovered that the yeast MAPK Hog1, homologous to human p38, when activated in response to stress, binds to numerous genes in the nucleus and promotes the cell's transcriptional response. Our results were published in Molecular Cell, and during a second postdoctoral period at the Pompeu Fabra University (Barcelona, Spain) in the laboratory of Dr Francesc Posas, I was able to continue this project and we published articles in the EMBO Journal and Nature showing that Hog1 bound to genes recruits specific transcription factors and RNA polymerase II to activate transcription.

My career as an independent researcher began at the end of 2003, when I obtained a contract from the competitive Spanish Ramón y Cajal programme and returned to the Department of Biochemistry and Molecular Biology at the University of Valencia. In 2009, I was appointed as a tenured university professor. In 2011 I was a visiting researcher at the University of Gothenburg in Sweden, where I started collaborating with Dr Per Sunnerhagen, and since 2023 I have been a full professor at the University of Valencia. I lead the Eukaryotic Gene Expression: from DNA to Protein (EGE: DtoP) group, where we study gene expression with an integrated approach to the different stages, mainly gene transcription and mRNA degradation and translation. In recent years, we have focused our efforts on the function and targets of the translational elongation factor eIF5A, an evolutionarily conserved factor essential in all eukaryotic cells and implicated in diseases such as cancer, viral infection and ageing. In recent years, we have described the peptide motifs under the control of eIF5A, found new target proteins in yeast and mammalian cells, such as formins and collagens, that require eIF5A for their synthesis, and unravelled a molecular mechanism by which eIF5A controls mitochondrial function. Most of our work is done in collaboration with national and international scientific groups and are the result of the efforts of many PhD, Master's and graduate students.

As a summary of my research, I have published around half a hundred scientific articles, I have presented more than 60 communications at conferences, I have given invited lectures at different research centres in Spain, Austria, Switzerland, Germany and Sweden, I have directed 13 national or local research projects and I have participated in another 10 projects, 3 of them international, I am currently a secondary proposer of the European action COST Translacore. I am a member of the Spanish Society of Biochemistry and Molecular Biology (SEBBM) and of the national research networks RNA Life and Spanish Yeast Network (REDIL). I also regularly review scientific manuscripts in journals such as Nature Communications, NAR or PNAS, among others. I am an editor of the journal Frontiers in Cell and Developmental Biology and I regularly carry out evaluation tasks for national bodies such as the National Agency for Evaluation and Prospective Studies (ANEP) and the Andalusian Agency for Knowledge (DEVA-AAC), and international bodies such as the European Commission and national evaluation agencies, private foundations or universities in Poland, Uruguay, Belgium, Sweden, the UK or Austria. I have also been actively involved in teaching, management and training activities at the University of Valencia, where I have supervised doctoral theses, master's and bachelor's theses and many undergraduate laboratory placements.

I have combined the tasks of researcher and professor with those of mother. I have had two interruptions in my work due to the birth and bringing up of my daughter (2005) and son (2010).

Finally, I participate in the tasks of scientific dissemination to society through articles at different levels, interviews with local newspapers or television stations, lectures in highschools and primary schools, and the promotion of research among students, especially girls, through lectures and experiments in schools.

Código ORCID: 0000-0003-1472-2373

Researcher ID: F-7849-2016

Scopus Author ID: 6603311983

M.L. Gil graduated in Pharmacy at the University of Valencia (UV) in 1985. She received a PhD in 1989 for research on the identification of cell-wall proteins of Candida albicans at the Microbiology Department (UV). As a post-doctoral fellow she joined Didier Fradelizi Immunoloy laboratory at the Institute Gustave Roussy, in Paris. During the post-doctoral she graduated in Immunology at the Pasteur Institute and also participated in research that led to the identification of a new human leukocyte molecule (CD82). Back in Spain, in 1994, she was appointed as Assitant Professor, and in 1999, as Associate Professor, at the University of Valencia. In 2004 she started an independent research group that focused on the antifungal innate immunity and was promoted to Full Professor at the University of Valencia in 2011.    

Since her return to Spain, her research has focused on studying the pathogen/host interaction during candidiasis. In the first years, the research focused on the characterization of virulence factors of the fungus, then to address the study of the immune response, and specifically the participation of Toll-like receptors (TLRs) in the recognition of C. albicans, Since 2007, it has extended the study of the participation of TLRs in the interaction of C. albicans with the immune system, to hematopoietic stem cells, following the discovery that these cells express functional TLRs. Her main line of current research examines how the activation of PRRs in stem cells and hematopoietic progenitors, induces myeloid differentiation as well as in the implications in the phenotype of the macrophages they generate and in the protection against candidiasis; the results obtained show that the "memory" of innate immunity affects not only monocytes and macrophages but also the progenitors.