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Facultat de Ciències Biològiques

http://www.uv.es/knockin/index_files/image5191.jpg  http://www.uv.es/knockin/image334.gif

LABORATORY: EXTRACELULAR MATRIX PROTEINS: adhesion & cell signaling.

Analysis of the role of Perlecan during brain development with knocout mice

 

Extracellulares matrices are networks that control cell proliferation and diferentiation. Among their components are the heparan sulfate proteoglycans, proteins that substituted by chains of sugars highly modified and bind diverse growth factors.

  http://www.uv.es/knockin/perlecan_files/matriz.jpg

 

Our group has long experience in the study of the function of one of these proteoglycans, perlecan, which plays an important role in processes such as maintaining the basement membrane integrity, morphogenesis, angiogenesis , tumor metastasis and tissue repairing.

http://www.uv.es/knockin/perlecan_files/hueso.jpg


 


 

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Laboratorio IX

2ºPlanta Edificio A

Facultat de Ciències Biològiques
Universitat de València


Dr. Moliner, 50
46100 Burjassot, València

Phone: 96 3543796/963543020

Fax: 96 354 43 72

e-mail: Mercedes.Costell@uv.es

http://www.uv.es/~knockin