English Español Biochemistry and Molecular Biology
Facultat de Ciències Biològiques
LABORATORY: EXTRACELULAR MATRIX PROTEINS: adhesion & cell signaling.Publications
1: Sun Z, Costell M, Fässler R. Integrin activation by talin, kindlin and mechanical forces. Nat Cell Biol. 2019 Jan;21(1):25-31. doi: 10.1038/s41556-018-0234-9.
2: Almonte-Becerril M, Gimeno-LLuch I, Villarroya O, Benito-Jardón M, Kouri JB, Costell M. Genetic abrogation of the fibronectin-α5β1 integrin interaction in articular cartilage aggravates osteoarthritis in mice. PLoS One. 2018 Jun 5;13(6):e0198559. doi: 10.1371/journal.pone.
3: Strohmeyer N, Bharadwaj M, Costell M, Fässler R, Müller DJ. Fibronectin-bound α5β1 integrins sense load and signal to reinforce adhesion in less than a second. Nat Mater. 2017 Dec;16(12):1262-1270. doi: 10.1038/nmat5023
4: Moulisová V, Gonzalez-García C, Cantini M, Rodrigo-Navarro A, Weaver J, Costell M, Sabater I Serra R, Dalby MJ, García AJ, Salmerón-Sánchez M. Engineered microenvironments for synergistic VEGF - Integrin signalling during vascularization. Biomaterials. 2017 May;126:61-74. doi: 10.1016/j.biomaterials.
5: Lin W, Izu Y, Smriti A, Kawasaki M, Pawaputanon C, Böttcher RT, Costell M, Moriyama K, Noda M, Ezura Y. Profilin1 is expressed in osteocytes and regulates cell shape and migration. J Cell Physiol. 2018 Jan;233(1):259-268. doi: 10.1002/jcp.25872.
6: Benito-Jardón M, Klapproth S, Gimeno-LLuch I, Petzold T, Bharadwaj M, Müller DJ, Zuchtriegel G, Reichel CA, Costell M. The fibronectin synergy site re-enforces cell adhesion and mediates a crosstalk between integrin classes. Elife. 2017 Jan 16;6. pii: e22264. doi: 10.7554/eLife.22264
7: Kullmann JA, Wickertsheim I, Minnerup L, Costell M, Friauf E, Rust MB. Profilin1 activity in cerebellar granule neurons is required for radial migration in vivo. Cell Adh Migr. 2015;9(3):247-53. doi: 10.4161/19336918.2014.983804.
8: Klingberg F, Chow ML, Koehler A, Boo S, Buscemi L, Quinn TM, Costell M, Alman BA, Genot E, Hinz B. Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation. J Cell Biol. 2014 Oct 27;207(2):283-97. doi: 10.1083/jcb.201402006.
9: Almonte-Becerril M, Costell M, Kouri JB. Changes in the integrins expression are related with the osteoarthritis severity in an experimental animal model in rats. J Orthop Res. 2014 Sep;32(9):1161-6. doi: 10.1002/jor.22649.
10: Montani L, Buerki-Thurnherr T, de Faria JP, Pereira JA, Dias NG, Fernandes R, Gonçalves AF, Braun A, Benninger Y, Böttcher RT, Costell M, Nave KA, Franklin RJ, Meijer D, Suter U, Relvas JB. Profilin 1 is required for peripheral nervous system myelination. Development. 2014 Apr;141(7):1553-61. doi: 10.1242/dev.101840.
11: Zheng J, Lu Z, Kocabas F, Böttcher RT, Costell M, Kang X, Liu X, Deberardinis RJ, Wang Q, Chen GQ, Sadek H, Zhang CC. Profilin 1 is essential for retention and metabolism of mouse hematopoietic stem cells in bone marrow. Blood. 2014 Feb 13;123(7):992-1001. doi: 10.1182/blood-2013-04-498469.
12: Gustafsson E, Almonte-Becerril M, Bloch W, Costell M. Perlecan maintains microvessel integrity in vivo and modulates their formation in vitro. PLoS One. 2013;8(1):e53715. doi: 10.1371/journal.pone.0053715.
13: Kullmann JA, Neumeyer A, Wickertsheim I, Böttcher RT, Costell M, Deitmer JW, Witke W, Friauf E, Rust MB. Purkinje cell loss and motor coordination defects in profilin1 mutant mice. Neuroscience. 2012 Oct 25;223:355-64. doi: 10.1016/j.neuroscience.2012.07.055.
14: Miyajima D, Hayata T, Suzuki T, Hemmi H, Nakamoto T, Notomi T, Amagasa T, Böttcher RT, Costell M, Fässler R, Ezura Y, Noda M. Profilin1 regulates sternum development and endochondral bone formation. J Biol Chem. 2012 Sep 28;287(40):33545-53.
15: Stenzel D, Lundkvist A, Sauvaget D, Busse M, Graupera M, van der Flier A, Wijelath ES, Murray J, Sobel M, Costell M, Takahashi S, Fässler R, Yamaguchi Y, Gutmann DH, Hynes RO, Gerhardt H. Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis. Development. 2011 Oct;138(20):4451-63. doi: 10.1242/dev.071381.
16: Girós A, Grgur K, Gossler A, Costell M. α5β1 integrin-mediated adhesion to fibronectin is required for axis elongation and somitogenesis in mice. PLoS One. 2011;6(7):e22002. doi: 10.1371/journal.pone.0022002.
17: Böttcher RT, Wiesner S, Braun A, Wimmer R, Berna A, Elad N, Medalia O, Pfeifer A, Aszódi A, Costell M, Fässler R. Profilin 1 is required for abscission during late cytokinesis of chondrocytes. EMBO J. 2009 Apr 22;28(8):1157-69. doi: 10.1038/emboj.2009.58.
18: Sasse P, Malan D, Fleischmann M, Roell W, Gustafsson E, Bostani T, Fan Y, Kolbe T, Breitbach M, Addicks K, Welz A, Brem G, Hescheler J, Aszodi A, Costell M, Bloch W, Fleischmann BK. Perlecan is critical for heart stability. Cardiovasc Res. 2008 Dec 1;80(3):435-44. doi: 10.1093/cvr/cvn225.
19: Leiss M, Beckmann K, Girós A, Costell M, Fässler R. The role of integrin binding sites in fibronectin matrix assembly in vivo. Curr Opin Cell Biol. 2008 Oct;20(5):502-7. doi: 10.1016/j.ceb.2008.06.001.
20: Girós A, Morante J, Gil-Sanz C, Fairén A, Costell M. Perlecan controls neurogenesis in the developing telencephalon. BMC Dev Biol. 2007 Apr 5;7:29.
21: Garl PJ, Wenzlau JM, Walker HA, Whitelock JM, Costell M, Weiser-Evans MC. Perlecan-induced suppression of smooth muscle cell proliferation is mediated through increased activity of the tumor suppressor PTEN. Circ Res. 2004 Feb 6;94(2):175-83.
22: González-Iriarte M, Carmona R, Pérez-Pomares JM, Macías D, Costell M, Muñoz-Chápuli R. Development of the coronary arteries in a murine model of transposition of great arteries. J Mol Cell Cardiol. 2003 Jul;35(7):795-802.
23: Sáez-Valero J, Costell M, Sjögren M, Andreasen N, Blennow K, Luque JM. Altered levels of cerebrospinal fluid reelin in frontotemporal dementia and Alzheimer's disease. J Neurosci Res. 2003 Apr 1;72(1):132-6.
24: Costell M, Carmona R, Gustafsson E, González-Iriarte M, Fässler R, Muñoz-Chápuli R. Hyperplastic conotruncal endocardial cushions and transposition of great arteries in perlecan-null mice. Circ Res. 2002 Jul 26;91(2):158-64.
25: Henry MD, Satz JS, Brakebusch C, Costell M, Gustafsson E, Fässler R, Campbell KP. Distinct roles for dystroglycan, beta1 integrin and perlecan in cell surface laminin organization. J Cell Sci. 2001 Mar;114(Pt 6):1137-44.
26: Costell M, Gustafsson E, Aszódi A, Mörgelin M, Bloch W, Hunziker E, Addicks K, Timpl R, Fässler R. Perlecan maintains the integrity of cartilage and some basement membranes. J Cell Biol. 1999 Nov 29;147(5):1109-22.
Presentation go -> Research main points go -> Fibronectin go -> Perlecan go -> Members go -> Publicatons go -> PhD
Laboratorio IX
2ºPlanta Edificio A
Facultat de Ciències Biològiques
Universitat de València
Dr. Moliner, 50
46100 Burjassot, València
Phone: 963543796 / 963543020
Fax: 96 354 43 72
Correo: Mercedes.Costell@uv.es