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EGE-DtoP Objectives

 
  1. To study the coordination of the different stages of gene expression, from transcription to translation, and the communication between them.
     
  2. To study the direct functions of eIF5A in the cell, both in translation and in other stages of gene expression.
     
  3. To identify the target proteins of eIF5A whose synthesis depends on this factor.
     
  4. To identify the mechanisms, direct or indirect through protein synthesis, by which eIF5A is involved in different pathologies.
     
  5. To verify whether the mechanisms of action of eIF5A identified in yeast are transferable to eukaryotic mammalian cells.