Genetics, Molecular and Cell Biology, Virology, Microbiology, Epidemiology, Evolutionary Biology, Systems Biology
The Evolution and Health ("EvoSalud") group is a mixed research unit based at the Institute for Integrative Systems Biology (I2SysBio) and the FISABIO Salud Pública. It is led by two PIs, who are both members of the Genetics Department of the University of Valencia:
The unit is currently funded by an ERC projects (Consolidator Grant to Rafael Sanjuán), two projects of the Spanish MINECO, and grants from other funding agencies.
We study evolutionary processes in real time and their practical implications, focusing on the following main topics:
Evolutionary epidemiology of pathogens (Fernando González-Candelas): we use gene and genome sequences for epidemiological surveillance, identification of routes of transmission, and analysis of the spread of drug resistances.
Evolutionary systems biology (Fernando González-Candelas):
using computational approaches, we integrate
genetic, epidemiologic, evolutionary, and
immunologic information about pathogens and their
hosts, with the hope of gaining insight into the
diseases caused by these pathogens.
Experimental virus evolution (Rafael Sanjuán): we are investigating how social traits such as cooperation and cheating evolve in viruses and how they deterimes viral fitness, drug resistance, and genetic diversity. We have also studied other topics such as spontaneous mutation, which is the ultimate source of genetic variation and a key factor determining the remarkable variability and adaptability of viruses.
Directed evolution of oncolytic
viruses (Rafael Sanjuán):
vesicular stomatitis virus (VSV) and other viruses
show natural selectivity for tumoral cells, which
makes them candidate therapeutic agents against
cancer. We use directed evolution as a tool for
improving the oncolytic properties of VSV.
Universitat de València, 2017