Individual research publications

JOVER ATIENZA, RAMIRO
PDI-Catedratic/a d'Universitat
- van Ertvelde J; Verhoeven A; Maerten A; Cooreman A; Santos Rodrigues BD; Sanz-Serrano J; Mihajlovic M; Tripodi I; Teunis M; Jover R; Luechtefeld T; Vanhaecke T; Jiang J; Vinken M. (2023) Optimization of an adverse outcome pathway network on chemical-induced cholestasis using an artificial intelligence-assisted data collection and confidence level quantification approach. Journal of Biomedical Informatics , 145, p. 104465 . ISSN: 1532-0464
- Pérez-Rubio Á; Soluyanova P; Moro E; Quintás G; Rienda I; Periañez MD; Painel A; Vizuete J; Pérez-Rojas J; Castell JV; Trullenque-Juan R; Pareja E; Jover R. (2023) Gut microbiota and plasma bile acids associated with non-alcoholic fatty liver disease resolution in bariatric surgery patients. Nutrients , 15(14), p. 3187 . ISSN: 2072-6643
- Rodríguez-Agudo R; González-Recio I; Serrano-Maciá M; Bravo M; Petrov P; Blaya D; Herranz JM; Mercado-Gómez M; Rejano-Gordillo CM; Lachiondo-Ortega S; Gil-Pitarch C; Azkargorta M; Van Liempd SM; Martinez-Cruz LA; Simão AL; Elortza F; Martín C; Nevzorova YA; Cubero FJ; Delgado TC; Argemi J; Bataller R; Schoonjans K; Banales JM; Castro RE; Sancho-Bru P; Avila MA; Julve J; Jover R; Mabe J; Simon J; Goikoetxea-Usandizaga N; Martínez-Chantar ML. (2023) Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1. Jhep Reports , 6(1), p. 100918 . ISSN: 2589-5559
- Rienda I; Ten-Doménech I; Moro E; Moreno-Torres M; Pérez-Rojas J; Pareja E; Pérez-Rubio Á; Trullenque R; Jover R; Lendl B; Pérez-Guaita D; Kuligowski J; Castell JV; Quintás G. (2023) Enhancing the accuracy of mid-infrared spectroscopy liver steatosis quantification using digital image analysis as reference. Analyst , 148(13), pp. 3097 - 3106 . ISSN: 0003-2654
- Crespo-Masip M; Pérez-Gómez A; Guzmán C; Rayego S; Doladé N; García-Carrasco A; Jover R; Valdivielso JM (2022) PTEN Deletion in Adult Mice Induces Hypoinsulinemia With Concomitant Low Glucose Levels. Frontiers In Endocrinology , 13, pp. 1 - 13 . ISSN: 1664-2392
- Crespo-Masip M; Perez-Gomez A; Garcia-Carrasco A; Jover R; Guzmán C; Dolcet X; Ibarz M; Martínez C; Eritja À; Diaz-Tocados JM; Valdivielso JM (2022) Elimination of Vitamin D Signaling Causes Increased Mortality in a Model of Overactivation of the Insulin Receptor: Role of Lipid Metabolism. Nutrients , 14(7), pp. 1 - 16 . ISSN: 2072-6643
- Rodríguez-Agudo R; Goikoetxea-Usandizaga N; Serrano-Maciá M; Fernández-Tussy P; Fernández-Ramos D; Lachiondo-Ortega S; González-Recio I; Gil-Pitarch C; Mercado-Gómez M; Morán L; Bizkarguenaga M; Lopitz-Otsoa F; Petrov P; Bravo M; Van Liempd SM; Falcon-Perez JM; Zabala-Letona A; Carracedo A; Castell JV; Jover R; Martínez-Cruz LA; Delgado TC; Cubero FJ; Lucena MI; Andrade RJ; Mabe J; Simón J; Martínez-Chantar (2022) Methionine cycle rewiring by targeting miR-873-5p modulates ammonia metabolism to protect the liver from acetaminophen. Antioxidants , 11(5), p. 897 . ISSN: 2076-3921
- Mercado-Gómez M; Prieto-Fernández E; Goikoetxea-Usandizaga N; Vila-Vecilla L; Azkargorta M; Bravo M; Serrano-Maciá M; Egia-Mendikute L; Rodríguez-Agudo R; Lachiondo-Ortega S; Lee SY; Eguileor Giné A; Gil-Pitarch C; González-Recio I; Simón J; Petrov P; Jover R; Martínez-Cruz LA; Ereño-Orbea J; Delgado TC; Elortza F; Jiménez-Barbero J; Nogueiras R; Prevot V; Palazon A; Martínez-Chantar ML (2022) The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes. Communications Biology , 5(1), p. 827 . ISSN: 2399-3642
- Quintás G; Caiment F; Rienda I; Pérez-Rojas J; Pareja E; Castell JV; Jover R. (2022) Quantitative prediction of steatosis in patients with non-alcoholic fatty liver by means of hepatic microRNAs present in serum and correlating with hepatic fat. International Journal Of Molecular Sciences , 23(16), p. 9298 . ISSN: 1661-6596
- González-Recio I; Simón J; Goikoetxea-Usandizaga N; Serrano-Maciá M; Mercado-Gómez M; Rodríguez-Agudo R; Lachiondo-Ortega S; Gil-Pitarch C; Fernández-Rodríguez C; Castellana D; Latasa MU; Abecia L; Anguita J; Delgado TC; Iruzubieta P; Crespo J; Hardy S; Petrov PD; Jover R; Avila MA; Martín C; Schaeper U; Tremblay ML; Dear JW; Masson S; McCain MV; Reeves HL; Andrade RJ; Lucena MI; Buccella D; Martínez-Cruz LA; Martínez-Chantar ML. (2022) Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage. Nature Communications , 13(1), p. 6816 . ISSN: 2041-1723
- Marta Moreno-Torres; Carla Guzmán; Petar D. Petrov; Ramiro Jover (2022) Valproate and Short-Chain Fatty Acids Activate Transcription of the Human Vitamin D Receptor Gene through a Proximal GC-Rich DNA Region Containing Two Putative Sp1 Binding Sites. Nutrients , 14(13), pp. 1 - 15 . ISSN: 2072-6643
- R. Jover, P. Soluyanova, E. Moro-Castaño, M. Moreno-Torres, A.V. Marco-Hernández, M. Tomas-Vila, J.V. Castell (2022) SOC-V-11 New serum miRNA biomarkers to predict liver steatosis by valproic acid in paediatric epileptic patients. Toxicology Letters , 368(2), p. 68 . ISSN: 0378-4274
- Vinken M; Benfenati E; Busquet F; Castell J; Clevert DA; de Kok TM; Dirven H; Fritsche E; Geris L; Gozalbes R; Hartung T; Jennen D; Jover R; Kandarova H; Kramer N; Krul C; Luechtefeld T; Masereeuw R; Roggen E; Schaller S; Vanhaecke T; Yang C; Piersma AH. (2021) Safer chemicals using less animals: kick-off of the European ONTOX project. Toxicology , 458, p. 152846 . ISSN: 0300-483X
- Juárez-Fernández M; Porras D; Petrov P; Román-Sagüillo S; García-Mediavilla MV; Soluyanova P; Martínez-Flórez S; González-Gallego J; Nistal E; Jover R; Sánchez-Campos S (2021) The Synbiotic combination of Akkermansia muciniphila and quercetin ameliorates early obesity and NAFLD through gut microbiota reshaping and bile acid metabolism modulation. Antioxidants , 10(12), p. 2001 . ISSN: 2076-3921
- Petrov PD; Soluyanova P; Sánchez-Campos S; Castell JV; Jover R (2021) Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food and Chemical Toxicology , 158, p. 112664 . ISSN: 0278-6915
- Pérez-Guaita D; Moreno-Torres M; Jover R; Pareja E; Lendl B; Kuligowski J; Quintás G; Castell JV (2020) Toward rapid screening of liver grafts at the operating room using mid-infrared spectroscopy. Analytical Chemistry , 92(21), pp. 14542 - 14549 . ISSN: 0003-2700
- Martínez-Sena T; Soluyanova P; Guzmán C; Valdivielso JM; Castell JV; Jover R (2020) The Vitamin D Receptor Regulates Glycerolipid and Phospholipid Metabolism in Human Hepatocytes. Biomolecules , 10(3), p. 493 . ISSN: 2218-273X
- Petrov PD; Fernández-Murga ML; Conde I; Martínez-Sena T; Guzmán C; Castell JV; Jover R (2020) Epistane, an anabolic steroid used for recreational purposes, causes cholestasis with elevated levels of cholic acid conjugates, by upregulating bile acid synthesis (CYP8B1) and cross-talking with nuclear receptors in human hepatocytes. Archives of Toxicology , 94(2), pp. 589 - 607 . ISSN: 0340-5761
- López-Riera M; Conde I; Castell JV; Jover R (2020) A novel microRNA signature for cholestatic drugs in human hepatocytes and its translation into novel circulating biomarkers for drug-induced liver injury patients. Toxicological Sciences , 173(2), pp. 229 - 243 . ISSN: 1096-6080
- Petrov PD; García-Mediavilla MV; Guzmán C; Porras D; Nistal E; Martínez-Flórez S; Castell JV; González-Gallego J; Sánchez-Campos S; Jover R (2019) A network involving gut microbiota, circulating bile acids, and hepatic metabolism genes that protects against non-alcoholic fatty liver disease. Molecular Nutrition & Food Research , 63(20), p. e1900487 . ISSN: 1613-4125
- Porras D; Nistal E; Martínez-Flórez S; Olcoz JL; Jover R; Jorquera F; González-Gallego J; García-Mediavilla MV; Sánchez-Campos S (2019) Functional Interactions between Gut Microbiota Transplantation, Quercetin, and High-Fat Diet Determine Non-Alcoholic Fatty Liver Disease Development in Germ-Free Mice. Molecular Nutrition & Food Research , 63(8), p. e1800930 . ISSN: 1613-4125
- García-Monzón C; Petrov PD; Rey E; Marañón P; Pozo-Maroto ED; Guzmán C; Rodríguez de Cía J; Casado-Collado AJ; Vargas-Castrillón J; Saez A; Miquilena-Colina ME; Lo Iacono O; Castell JV; González-Rodríguez Á; Jover R (2018) Angiopoietin-like protein 8 is a novel vitamin D receptor target gene involved in non-alcoholic fatty liver pathogenesis. American Journal of Pathology , 188(12), pp. 2800 - 2810 . ISSN: 0002-9440
- López-Riera M; Conde I; Quintas G; Pedrola L; Zaragoza Á; Perez-Rojas J; Salcedo M; Benlloch S; Castell JV; Jover R (2018) Non-invasive prediction of NAFLD severity: a comprehensive, independent validation of previously postulated serum microRNA biomarkers. Scientific Reports , 8(1), p. 10606 . ISSN: 2045-2322
- Fernández-Murga ML; Petrov PD; Conde I; Castell JV; Goméz-Lechón MJ; Jover R (2018) Advances in drug-induced cholestasis: Clinical perspectives, potential mechanisms and in vitro systems. Food and Chemical Toxicology , 120, pp. 196 - 212 . ISSN: 0278-6915
- Petrov PD; Fernández-Murga ML; López-Riera M; Goméz-Lechón MJ; Castell JV; Jover R (2018) Predicting drug-induced cholestasis: preclinical models. Expert Opinion On Drug Metabolism & Toxicology , 14(7), pp. 721 - 738 . ISSN: 1742-5255
- López-Riera M; Conde I; Tolosa L; Zaragoza A; Castell JV; Gómez-Lechón MJ; Jover R (2017) New microRNA biomarkers for drug-induced steatosis and their potential to predict the contribution of drugs to non-alcoholic fatty liver disease. Frontiers In Pharmacology , 8(3), pp. 1 - 12 . ISSN: 1663-9812
- Porras D; Nistal E; Martínez-Flórez S; Pisonero-Vaquero S; Olcoz JL; Jover R; González-Gallego J; García-Mediavilla MV; Sánchez-Campos S (2017) Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation. Free Radical Biology and Medicine , 102, pp. 188 - 202 . ISSN: 0891-5849
- Colleypriest BJ; Burke ZD; Griffiths LP; Chen Y; Yu WY; Jover R; Bock M; Biddlestone L; Quinlan JM; Ward SG; Mark Farrant J; Slack JM; Tosh D (2017) Hnf4α is a key gene that can generate columnar metaplasia in oesophageal epithelium. Differentiation , 93, pp. 39 - 49 . ISSN: 0301-4681
- Ramiro Jover (2017) Esteatosis y colestasis inducida por medicamentos: mecanismos y biomarcadores. Anales de la Real Academia Nacional de Farmacia , 83(2), pp. 284 - 293 . ISSN: 1697-4271
- Bozic M; Guzmán C; Benet M; Sánchez-Campos S; García-Monzón C; Gari E; Gatius S; Valdivielso JM; Jover R (2016) Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis. Journal of Hepatology , 65(4), pp. 748 - 757 . ISSN: 0168-8278
- Donato MT, López-Riera M, Castell JV, Gómez-Lechón MJ, Jover R. (2016) Both cholestatic and steatotic drugs trigger extensive alterations in the mRNA level of biliary transporters in rat hepatocytes: Application to develop new predictive biomarkers for early drug development. Toxicology Letters , 263, pp. 58 - 67 . ISSN: 0378-4274
- Tolosa L; Gómez-Lechón MJ; López S; Guzmán C; Castell JV; Donato MT; Jover R (2016) Human upcyte hepatocytes: Characterization of the hepatic phenotype and evaluation for acute and long-term hepatotoxicity routine testing. Toxicological Sciences , 152(1), pp. 214 - 229 . ISSN: 1096-6080
- Tolosa L; Gómez-Lechón MJ; Jiménez N; Hervás D; Jover R; Donato MT; (2016) Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis. Toxicology and Applied Pharmacology , 302, pp. 1 - 9 . ISSN: 0041-008X
- Benet M, Jover R, Bort R. (2015) Transfection of Primary Hepatocytes with Liver-Enriched Transcription Factors Using Adenoviral Vectors. Methods in Molecular Biology , 1250, pp. 213 - 221 . ISSN: 1064-3745
- Sangan CB; Jover R; Heimberg H; Tosh D (2015) In vitro reprogramming of pancreatic alpha cells towards a beta cell phenotype following ectopic HNF4α expression. Molecular and Cellular Endocrinology , 399, pp. 50 - 59 . ISSN: 0303-7207
- Benet M; Guzmán C; Pisonero-Vaquero S; García-Mediavilla MV; Sánchez-Campos S; Martínez-Chantar ML; Donato MT; Castell JV; Jover R (2015) Repression of the nuclear receptor small heterodimer partner by steatotic drugs and in advanced nonalcoholic fatty liver disease. Molecular Pharmacology , 87(4), pp. 582 - 594 . ISSN: 0026-895X
- Pisonero-Vaquero S; Martínez-Ferreras Á; García-Mediavilla MV; Martínez-Flórez S; Fernández A; Benet M; Olcoz JL; Jover R; González-Gallego J; Sánchez-Campos S (2015) Quercetin ameliorates dysregulation of lipid metabolism genes via the PI3K/AKT pathway in a diet-induced mouse model of nonalcoholic fatty liver disease. Molecular Nutrition & Food Research , 59(5), pp. 879 - 893 . ISSN: 1613-4125
- Moscardó A; Vallés J; Latorre A; Jover R; Santos MT (2015) The histone deacetylase sirtuin 2 is a new player in the regulation of platelet function. Journal Of Thrombosis And Haemostasis , 13(7), pp. 1335 - 1344 . ISSN: 1538-7933
- Pisonero-Vaquero S; García-Mediavilla MV; Jorquera F; Majano PL; Benet M; Jover R; González-Gallego J; Sánchez-Campos S (2014) Modulation of PI3K-LXRα-dependent lipogenesis mediated by oxidative/nitrosative stress contributes to inhibition of HCV replication by quercetin. Laboratory Investigation , 94(3), pp. 262 - 274 . ISSN: 0023-6837
- Benet M; Moya M; Donato MT; Lahoz A; Hervás D; Guzmán C; Gómez-Lechón MJ; Castell JV; Jover R (2014) A simple transcriptomic signature able to predict drug-induced hepatic steatosis. Archives of Toxicology , 88(4), pp. 967 - 982 . ISSN: 0340-5761
- M. Moreno Torres; E. Lopez Pascual; A. S. Rapisarda; G. López; T. Bozada Jr; J. Jiang; J. van Ertvelde; I.-L. Steffensen; B. Lindeman; T. Luechtefeld; H. Dirven; M. Vinken; R. Jover (2023) OS02 | Short Orals Session 2 OS02-01 Novel clinical phenotypes and chemical classifications in drug-induced cholestasis: analysis of a database of 390 patients developed by collaborative literature review and machine learning support. Toxicology Letters , 384S1, pp. S63 - S64 . ISSN: 0378-4274
- T. Martinez-Sena; E. Moro; M. Moreno-Torres; G. Quintas; J. Hengstler; R. Jover; J. V. Castell Ripoll (2023) P16-55. Using Metabolomics to Uncover Ontogeny of Drug-Induced Hepatotoxicity and Underlying AOP Mechanisms. Toxicology Letters , 384S1, pp. S207 - S207 . ISSN: 0378-4274
DONATO MARTIN, MARIA TERESA
PDI-Prof. Permanent Laboral Ppl
- Carretero A, León Z, García-Cañaveras JC, Zaragoza A, Gómez-Lechón MJ, Donato MT, Lahoz A (2014) In vitro/in vivo screening of oxidative homeostasis and damage to DNA, protein, and lipids using UPLC/MS-MS. Analytical and Bioanalytical Chemistry , 406(22), pp. 5465 - 5476 . ISSN: 1618-2642
- Cortes M, Pareja E, García-Cañaveras JC, Donato MT, Montero S, Mir J, Castell JV, Lahoz A (2014) Metabolomics discloses donor liver biomarkers associated with early allograft dysfunction. Journal of Hepatology , 61(3), pp. 564 - 574 . ISSN: 0168-8278
- Gómez-Lechón MJ, Tolosa L, Conde I, Donato MT (2014) Competency of different cell models to predict human hepatotoxic drugs. Expert Opinion On Drug Metabolism & Toxicology , 10(11), pp. 1553 - 1568 . ISSN: 1742-5255
- García-Cañaveras JC, Donato MT, Lahoz A (2014) Ultra-performance liquid chromatography-mass spectrometry targeted profiling of bile acids: application to serum, liver tissue, and cultured cells of different species. Methods in Molecular Biology , 1198, pp. 233 - 247 . ISSN: 1064-3745
- Gómez-Lechón MJ, Tolosa L, Donato MT (2014) Cell-based models to predict human hepatotoxicity of drugs. Revista de Toxicología , 31(2), pp. 149 - 156 . ISSN: 0212-7113
- Benet M; Guzmán C; Pisonero-Vaquero S; García-Mediavilla MV; Sánchez-Campos S; Martínez-Chantar ML; Donato MT; Castell JV; Jover R (2015) Repression of the nuclear receptor small heterodimer partner by steatotic drugs and in advanced nonalcoholic fatty liver disease. Molecular Pharmacology , 87(4), pp. 582 - 594 . ISSN: 0026-895X
- Tolosa L, López S, Pareja E, Donato MT, Myara A, Nguyen TH, Castell JV, Gómez-Lechón MJ. (2015) Human neonatal hepatocyte transplantation induces long-term rescue of unconjugated hyperbilirubinemia in the Gunn rat. Liver Transplantation , 21(6), pp. 801 - 811 . ISSN: 1527-6465
- Tolosa L, Gómez-Lechón MJ, Donato MT (2015) High-content screening technology for studying drug-induced hepatotoxicity in cell models. Archives of Toxicology , 89(7), pp. 1007 - 1022 . ISSN: 0340-5761
- Benet M; Moya M; Donato MT; Lahoz A; Hervás D; Guzmán C; Gómez-Lechón MJ; Castell JV; Jover R (2014) A simple transcriptomic signature able to predict drug-induced hepatic steatosis. Archives of Toxicology , 88(4), pp. 967 - 982 . ISSN: 0340-5761
- Tolosa L, Carmona A, Castell JV, Gómez-Lechón MJ, Donato MT. (2015) High-content screening of drug-induced mitochondrial impairment in hepatic cells: effects of statins. Archives of Toxicology , 89(10), pp. 1847 - 1860 . ISSN: 0340-5761
- Donato MT, Tolosa L, Gómez-Lechón MJ (2015) Culture and functional characterization of human hepatoma HepG2 cells. Methods in Molecular Biology , 1250, pp. 77 - 93 . ISSN: 1064-3745
- Tolosa L, Donato MT, Gómez-Lechón MJ (2015) General cytotoxicity assessment by means of the MTT assay. Methods in Molecular Biology , 1250, pp. 333 - 348 . ISSN: 1064-3745
- García-Cañaveras JC; López S; Castell JV; Donato MT; Lahoz A (2016) Extending metabolome coverage for untargeted metabolite profiling of adherent cultured hepatic cells. Analytical and Bioanalytical Chemistry , 408(4), pp. 1217 - 1230 . ISSN: 1618-2642
- García-Cañaveras JC; Jiménez N; Gómez-Lechón MJ; Castell JV; Donato MT; Lahoz A (2015) LC-MS untargeted metabolomic analysis of drug-induced hepatotoxicity in HepG2 cells. Electrophoresis , 36(18), pp. 2294 - 2302 . ISSN: 0173-0835
- Tolosa L; Gómez-Lechón MJ; Jiménez N; Hervás D; Jover R; Donato MT; (2016) Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis. Toxicology and Applied Pharmacology , 302, pp. 1 - 9 . ISSN: 0041-008X
- García-Cañaveras JC; Castell JV; Donato MT; Lahoz A (2016) A metabolomics cell-based approach for anticipating and investigating drug-induced liver injury. Scientific Reports , 6, p. 27239 . ISSN: 2045-2322
- Tolosa L; Gómez-Lechón MJ; López S; Guzmán C; Castell JV; Donato MT; Jover R (2016) Human upcyte hepatocytes: Characterization of the hepatic phenotype and evaluation for acute and long-term hepatotoxicity routine testing. Toxicological Sciences , 152(1), pp. 214 - 229 . ISSN: 1096-6080
- Gómez-Lechón MJ; Tolosa L; Donato MT (2016) Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs. Journal of Applied Toxicology , 36(6), pp. 752 - 768 . ISSN: 0260-437X
- Donato MT, López-Riera M, Castell JV, Gómez-Lechón MJ, Jover R. (2016) Both cholestatic and steatotic drugs trigger extensive alterations in the mRNA level of biliary transporters in rat hepatocytes: Application to develop new predictive biomarkers for early drug development. Toxicology Letters , 263, pp. 58 - 67 . ISSN: 0378-4274
- Gómez-Lechón MJ; Tolosa L; Donato MT (2017) Upgrading HepG2 cells with adenoviral vectors that encode drug-metabolizing enzymes: Application for Drug hepatotoxicity testing. Expert Opinion On Drug Metabolism & Toxicology , 13(2), pp. 137 - 148 . ISSN: 1742-5255
- Donato MT; Gómez-Lechón MJ; Tolosa L (2017) Using high-content screening technology for studying drug-induced hepatotoxicity in preclinical studies. Expert Opinion On Drug Discovery , 12(2), pp. 201 - 211 . ISSN: 1746-0441
- Donato MT (2017) Hepatotoxicidad idiosincrásica por fármacos: promesas y limitaciones de las estrategias in vitro. Anales de la Real Academia Nacional de Farmacia , 83(2), pp. 268 - 283 . ISSN: 1697-4271
- García-Cañaveras JC, Peris-Díaz MD, Alcoriza-Balaguer MI, Cerdán-Calero M, Donato MT, Lahoz A (2017) A lipidomic cell-based assay for studying drug-induced phospholipidosis and steatosis. Electrophoresis , 38(18), pp. 2331 - 2340 . ISSN: 0173-0835
- Tolosa L, Gómez-Lechón MJ, Donato MT (2017) A Multi-Parametric Fluorescent Assay for the Screening and Mechanistic Study of Drug-Induced Steatosis in Liver Cells in Culture. Current Protocols in Toxicology , 72, pp. 14.15.1 - 14.15.11 . ISSN: 1934-9254
- Pérez CL; Donato MT; Hernández I; Paz Lopes MT; Marrero E; Herrera JA; Gómez-Lechón MJ; Rodeiro I (2017) In vitro modulation of the cytochrome P450 and ABCB1/P-glycoprotein activities of the aqueous extract of Allophylus cominia (L) Sw. leaves. Drug Metabolism and Personalized Therapy , 32(4), pp. 201 - 220 . ISSN: 2363-8907
- Pelechá M, Gómez-Lechón MJ, Tolosa L, Donato MT (2017) Hepatocitos Humanos Upcytes como modelo experimental in vitro para el estudio del daño hepático inducido por fármacos a largo plazo. Revista de Toxicología , 34(2), pp. 109 - 117 . ISSN: 0212-7113
- Rodeiro I, Hernández I, Herrera JA, Riera M, Donato MT, Tolosa L, González K, Ansoar Y, Gómez-Lechón MJ, Vanden Berghe W, Lopes M (2018) Assessment of the cytotoxic potential of an aqueous-ethanolic extract from Thalassia testudinum angiosperm marine grown in the Caribbean Sea. Journal of Pharmacy and Pharmacology , 70(11), pp. 1553 - 1560 . ISSN: 0022-3573
- Donato MT, Tolosa L (2019) Stem-cell derived hepatocyte-like cells for the assessment of drug-induced liver injury. Differentiation , 10622, pp. 15 - 22 . ISSN: 0301-4681
- Tolosa L, Jiménez N, Pelechá M, Castell JV, Gómez-Lechón MJ, Donato MT (2019) Long-term and mechanistic evaluation of drug-induced liver injury in Upcyte human hepatocytes. Archives of Toxicology , 93(2), pp. 519 - 532 . ISSN: 0340-5761
- Tolosa L; Jiménez N; Pérez G; Castell JV; Gómez-Lechón MJ; Donato MT (2018) Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury. Archives of Toxicology , 92(1), pp. 383 - 399 . ISSN: 0340-5761
- Donato MT, Bolonio M, Cabezas E, Pelechá M, Pareja E, Domènech A, Castell JV, Gómez-Lechón MJ, Tolosa L (2020) Improved in vivo efficacy of clinical-grade cryopreserved human hepatocytes in mice with acute liver failure. Cytotherapy , 22(2), pp. 114 - 121 . ISSN: 1465-3249
- Donato MT, Tolosa L (2021) Application of high-content screening for the study of hepatotoxicity: Focus on food toxicology. Food and Chemical Toxicology , 147, p. 111872 . ISSN: 0278-6915
- Donato MT, Tolosa L (2021) High-Content Screening for the Detection of Drug-Induced Oxidative Stress in Liver Cells. Antioxidants , 10(1), p. 106 . ISSN: 2076-3921
- Pelechá M; Villanueva-Badenas E; Timor-Lopez E; Donato MT; Tolosa L (2021) Cell models and omics techniques for the study of non-alcoholic fatty liver disease: focusing on stem cell-derived cell models. Antioxidants , 11(1), p. 86 . ISSN: 2076-3921
- Donato MT; Jiménez N; Pelechá M; Tolosa L (2022) Oxidative-stress and long-term hepatotoxicity: comparative study in Upcyte human hepatocytes and hepaRG cells. Archives of Toxicology , 96(4), pp. 1021 - 1037 . ISSN: 0340-5761
- Donato MT; Gallego-Ferrer G; Tolosa L (2022) In Vitro Models for Studying Chronic Drug-Induced Liver Injury. International Journal Of Molecular Sciences , 23(19), p. 11428 . ISSN: 1661-6596
- Villanueva-Bádenas E, Donato MT; Tolosa L (2023) Mechanistic understanding of idiosyncratic drug-induced hepatotoxicity using co-cultures of hepatocytes and macrophages. Antioxidants . ISSN: 2076-3921
- Rodriguez-Fernandez J; Garcia-Legler E; Villanueva-Badenas E: Donato MT; Gomez-Ribelles JL; Salmeron-Sanchez M; Gallego-Ferrer G; Tolosa L. (2023) Primary human hepatocytes-laden scaffolds for the treatment of acute liver failure. Biomaterials Advances . ISSN: 2772-9516
- Gómez-Lechón MJ, Tolosa L, Donato MT, (2015). Safety risk assessment of hepatotoxicity in early phase of drug development. Hepatotoxicity: Symptoms, management and Health implications. . (pp. 123 - 159). .
- Donato M.T., Pelechá M., Tolosa L., (2021). Induced pluripotent stem cells in liver disease. Advances in Stem Cell Biology. Recent Advances in iPSCs for Therapy, Volume 3. . (pp. 225 - 250). .
MORENO TORRES, MARTA
PI-Invest Cont Ramon y Cajal
- Guillermo Quintás; José V Castell; Marta Moreno-Torres (2023) The assessment of the potential hepatotoxicity of new drugs by in vitro metabolomics. Frontiers In Pharmacology , 14, pp. 1 - 22 . ISSN: 1663-9812
- Teresa Martínez-Sena; Erika Moro; Marta Moreno-Torres; Guillermo Quintás; Jan Hengstler; José V Castell (2023) Metabolomics-based strategy to assess drug hepatotoxicity and uncover the mechanisms of hepatotoxicity involved. Archives of Toxicology (97), pp. 1723 - 1738 . ISSN: 0340-5761
- Isabel Ten-Doménech; MariMerce Cascant Vilaplana; Víctor Navarro Esteve; Birgit Felderer; Alba Moreno-Giménez; Iván Rienda ;María Gormaz; Marta Moreno-Torres; David Pérez-Guaita; Guillermo Quintás; Julia Kuligowski (2023) Metabolomic Diversity of Human Milk Cells over the Course of Lactation - A Preliminary Study. Nutrients , 15(5), pp. 1 - 15 . ISSN: 2072-6643
- Isabel Ten-Doménech; Marta Moreno-Torres; Juan Daniel Sanjuan-Herráez; David Pérez-Guaita; Guillermo Quintás; Julia Kuligowski (2023) Analysis of longitudinal metabolomic data using multivariate curve resolution-alternating least squares and pathway analysis. Chemometrics and Intelligent Laboratory Systems (232) . ISSN: 0169-7439
- R. Jover, P. Soluyanova, E. Moro-Castaño, M. Moreno-Torres, A.V. Marco-Hernández, M. Tomas-Vila, J.V. Castell (2022) SOC-V-11 New serum miRNA biomarkers to predict liver steatosis by valproic acid in paediatric epileptic patients. Toxicology Letters , 368(2), p. 68 . ISSN: 0378-4274
- Marta Moreno-Torres; Carla Guzmán; Petar D. Petrov; Ramiro Jover (2022) Valproate and Short-Chain Fatty Acids Activate Transcription of the Human Vitamin D Receptor Gene through a Proximal GC-Rich DNA Region Containing Two Putative Sp1 Binding Sites. Nutrients , 14(13), pp. 1 - 15 . ISSN: 2072-6643
- Marta Moreno-Torres; Guillermo Quintás; José V. Castell (2022) The Potential Role of Metabolomics in Drug-Induced Liver Injury (DILI) Assessment. Metabolites , 12(6), pp. 564 - 582 . ISSN: 2218-1989
- Isabel Ten-Doménech; Victoria Ramos-Garcia; Marta Moreno-Torres; Anna Parra-Llorca; María Gormaz; Máximo Vento; Julia Kuligowski; Guillermo Quintás (2022) The effect of Holder pasteurization on the lipid and metabolite composition of human milk. Food Chemistry , 384, pp. 1 - 9 . ISSN: 0308-8146
- Diana Horta; Marta Moreno-Torres, María José Ramírez-Lázaro, Sergio Lario, Julia Kuligowski, Juan Daniel Sanjuan-Herráez, Guillermo Quintas*, Albert Villoria, and Xavier Calvet* (2020) Analysis of the Association between Fatigue and the Plasma Lipidomic Profile of Inflammatory Bowel Disease Patients. Journal of Proteome Research , 20(1), pp. 381 - 392 . ISSN: 1535-3893
- Fernando Martínez-Montañés; Albert Casanovas; Richard R Sprenger; Magdalena Topolska; David L Marshall; Marta Moreno-Torres; Berwyck L J Poad; Stephen J Blanksby; Martin Hermansson; Ole N Jensen; Christer S Ejsing (2020) Phosphoproteomic analysis accross the yeast life cycle reveals homeostatic regulation of fatty acyl chain-length by phosphorylation of the fatty acid synthase complex. Cell Reports , 32(6), pp. 1 - 25 . ISSN: 2211-1247
- Isabel Ten-Doménech; Teresa Martínez-Sena; Marta Moreno-Torres; Juan Daniel Sanjuan-Herráez; José V Castell; Anna Parra-Llorca; Máximo Vento; Guillermo Quintás; Julia Kuligowski (2020) Comparing Targeted vs. Untargeted MS2 Data-Dependent Acquisition for Peak Annotation in LC-MS Metabolomics. Metabolites , 10(4), pp. 126 - 136 . ISSN: 2218-1989
- Elahu G Sustarsic; Tao Ma; Matthew D Lynes; Michael Larsen; Iuliia Karavaeva; Jesper F Havelund; Carsten H Nielsen; Mark P Jedrychowski; Marta Moreno-Torres; Morten Lundh; Kaja Plucinska; Naja Z Jespersen; Trisha J Grevengoed; Barbara Kramar; Julia Peics; Jakob B Hansen; Farnaz Shamsi; Isabel Forss; Ditte Neess; Susanne Keipert; Jianing Wang; Katharina Stohlmann; Ivan Brandslund; Cramer Christensen; Marit E Jørgensen; Allan Linneberg; Oluf Pedersen; Michael A Kiebish; Klaus Qvortrup; Xianlin Han; Bente Klarlund Pedersen; Martin Jastroch; Susanne Mandrup; Andreas Kjær; Steven P Gygi; Torben Hansen; Matthew P Gillum; Niels Grarup; Brice Emanuelli; Søren Nielsen; Camilla Scheele; Yu-Hua Tseng; Nils J Færgeman; Zachary Gerhart-Hines (2018) Cardiolipin synthesis in brown and beige fat mitochondria is essential for systemic energy homeostasis. Cell Metabolism , 28(3), pp. 159 - 174 . ISSN: 1550-4131
- Marta Moreno-Torres; Malika Jaquenoud; Marie-Pierre Péli-Gulli; Raffaele Nicastro; Claudio De Virgilio (2017) TORC1 coordinates the conversion of Sic1 from a target to an inhibitor of cyclin-CDK-Cks1. Cell Discovery (17012), pp. 1 - 12 . ISSN: 2056-5968
- Marta Moreno-Torres; Malika Jaquenoud; Claudio De Virgilio (2015) TORC1 controls G1-S cell cycle transition in yeast via Mpk1 and the greatwall kinase pathway. Nature Communications , 6(8256), pp. 1 - 10 . ISSN: 2041-1723
- Marta Moreno Torres; José Ramón Murguía (2011) Between Scylla and Charibdis: eIF2alpha kinases as targets for cancer chemotherapy. Clinical & Translational Oncology , 13, pp. 442 - 445 . ISSN: 1699-048X
- Pérez-Guaita D; Moreno-Torres M; Jover R; Pareja E; Lendl B; Kuligowski J; Quintás G; Castell JV (2020) Toward rapid screening of liver grafts at the operating room using mid-infrared spectroscopy. Analytical Chemistry , 92(21), pp. 14542 - 14549 . ISSN: 0003-2700
- Isabel Ten-Doménech; Marta Moreno-Torres; José Vicente Castell; Guillermo Quintás; Julia Kuligowski; (2021) Extracting consistent biological information from functional results of metabolomic pathway analysis using the Mantel's test. Analytica Chimica Acta , 1187, p. 336173 . ISSN: 0003-2670
- Marta Moreno-Torres; Guillem García-Llorens; Erika Moro; Rebeca Méndez; Guillermo Quintás; José Vicente Castell; (2021) Factors that influence the quality of metabolomics data in in vitro cell toxicity studies: a systematic survey. Scientific Reports , 11(1), p. 22119 . ISSN: 2045-2322
- Marta Moreno-Torres; Manoj Kumar; Guillem García-Llorens; Guillermo Quintás; Tine Tricot; Ruben Boon; Laia Tolosa; Burak Toprakhisar; Francois Chesnais; Catherine Verfaillie; José V Castell; (2022) A Novel UPLC-MS Metabolomic Analysis-Based Strategy to Monitor the Course and Extent of iPSC Differentiation to Hepatocytes. Journal of Proteome Research , 21(3), pp. 702 - 712 . ISSN: 1535-3893
- Alessandro Agostini, Laura Mondragón, Andrea Bernardos, Ramón Martínez-Máñez,M. Dolores Marcos, Félix Sancenón, Juan Soto, Ana Costero, Cristina Manguan-García, Rosario Perona, Marta Moreno-Torres, Rafael Aparicio-Sanchis, José Ramón Murguía (2012) Targeted Cargo Delivery in Senescent Cells Using Capped Mesoporous Silica Nanoparticles. Angewandte Chemie , 51, pp. 10556 - 10560 . ISSN: 1433-7851
- Rienda I; Ten-Doménech I; Moro E; Moreno-Torres M; Pérez-Rojas J; Pareja E; Pérez-Rubio Á; Trullenque R; Jover R; Lendl B; Pérez-Guaita D; Kuligowski J; Castell JV; Quintás G. (2023) Enhancing the accuracy of mid-infrared spectroscopy liver steatosis quantification using digital image analysis as reference. Analyst , 148(13), pp. 3097 - 3106 . ISSN: 0003-2654
- Isabel Ten-Doménech, Ivan Rienda, Judith Pérez-Rojas, Eugenia Pareja, Marta Moreno-Torres, José V Castell, Bernhard Lendl, Andreas Schwaighofer, David Pérez-Guaita, Julia Kuligowski, Guillermo Quintás (2023) Progress and challenges of mid-infrared spectroscopy for liver characterization focusing on steatosis, fibrosis and cancer. Applied Spectroscopy Reviews , 59(4), pp. 578 - 599 . ISSN: 0570-4928
- M. Moreno Torres; E. Lopez Pascual; A. S. Rapisarda; G. López; T. Bozada Jr; J. Jiang; J. van Ertvelde; I.-L. Steffensen; B. Lindeman; T. Luechtefeld; H. Dirven; M. Vinken; R. Jover (2023) OS02 | Short Orals Session 2 OS02-01 Novel clinical phenotypes and chemical classifications in drug-induced cholestasis: analysis of a database of 390 patients developed by collaborative literature review and machine learning support. Toxicology Letters , 384S1, pp. S63 - S64 . ISSN: 0378-4274
- T. Martinez-Sena; E. Moro; M. Moreno-Torres; G. Quintas; J. Hengstler; R. Jover; J. V. Castell Ripoll (2023) P16-55. Using Metabolomics to Uncover Ontogeny of Drug-Induced Hepatotoxicity and Underlying AOP Mechanisms. Toxicology Letters , 384S1, pp. S207 - S207 . ISSN: 0378-4274
- Marta Moreno-Torres; Jesper F Havelund; Nils J Faergeman, (2019). LC-MS Analyses of Lipid Species in Skeletal Muscle Cells and Tissue. Methods in Molecular Biology: Myogenesis. . Volume. 1889 . (pp. 213 - 229). .

Individual research publications

Journal Publications

Journal Publications

Other publications

Journal Publications

Other publications

Latest news

Advances in the integration of metabolomics in an in vitro study of hepatotoxicity of new medical drugs

New Research Group website