- JOVER ATIENZA, RAMIROPDI-Catedratic/a d'Universitat
- González-Recio I; Goikoetxea-Usandizaga N; Rejano-Gordillo CM; Conter C; Rodríguez Agudo R; Serrano-Maciá M; Zapata-Pavas LE; Peña-Sanfélix P; Azkargorta M; Elortza F; Herranz JM; Guillamon Thiery Á; Guerra-Ruiz AR; Jover R; Galicia-Garcia U; Martín C; Schaeper U; Delgado TC; Díaz-Moreno I; Díaz Quintana A; Buccella D; Nogueiras R; Argemi J; Ávila MA; Gratacós-Ginès J; Iruzubieta P; Pose E; Bataller R; Crespo J; Martínez-Cruz LA; Martínez-Chantar ML (2025) Modulatory effects of CNNM4 on protein- l -isoaspartyl- O -methyltransferase repair function during alcohol-induced hepatic damage. Hepatology . ISSN: 0270-9139
- Soluyanova P; Quintás G; Pérez-Rubio Á; Rienda I; Moro E; van Herwijnen M; Verheijen M; Caiment F; Pérez-Rojas J; Trullenque-Juan R; Pareja E; Jover R (2024) The Development of a Non-Invasive Screening Method Based on Serum microRNAs to Quantify the Percentage of Liver Steatosis. Biomolecules , 14(11), p. 1423 . ISSN: 2218-273X
- Soluyanova P; Del Pozo M; Moro-Castaño E; Marco-Hernández AV; Castell JV; Jover R (2024) A microRNA signature for valproate-induced steatosis in human hepatocytes and its application to predict fatty liver in paediatric epileptic patients on valproate therapy. Toxicology , 509, p. 153974 . ISSN: 0300-483X
- Román-Sagüillo S; Quiñones-Castro R; Juárez-Fernández M; Soluyanova P; Stephens C; Robles-Díaz M; Jorquera Plaza F; González-Gallego J; Martínez-Flórez S; García-Mediavilla MV; Nistal E; Jover R; Sánchez-Campos S (2024) Idiosyncratic Drug-induced liver injury and amoxicillin-clavulanate: Spotlight on gut microbiota; fecal metabolome and bile acid profile in patients. International Journal Of Molecular Sciences , 25(13), p. 6863 . ISSN: 1661-6596
- López-Pascual E; Rienda I; Perez-Rojas J; Rapisarda A; Garcia-Llorens G; Jover R; Castell JV (2024) Drug-Induced Fatty Liver Disease (DIFLD): A comprehensive analysis of clinical; biochemical; and histopathological data for mechanisms identification and consistency with current adverse outcome pathways. International Journal Of Molecular Sciences , 25(10), p. 5203 . ISSN: 1661-6596
- Verhoeven A; van Ertvelde J; Boeckmans J; Gatzios A; Jover R; Lindeman B; Lopez-Soop G; Rodrigues RM; Rapisarda A; Sanz-Serrano J; Stinckens M; Sepehri S; Teunis M; Vinken M; Jiang J; Vanhaecke T (2024) A quantitative weight-of-evidence method for confidence assessment of adverse outcome pathway networks: A case study on chemical-induced liver steatosis. Toxicology , 505, p. 153814 . ISSN: 0300-483X
- Marta Moreno-Torres; Guillermo Quintás; Teresa Martínez-Sena; Ramiro Jover; José V. Castell (2024) Exploring Individual Variability in Drug-Induced Liver Injury (DILI) Responses through Metabolomic Analysis. International Journal Of Molecular Sciences , 25(5), p. 3003 . ISSN: 1661-6596
- Iván Rienda; Marta Moreno-Torres; Erika Moro; Judith Pérez-Rojasa; Eugenia Pareja; Álvaro Pérez-Rubio; Nuria Peris; José Angel Díez Ares; Ramón Trullenque; Ramiro Jover; Bernhard Lendlf; Julia Kuligowskig; José V. Castell; Guillermo Quintás (2024) Assessing ATR-FTIR spectroscopy for steatosis quantification in liver biopsies in a long-duration cross-sectional study. Microchemical Journal , 198, p. 110135 . ISSN: 0026-265X
- Julia Kuligowski; Álvaro Pérez-Rubio; Marta Moreno-Torres; Polina Soluyanova; Judith Pérez-Rojas; Iván Rienda; David Pérez-Guaita; Eugenia Pareja; Ramón Trullenque-Juan; José V. Castell; Marcha Verheijen; Florian Caiment; Ramiro Jover; Guillermo Quintás; (2024) Cluster-Partial Least Squares (c-PLS) regression analysis: Application to miRNA and metabolomic data. Analytica Chimica Acta , 1286, p. 342502 . ISSN: 0003-2670
- T. Martinez-Sena; E. Moro; M. Moreno-Torres; G. Quintas; J. Hengstler; R. Jover; J. V. Castell Ripoll (2023) P16-55. Using Metabolomics to Uncover Ontogeny of Drug-Induced Hepatotoxicity and Underlying AOP Mechanisms. Toxicology Letters , 384(supplement 1), pp. S207 - S207 . ISSN: 0378-4274
- M. Moreno Torres; E. Lopez Pascual; A. S. Rapisarda; G. López; T. Bozada Jr; J. Jiang; J. van Ertvelde; I.-L. Steffensen; B. Lindeman; T. Luechtefeld; H. Dirven; M. Vinken; R. Jover (2023) OS02 | Short Orals Session 2 OS02-01 Novel clinical phenotypes and chemical classifications in drug-induced cholestasis: analysis of a database of 390 patients developed by collaborative literature review and machine learning support. Toxicology Letters , 384(Supplement 1), pp. S63 - S64 . ISSN: 0378-4274
- van Ertvelde J; Verhoeven A; Maerten A; Cooreman A; Santos Rodrigues BD; Sanz-Serrano J; Mihajlovic M; Tripodi I; Teunis M; Jover R; Luechtefeld T; Vanhaecke T; Jiang J; Vinken M. (2023) Optimization of an adverse outcome pathway network on chemical-induced cholestasis using an artificial intelligence-assisted data collection and confidence level quantification approach. Journal of Biomedical Informatics , 145, p. 104465 . ISSN: 1532-0464
- Pérez-Rubio Á; Soluyanova P; Moro E; Quintás G; Rienda I; Periañez MD; Painel A; Vizuete J; Pérez-Rojas J; Castell JV; Trullenque-Juan R; Pareja E; Jover R. (2023) Gut microbiota and plasma bile acids associated with non-alcoholic fatty liver disease resolution in bariatric surgery patients. Nutrients , 15(14), p. 3187 . ISSN: 2072-6643
- Rodríguez-Agudo R; González-Recio I; Serrano-Maciá M; Bravo M; Petrov P; Blaya D; Herranz JM; Mercado-Gómez M; Rejano-Gordillo CM; Lachiondo-Ortega S; Gil-Pitarch C; Azkargorta M; Van Liempd SM; Martinez-Cruz LA; Simão AL; Elortza F; Martín C; Nevzorova YA; Cubero FJ; Delgado TC; Argemi J; Bataller R; Schoonjans K; Banales JM; Castro RE; Sancho-Bru P; Avila MA; Julve J; Jover R; Mabe J; Simon J; Goikoetxea-Usandizaga N; Martínez-Chantar ML. (2023) Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1. Jhep Reports , 6(1), p. 100918 . ISSN: 2589-5559
- Rienda I; Ten-Doménech I; Moro E; Moreno-Torres M; Pérez-Rojas J; Pareja E; Pérez-Rubio Á; Trullenque R; Jover R; Lendl B; Pérez-Guaita D; Kuligowski J; Castell JV; Quintás G. (2023) Enhancing the accuracy of mid-infrared spectroscopy liver steatosis quantification using digital image analysis as reference. Analyst , 148(13), pp. 3097 - 3106 . ISSN: 0003-2654
- Crespo-Masip M; Pérez-Gómez A; Guzmán C; Rayego S; Doladé N; García-Carrasco A; Jover R; Valdivielso JM (2022) PTEN Deletion in Adult Mice Induces Hypoinsulinemia With Concomitant Low Glucose Levels. Frontiers In Endocrinology , 13, pp. 1 - 13 . ISSN: 1664-2392
- Crespo-Masip M; Perez-Gomez A; Garcia-Carrasco A; Jover R; Guzmán C; Dolcet X; Ibarz M; Martínez C; Eritja À; Diaz-Tocados JM; Valdivielso JM (2022) Elimination of Vitamin D Signaling Causes Increased Mortality in a Model of Overactivation of the Insulin Receptor: Role of Lipid Metabolism. Nutrients , 14(7), pp. 1 - 16 . ISSN: 2072-6643
- Rodríguez-Agudo R; Goikoetxea-Usandizaga N; Serrano-Maciá M; Fernández-Tussy P; Fernández-Ramos D; Lachiondo-Ortega S; González-Recio I; Gil-Pitarch C; Mercado-Gómez M; Morán L; Bizkarguenaga M; Lopitz-Otsoa F; Petrov P; Bravo M; Van Liempd SM; Falcon-Perez JM; Zabala-Letona A; Carracedo A; Castell JV; Jover R; Martínez-Cruz LA; Delgado TC; Cubero FJ; Lucena MI; Andrade RJ; Mabe J; Simón J; Martínez-Chantar (2022) Methionine cycle rewiring by targeting miR-873-5p modulates ammonia metabolism to protect the liver from acetaminophen. Antioxidants , 11(5), p. 897 . ISSN: 2076-3921
- Mercado-Gómez M; Prieto-Fernández E; Goikoetxea-Usandizaga N; Vila-Vecilla L; Azkargorta M; Bravo M; Serrano-Maciá M; Egia-Mendikute L; Rodríguez-Agudo R; Lachiondo-Ortega S; Lee SY; Eguileor Giné A; Gil-Pitarch C; González-Recio I; Simón J; Petrov P; Jover R; Martínez-Cruz LA; Ereño-Orbea J; Delgado TC; Elortza F; Jiménez-Barbero J; Nogueiras R; Prevot V; Palazon A; Martínez-Chantar ML (2022) The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes. Communications Biology , 5(1), p. 827 . ISSN: 2399-3642
- Quintás G; Caiment F; Rienda I; Pérez-Rojas J; Pareja E; Castell JV; Jover R. (2022) Quantitative prediction of steatosis in patients with non-alcoholic fatty liver by means of hepatic microRNAs present in serum and correlating with hepatic fat. International Journal Of Molecular Sciences , 23(16), p. 9298 . ISSN: 1661-6596
- González-Recio I; Simón J; Goikoetxea-Usandizaga N; Serrano-Maciá M; Mercado-Gómez M; Rodríguez-Agudo R; Lachiondo-Ortega S; Gil-Pitarch C; Fernández-Rodríguez C; Castellana D; Latasa MU; Abecia L; Anguita J; Delgado TC; Iruzubieta P; Crespo J; Hardy S; Petrov PD; Jover R; Avila MA; Martín C; Schaeper U; Tremblay ML; Dear JW; Masson S; McCain MV; Reeves HL; Andrade RJ; Lucena MI; Buccella D; Martínez-Cruz LA; Martínez-Chantar ML. (2022) Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage. Nature Communications , 13(1), p. 6816 . ISSN: 2041-1723
- Marta Moreno-Torres; Carla Guzmán; Petar D. Petrov; Ramiro Jover (2022) Valproate and Short-Chain Fatty Acids Activate Transcription of the Human Vitamin D Receptor Gene through a Proximal GC-Rich DNA Region Containing Two Putative Sp1 Binding Sites. Nutrients , 14(13), pp. 1 - 15 . ISSN: 2072-6643
- R. Jover, P. Soluyanova, E. Moro-Castaño, M. Moreno-Torres, A.V. Marco-Hernández, M. Tomas-Vila, J.V. Castell (2022) SOC-V-11 New serum miRNA biomarkers to predict liver steatosis by valproic acid in paediatric epileptic patients. Toxicology Letters , 368(2), p. 68 . ISSN: 0378-4274
- Vinken M; Benfenati E; Busquet F; Castell J; Clevert DA; de Kok TM; Dirven H; Fritsche E; Geris L; Gozalbes R; Hartung T; Jennen D; Jover R; Kandarova H; Kramer N; Krul C; Luechtefeld T; Masereeuw R; Roggen E; Schaller S; Vanhaecke T; Yang C; Piersma AH. (2021) Safer chemicals using less animals: kick-off of the European ONTOX project. Toxicology , 458, p. 152846 . ISSN: 0300-483X
- Juárez-Fernández M; Porras D; Petrov P; Román-Sagüillo S; García-Mediavilla MV; Soluyanova P; Martínez-Flórez S; González-Gallego J; Nistal E; Jover R; Sánchez-Campos S (2021) The Synbiotic combination of Akkermansia muciniphila and quercetin ameliorates early obesity and NAFLD through gut microbiota reshaping and bile acid metabolism modulation. Antioxidants , 10(12), p. 2001 . ISSN: 2076-3921
- Petrov PD; Soluyanova P; Sánchez-Campos S; Castell JV; Jover R (2021) Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food and Chemical Toxicology , 158, p. 112664 . ISSN: 0278-6915
- Pérez-Guaita D; Moreno-Torres M; Jover R; Pareja E; Lendl B; Kuligowski J; Quintás G; Castell JV (2020) Toward rapid screening of liver grafts at the operating room using mid-infrared spectroscopy. Analytical Chemistry , 92(21), pp. 14542 - 14549 . ISSN: 0003-2700
- Martínez-Sena T; Soluyanova P; Guzmán C; Valdivielso JM; Castell JV; Jover R (2020) The Vitamin D Receptor Regulates Glycerolipid and Phospholipid Metabolism in Human Hepatocytes. Biomolecules , 10(3), p. 493 . ISSN: 2218-273X
- Petrov PD; Fernández-Murga ML; Conde I; Martínez-Sena T; Guzmán C; Castell JV; Jover R (2020) Epistane, an anabolic steroid used for recreational purposes, causes cholestasis with elevated levels of cholic acid conjugates, by upregulating bile acid synthesis (CYP8B1) and cross-talking with nuclear receptors in human hepatocytes. Archives of Toxicology , 94(2), pp. 589 - 607 . ISSN: 0340-5761
- López-Riera M; Conde I; Castell JV; Jover R (2020) A novel microRNA signature for cholestatic drugs in human hepatocytes and its translation into novel circulating biomarkers for drug-induced liver injury patients. Toxicological Sciences , 173(2), pp. 229 - 243 . ISSN: 1096-6080
- Petrov PD; García-Mediavilla MV; Guzmán C; Porras D; Nistal E; Martínez-Flórez S; Castell JV; González-Gallego J; Sánchez-Campos S; Jover R (2019) A network involving gut microbiota, circulating bile acids, and hepatic metabolism genes that protects against non-alcoholic fatty liver disease. Molecular Nutrition & Food Research , 63(20), p. e1900487 . ISSN: 1613-4125
- Porras D; Nistal E; Martínez-Flórez S; Olcoz JL; Jover R; Jorquera F; González-Gallego J; García-Mediavilla MV; Sánchez-Campos S (2019) Functional Interactions between Gut Microbiota Transplantation, Quercetin, and High-Fat Diet Determine Non-Alcoholic Fatty Liver Disease Development in Germ-Free Mice. Molecular Nutrition & Food Research , 63(8), p. e1800930 . ISSN: 1613-4125
- García-Monzón C; Petrov PD; Rey E; Marañón P; Pozo-Maroto ED; Guzmán C; Rodríguez de Cía J; Casado-Collado AJ; Vargas-Castrillón J; Saez A; Miquilena-Colina ME; Lo Iacono O; Castell JV; González-Rodríguez Á; Jover R (2018) Angiopoietin-like protein 8 is a novel vitamin D receptor target gene involved in non-alcoholic fatty liver pathogenesis. American Journal of Pathology , 188(12), pp. 2800 - 2810 . ISSN: 0002-9440
- López-Riera M; Conde I; Quintas G; Pedrola L; Zaragoza Á; Perez-Rojas J; Salcedo M; Benlloch S; Castell JV; Jover R (2018) Non-invasive prediction of NAFLD severity: a comprehensive, independent validation of previously postulated serum microRNA biomarkers. Scientific Reports , 8(1), pp. 10606-1 - 15 . ISSN: 2045-2322
- Fernández-Murga ML; Petrov PD; Conde I; Castell JV; Goméz-Lechón MJ; Jover R (2018) Advances in drug-induced cholestasis: Clinical perspectives, potential mechanisms and in vitro systems. Food and Chemical Toxicology , 120, pp. 196 - 212 . ISSN: 0278-6915
- Petrov PD; Fernández-Murga ML; López-Riera M; Goméz-Lechón MJ; Castell JV; Jover R (2018) Predicting drug-induced cholestasis: preclinical models. Expert Opinion On Drug Metabolism & Toxicology , 14(7), pp. 721 - 738 . ISSN: 1742-5255
- López-Riera M; Conde I; Tolosa L; Zaragoza A; Castell JV; Gómez-Lechón MJ; Jover R (2017) New microRNA biomarkers for drug-induced steatosis and their potential to predict the contribution of drugs to non-alcoholic fatty liver disease. Frontiers In Pharmacology , 8(3), pp. 1 - 12 . ISSN: 1663-9812
- Porras D; Nistal E; Martínez-Flórez S; Pisonero-Vaquero S; Olcoz JL; Jover R; González-Gallego J; García-Mediavilla MV; Sánchez-Campos S (2017) Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation. Free Radical Biology and Medicine , 102, pp. 188 - 202 . ISSN: 0891-5849
- Colleypriest BJ; Burke ZD; Griffiths LP; Chen Y; Yu WY; Jover R; Bock M; Biddlestone L; Quinlan JM; Ward SG; Mark Farrant J; Slack JM; Tosh D (2017) Hnf4α is a key gene that can generate columnar metaplasia in oesophageal epithelium. Differentiation , 93, pp. 39 - 49 . ISSN: 0301-4681
- Ramiro Jover (2017) Esteatosis y colestasis inducida por medicamentos: mecanismos y biomarcadores. Anales de la Real Academia Nacional de Farmacia , 83(2), pp. 284 - 293 . ISSN: 1697-4271
- Bozic M; Guzmán C; Benet M; Sánchez-Campos S; García-Monzón C; Gari E; Gatius S; Valdivielso JM; Jover R (2016) Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis. Journal of Hepatology , 65(4), pp. 748 - 757 . ISSN: 0168-8278
- Donato MT, López-Riera M, Castell JV, Gómez-Lechón MJ, Jover R. (2016) Both cholestatic and steatotic drugs trigger extensive alterations in the mRNA level of biliary transporters in rat hepatocytes: Application to develop new predictive biomarkers for early drug development. Toxicology Letters , 263, pp. 58 - 67 . ISSN: 0378-4274
- Tolosa L; Gómez-Lechón MJ; López S; Guzmán C; Castell JV; Donato MT; Jover R (2016) Human upcyte hepatocytes: Characterization of the hepatic phenotype and evaluation for acute and long-term hepatotoxicity routine testing. Toxicological Sciences , 152(1), pp. 214 - 229 . ISSN: 1096-6080
- Tolosa L; Gómez-Lechón MJ; Jiménez N; Hervás D; Jover R; Donato MT; (2016) Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis. Toxicology and Applied Pharmacology , 302, pp. 1 - 9 . ISSN: 0041-008X
- Benet M, Jover R, Bort R. (2015) Transfection of Primary Hepatocytes with Liver-Enriched Transcription Factors Using Adenoviral Vectors. Methods in Molecular Biology , 1250, pp. 213 - 221 . ISSN: 1064-3745
- Sangan CB; Jover R; Heimberg H; Tosh D (2015) In vitro reprogramming of pancreatic alpha cells towards a beta cell phenotype following ectopic HNF4α expression. Molecular and Cellular Endocrinology , 399, pp. 50 - 59 . ISSN: 0303-7207
- Benet M; Guzmán C; Pisonero-Vaquero S; García-Mediavilla MV; Sánchez-Campos S; Martínez-Chantar ML; Donato MT; Castell JV; Jover R (2015) Repression of the nuclear receptor small heterodimer partner by steatotic drugs and in advanced nonalcoholic fatty liver disease. Molecular Pharmacology , 87(4), pp. 582 - 594 . ISSN: 0026-895X
- Pisonero-Vaquero S; Martínez-Ferreras Á; García-Mediavilla MV; Martínez-Flórez S; Fernández A; Benet M; Olcoz JL; Jover R; González-Gallego J; Sánchez-Campos S (2015) Quercetin ameliorates dysregulation of lipid metabolism genes via the PI3K/AKT pathway in a diet-induced mouse model of nonalcoholic fatty liver disease. Molecular Nutrition & Food Research , 59(5), pp. 879 - 893 . ISSN: 1613-4125
- Moscardó A; Vallés J; Latorre A; Jover R; Santos MT (2015) The histone deacetylase sirtuin 2 is a new player in the regulation of platelet function. Journal Of Thrombosis And Haemostasis , 13(7), pp. 1335 - 1344 . ISSN: 1538-7933
- Marta Moreno-Torres; Annika Drees; Ernesto López-Pascual; Inger-Lise Steffensen; Anna Rapisarda; Thomas Luechtefeld; Guillermo Quintás; Eva Serrano-Candelas; Marina Garcia de Lomana; Domenico Gadaleta; Hubert Dirven; Mathieu Vinken; Ramiro Jover (2024) Novel clinical phenotypes, drug categorization, and outcome prediction in drug-induced cholestasis: Analysis of a database of 432 patients developed by literature review and machine learning support. Biomedicine & Pharmacotherapy , 174 . ISSN: 0753-3322
Publicacions en revistes
- DONATO MARTIN, MARIA TERESAPDI-Prof. Permanent Laboral Ppl
- Benet M; Guzmán C; Pisonero-Vaquero S; García-Mediavilla MV; Sánchez-Campos S; Martínez-Chantar ML; Donato MT; Castell JV; Jover R (2015) Repression of the nuclear receptor small heterodimer partner by steatotic drugs and in advanced nonalcoholic fatty liver disease. Molecular Pharmacology , 87(4), pp. 582 - 594 . ISSN: 0026-895X
- Tolosa L, López S, Pareja E, Donato MT, Myara A, Nguyen TH, Castell JV, Gómez-Lechón MJ. (2015) Human neonatal hepatocyte transplantation induces long-term rescue of unconjugated hyperbilirubinemia in the Gunn rat. Liver Transplantation , 21(6), pp. 801 - 811 . ISSN: 1527-6465
- Tolosa L, Gómez-Lechón MJ, Donato MT (2015) High-content screening technology for studying drug-induced hepatotoxicity in cell models. Archives of Toxicology , 89(7), pp. 1007 - 1022 . ISSN: 0340-5761
- Tolosa L, Carmona A, Castell JV, Gómez-Lechón MJ, Donato MT. (2015) High-content screening of drug-induced mitochondrial impairment in hepatic cells: effects of statins. Archives of Toxicology , 89(10), pp. 1847 - 1860 . ISSN: 0340-5761
- Donato MT, Tolosa L, Gómez-Lechón MJ (2015) Culture and functional characterization of human hepatoma HepG2 cells. Methods in Molecular Biology , 1250, pp. 77 - 93 . ISSN: 1064-3745
- Tolosa L, Donato MT, Gómez-Lechón MJ (2015) General cytotoxicity assessment by means of the MTT assay. Methods in Molecular Biology , 1250, pp. 333 - 348 . ISSN: 1064-3745
- García-Cañaveras JC; López S; Castell JV; Donato MT; Lahoz A (2016) Extending metabolome coverage for untargeted metabolite profiling of adherent cultured hepatic cells. Analytical and Bioanalytical Chemistry , 408(4), pp. 1217 - 1230 . ISSN: 1618-2642
- García-Cañaveras JC; Jiménez N; Gómez-Lechón MJ; Castell JV; Donato MT; Lahoz A (2015) LC-MS untargeted metabolomic analysis of drug-induced hepatotoxicity in HepG2 cells. Electrophoresis , 36(18), pp. 2294 - 2302 . ISSN: 0173-0835
- Tolosa L; Gómez-Lechón MJ; Jiménez N; Hervás D; Jover R; Donato MT; (2016) Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis. Toxicology and Applied Pharmacology , 302, pp. 1 - 9 . ISSN: 0041-008X
- García-Cañaveras JC; Castell JV; Donato MT; Lahoz A (2016) A metabolomics cell-based approach for anticipating and investigating drug-induced liver injury. Scientific Reports , 6, p. 27239 . ISSN: 2045-2322
- Tolosa L; Gómez-Lechón MJ; López S; Guzmán C; Castell JV; Donato MT; Jover R (2016) Human upcyte hepatocytes: Characterization of the hepatic phenotype and evaluation for acute and long-term hepatotoxicity routine testing. Toxicological Sciences , 152(1), pp. 214 - 229 . ISSN: 1096-6080
- Gómez-Lechón MJ; Tolosa L; Donato MT (2016) Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs. Journal of Applied Toxicology , 36(6), pp. 752 - 768 . ISSN: 0260-437X
- Donato MT, López-Riera M, Castell JV, Gómez-Lechón MJ, Jover R. (2016) Both cholestatic and steatotic drugs trigger extensive alterations in the mRNA level of biliary transporters in rat hepatocytes: Application to develop new predictive biomarkers for early drug development. Toxicology Letters , 263, pp. 58 - 67 . ISSN: 0378-4274
- Gómez-Lechón MJ; Tolosa L; Donato MT (2017) Upgrading HepG2 cells with adenoviral vectors that encode drug-metabolizing enzymes: Application for Drug hepatotoxicity testing. Expert Opinion On Drug Metabolism & Toxicology , 13(2), pp. 137 - 148 . ISSN: 1742-5255
- Donato MT; Gómez-Lechón MJ; Tolosa L (2017) Using high-content screening technology for studying drug-induced hepatotoxicity in preclinical studies. Expert Opinion On Drug Discovery , 12(2), pp. 201 - 211 . ISSN: 1746-0441
- Donato MT (2017) Hepatotoxicidad idiosincrásica por fármacos: promesas y limitaciones de las estrategias in vitro. Anales de la Real Academia Nacional de Farmacia , 83(2), pp. 268 - 283 . ISSN: 1697-4271
- García-Cañaveras JC, Peris-Díaz MD, Alcoriza-Balaguer MI, Cerdán-Calero M, Donato MT, Lahoz A (2017) A lipidomic cell-based assay for studying drug-induced phospholipidosis and steatosis. Electrophoresis , 38(18), pp. 2331 - 2340 . ISSN: 0173-0835
- Tolosa L, Gómez-Lechón MJ, Donato MT (2017) A Multi-Parametric Fluorescent Assay for the Screening and Mechanistic Study of Drug-Induced Steatosis in Liver Cells in Culture. Current Protocols in Toxicology , 72, pp. 14.15.1 - 14.15.11 . ISSN: 1934-9254
- Pérez CL; Donato MT; Hernández I; Paz Lopes MT; Marrero E; Herrera JA; Gómez-Lechón MJ; Rodeiro I (2017) In vitro modulation of the cytochrome P450 and ABCB1/P-glycoprotein activities of the aqueous extract of Allophylus cominia (L) Sw. leaves. Drug Metabolism and Personalized Therapy , 32(4), pp. 201 - 220 . ISSN: 2363-8907
- Pelechá M, Gómez-Lechón MJ, Tolosa L, Donato MT (2017) Hepatocitos Humanos Upcytes como modelo experimental in vitro para el estudio del daño hepático inducido por fármacos a largo plazo. Revista de Toxicología , 34(2), pp. 109 - 117 . ISSN: 0212-7113
- Rodeiro I, Hernández I, Herrera JA, Riera M, Donato MT, Tolosa L, González K, Ansoar Y, Gómez-Lechón MJ, Vanden Berghe W, Lopes M (2018) Assessment of the cytotoxic potential of an aqueous-ethanolic extract from Thalassia testudinum angiosperm marine grown in the Caribbean Sea. Journal of Pharmacy and Pharmacology , 70(11), pp. 1553 - 1560 . ISSN: 0022-3573
- Donato MT, Tolosa L (2019) Stem-cell derived hepatocyte-like cells for the assessment of drug-induced liver injury. Differentiation , 10622, pp. 15 - 22 . ISSN: 0301-4681
- Tolosa L, Jiménez N, Pelechá M, Castell JV, Gómez-Lechón MJ, Donato MT (2019) Long-term and mechanistic evaluation of drug-induced liver injury in Upcyte human hepatocytes. Archives of Toxicology , 93(2), pp. 519 - 532 . ISSN: 0340-5761
- Tolosa L; Jiménez N; Pérez G; Castell JV; Gómez-Lechón MJ; Donato MT (2018) Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury. Archives of Toxicology , 92(1), pp. 383 - 399 . ISSN: 0340-5761
- Donato MT, Bolonio M, Cabezas E, Pelechá M, Pareja E, Domènech A, Castell JV, Gómez-Lechón MJ, Tolosa L (2020) Improved in vivo efficacy of clinical-grade cryopreserved human hepatocytes in mice with acute liver failure. Cytotherapy , 22(2), pp. 114 - 121 . ISSN: 1465-3249
- Donato MT, Tolosa L (2021) Application of high-content screening for the study of hepatotoxicity: Focus on food toxicology. Food and Chemical Toxicology , 147, p. 111872 . ISSN: 0278-6915
- Donato MT, Tolosa L (2021) High-Content Screening for the Detection of Drug-Induced Oxidative Stress in Liver Cells. Antioxidants , 10(1), p. 106 . ISSN: 2076-3921
- Pelechá M; Villanueva-Badenas E; Timor-Lopez E; Donato MT; Tolosa L (2021) Cell models and omics techniques for the study of non-alcoholic fatty liver disease: focusing on stem cell-derived cell models. Antioxidants , 11(1), p. 86 . ISSN: 2076-3921
- Donato MT; Jiménez N; Pelechá M; Tolosa L (2022) Oxidative-stress and long-term hepatotoxicity: comparative study in Upcyte human hepatocytes and hepaRG cells. Archives of Toxicology , 96(4), pp. 1021 - 1037 . ISSN: 0340-5761
- Donato MT; Gallego-Ferrer G; Tolosa L (2022) In Vitro Models for Studying Chronic Drug-Induced Liver Injury. International Journal Of Molecular Sciences , 23(19), p. 11428 . ISSN: 1661-6596
- Villanueva-Bádenas E, Donato MT; Tolosa L (2023) Mechanistic understanding of idiosyncratic drug-induced hepatotoxicity using co-cultures of hepatocytes and macrophages. Antioxidants . ISSN: 2076-3921
- Rodriguez-Fernandez J; Garcia-Legler E; Villanueva-Badenas E: Donato MT; Gomez-Ribelles JL; Salmeron-Sanchez M; Gallego-Ferrer G; Tolosa L. (2023) Primary human hepatocytes-laden scaffolds for the treatment of acute liver failure. Biomaterials Advances . ISSN: 2772-9516
- Rodríguez-Fernandez J; Donato MT; Gallego-Ferrer G; Tolosa L. (2024) Challenges and perspectives of liver tissue engineering: From cell therapy to bioprinting. International Journal of Bioprinting , 10(3), pp. 116 - 140 . ISSN: 2424-8002
Publicacions en revistes
- Gómez-Lechón MJ, Tolosa L, Donato MT, (2015). Safety risk assessment of hepatotoxicity in early phase of drug development. Hepatotoxicity: Symptoms, management and Health implications. . (pp. 123 - 159). .
- Donato M.T., Pelechá M., Tolosa L., (2021). Induced pluripotent stem cells in liver disease. Advances in Stem Cell Biology. Recent Advances in iPSCs for Therapy, Volume 3. . (pp. 225 - 250). .
Altres Publicacions
- MORENO TORRES, MARTAPI-Invest Cont Ramon y Cajal
- Guillermo Quintás; José V Castell; Marta Moreno-Torres. 2023 The assessment of the potential hepatotoxicity of new drugs by in vitro metabolomics Frontiers In Pharmacology Volum 14.
- Teresa Martínez-Sena; Erika Moro; Marta Moreno-Torres; Guillermo Quintás; Jan Hengstler; José V Castell. 2023 Metabolomics-based strategy to assess drug hepatotoxicity and uncover the mechanisms of hepatotoxicity involved Archives of Toxicology Número 97.
- Isabel Ten-Doménech; MariMerce Cascant Vilaplana; Víctor Navarro Esteve; Birgit Felderer; Alba Moreno-Giménez; Iván Rienda ;María Gormaz; Marta Moreno-Torres; David Pérez-Guaita; Guillermo Quintás; Julia Kuligowski. 2023 Metabolomic Diversity of Human Milk Cells over the Course of Lactation - A Preliminary Study Nutrients Volum 15. Número 5.
- Isabel Ten-Doménech; Marta Moreno-Torres; Juan Daniel Sanjuan-Herráez; David Pérez-Guaita; Guillermo Quintás; Julia Kuligowski. 2023 Analysis of longitudinal metabolomic data using multivariate curve resolution-alternating least squares and pathway analysis Chemometrics and Intelligent Laboratory Systems Número 232.
- R. Jover, P. Soluyanova, E. Moro-Castaño, M. Moreno-Torres, A.V. Marco-Hernández, M. Tomas-Vila, J.V. Castell. 2022 SOC-V-11 New serum miRNA biomarkers to predict liver steatosis by valproic acid in paediatric epileptic patients Toxicology Letters Volum 368. Número 2.
- Marta Moreno-Torres; Carla Guzmán; Petar D. Petrov; Ramiro Jover. 2022 Valproate and Short-Chain Fatty Acids Activate Transcription of the Human Vitamin D Receptor Gene through a Proximal GC-Rich DNA Region Containing Two Putative Sp1 Binding Sites Nutrients Volum 14. Número 13.
- Marta Moreno-Torres; Guillermo Quintás; José V. Castell. 2022 The Potential Role of Metabolomics in Drug-Induced Liver Injury (DILI) Assessment Metabolites Volum 12. Número 6.
- Isabel Ten-Doménech; Victoria Ramos-Garcia; Marta Moreno-Torres; Anna Parra-Llorca; María Gormaz; Máximo Vento; Julia Kuligowski; Guillermo Quintás. 2022 The effect of Holder pasteurization on the lipid and metabolite composition of human milk Food Chemistry Volum 384.
- Diana Horta; Marta Moreno-Torres, María José Ramírez-Lázaro, Sergio Lario, Julia Kuligowski, Juan Daniel Sanjuan-Herráez, Guillermo Quintas*, Albert Villoria, and Xavier Calvet*. 2020 Analysis of the Association between Fatigue and the Plasma Lipidomic Profile of Inflammatory Bowel Disease Patients Journal of Proteome Research Volum 20. Número 1.
- Fernando Martínez-Montañés; Albert Casanovas; Richard R Sprenger; Magdalena Topolska; David L Marshall; Marta Moreno-Torres; Berwyck L J Poad; Stephen J Blanksby; Martin Hermansson; Ole N Jensen; Christer S Ejsing. 2020 Phosphoproteomic analysis accross the yeast life cycle reveals homeostatic regulation of fatty acyl chain-length by phosphorylation of the fatty acid synthase complex Cell Reports Volum 32. Número 6.
- Isabel Ten-Doménech; Teresa Martínez-Sena; Marta Moreno-Torres; Juan Daniel Sanjuan-Herráez; José V Castell; Anna Parra-Llorca; Máximo Vento; Guillermo Quintás; Julia Kuligowski. 2020 Comparing Targeted vs. Untargeted MS2 Data-Dependent Acquisition for Peak Annotation in LC-MS Metabolomics Metabolites Volum 10. Número 4.
- Elahu G Sustarsic; Tao Ma; Matthew D Lynes; Michael Larsen; Iuliia Karavaeva; Jesper F Havelund; Carsten H Nielsen; Mark P Jedrychowski; Marta Moreno-Torres; Morten Lundh; Kaja Plucinska; Naja Z Jespersen; Trisha J Grevengoed; Barbara Kramar; Julia Peics; Jakob B Hansen; Farnaz Shamsi; Isabel Forss; Ditte Neess; Susanne Keipert; Jianing Wang; Katharina Stohlmann; Ivan Brandslund; Cramer Christensen; Marit E Jørgensen; Allan Linneberg; Oluf Pedersen; Michael A Kiebish; Klaus Qvortrup; Xianlin Han; Bente Klarlund Pedersen; Martin Jastroch; Susanne Mandrup; Andreas Kjær; Steven P Gygi; Torben Hansen; Matthew P Gillum; Niels Grarup; Brice Emanuelli; Søren Nielsen; Camilla Scheele; Yu-Hua Tseng; Nils J Færgeman; Zachary Gerhart-Hines. 2018 Cardiolipin synthesis in brown and beige fat mitochondria is essential for systemic energy homeostasis Cell Metabolism Volum 28. Número 3.
- Marta Moreno-Torres; Malika Jaquenoud; Marie-Pierre Péli-Gulli; Raffaele Nicastro; Claudio De Virgilio. 2017 TORC1 coordinates the conversion of Sic1 from a target to an inhibitor of cyclin-CDK-Cks1 Cell Discovery Número 17012.
- Marta Moreno-Torres; Malika Jaquenoud; Claudio De Virgilio. 2015 TORC1 controls G1-S cell cycle transition in yeast via Mpk1 and the greatwall kinase pathway Nature Communications Volum 6. Número 8256.
- Marta Moreno Torres; José Ramón Murguía. 2011 Between Scylla and Charibdis: eIF2alpha kinases as targets for cancer chemotherapy Clinical & Translational Oncology Volum 13.
- Pérez-Guaita D; Moreno-Torres M; Jover R; Pareja E; Lendl B; Kuligowski J; Quintás G; Castell JV. 2020 Toward rapid screening of liver grafts at the operating room using mid-infrared spectroscopy Analytical Chemistry Volum 92. Número 21.
- Isabel Ten-Doménech; Marta Moreno-Torres; José Vicente Castell; Guillermo Quintás; Julia Kuligowski. 2021 Extracting consistent biological information from functional results of metabolomic pathway analysis using the Mantel's test Analytica Chimica Acta Volum 1187.
- Marta Moreno-Torres; Guillem García-Llorens; Erika Moro; Rebeca Méndez; Guillermo Quintás; José Vicente Castell. 2021 Factors that influence the quality of metabolomics data in in vitro cell toxicity studies: a systematic survey Scientific Reports Volum 11. Número 1.
- Marta Moreno-Torres; Manoj Kumar; Guillem García-Llorens; Guillermo Quintás; Tine Tricot; Ruben Boon; Laia Tolosa; Burak Toprakhisar; Francois Chesnais; Catherine Verfaillie; José V Castell. 2022 A Novel UPLC-MS Metabolomic Analysis-Based Strategy to Monitor the Course and Extent of iPSC Differentiation to Hepatocytes Journal of Proteome Research Volum 21. Número 3.
- Alessandro Agostini, Laura Mondragón, Andrea Bernardos, Ramón Martínez-Máñez,M. Dolores Marcos, Félix Sancenón, Juan Soto, Ana Costero, Cristina Manguan-García, Rosario Perona, Marta Moreno-Torres, Rafael Aparicio-Sanchis, José Ramón Murguía. 2012 Targeted Cargo Delivery in Senescent Cells Using Capped Mesoporous Silica Nanoparticles Angewandte Chemie Volum 51.
- Rienda I; Ten-Doménech I; Moro E; Moreno-Torres M; Pérez-Rojas J; Pareja E; Pérez-Rubio Á; Trullenque R; Jover R; Lendl B; Pérez-Guaita D; Kuligowski J; Castell JV; Quintás G. 2023 Enhancing the accuracy of mid-infrared spectroscopy liver steatosis quantification using digital image analysis as reference Analyst Volum 148. Número 13.
- Isabel Ten-Doménech, Ivan Rienda, Judith Pérez-Rojas, Eugenia Pareja, Marta Moreno-Torres, José V Castell, Bernhard Lendl, Andreas Schwaighofer, David Pérez-Guaita, Julia Kuligowski, Guillermo Quintás. 2023 Progress and challenges of mid-infrared spectroscopy for liver characterization focusing on steatosis, fibrosis and cancer Applied Spectroscopy Reviews Volum 59. Número 4.
- Julia Kuligowski; Álvaro Pérez-Rubio; Marta Moreno-Torres; Polina Soluyanova; Judith Pérez-Rojas; Iván Rienda; David Pérez-Guaita; Eugenia Pareja; Ramón Trullenque-Juan; José V. Castell; Marcha Verheijen; Florian Caiment; Ramiro Jover; Guillermo Quintás. 2024 Cluster-Partial Least Squares (c-PLS) regression analysis: Application to miRNA and metabolomic data Analytica Chimica Acta Volum 1286.
- M. Moreno Torres; E. Lopez Pascual; A. S. Rapisarda; G. López; T. Bozada Jr; J. Jiang; J. van Ertvelde; I.-L. Steffensen; B. Lindeman; T. Luechtefeld; H. Dirven; M. Vinken; R. Jover. 2023 OS02 | Short Orals Session 2 OS02-01 Novel clinical phenotypes and chemical classifications in drug-induced cholestasis: analysis of a database of 390 patients developed by collaborative literature review and machine learning support Toxicology Letters Volum 384. Número Supplement 1.
- T. Martinez-Sena; E. Moro; M. Moreno-Torres; G. Quintas; J. Hengstler; R. Jover; J. V. Castell Ripoll. 2023 P16-55. Using Metabolomics to Uncover Ontogeny of Drug-Induced Hepatotoxicity and Underlying AOP Mechanisms Toxicology Letters Volum 384. Número supplement 1.
- Marta Moreno-Torres; Annika Drees; Ernesto López-Pascual; Inger-Lise Steffensen; Anna Rapisarda; Thomas Luechtefeld; Guillermo Quintás; Eva Serrano-Candelas; Marina Garcia de Lomana; Domenico Gadaleta; Hubert Dirven; Mathieu Vinken; Ramiro Jover. 2024 Novel clinical phenotypes, drug categorization, and outcome prediction in drug-induced cholestasis: Analysis of a database of 432 patients developed by literature review and machine learning support Biomedicine & Pharmacotherapy Volum 174.
- Marta Moreno-Torres; Guillermo Quintás; Teresa Martínez-Sena; Ramiro Jover; José V. Castell. 2024 Exploring Individual Variability in Drug-Induced Liver Injury (DILI) Responses through Metabolomic Analysis International Journal Of Molecular Sciences Volum 25. Número 5.
- Iván Rienda; Marta Moreno-Torres; Erika Moro; Judith Pérez-Rojasa; Eugenia Pareja; Álvaro Pérez-Rubio; Nuria Peris; José Angel Díez Ares; Ramón Trullenque; Ramiro Jover; Bernhard Lendlf; Julia Kuligowskig; José V. Castell; Guillermo Quintás. 2024 Assessing ATR-FTIR spectroscopy for steatosis quantification in liver biopsies in a long-duration cross-sectional study Microchemical Journal Volum 198.
- Julia Kuligowski, Marta Moreno-Torres, Guillermo Quintás. 2024 Improving insights from metabolomic functional analysis combining multivariate tools Analytica Chimica Acta
- María Payá-García, Gemma M. Rodríguez-Muñiz, Marta Moreno-Torres, Erika Moro, Lucas Santos-Juanes, Ana M. Amat, Salvador Gil, José V. Castell, Virginie Lhiaubet-Vallet, Miguel A. Miranda. 2025 The acyl glucuronide of 2-(4-diethylamino-2-hydroxybenzoyl)benzoic acid: Synthesis, structural assignment, occurrence as a human phase II metabolite of Uvinul® A Plus and acute aquatic toxicity Chemosphere
Publicacions en revistes
- Marta Moreno-Torres; Jesper F Havelund; Nils J Faergeman, (2019). LC-MS Analyses of Lipid Species in Skeletal Muscle Cells and Tissue. Methods in Molecular Biology: Myogenesis. . Volum. 1889 . (pp. 213 - 229). .
Altres Publicacions
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