SUMOylation modulates eIF5A activities in both yeast and pancreatic ductal adenocarcinoma cells
- Autors: Seoane R, Lama-Díaz T, Romero AM, El Motiam A, Martínez-Férriz A, Vidal S, Bouzaher YH, Blanquer M, Tolosa RM, Castillo Mewa J, Rodríguez MS, García-Sastre A, Xirodimas D, Sutherland JD, Barrio R, Alepuz P, Blanco MG, Farràs R, Rivas C*. (2024).
- Tipus de publicació: Article
- URL Publicacio: SUMOylation modulates eIF5A activities in both yeast and pancreatic ductal adenocarcinoma cells
- Titol publicació (nom del llibre o de la revista): Cellular & Molecular Biology Letters. Num.29, Article number: 15 (2024)
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Resum:
The eukaryotic translation initiation protein eIF5A is a highly conserved and essential factor that plays a critical role in different physiological and pathological processes including stress response and cancer. Different proteomic studies suggest that eIF5A may be a small ubiquitin-like modifier (SUMO) substrate, but whether eIF5A is indeed SUMOylated and how relevant is this modification for eIF5A activities are still unknown.
PMID: 38229033
*corresponding author
DOI: 10.1186/s11658-024-00533-5
