23 July 2021: From this historical date, AlphaFold DB will provide open access to protein structure predictions for the human proteome and 20 other key organisms.
is an AI system
developed by DeepMind
that predicts the 3D structure of a protein from its amino acid sequence. It regularly achieves accuracy competitive with experiments. The information released today includes over 360000
atomic resolution structuresr; about double than the total number of experimental structures of macromolecules available to date via
(of which only ~100000 correspond to unique proteins). In coming months, the AlphaFold Protein Structure Database
plans to expand 'to cover a large proportion of all catalogued proteins'
(over 100 million!
In an article in the journal Structure Stephen Burley and Helen Berman
name this event A cornerstone for artificial intelligence approaches to protein structure prediction
. We believe that the latest achievements of AlphaFold
, able to accurately predict the structures of proteins in numbers that reach the complete proteome of organisms, are only comparable with the scientific revolution in the 50's
of the 20th
century, represented by the experimental elucidation of the structure of the DNA double helix (Rosalind Franklin
together with Watson, Crick and Wilkins
) and first structures of globular proteins (Perutz and Kendrew
). The AlphaFold DB
has been jointly developed by DeepMind
and the EMBL's European Bioinformatics Institute (EMBL-EBI)
. It will undoubtedly boost our understanding of biology at a molecular level and quickly become an invaluable new tool to accelerate scientific research in all life and molecular science fields.
María Zambrano postdoc grants
Young doctors of any field and any nationality can now apply to these fellowships. Applicants need to contact first to a research group of the University of Valencia
which must agree to support the applicant's project. Eligible cadidates must have at least two years of postdoc experience in a research center different from the University of Valencia and also different from the University where they made their PhD. In addition, they must be working at the moment outside Spain. The contracts will be offered for 1-3 years
. The deadline
for applications is September 8th 2021
As part of a new package
that intends to modernise Spanish public Universities by suppoting requalification of their scientists, the Spanish Government has just approved María Zambrano postdoc grants
. This is a talent-attraction pluri-annual program for the 2021-2023 period
that targets young researchers of any nationality with at least two years postdoc experience outside Spain.
We offer one Internship Contract for a Master's Student
(undergraduate) with a duration of 4 months
within the current academic year. This will include support and supervision to perform your master's project
and a salary
of €400 per month. Candidates must hold a degree in Chemistry, Physics, Biochemistry or Biotechnology, completed during the latest academic year, with an average mark of at least 8.0 over 10. They must be ready to enroll in a master's study of the Universitat de València
in the course 2020/21. See the Positions page
for more details.
4 June 2020: Predoctoral position to work in a new project.
NOTE: Suitable candidates for this project have already been found.
aims to implement optical control
for the insertion
of hydrophobic protein fragments in lipid membranes
, to better understand these relevant processes at the molecular level. The candidate will use chemical
strategies to achieve this goal, including: the synthesis of light-sensitive membrane protein fragments, their characterization by static and time-resolved spectroscopies, and the development of novel applications based on the achieved results.
Monumental review, just published by Victor
14 May 2020: Chem Rev (2020) 120: 3466-3576.
Infrared Difference Spectroscopy
, applied to proteins or other biomolecules, is a very powerful methodology that allows us to discover detailed structural and dynamical aspects
with high temporal resolution and with specificity of chemical groups. In terms of the quality and quantity of information that it provides, it has nothing to envy from other, more 'popular', spectroscopies, like NMR. Yet, the tremendous capabilities of IDS
in Biophysics are still not widely known or used by most researchers. This probably has to do with the sophistication of specific pieces of hardware
that are required for some of these applications, which are normally not available in most laboratories, and with the high level of expertise that is needed to plan, run and interpret the IDS
experiments. Víctor has used his many years of experience in all of that to gather and summarize the most important recent discoveries made by using IDS
specially in he field of membrane proteins
. The result is a large and very thorough account just published in Chemical Reviews
Eduardo Santamaría visits our lab
22 Oct 2018
He gave a seminar (Wed. 24 Oct) entitled Design and synthesis of photomodulable peptides for biological applications
. Eduardo works in Diego Sampedro's group
, at the University of La Rioja
. They collaborate with us in the design, synthesis and characterization of biologically active peptides coupled to photoswitches, closely in connection to one of our projects
Publication in JACS by Victor
8 Aug 2018: Clues about how channelrhodopsin-2 desensitizates
The work is entitled Photoexcitation of the P4480 State Induces a Secondary Photocycle That Potentially Desensitizes Channelrhodopsin-2
and is a collaboration with the groups of Joachim Heberle
and Ramona Schlesinger
(Free University, Berlin).
Our Explora-Science project was selected
26 Jun 2018
Explora-Science, founding high-risk high-gain projects, has approved our project entitled Vibrational pH-sensors with sub-microsecond and sub-micrometer resolution
. Soon we will start looking for PhD candidates. Find here
more about the project
Positions available !
25 Jan 2018: We look for PhD and PostDoc candidates
The positions are linked to the project Optical control of folding, membrane insertion and biological activity of photoswitchable hydrophobic peptides
, founded by the Spanish Ministry of Economy and Competitiveness. Candicates will be selected at the end of March
and expected to start by June 2018
. See the PhD
call for details on the application procedure
Victor just published in Nature Communications
22 Jan 2018: A collaborative work about protonated water clusters in proteins
The work is entitled Orientation of non-spherical protonated water clusters revealed by infrared absorption dichroism
and is a collaboration between the experimental group of Joachim Heberle
and the theoretical group of Roland R. Netz
(Free University, Berlin).
Our new website is up and running!
22 Jan 2018: You are seeing it now!
Our group was recently registered at the University of Valencia with its new name Biofísica de Membranas
. Apart from the standard website
provided by the University, we have 'coded' a new one.
Víctor's new publication is available
05 Dec 2017: Just published in PNAS
The work is entitled pH-sensitive vibrational probe reveals a cytoplasmic protonated cluster in bacteriorhodopsin
and is a collaboration with the group of Joachim Heberle
(Free University, Berlin).