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Description

The purposes of our projects are to explore the mechanistic principles of membrane protein insertion, folding and assembly into lipid membranes and to investigate the factors that determine membrane protein stability. Our interest focuses on protein/protein-interactions relevant for maintaining tertiary and quaternary structure and function of integral membrane protein complexes. More specifically, we investigate the role of membrane-spanning domains, i.e. of transmembrane segments. The study is performed through an exhaustive investigation of glycophorin A as a model dimeric membrane protein, and from the knowledge of this system we try to understand the structure and function of the pulmonary surfactant SP-C protein, an extremely hydrophobic membrane protein.

On the other hand, we are interested in the cell-to-cell transport of plant virus. This transport process is mediated by specialized viral movement proteins, which in same cases are membrane proteins, that drive the viral genome to the cellular membrane in order to be transported into neighbouring uninfected host cells through the plasmodesmal channel. We are currently investigating the targeting and the insertion mechanisms of these viral membrane proteins into the biological membranes.

Goals CT

Our Group focuses on basic aspects of the folding and assembly of proteins in lipid membranes.

Research lines
  • Membrane Protein assembly

    Our goal is to explore the mechanistic principles of membrane protein insertion, folding and assembly into lipid membranes and to investigate the factors that determine membrane protein stability.

  • Membrane Protein proteomics

    Overexpression of membrane proteins is often essential for structural and functional studies, but yields are frequently too low. Therefore, we investigate the consequences of overexpression of different membrane proteins in search for new components to improve such yields.

Management
  • MINGARRO MUÑOZ, ISMAEL
  • PDI-Catedratic/a d'Universitat
  • Dega/Degana / Director/a Ets
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Members
  • GARCIA MURRIA, MARIA JESUS
  • PDI-Contractat/Da Doctor/A
  • Secretari/a de Facultat/Secretari/a Ets
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  • SANCHEZ DEL PINO, MANUEL MATEO
  • PDI-Titular d'Universitat
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Scientific production by UV researcher
  • MINGARRO MUÑOZ, ISMAEL
    PDI-Catedratic/a d'UniversitatDega/Degana / Director/a Ets
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  • GARCIA MURRIA, MARIA JESUS
    PDI-Contractat/Da Doctor/ASecretari/a de Facultat/Secretari/a Ets
    Expandir
  • SANCHEZ DEL PINO, MANUEL MATEO
    PDI-Titular d'Universitat
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Associated structure
Institute of Biotechnology and Biomedicine (BIOTECMED)
Contact group details
Research Group on Membrane Proteins (MemProt Lab)

Burjassot/Paterna Campus

C/ Doctor Moliner, 50

46100 Burjassot (Valencia)

+34 963 543 796

Geolocation

www.uv.es/membrana

ismael.mingarro@uv.es

Contact people
  • MINGARRO MUÑOZ, ISMAEL
  • PDI-Catedratic/a d'Universitat
  • Dega/Degana / Director/a Ets
View details