• Castellano
  • Valencià

University of València COVID Scientific and Technological Offer COVID Scientific and Technological Offer Logo del portal

The group of Dr. Mar Siles Lucas at IRNASA handles in vitro and in vivo models of parasitic-host interactions with Fasciola hepatica, which could be used to evaluate the potential of the parasite and its molecules to modulate relevant entry routes and inflammation routes in COVID-19. On one hand, this parasite has shown influence on the expression of endocytosis-related molecules (e.g. clathrins) on in vitro mouse epithelial cells, routes that may be relevant for SARS-Cov-2 entry to human cells. In addition, F. hepatica results in a modified Th2 response without the inflammatory component in its host in vivo, and this modulation may result in a controlled inflammatory response to COVID-19.
Description

Title: COVID-19: anti-infectious and anti-inflammatory action of immunomodulatory parasite molecules in a safe-to-use synthetic format

Research groups: Viral Biology and Virus Experimental Evolution

The group of Dr. Mar Siles Lucas at IRNASA handles in vitro and in vivo models of parasitic-host interactions with Fasciola hepatica, which could be used to evaluate the potential of the parasite and its molecules to modulate relevant entry routes and inflammation routes in COVID-19. On one hand, this parasite has shown influence on the expression of endocytosis-related molecules (e.g. clathrins) on in vitro mouse epithelial cells, routes that may be relevant for SARS-Cov-2 entry to human cells. In addition, F. hepatica results in a modified Th2 response without the inflammatory component in its host in vivo, and this modulation may result in a controlled inflammatory response to COVID-19.

Total amount: 100.000 €

CRUE - Universidades Españolas Consejo Superior de Investigaciones Científicas (CSIC) Banco Santander

Non-UV principal researchers

Mar Siles Lucas (Instituto de Recursos Naturales y Agrobiología de Salamanca, IRNASA)

Non-UV participating researchers

  • Ron Geller, Rafael Sanjuan (Universitat de València)
  • Prof. José Pérez, Prof. Álvaro Martínez (Universidad de Córdoba)
  • John Pius Dalton (National University of Ireland, Galway)

Start date
2020 May
End date
2021 May
Funding agencies:

CSIC-CRUE-Santander

Partners:

  • Universitat de València
  • Instituto de Recursos Naturales y Agrobiología de Salamanca (IRNASA)
  • Universidad de Córdoba
  • NUI Galway