foto Rosario Gil Garcia
PDI Titular d'Universitat
Director/a Titulacion Master Oficial
Knowledge area: GENETICS
Department: Genetics
Grup de Genètica Evolutiva, despatx 3.2.3 Institut de Biologia Integrativa de Sistemes (I2SysBio), Parc Científic de la Universitat de València C/ Catedràtic José Beltrán, 2 46980 Paterna (València)
(9635) 43824

PhD in Pharmacy from the Universitat de València (1991), I did a postdoctoral stay of more than 3 years at the Eccles Institute of Human Genetics (University of Utah, USA). After 15 years dedicated to the study of the yeast Saccharomyces cerevisiae from almost any point of view (study of the cell wall, model system for the study of human tumor suppressor genes, analysis of stress and contamination in brewing yeast or global gene expression in wine yeasts), I joined the field of bacterial genomic evolution, in which I have been working since 2001 as a member of the Evolutionary Genetics group of the Universitat de València, where I am currently Associate Professor of Genetics.

I do my research at the Institute for Integrative Systems Biology (I2SysBio), a joint collaborative center Universitat de València - CSIC. My current work focuses on the study of the genome of endosymbiotic bacteria, which live inside specialized cells of  insect with restricted diets (such as aphids, weevils or mealybugs), to understand the relationship between these bacteria and their hosts, the bacterial genome reduction in these conditions, and its consequences for the inferred metabolic network. As a complement to these studies, I am also involved in studies on the definition of the minimal genome, essential for the maintenance of a living cell, and its implications in the field of Synthetic Biology.

Current research projects

Synthetic and systems biology of endo and exosymbionts for the intervention on eukaryotic hosts. BFU2015-64322-C2-1-R (co-financed by FEDER funds and Ministerio de Economía y Competitividad, Spain)

Evolution, experimental epidemiology and therapeutic engineering of the microbiota. PROMETEO/2018/133 (Generalitat Valenciana, Spain).

Communication role on perception and beliefs of EU Citizens about Science (CONCISE). 824537 (European Union H2020)


Recent and selected publications

Gil, R., C. Vargas-Chavez, S. López-Madrigal, D. Santos-García, A. Latorre, A. Moya (2018). Tremblaya phenacola PPER: An evolutionary beta-gammaproteobacterium collage. ISME J. 12:124-135. doi: 10.1038/ismej.2017.144

López-Madrigal, S., R. Gil (2017). Et tu, Brute? Not even intracellular mutualistic symbionts escape horizontal gene transfer. Genes 8:247. doi: 10.3390/genes8100247

Lloréns-Rico, V., J. Cano, T. Kamminga, R. Gil, A. Latorre, W. H. Chen, P. Bork, J. I. Glass, L. Serrano, M. Lluch-Senar (2016). Bacterial antisense RNAs are mainly the product of transcriptional noise. Sci. Adv. 2:e1501363. doi: 10.1126/sciadv.1501363

Klein, A., L. Schrader, R. Gil, A. Manzano-Marín, L. Flórez, D. Wheeler, J. H. Werren, A. Latorre, J. Heinze, M. Kaltenpoth, A. Moya, J. Oettler (2016). A novel intracellular mutualistic bacterium in the invasive ant Cardiocondyla obscurior. ISME J. 10:376-388. doi: 10.1038/ismej.2015.119

Martínez-Díaz, V., A. Latorre, R. Gil (2016). Seasonal changes in the endosymbiotic consortia of aphids from the genus Cinara. Microbes Environ. 31:137-144. doi: 10.1264/jsme2.ME15118

Gil, R., J. Peretó (2015). Small genomes and the difficulty to define minimal translation and metabolic machineries. Front. Ecol. Evol. 3:123. doi: 10.3389/fevo.2015.00123

López-Madrigal, S., A. Latorre, A. Moya, R. Gil (2015). The link between independent acquisition of intracellular gamma-endosymbionts and concerted evolution in Tremblaya princeps. Front. Microbiol. 6:642. doi: 10.3389/fmicb.2015.00642

Gil, R. (2014). The minimal gene-set machinery. In Encyclopedia of Molecular Cell Biology and Molecular Medicine: Synthetic Biology, 2nd edition. Meyers RA (ed.). Wiley-VCH Verlag GmbH & Co. pp. 1-36. doi: 10.1002/3527600906.mcb.20130079

López-Madrigal, S., A. Beltrà, S. Resurrección, A. Soto, A. Latorre, A. Moya, R. Gil (2014). Molecular evidence for ongoing complementarity and horizontal gene transfer in endosymbiotic systems of mealybugs. Front. Microbiol. 5:449. doi: 10.3389/fmicb.2014.00449

Oakeson, K. F.*, R. Gil*, A. L. Clayton, D. M. Dunn, A. C. von Niederhausern, C. Hamil, A. Aoyagi, B. Duval, A. Baca, F.J. Silva, A. Vallier, D. G. Jackson, A. Latorre, R. B. Weiss, A. Heddi, A. Moya, C. Dale (2014). Genome degeneration and adaptation in a nascent stage of symbiosis. Genome Biol. Evol. 6:76-93. doi: 10.1093/gbe/evt210 *Equal contribution.

López-Madrigal, S., A. Latorre, M. Porcar, A. Moya, R. Gil (2013). Mealybugs nested endosymbiosis: going into the ‘matryoshka’system in Planococcus citri in depth. BMC Microbiol. 13:74. doi: 10.1186/1471-2180-13-74

Moya, A., R. Gil, A. Latorre., J. Peretó, M.P. Garcillán-Barcia, F. de la Cruz (2009). Towards minimal bacterial cells: evolution versus design. FEMS Microbiol. Rev. 33:225-235. doi: 10.1111/j.1574-6976.2008.00151.x

Moya, A., J. Peretó, R. Gil, A. Latorre (2008). Learning how to live together: genomic insights into prokaryote-animal symbioses. Nature Rev. Genet. 9:218-229. doi: 10.1038/nrg2319

Tamames, J.*, R. Gil*, A. Latorre, J. Peretó, F.J. Silva, A. Moya (2006). The frontier between cell and organelle: genome analysis of Candidatus Carsonella ruddii. Science 314:312-313. doi: 10.1186/1471-2148-7-181 *Equal contribution.

T. Gabaldón, J. Peretó, F. Montero, R. Gil, A. Latorre, A. Moya (2007). Structural analyses of a hypothetical minimal metabolism. Phil. Trans. R. Soc. B. Biol. Sci. 362:1751-1762. doi:  10.1098/rstb.2007.2067

Pérez-Brocal, V., R. Gil, S. Ramos, A. Lamelas, M. Postigo, J. M. Michelena, F. J. Silva, A. Moya, A. Latorre (2006). A small microbial genome: the end of a long symbiotic relationship? Science 314:312-313. doi: 10.1126/science.1130441

Gil, R., F. J. Silva, J. Peretó, A. Moya (2004). Determination of the core of the minimal bacterial gene set. Microbiol. Mol. Biol. Rev. 68: 518-537. doi: 10.1128/MMBR.68.3.518-537.2004

Gil, R., B. Sabater-Muñoz, A. Latorre, F. J. Silva, A. Moya (2002). Extreme genome reduction in Buchnera spp.: towards the minimal genome needed for symbiotic life. Proc. Natl. Acad. Sci. USA 99: 4454-4458. doi: 10.1073/pnas.062067299

Subjects taught and teaching methods
33175 - Molecular geneticsPractices, Theory, Tutoring
33200 - Degree final project in biotechnologyWork end of studies
42596 - Master's final projectWork end of studies
42709 - Omics techniques for massive data collectionTheory
43458 - Omic technologiesComputer Classroom, Others, Practices, Theory
Thursday de 11:30 a 13:00. DESPACHO 3.2.3- I2SYSBIO (PARC CIENTIFIC)
Friday de 11:30 a 13:00. DESPACHO 3.2.3- I2SYSBIO (PARC CIENTIFIC)
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