Resultats de la cerca126 resultats

• FOXP2 expression and gray matter density in the male brains of patients with schizophrenia

  Sanjuán J, Castro-Martínez XH, García-Martí G, González-Fernández J, Sanz-Requena R, Haro JM, Meana JJ, Martí-Bonmatí L, Nacher J, Sebastiá-Ortega N, Gilabert-Juan J, Moltó MD

  (2020). Article

  Brain Imaging Behav.

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• Phylogenetic variation in cortical layer II immature neuron reservoir of mammals

  La Rosa C, Cavallo F, Pecora A, Chincarini M, Ala U, Faulkes CG, Nacher J, Cozzi B, Sherwood CC, Amrein I, Bonfanti L

  (2020). Article

  Elife.

  9:e55456

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• Semilunar Granule Cells Are the Primary Source of the Perisomatic Excitatory Innervation onto Parvalbumin-Expressing Interneurons in the Dentate Gyrus

  Rovira-Esteban L, Hájos N, Nagy GA, Crespo C, Nacher J, Varea E, Blasco-Ibáñez JM

  (2020). Article

  eNeuro.

  7(4):ENEURO.0323-19.2020. doi: 10.1523/ENEURO.0323-19.2020. Print 2020 Jul/Aug

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• Phenotypic characterization of MCP-1 expressing neurons in the rat cerebral cortex

  Mulet M, Blasco-Ibáñez JM, Kirstein M, Crespo C, Nacher J, Varea E

  (2020). Article

  J Chem Neuroanat.

  106:101785

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• Perineuronal Nets Regulate the Inhibitory Perisomatic Input onto Parvalbumin Interneurons and γ Activity in the Prefrontal Cortex

  Carceller H, Guirado R, Ripolles-Campos E, Teruel-Marti V, Nacher J

  (2020). Article

  Neurosci.

  40(26):5008-5018

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• Protective effects of mirtazapine in mice lacking the Mbnl2 gene in forebrain glutamatergic neurons: Relevance for myotonic dystrophy 1

  Ramon-Duaso C, Rodríguez-Morató J, Selma-Soriano E, Fernández-Avilés C, Artero R, de la Torre R, Pozo ÓJ, Robledo P - 2020 - Neuropharmacology

  (2020). Article

  Myotonic dystrophy type 1 (DM1) is a multisystemic disorder characterized by muscle weakness and wasting and by important central nervous system-related symptoms including impairments in executive functions, spatial abilities and increased anxiety and depression. The Mbnl2 gene has been implicated in several phenotypes consistent with DM1 neuropathology. In this study, we developed a tissue-specific knockout mouse model lacking the Mbnl2 gene in forebrain glutamatergic neurons to examine its specific contribution to the neurobiological perturbations related to DM1. We found that these mice exhibit long-term cognitive deficits and a depressive-like state associated with neuronal loss,...

  Myotonic dystrophy type 1 (DM1) is a multisystemic disorder characterized by muscle weakness and wasting and by important central nervous system-related symptoms including impairments in executive functions, spatial abilities and increased anxiety and depression. The Mbnl2 gene has been implicated in several phenotypes consistent with DM1 neuropathology. In this study, we developed a tissue-specific knockout mouse model lacking the Mbnl2 gene in forebrain glutamatergic neurons to examine its specific contribution to the neurobiological perturbations related to DM1. We found that these mice exhibit long-term cognitive deficits and a depressive-like state associated with neuronal loss, increased microglia and decreased neurogenesis, specifically in the dentate gyrus (DG). Chronic treatment with the atypical antidepressant mirtazapine (3 and 10 mg/kg) for 21 days rescued these behavioral alterations, reduced inflammatory microglial overexpression, and reversed neuronal loss in the DG. We also show that mirtazapine re-established 5-HT1A and histaminergic H1 receptor gene expression in the hippocampus. Finally, metabolomics studies indicated that mirtazapine increased serotonin, noradrenaline, gamma-aminobutyric acid and adenosine production. These data suggest that loss of Mbnl2 gene in the glutamatergic neurons of hippocampus and cortex may underlie the most relevant DM1 neurobiological and behavioral features, and provide evidence that mirtazapine could be a novel potential candidate to alleviate these debilitating symptoms in DM1 patients.

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  DOI: 10.1016/j.neuropharm.2020.108030

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• Personalized medicine begins with the phenotype: identifying antipsychotic response phenotypes in a first-episode psychosis cohort

  Mas S, Gassó P, Rodríguez N, Cabrera B, Mezquida G, Lobo A, González-Pinto A, Parellada M, Corripio I, Vieta E, Castro-Fornieles J, Bobes J, Usall J, Saiz-Ruiz J, Contreras F, Parellada E, Bernardo M

  (2020). Article

  Acta Psychiatr Scand.

  141(6):541-552

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• Dark exposure affects plasticity-related molecules and interneurons throughout the visual system during adulthood

  Carceller H, Guirado R, Nacher J

  (2020). Article

  J Comp Neurol.

  528(8):1349-1366

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• Δ-9-Tetrahydrocannabinol treatment during adolescence and alterations in the inhibitory networks of the adult prefrontal cortex in mice subjected to perinatal NMDA receptor antagonist injection and to postweaning social isolation.

  Garcia-Mompo C, Curto Y, Carceller H, Gilabert-Juan J, Rodriguez-Flores E, Guirado R, Nacher J

  (2020). Article

  Transl Psychiatry.

  10(1):177

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• A Critical Period for Prefrontal Network Configurations Underlying Psychiatric Disorders and Addiction

  Guirado R, Perez-Rando M, Ferragud A, Gutierrez-Castellanos N, Umemori J, Carceller H, Nacher J, Castillo-Gómez E

  (2020). Article

  Front Behav Neurosci.

  14:51.

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