Aquest dimecres dia 27 de març David de Agustín del grup de Neurobiologia Molecular, concretament del grupo de Cristina Gil-Sanz (Neural Development) donarà una xarrada amb el títol:
“Cdh2 and Afadin as regulators of neocortical development”
Serà a les 9:45h al SALÓ DE ACTOS DE FARMACIA
Resum de la xarrada:
The neocortex is, in evolutionary terms, the most recent acquisition of the mammalian brain and accomplishes a wide range of crucial functions, including sensory perception, the elaboration of motor responses, language, reasoning or complex thought. To that end, it displays an extraordinary diversity of neurons and macroglia arising from telencephalic radial glial stem cells (RGCs) in a tightly regulated manner. When this process is defective, it can lead to neurodevelopmental disorders. Among the vast variety of molecular players involved in the control of neocortical development, cell-cell adhesion-related molecules have been described to be of great importance. In fact, the lack of some of such molecules, like Cdh2 and afadin, profoundly alters neocorticogenesis in mice resulting in aberrant proliferation of RGCs and macrocephaly. However, the underlying mechanisms and the consequences on mouse behavior remained unknown. In our lab, we have identified Cdh2 as a key regulator of Gli1-mediated Sonic Hedgehog signaling for proper neocortical development and unveiled social interaction deficits as a consequence of Cdh2’s and afadin’s absence. Together, our findings will help shed light on the understanding of the molecular principles governing neocortical development and reinforce the interest of cell-cell adhesion molecules as potential biomarkers of neurodevelopmental disorders such as autism.
Os adjunte el cartell amb l'anunci
Després haurà café com sempre al bar de Farmàcia
