The Developmental Molecular Genetics and Biomedical Models group uses the fruit fly Drosophila melanogaster (or vinegar fly) as an experimental organism. In recent years, Drosophila has become a highly useful tool in biomedical research. The development of powerful genetic techniques to study gene function in this organism, along with its shared biology with humans and the presence of homologs of most genes involved in human diseases, justify its success. In this context, our group is using various approaches to study human genetic diseases in Drosophila, with the aim of dissecting their pathogenesis pathways and identifying biomarkers for diagnosis and/or disease progression, as well as discovering potential therapeutic molecules to alleviate or delay symptoms. On the other hand, we are also studying basic developmental processes in Drosophila, such as dorsal closure during embryogenesis and planar cell polarity establishment, using them as models for human health-relevant processes like wound healing, convergent extension during gastrulation, or cell migration related to metastasis..

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