Our group studies the cell adhesion to the extracellular matrix (ECM). This adhesion modulates mechanical signals and control the union in growth factors, determining the survival, differentiation, migration and extravasation of cells. ECM are organised in fiber networks of different complexity. There is a particular interest in the fibronectin protein since it offers multiple cell adhesion motives and its polymerisation is the first step for other protein stool, like Type I collagen and various proteoglycans. Fibroectin fibers are constantly remodelled and the alteration of this process can cause fibrosis, arthritis and development and angiogenesis failures or difficulties.