ANTICOR
The project proposes a new strategy for the screening of drugs and antibodies against the SARS-CoV-2 coronavirus. This is an innovative technology for drug screening that uses an affordable, fast, safe and efficient system to evaluate all types of antiviral compounds and antibodies that block the entry of SARS-CoV-2 virus into human cells. The use of recombinant viruses has been successfully used in drug screening for various medically important viruses, as well as in serological screening. The advantages of the proposal are well founded, highlighting that this technology may be applicable in the future to other viruses that constitute an emerging public health problem.
Antiviral platform
We are part of a joint effort to establish a platform for the screening of antivirals against current and future viral threats. The work combines groups that span the full drug discovery and development process.
Bacterial glycosyl hydrolases and their role in viral infectivity
This project aims to understand the role of microbiota-specific glycosidases in rotavirus and norovirus infections in humans.
BlockAce
This collaboration will employ a multi-disciplinary approach to identify inhibitors of SARS-CoV-2 receptor binding and entry. Combining expertise in medicinal chemistry, computational chemical biology, structural biology, and virology, 3 parallel approaches will be employed: (1) Immediate testing of compound libraries (>1,400) using a high-throughput cell assay for SARS-CoV-2 receptor binding and entry. (2) Computational screening and design, synthesis, and evaluation (3). Development of protein-based inhibitors derived from the ACE2 receptor. The final evaluation of hits for effectiveness and drug resistance will be done with SARS-CoV-2.
CDEIGENT
There is a lot of interest in using bacteriophages for treating diseases caused by multi-drug resistant bacteria. In the project CDEIGENT/2021/008 we will investigate the ability of the bacteriophages to modify the bacterial composition in the human intestine affected by Clostridioides difficile infection using methods of microbial single-cell genomics.
COV-CRISPIS
Traditional viral infection diagnostic techniques in the clinic are based on (RT-)PCR procedures, which are time consuming and require precise equipment and human resources, which preclude a rapid and massive intervention. Here, we will engineer a novel class of stand-alone biosystems aimed at diagnosing the presence of SARS-CoV-2. These biosystems consist of three reaction steps following sample collection without the need of sophisticated equipment: i) isothermal amplification of viral RNA, ii) CRISPR-based nucleic acid detection (working like an on-the-fly sequencing reaction), and iii) output disclosure by immunochromatographic assay.
COVID-19: anti-infectious and anti-inflammatory action of immunomodulatory parasite molecules in a safe-to-use synthetic format
The group of Dr. Mar Siles Lucas at IRNASA handles in vitro and in vivo models of parasitic-host interactions with Fasciola hepatica, which could be used to evaluate the potential of the parasite and its molecules to modulate relevant entry routes and inflammation routes in COVID-19. On one hand, this parasite has shown influence on the expression of endocytosis-related molecules (e.g. clathrins) on in vitro mouse epithelial cells, routes that may be relevant for SARS-Cov-2 entry to human cells. In addition, F. hepatica results in a modified Th2 response without the inflammatory component in its host in vivo, and this modulation may result in a controlled inflammatory response to COVID-19.
CoV2TIP
Defective interfering particles (DIP) are degenerate forms of viral genomes that are non-replicative but remain infectious by complementation with the wildtype (WT) virus. DIPs play a significant role in modulating the outcome of infection and immune responses, and can be artificially selected to strengthen their interfering activity and suppress replication of the full virus (therapeutic interfering particles, or TIPs). We propose to produce DIPs during SARS-CoV-2 replication in cell culture, purify them, test their antiviral effects, and characterize them molecularly. The outcome of the project will be a SARS-CoV-2 specific set of TIPs that could be used right away to treat COVID19.
Development of advanced measures against COVID-type infections
Design and construction of an autonomous mobile robot that will be in charge of a faster and more effective disinfection of the most sensitive sanitary areas of hospitals, such as operating rooms, intensive care areas or patient resuscitation rooms.
EnvironmentalCOVID
Although SARS-CoV-2 and other coronaviruses are primarily transmitted directly between individuals during epidemic phases, the permanence of the virus in the environment has the potential to cause new outbreaks despite mitigation efforts. SARS-CoV-1 was detected in hospital wastewater in China and it was shown that the viral particles could remain infective long enough to pose a risk.
EvolCovid
Strengthening genomic surveillance of SARS-CoV-2 has been endorsed by the World Health Organization (WHO) to increase the capacity to detect new threats and achieve quality, timely and appropriate public health actions.
FecOrSARS
SARS-CoV-2 is mainly a respiratory virus, although it’s been shown that it can replicate in the intestinal mucosa and be excreted via faecal matter. Molecular data proved the presence of the virus’s genetic material in faeces, while detection studies for infective viral particles are still incipient and based on a small number of patients.
Genomic monitoring
The objectives of this platform will be the identification of mutations associated with epidemiological/clinical changes of SARS-CoV-2 with special attention to breakthrough infections.
Mutaciones
We are part of a joint effort to better understand the effects of mutations in SARS-CoV-2 in real time. This grant aims at building a platform to deal with current and future threats.
PTI+: Transmission and contention
La detección de virus patógenos para humanos en aguas residuales es una herramienta muy útil y conocida para la vigilancia epidemiológica.
Performing a clinical trial with a GPBP inhibitor in COVID-19 patients
Reading habits during the COVID-19 lockdown
In this study we anaylse how the confinement by COVID-19 is affecting our reading habits. Do we read more or less? How much time do we invest in recreational reading? And in reading news? In what format: paper or digital?
SeqCOVID
An ambitious scientific project led by researchers from the National Scientific Research Council (CSIC) in partnership with 40 hospitals all over Spain will study the compared genomes of the new coronavirus from patients with COVID-19 in order to understand and predict the evolution and epidemiology of the virus.
The COvid-19 ROstros. Gender and Socioeconomic Impacts (ROCOGIS)
