Educational, creative and artistic applications in different types of environments, including digital environments and the use of ICTs.

Study of positive adolescent development. Study of the needs of adolescents. Design and validation of assessment instruments. Design of interventions to promote the positive development of adolescents and young people. Elaboration of models of extensive educational accompaniment for adolescents. Proposal of services.

Using Monte Carlo simulations and the ACE system, to which the group has access thanks to the Elekta-La Fe-UV collaboration, we will proceed to locate systems where the formalism currently used in high-rate brachytherapy treatment planning is no longer valid.

The project aims to analyse NSCs, neurogenic niches and neurogenesis with age, as well as their involvement in AD. On the other hand, the role of GSK3 in the proliferation and differentiation processes of NSCs both in vitro and in vivo will be studied, as well as its regulation as a target.

Study of the relationship between air pollution and health effects, with multi-centre studies being carried out. Studies are also carried out to evaluate the impact of pollution on the health of populations.

Study of the role of the amygdala in the generation of emotional and motivated behaviours and its pathologies.

Quantification of the main vasoactive compounds and study of the regulatory pathways involved.

• With the introduction of CBCT in orthodontic diagnostics we have improved the traditional two-dimensional model analysis.
• Comparison of two-dimensional and three-dimensional model analysis.
• Tooth size prediction studies using a digital programme.

Identification of the anatomical variants of the spinal column that can lead to the appearance of clinical symptoms such as headache, dizziness, tinnitus, vertebrobasilar insufficiency syndrome, etc.

Study of interrelationships between tumour neovascularisation, the presence of immunoregulatory cell populations and recurrence or progression in the tumour microenvironment.

• Amb la introducció del CBCT en el diagnòstic ortodòncic hem millorat la tradicional anàlisi models en dues dimensions.
• Comparació de l'anàlisi de models en dos i en tres dimensionals.
• Estudis de predicció de grandàries dentàries mitjançant un programa digital.

Training in the teaching of social sciences for preschool and primary school teachers, for secondary school teachers, for university teachers and for educators in museums and heritage and other informal areas. To train educators and generate cultural criteria for application in institutional settings between archaeology, anthropology, education and cinema.

Generate theoretical activity and experiences from art and visual culture.

The study of musculoskeletal injuries via functional assessment with the use of ultrasound scanning and biomechanical material for the improvement of overall function and performance and the prevention of injuries.

Asymmetric tandem reactions. The combination of several organocatalytic processes or, alternatively, an organocatalytic process with an intramolecular dipolar cycloaddition, with the aim of generating new enantiomerically enriched skeletons is one of the group's lines of action.

Neurodevelopmental disorders (NDD) are, by definition, dynamic and changing over time. This dynamism of neurodevelopmental disorders means that comorbidity with other disorders and diseases is very high throughout the life cycle, especially in adulthood and ageing. The aim of the Research Group is to study these disorders and their evolution over time, with special emphasis on techniques and methods that improve the abilities of the people who suffer from them and their family environment, so as to generate a better quality of life, promoting the general health not only of the person with a Developmental Disorder but of all the members of the family unit.

Basic studies in psychophysics, mechanisms and models of visual processing. Physiological optics.

The pattern of heavy alcohol consumption, alone or in polydrinking with cannabis, initiated early in adolescence is a precipitant for the development of cognitive impairment and stress response and should therefore be studied in this at-risk population with special attention.

Role of Health Care Bioethics Committees, problems and functioning. Research Ethics Committees. National and Autonomous Region Committees. Methodologies for analysing bioethical cases. Analysis of health legislation related to bioethics.

The analysis of biographical events and life trajectories from micro- and macro-analytical perspectives has as its areas of study education, emancipation, integration into the labour market, the formation and dissolution of unions, motherhood and fatherhood, family changes, gender gaps throughout life and in the private and public spheres, life episodes during old age.

Biomedical applications of bacteriophages, including diagnosis, prevention, and therapy, as an alternative tool against multidrug-resistant bacteria. Isolation and characterization of novel phages, directed evolution for phage optimization, resistant emergence, and nanotechnology.

Study of the effects of biopower applied to the analysis of bodies, genders and sexualities. Social construction of health and illness.

Competitor analysis, market segmentation, positioning strategy design, creation of perceptual maps of competitors based on their positioning, brand design based on visual identity (form) and message (content).

Identification of molecular mechanisms, new pharmacological targets and active molecules in cardiovascular pathologies and obesity.

Compilation of demographic data sources prior to the digitisation of current censuses and registers, production of socio-demographic data on the Valencian population and elaboration of demographic, resilience, social vulnerability and health indicators.

The project deals with the application of cell therapy with genetically modified mesenchymal cells (episomal plasmid) to treat progression and repair neurological deterioration in the animal model of multiple sclerosis.

Brain cell senescence remains unexplored as a target for neuroprotection in stroke. The aim is to characterise brain cell senescence associated with ageing and stroke in a rat model, and to reposition a senolytic drug, Navitoclax, as an effective neuroprotectant for use as an adjunct to endovascular treatment in ischaemic stroke. The influence of gender will also be analysed.

Characterisation of electronic brachytherapy systems using Monte Carlo techniques. The response of commercially available ionisation chambers will then be calculated in order to obtain the correspondence factors that will allow their use in clinical practice.

Our group has characterised a new important regulator of the Start transition: Whi7. Whi7 acts as a transcriptional repressor of the Start programme, collaborating with Whi5 in this function, so that, as occurs in mammals with the Rb family, the control of cell cycle initiation depends on the interplay between different repressors. The group's work aims to advance in the characterisation of the regulation and function of Whi7 and its comparison with Whi5 in different physiological conditions, which may help to understand how the action of different repressors is coordinated in the control of cell cycle initiation. In addition, the relationship between Whi7 and the protein kinase C pathway is being investigated. The fact that a member of the Rb family is mutated in almost all tumours further reinforces the importance of studying the role of these G1 repressors.

Describe the level of exposure and pollution during gestation and early childhood, assess the role of common environmental pollutants and protective dietary factors on foetal growth and neuro-endocrine-immune development to develop health indicators.

Children, adolescents and young people constitute the future of the new societies. Family relationships operate in unison with global changes: the family has lost the capacity to generate synergies on its own and needs guidance to overcome them. Family societies have lost the intensity they had in previous decades, due to the processes of individualisation and the loss of collective values. Therefore, it is a commitment of GESinn to analyse the socialisation processes of adolescents and the family networks of which they form part, to investigate their risks, to prevent difficulties and to promote and strengthen the mechanisms of social adjustment for the development of a positive life. The aim of the study is to investigate adolescence from different intervention perspectives: prevention, protection and re-education. The previous professional experience of the members of GESinn in the care of this group constitutes an added value to the empirical dimension.

The aim of this line is to investigate the pathophysiological mechanisms underlying chronic pain and to test the therapeutic efficacy of treatments targeting these mechanisms.

Analysis of the components of population dynamics such as birth rate, fertility, morbidity, infant mortality, adult mortality, mortality shocks, migration, and population structure.

This line focuses on the analysis of the physical conditions and human movement for the development of tools for the assessment and diagnose as well as for the design of interventions programs.

The aims of this work are to establish morphological and genetic profiles of recurrent meningioma with a diagnostic and prognostic objective.

Molecular and genetic basis of neurocognitive alterations in patients with SMI, in order to develop biomarkers, diagnostic assessment tools and therapeutic interventions helping to improve the functional prognosis, the autonomy and the life quality of these people.

Pelvic floor surgery. Diagnosis and treatment of colon cancer using advanced surgical techniques. Prehabilitation of patients in colorectal surgery.

The combination of HPLC separation mechanisms allows unreachable selectivities with individual columns to be obtained. Several strategies are proposed, including the use of parallel columns, sequential column coupling and two-dimensional HPLC.

Community Social Services are the gateway to the social welfare system and its different benefits and programmes that address the needs of the most vulnerable groups. Its analysis and evaluation allows to make improvements in local social welfare structures.

The end-of-life care line began with the participation of Enric Benito and Pilar Barreto in agreements between the UV and the SECPAL (Spanish Society of Palliative Care) to jointly design a measure of spirituality in patients that was clinically, psychometrically and culturally relevant to measure the resources to deal with symptomatology beyond the physical at the end of life. After a decade of productive collaboration, research in this field (EPIONE study) progressed towards intervention (KIBO protocol). On the other hand, always with the emphasis on methodology, the proposal and validation of new measurement tools, research was extended to other relevant topics such as dignity or demoralisation syndrome in patients.

The efficiency of interventions on quality of life is designed and studied in patients and their environment as well as in professionals. In the case of professionals, research is carried out not only in the health field, whether in palliative care, intensive care or home care, but also in general in professional activities with high emotional demand, such as care for people with functional diversity, children with developmental disorders or police. There are several interventions based on Positive Psychology that show effectiveness in reducing stress in professionals with high emotional demand.

From ARMAQoL, with an emphasis on methodology and in collaboration with clinical experts from the UV, we investigate the use of different mechanisms and formats of these interventions, making them more appealing, and trying to reduce dropout rates. In professionals, the multicentre YASO study, in collaboration with the UIB (Noemí Sansó, member of the team) was our first incursion into the inner curriculum of palliative care professionals. Nowadays, this research, with a strong theoretical basis, has been consolidated as a diagnostic approach in health systems in numerous countries, in different languages.

Currently, in this line, we are developing the project ‘Longitudinal study of compassion’ and other determinants of professional quality of life: A research on palliative care professionals at national level (CompPal), financed by the State Research Agency - 2018 Calls, R&D&I Projects Research Challenges.

• Galiana, L., Sansó, N., Muñoz-Martínez, I., Vidal-Blanco, G., Oliver, A., & Larkin, P. J. (2021). Palliative Care Professionals' Inner Life: Exploring the Mediating Role of Self-Compassion in the Prediction of Compassion Satisfaction, Compassion Fatigue, Burnout and Wellbeing. Journal of Pain and Symptom Management.
• Sansó, N., Vidal-Blanco, G., & Galiana, L. (2021). Development and Validation of the Brief Nursing Stress Scale (BNSS) in a Sample of End-of-Life Care Nurses. Nursing Reports, 11(2), 311-319.
• Moreno-Mulet, C., Sansó, N., Carrero-Planells, A., López-Deflory, C., Galiana, L., García-Pazo, P., ... & Miró-Bonet, M. (2021). The Impact of the COVID-19 Pandemic on ICU Healthcare Professionals: A Mixed Methods Study. International Journal of Environmental Research and Public Health, 18(17), 9243. 
• Sansó, N., Vidal-Blanco, G., Galiana, L., & Oliver, A. (2021). Development and Psychometric Validation of the Brief Nurses' Practice Environment Scale and Its Relation to Burnout Syndrome and Job Satisfaction: A Study in Spanish Nurses. Frontiers in public health, 9.
• Pérez-Belmonte, S., Galiana, L., Fernández, I., Vidal-Blanco, G., & Sansó, N. (2021). The Personal Wellbeing Index in Spanish Palliative Care Professionals: A Cross-Sectional Study of Wellbeing. Frontiers in Psychology, 12.
• Oliver, A., Galiana, L., Simone, G. D., Tomás, J. M., Arena, F., Linzitto, J., ... & Sansó, N. (2021, January). Palliative care professionals' inner lives: Cross-cultural application of the awareness model of self-care. In Healthcare (Vol. 9, No. 1, p. 81). Multidisciplinary Digital Publishing Institute.
• Rudilla, D., Oliver, A., Galiana, L., Valenzuela, C., & Ancochea, J. (2021). Patients Suffering from a Chronic, Irreversible Illness: A Novel Study on the Psychological Intervention out of the Hospital. In Palliative Care for Chronic Cancer Patients in the Community (pp. 133-143). Springer, Cham.
• Galiana, L., Oliver, A., Arena, F., De Simone, G., Tomás, J. M., Vidal-Blanco, G., ... & Sansó, N. (2020). Development and validation of the Short Professional Quality of Life Scale based on versions IV and V of the Professional Quality of Life Scale. Health and Quality of Life Outcomes, 18(1), 1-12.
• Soto-Rubio, A., Perez-Marin, M., Rudilla, D., Galiana, L., Oliver, A., Fombuena, M., & Barreto, P. (2020). Responding to the Spiritual Needs of Palliative Care Patients: A Randomized Controlled Trial to Test the Effectiveness of the Kibo Therapeutic Interview. Frontiers in Psychology, 11, 1979.
• Sansó, N., Galiana, L., Oliver, A., Tomás-Salvá, M., & Vidal-Blanco, G. (2020). Predicting professional quality of life and life satisfaction in Spanish nurses: a cross-sectional study. International journal of environmental research and public health, 17(12), 4366.
• Arena, F., Oliver, A., & Galiana, L. (2019). Overview of the Quality of Work Life of Palliative Caregivers in Brazil. Revista Colombiana de Psicología, 28(2), 33-45.
• Sansó, N., Galiana, L., González, B., Sarmentero, J., Reynes, M., Oliver, A., & Garcia-Toro, M. (2019). Differential effects of two contemplative practice-based programs for health care professionals. Psychosocial Intervention, 28(3), 131-138.
• Galiana, L., Oliver, A., De Simone, G., Linzitto, J. P., Benito, E., & Sansó, N. (2019). A brief measure for the assessment of competence in coping with death: The coping with death scale short version. Journal of pain and symptom management, 57(2), 209-215.
• Sanso, N., Galiana, L., Oliver, A., Cuesta, P., Sanchez, C., & Benito, E. (2018). Evaluation of a mindfulness intervention in palliative care teams. Psychosocial Intervention, 27(2), 81-88.

It is based on the cultural and linguistic contrast, using corpus linguistics as a basis, between several modern majority languages such as Peninsular Spanish and English. The aim is to clarify concepts and look for practical applications both at a particular level between specific communicative communities and at a global level within the educational setting, as well as in social and professional communication, such as business communication. The tools of corpus linguistics, from a cross-cultural perspective, prove to be essential both for the collection of real data and compilation of corpora and for their analysis and application of results. In this team, the study of current social and professional communication is approached in symbiosis with the digital world, not only as a mediator, but also as a target for new generation applications.

Yeast Pkc1 and the mammalian PKCd isoform share the same function of controlling the genomic integrity checkpoint. A parallel study in both organisms is proposed to characterise the molecular keys to this mechanism.

Study on the use of molecular gates in drug release. Application to different pathologies with emphasis inflammatory bowel disease.

Train educators and generate cultural criteria for application in institutional settings between creativity, psychology, educational practices and teacher training.

Study of procedures for the development of tolerance and the promotion of coexistence. Design and validation of evaluation instruments. Proposal of optimising interventions. Creation of local plans for the promotion of coexistence. Proposal of services.

Several studies on the analysis of models related to the prediction of tooth size, these are: Studies on plaster models. Studies of tooth size prediction using a digital programme developed by the research group itself. Studies of Bolton alterations.

The aim of this work is to generate experimental models to study the modulation of gene activity by transfection methods (inhibition and overexpression) of miRNAs in primary cell cultures and established Glioblastoma multiforme cell lines.

Research in emotional education focuses on the knowledge and skills (competences), which children and adolescents have and which allow them to identify their own and other people's emotions, as well as to express and regulate pleasant and unpleasant emotions.

Design and synthesis of new chiral ligands capable of forming complexes with metal ions useful as chiral catalysts (Lewis acids). Design and synthesis of new chiral organic catalysts by proton transfer, hydrogen bridge formation or phase transfer.

Use of chiral catalysts (metal complexes and organocatalysts) in new reactions of interest in organic synthesis in which C-C bonds and stereogenic centres are generated simultaneously. Synthesis of chiral building blocks.

Due to the increasing number of analyses performed in laboratories, there is an interest in reducing the analysis time. For this purpose, instrumental techniques and rapid columns, as well as direct injection strategies of the analysed samples, are used.

Protection of the worker’s health and personal sphere outside the workplace.

Study of the most appropriate methods for the assessment and selection of drivers who aspire to obtain their driving licence.

Modelling social systems, values and quality of life, and demographic flows.

Philosophy and political ecology, responsibility for future generations, intergenerational justice. Precautionary principle. Ethics of animals. Ethics of food production, distribution and consumption. Promotion of healthy nutrition. Bioethical issues related to chemistry.

The identification of those products and methods that safely and effectively promote the increase of mental and motor performance and even stimulate its recovery in case of loss is necessary nowadays due to the diversity of offers, objectives and existing populations. 

It aims to explore the importance of emotional management, as a key element of what constitutes optimal or healthy functioning of the person throughout the life cycle. In this sense, it considers not only the relationship of emotional self-efficacy with relevant variables of individual differences (such as personality dimensions and coping styles), but also its association with important life outcomes (health, subjective well-being, academic and occupational commitment and performance, etc.).

Innovative diagnostic techniques in hyperparathyroidism.
Pathophysiology of patients undergoing metabolic/bariatric surgery.

Biopsychosocial variables aimed at improving the quality of life in the life cycle. José Manuel Tomás' career in the field of his research line is well known. He has co-directed with Amparo Oliver competitive longitudinal projects in the field under the MICIN/AEI/FEDER Challenges call for proposals. Currently in 2021-2022, together with Laura Badenes, he is the Director of the Official Master's Degree in Social and Health Care in Dependency at the Universitat de València. The scientific and technical objectives focus on identifying the variables that most influence the quality of life of the elderly, how they relate to each other and how we can work on them according to theoretical reference models from different cultures. We research both in the field of so-called successful elderly (such as active and healthy people who attend educational programmes for older adults), as well as older people living in community or those who are institutionalised. The research with national and international impact of the team members in this line is reflected in impact journals and includes research collaborations in the field with researchers from our own university, or collaborations with universities such as UNCC Charlotte in the USA, Universidad Privada del Norte in Lima-Peru or the Universidad de Costa Rica.

• Sentandreu-Mañó, T., Cezón-Serrano, N., Cebrià I Iranzo, MA., et al. (2021). Kihon Checklist to assess frailty in older adults: Some evidence on the internal consistency and validity of the Spanish version. Geriatrics & Gerontology International, 21, 262-267. https://doi.org/10.1111/ggi.14126.
• Caycho-Rodríguez, T.; Tomás, J. M.; Barboza-Palomino, M.; Ventura-León, J.; Gallegos, M.; Reyes-Bossio, M.; Vilca; L. W. (2021) Assessment of Fear of COVID-19 in Older Adults: Validation of the Fear of COVID-19 Scale. International Journal Of Mental Health And Addiction, 6, pp. 1 - 15 . ISSN: 1557-1874.
• Galiana, L., Tomás, J. M., Fernández, I., & Oliver, A. (2020). Predicting Well-Being Among the Elderly: The Role of Coping Strategies. Frontiers in Psychology, 616. https://doi.org/10.3389/fpsyg.2020.00616.
• Fernández, I., Sentandreu-Mañó, T., & Tomás, J. M. (2020). Impacto del estatus de fragilidad sobre la salud y calidad de vida en personas mayores españolas. Atención Primaria, 52, 731-737. https://doi.org/10.1016/j.aprim.2019.11.006.
• Pérez-Belmonte, S., Galiana, L., Sancho, P., Oliver, A., & Tomás, J. M. (2020). Subtypes of Depression: Latent Class Analysis in Spanish Old People with Depressive Symptoms. Life, 10, 70. https://doi.org/10.3390/life10050070.
• Sentandreu-Mañó, T., & Tomás, J. M. (2020). Indicators of pain management and their relationship with frailty. En M. C. Pérez-Fuentes et al. (2020): Investigación e intervención en salud: revisando la evidencia científica (pp. 95-106). Dykinson: Madrid, España.
• Tomás, J. M., Sentandreu-Mañó, T., & Fernández, I. (2020). Frailty status typologies in Spanish older population: Associations with successful aging. International Journal of Environmental Research and Public Health, 17, 6772. https://doi.org/10.3390/ijerph17186772.
• Sancho, P. Tomás, J. M., Oliver, A., Galiana, L., and Gutiérrez, M. (2020) Predicting Life satisfaction in Spanish Adults of Advancing Age Attending University Educational Programs. Journal Of Happiness Studies, 21, pp. 271 - 287 . ISSN: 1389-4978.
• Cebrià i Iranzo, Maria dels Àngel; Arnal Gómez, Anna; Tortosa Chuliá, María Angeles; Balasch i Bernat, Mercè; Forcano, Silvia; Sentandreu Mañó, Trinidad; Tomas Miguel, Jose Manuel; Cezón Serrano, Natalia (2020) Functional and Clinical Characteristics for Predicting Sarcopenia in Institutionalised Older Adults: Identifying Tools for Clinical Screening. International Journal Of Environmental Research And Public Health, 17(12), p. 4483 . ISSN: 1661-7827.
• Constanza San Martín Valenzuela; Lirios Dueñas Moscardó; JuanLópez-Pascual; Pilar Serra-Añó; José M.Tomás (2020) Effects of Dual-Task Group Training on Gait, Cognitive Executive Function, and Quality of Life in People With Parkinson Disease: Results of Randomized Controlled DUALGAIT Trial. Archives of Physical Medicine and Rehabilitation. ISSN: 0003-9993.
• Constanza San Martín Valenzuela, Lirios Dueñas Moscardó, Juan López-Pascual, Pilar Serra-Añó, José M. Tomás. (2020) Interference of functional dual-tasks on gait in untrained people with Parkinson's disease and healthy controls: a cross-sectional study. Bmc Musculoskeletal Disorders, 21(396) . ISSN: 1471-2474.
• Sancho, P; Pinazo-Hernandis, S.; Donio-Bellegarde, M.; Tomás, J. M.; (2020) Validation of the University of California, Los Angeles Loneliness Scale (version 3) in Spanish older population: An application of exploratory structural equation modelling. Australian Psychologist, 55, pp. 283 - 292 . ISSN: 0005-0067.
• Caycho-Rodríguez, T.; Sancho, P.; Tomás, J. M.; Carranza, R. F.; Ventura-Leóne,J.; Neto, F.; Reyes-Bossiog, M.; Cabrera-Orosco; I. (2020) Validity and Invariance of Measurement of the Satisfaction with Love Life Scale in Older Adults. Psychological Thought, 13(2), pp. 439 - 458 . ISSN: 2193-7281.
• José M. Tomás;Trinidad Sentandreu-Mañó; Irene Fernández (2020) Frailty status typologies in Spanish older population: associations with successful aging. International Journal Of Environmental Research And Public Health, 17(18), p. 6772 . ISSN: 1661-7827.
• Tomás, JM; J; Pinazo-Hernandis, S; Oliver, A; Donio-Bellegarde, M.; Tomás-Aguirre, F. (2019) Loneliness and social support: differential predictive power on depression and satisfaction in the old age. Journal of Community Psychology, 47(4), pp. 1225 - 1234 . ISSN: 0090-4392.
• Sentandreu-Mañó, T., Badenes-Ribera, L., Fernández, I., Oliver, A., Burks, D. J., & Tomás, J. M. (2019). Frailty in the Old Age as a Direct Marker of Quality of Life and Health: Gender Differences.Social Indicators Research. OnlineFirst. https://doi.org/10.1007/s11205-019-02246-1.
• Sentandreu?Mañó, T., Fernández, I., Cebrià i Iranzo, M. À., & Tomás, J. M. (2019). Dimensions underlying frailty indicators in the Kihon Checklist. Geriatrics & Gerontology International, 19, 982-987. https://doi.org/10.1111/ggi.13754.

Study of the frequency, characteristics and causal processes of traffic accidents.

Ethical problems at the beginning of life. Bioethics in the face of the new challenges of genetics, neurosciences and nanotechnology. Neuroethics, Neuroeducation, Neurotheology, Neurolaw, Neuropolitics. Nanoethics. Ethics of sport. Ethics of doping. Ethics of human enhancement.

We are evaluating the usefulness of eye movement abnormalities for early diagnosis of MHE. This is being addressed in collaboration with AURA Innovative Robotics, which has developed sensitive equipment for fine analysis of various parameters of eye movements.

We are evaluating the effects of treatment of patients with MHE with rifaximin on neurological, cerebral, immunological, metabolic and exosome alterations. Line funded by the ISCIII (PI18/00150).

Our major aim was originally to test whether free radicals associated with exercise could lead to damage in muscle and to protect these muscles by various interventions such as training and nutrition.

Strategy analysis of the extension of a consolidated brand, creation of umbrella brands among several competitors, transfer of value and brand image through various communication tools. Brand registration and other legal aspects.

Study of individual differences in psychophysiological response and recovery to stress, taking into account factors such as age, sex/gender, personality, social status and demographic characteristics, coping strategies and styles, among others.

The esTOCma app was developed to fight against the stigma associated with mental illness in general, and OC spectrum disorders in particular, by disseminating current knowledge and the possibilities for effective treatment and recovery from these disorders. https://estocma.blogs.uv.es/

Prevention of fragility signs in populations at risk by assessing human functions (functional and neurocognitive assessment) and by incorporating nutritional medicine studies on Omega 3.

Research on frailty sydnrome, a syndrome that appears as a response to different stressful situations and that can serve as a conceptual and experimental framework to explain some of the different pathways that lead to disability and dependence in elderly or vulnerable patients. Study of effective interventions to prevent or delay the progression of the frailty syndrome.

Study of sex differences in the different processes of drug addiction and in the presence and manifestation of dual pathology.

Study of gene expression, identification of biomarkers of treatment response in schizophrenia, and characterisation of the cell response to the drug in models derived from Induced Pluripotent Stem Cells (iPSCs).

The complexity of the phenomenon of gene expression will be better understood if techniques for measuring transcription in vivo at the genomic level are improved and genetic and genomic approaches are used to clarify the functional connections that control transcription.

Networking on the burden of disease.

Socio-health strategies related to physiotherapy treatment of the elderly.

The main goal of this line of research is to analyse the characteristics of teenage lifestyles, exploring their psychosocial correlates, with the purpose of promoting healthy behaviours.

Pathophysiology of acute pancreatitis. 3D diagnostic reconstruction of liver and pancreatic pathology. Incidence of postoperative complications in the oncological prognosis of liver and pancreatic tumours.

Design of printed circuit boards for high-speed digital electronics.

Study of the effects of chronic and acute HHA axis activity on cognitive performance in children, young people and the elderly. Effects of cortisol on performance in memory, executive function, attention, processing speed, etc.

To examine transcultural variants of IMD (for its Spanish acronym, Unpleasant Mental Intrusions) with obsessive, dysmorphic, hypochondriacal and alimentary content.

We are characterising inflammatory processes in detail to create a bioinformatic model of molecular, cellular and intercellular communication events associated with the development of MHE. We will evaluate its usefulness in predicting the onset of MHE. Funded by the Ramón Areces Foundation.

Studies on buttress implants and rehabilitation of patients with large maxillary atrophies. Studies of zygomatic, palatalised, frontomaxillary and pterygoid implants.

This research line seeks to understand how ovaries in female patients undergoing in vitro fertilisation work and to improve the results by reducing complications.

Using intravital microscopy experiments in mouse cremaster muscle venules after injury, we are studying the speed of clot formation and clot stability in FN-Syn mice.

Study of injuries in the work environment (health and non-health), and action for their prevention through physical exercise programmes.

Integration of different omics (genomics, metabolomics, transcriptomics, epigenomics, metabolomics, proteomics) with environmental factors for the study of gene-diet interactions in different health-disease phenotypes.

Epidemiological studies of intestinal parasitosis in populations living in poverty and/or exclusion or similar situations.

The aim of this line of research is to deepen our understanding of the communication and language difficulties of people with aphasia and dementia, and their relationship with executive functions; to develop tests and protocols for language and communication exploration and rehabilitation.

Study of emotional attachments: formation, development and loss. Design and validation of assesment instruments. Intervention in the promotion of healthy attachments and modification of dysfunctional attachments. Proposal of services for the improvement of emotional attachments.

Analysis of biomarkers in minimally invasive samples (saliva, blood, cerebrospinal fluid, pleural fluid, etc.), with the aim of improving diagnosis, personalising treatments and monitoring patients more closely (detection of resistance and relapses).

Design of low-noise analogue circuits.

Our study must be considered an initial attempt to create an in vitro model for the direct conversion of somatic cells from patients with gamete-alterations production into germ cells in vitro, opening the field to discover new cell therapies to treat them in the future.

Direct and indirect sinus floor elevation studies. Bone graft studies in maxillary sinus floor elevation.

Psychomotor aspects (motor skills) and their relation with psychosocial aspects in adolescents (e.g., self-concept) are analysed, analysing how both aspects interact.

Study of psychosocial aspects in adolescents, in particular, the measurement of socialisation, aggressive behaviour and meaning of life, analysing its interrelation.

Influence of the Mediterranean diet on different states of health and disease.

Overexpression of membrane proteins is often essential for structural and functional studies, but yields are frequently too low. Therefore, we investigate the consequences of overexpression of different membrane proteins in search for new components to improve such yields.

Identification of metabolomic patterns of nutritional behaviour and patterns, diet-nutrigenomics interaction, etc.

Based on the fundamental advances in HPLC made by the research group, analytical methods for several samples in the pharmaceutical, clinical and food fields are designed. Method development is accompanied by an extensive validation.

Reliable optimisation of chromatographic separation conditions requires tools that use retention and peak shape models. Diverse tools and new strategies for the analysis of complex samples are developed, which consider one to three experimental factors.

Diagnostic, prognostic and/or predictive biomarkers: in lung cancer, head and neck cancer, colon cancer, breast cancer, melanoma, among others, through different omics approaches (genomics, transcriptomics, metabolomics).

Exosomes have been discussed in science as a possible route for long-distance communication, using vesicles. They contain proteins and nucleic acids. The project aims to learn more about these vesicles in blood, their morphology and molecular content from metastatic cancer.

Music is a common element in practically all cultures. However, taking into account the diversity of music, it is necessary a more precise and rigorous analysis of it. This line studies the emotional, cognitive and psychophysiological response to music. 

Establishing reciprocal recognition as the core of intercultural and global bioethics. Relational sociology. Global citizenship, cosmopolitanism and deliberative politics. Immigration and bioethics. Reciprocal recognition between health professionals, patients and relatives.

Various studies related to the epidemiology of malocclusion, these are: Cross-sectional studies on the prevalence of malocclusion in a given population applying various occlusal or orthodontic treatment need indexes.

Study of the biological and environmental factors involved in cocaine addiction. Study of different neurotransmitter systems on the reinforcing effects of cocaine. Influence of environmental factors, exposure to stress (physical, social or psychological) or personality.

Study of the biological bases of violent and criminal behaviour, with its applications at diagnosis, prevention and intervention levels in violence.

Study of the plasticity of the nervous system and the role played by genetic, biological and cognitive alterations in people with psychotic and affective disorders, in order to develop strategies to prevent and intervene in their functional impairment.

Digital humanities and education with digital formats provide us with many opportunities to improve many aspects that can be changed by digital technologies.

The group's work also focuses on the study of spatial regulatory mechanisms in cell cycle control, mechanisms that involve the control of the sub-cellular localisation of key proteins for progression in the cycle. In particular, the role of karyopherin Msn5 in the control of transcription factors (Swi6, Swi4, Mbp1, Swi1, Whi5) as well as Start cyclins (Cln1, Cln2) has been studied. Furthermore, determinants of cyclin functional specificity and the identification of new mechanisms controlling cyclin synthesis and degradation (Cln2, Clb2) are investigated.

The main objective of this line is to better understand, from a molecular point of view, non-alcoholic fatty liver disease. This disease has pandemic overtones as it affects a high percentage of our population. The difficulty lies in the fact that it is a multifactorial disease, with diverse and incompletely understood aetiological mechanisms. The group is mainly investigating transcriptional causal mechanisms. We are also interested in the specific pathways leading to metabolic steatosis and steatosis caused by xenobiotics, such as drugs. From basic knowledge we hope to find predictive and diagnostic biomarkers that allow better management of this disease.

Description and analysis of the wide variety of nutritional, therapeutic, esoteric and spiritual disciplines and techniques that have arrived in the West and through which the imaginaries of the body, health and spirituality have been modified to form a new field of social action.

Identification of new markers and molecular targets for the treatment of pulmonary fibrosis. Identification of molecular determinants of fibroblast-myofibroblast transition using omics technologies. Role of inflammation and stroma in the tumour microenvironment and lung cancer progression.

Design and validate new models of CBT dispensing for OC spectrum disorders, specifically Virtual Reality and mobile applications (App) to facilitate CBT dispensing and dissemination.

Study of nutrition and eating disorders on the visual system. Nutrition, vitamins, antioxidants, eye diseases and eating disorders (obesity and anorexia nervosa).

Analyse whether the different symptomatic manifestations of OCD are:

• Consequence of diffeent aetiopathogenic factors.
• Respond differently to empirically validated psychological treatments (i.e., Cognitive Behavioural Therapy, CBT).
•  They present a different comorbidity.

Instrument development: The ongoing evaluation of the psychometric properties of the CITMI-R and the SOC-III in their English, Spanish and Portuguese versions. Development of optimal methods for the training of coders. Dissemination through new media among researchers and practitioners.

Cognitive and emotional processes study in healthy elderly people by means of psychological techniques and psychological intervention for the optimisation of basic processes such as memory, coping and emotions.

Analysis of point-of-sale positioning of tangible products through packaging to stimulate consumption. Key elements in packaging: visual and informative elements (colour, shape, label, images, etc.).

There's an analysis for the parasites-food intolerance relationship and the prevalence, transmission routes and risk factors of suffering from intestinal parasitosis, the correlation between parasitosis and the reception of breastfeeding, as well as the parasites-child development relationship.

Intervention and study of cognitive processes (memory, executive function, learning) with patients with Alzheimer's type dementia and others, mild cognitive impairment and Parkinson's disease.

Pathophysiology of Fanconi anaemia and Friedreich's ataxia.

Development of effective therapeutic approaches that enable both therapeutic avoidance and eradication of the disease before metastasis. 

Analysis of the production of pedagogical identity in specific contexts of educational and professional transition from a Social Justice perspective. Construction of the social positioning of young people in institutional transition processes. Analysis of Educational Policies from a critical perspective: conservative modernisation.

Study of optimising and risk conditions to promote optimal perinatal development. Design and validation of assessment instruments. Design of optimising perinatal interventions. Collaboration with associations and institutions in the improvement of perinatal health. Proposal of services.

Search for pharmacological targets and active drugs in respiratory pathologies.

This line of research deals with physical activity, exercise, sport and sedentary lifestyles from a public health perspective, with a special focus on vulnerable populations.

In this line of research, studies are carried out to quantify the habitual physical activity of groups of people with some special situation, usually a pathology that affects the musculoskeletal system. In this way, the aim is to establish the effect of the practice of physical activity on parameters related to the health and functionality of these people.

Physical conditioning and motor rehabilitation in the aquatic environment is one of the applications that, when carried out in an appropriate manner, can stimulate performance and physical-sports recovery for any type of population and with the most diverse needs. 

This line will analyse the effects of different physical exercise protocols on chronic non-specific pain in order to identify their efficacy on pain, quality of life, physical performance, body composition and other health markers. 

To determine the intercellular mechanisms of toxicity of amyloid beta, its interaction with mitochondrial metabolism and its consequences in cell signalling. Our idea is that Alzheimer’s and Tau toxicities are related and that free radicals play a major signalling role in this process.

Physiotherapy from a global perspective can improve the health of patients with respiratory problems. This line of research aims to develop new tools and implement interventions to assess the prognosis and improve the functional capacity of these patients.

This line focuses on the search for assessment tools and the definition of health promotion and specialised physiotherapy intervention programmes for young children with psychomotor developmental disorders as well as for children or adults with neurological pathologies.

Pedagogical relations in contexts of social and educational exclusion (poverty, ghettoisation, ethnic minorities). Analysis of policies to combat failure and early school leaving. Curricular justice and educational equity. Childhood and RECE.

Predicting adverse drug effects using Molecular Topology.

Women have a specific disease profile, which is particularly evident in some pathologies, such as osteoporosis, heart disease, etc. It is important to develop prevention policies, especially through healthy lifestyles, including physical activity, and with the support of ICTs. 

The aim of this work is to define the phenotypic and genetic characteristics of glioblastoma multiforme (GBM). To analyse the angiogenic and infiltrative characteristics of the nodular and diffuse pattern of GBM, the genetic profiles and the molecular networks responsible for these GBM patterns in relation to the EGFR receptor amplification profiles.

Separation is a highly stressful event that requires the family to adapt to the changes brought about by the break-up. When parents maintain a very conflictive relationship with children or use them in their confrontational dynamics, emotional abuse occurs with adverse effects.

To analyse attitudes, professional values and other parameters related to professional ethics and health in physiotherapists, physiotherapy students and patients. To design and validate assessment tools. To study the effectiveness of innovative programmes on ethics and health in physiotherapy.

Through the design of specific physical exercise programmes, the effect on the musculoskeletal system of elderly people is investigated, as well as the promotion of active ageing in this population.

Study of the adaptation to the disease of both the patient and the family environment - at different times or in different areas that include not only the process of diagnosis and treatment, but also other phases such as the prevention of the disease or its survival. It also deals with different aspects related to the performance of the healthcare professional in oncology (e.g. burnout, communication skills and management of crisis and stressful situations in the interaction with the patient).

This research line studies the effects of the psychophysiological response to stress on behaviour, emotions and cognition, taking into account the adaptive/maladaptive value of these changes and their relationship with health/illness.

Application of psychological intervention techniques (self-regulation therapy) to modify personality and drug management.

Development and implementation of intervention programmes focused on the improvement of social skills, neurocognitive and social cognition training and psychoeducational programmes for the improvement of social functioning and quality of life from a recovery perspective.

Active and healthy ageing is a construct of growing relevance. In its psychological aspect, clinical (cognitive and emotional), functional, cultural and socio-familial aspects must be included, as well as different demographic and lifestyle variables. Among the objectives of the group is the assessment and intervention throughout the life cycle, including the optimisation of their development, both of the persons or patients involved and their family environment, carers, etc., especially in the cognitive, emotional, functional and lifestyle areas. Within frailty in ageing, the topic of cognitive frailty and the variables involved in it is of particular interest.

This line of research explores the psychosocial processes, such as self-efficacy, confidence, self-concept, attributions, etc., that contribute to sport performance and satisfaction with the sport experience.

To study the psychosocial functioning of people diagnosed with schizophrenia, other psychoses and bipolar disorder, at different points in the development of these mental health issues.

FN-RGE mice express FN that cannot bind a5ß1 integrins, but does bind av class integrins. We are studying how knee cartilage evolves in these mice after injury induction.

Role of p38 alpha MAP kinase in the regulation of antioxidant defence in hepatocytes.

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Study of the main risk factors causing traffic accidents (speed, alcohol, drugs, medicines, illnesses...) and the vulnerable groups most involved in them.

Basic translational research on biochemical and molecular mechanisms related to free radical formation and oxidative stress in metabolic, cardiovascular and tumour diseases. Molecular signalling pathways in DNA damage and repair.

The aims of this work are to study the expression of miRNAs in high-grade gliomas, such as primary glioblastoma multiforme, secondary glioblastomas and high-grade astrocytomas.

Analysis of the role of human resources in brand positioning.

Historical analysis of science in medieval and modern society. Specifically, the degree of penetration, popularisation and influence of medicine, astronomy and natural history in different spheres and social groups.

Search for new drugs for colon cancer using Molecular Topology.

Theoretical studies for the improvement of signal integrity (reduction of coupling and electromagnetic emission in high-speed digital transmission systems. Study of power distribution schemes to improve the quality of digital signals.

Our hypothesis suggests that the adhesions made by the keratinocyte with FN, which are necessarily mediated by a5ß1 integrins, are weaker. To study this, we are using microprinting of FN-syn lines of different thicknesses and distances that force the cell to withstand more stress.

Improving the living conditions of the population is accompanied by innovation processes, especially in the field of social sciences and education, where changes affect both structural and circumstantial dimensions. For this reason, we are committed to transferring the results of intervention and research to society so that it can replicate its experiences in other latitudes and generate new challenges in terms of development.

To contribute to the body of knowledge on human behaviour and social interaction by collecting data of interest from different social sectors and decision-makers in the public and private spheres, as well as from research personnel.

This line of research has two clearly differentiated objectives:

1. To deepen our knowledge, assessment and treatment of speech disorders of organic, anatomical or structural aetiology.
2. To deepen knowledge of oro-facial motor skills in repetition and associated with different activities.

Biomechanical evaluation and analysis of any type of physical activity, especially during running, walking and cycling, as well as the analysis of sports activity from the applied perspective of sports biomechanics and physiological variables.

Our group has characterised a new important regulator of the Start transition: Whi7. Whi7 acts as a transcriptional repressor of the Start programme, collaborating with Whi5 in this function. So that, as occurs in mammals with the Rb family, the control of cell cycle initiation depends on the interplay between different repressors. The group's work aims to advance in the characterisation of the regulation and function of Whi7 and its comparison with Whi5 in different physiological conditions, which may help to understand how the action of different repressors is coordinated in the control of cell cycle initiation. In addition, the relationship between Whi7 and the protein kinase C pathway is being investigated. The fact that a member of the Rb family is mutated in almost all tumours further reinforces the importance of studying the role of these G1 repressors.

Corresponding to its complexity and wide range, it focuses on studies and developments concerning strategy (including tactical and operational levels) and all the components involved in the decision-making process, based on normative or descriptive models (mathematical versus psychological), as well as at the individual and group level.

Effects of stress and treatment on cognitive aspects, hormone levels and quality of life in people with epilepsy.

Fundamental studies are carried out to explain the shape of chromatographic peaks which continue or question historical studies by other authors on this subject. Peak models and peak prediction strategies are developed to optimise separation conditions.

Tissue engineering applied to the osteoarticular system. We evaluate different biomaterials for their application to articular cartilage regeneration. We have evaluated substitutes based on chitosan discs, PCL and hyaluronic acid, as well as other elements including mixed hydrogels and microspheres both in vitro and in vivo. This line of research has been funded by the ministry without interruption since 2004 (MAT2004-04980, MAT2007-66759, MAT2013-46467-C4-4-R and MAT2016-76039-C4-2-R).

Study of the molecular mechanisms responsible for the maintenance and correct functioning of NSCs in the adult brain. Specifically, we aim to address the study of how quiescence is regulated at the molecular level and how quiescence-activation responds to niche elements.

Once the development of effective algorithms has been completed, the necessary computed tomography-ultrasound fusion-strain techniques will be implemented. They will then be implemented in a commercial planning system and clinically verified.

Study of the population affected by or at risk of osteoporosis and its improvement and prevention through physical exercise using a working system with elastic bands that is easy to handle and applicable to home treatment.

Study of tendon pathologies in general and tendon injuries in sports in particular, and their recovery using a work methodology with physical activity.

We will analyse the earliest effects that occur in the neurons of the spinal cord, as well as the role played by glia, with the aim of identifying the mechanisms that cause and are involved in the disease. On the other hand, a potential pathway of propagation between neurons will be studied.

Study of the alterations associated with or causing the degeneration of dopaminergic neurons and their relationship with ageing and associated conditioning factors. Studies of the effects of Parkinsonism on the behaviour of NSCs.

eIF5A is an elongation factor that binds to ribosomes when they get stuck during the synthesis of some proteins containing proline, glycine and charged amino acid motifs. Our group has determined that eIF5A is required for the synthesis of formins (yeast, fly and mouse), collagen (mouse and human) and human proteins that are prone to aggregation in aged cells. Our aim is to mechanistically determine the function of eIF5A, through the synthesis of its target proteins, in pathologies such as fibrosis, cancer or during ageing. Understanding these mechanisms will help in the development of specific therapies aimed at regulating eIF5A function.

The aim of this study is to search for biomarkers of cognitive impairment associated with liver disease by characterising the salivary and faecal microbiota in cirrhotic patients and in patients with non-alcoholic steatohepatitis.

Study of molecular interactions between helminth parasites and their hosts. Tools destined to the control of said parasitosis (proteins and recombinant peptides along with polyclonal antibodies) stem from identified molecules.

Ethics in the use of health resources. Sustainability. Equity, efficiency and health quality. Public health. Knowledge and attitudes of the population regarding HIV. Preventive actions in one's own health. Ethics of health organisations. Ethics of pharmaceutical laboratories.

A systematic review is an objective review of a clearly formulated question whose answer requires the integration of the empirical studies that have been carried out on it. Its aim is to systematically and objectively accumulate the evidence obtained in empirical studies on a given problem. Therefore, systematic reviews are secondary studies that synthesise the available scientific information through rigorous and explicit methods, which saves time for health and social care professionals and provides them with an overview of what the scientific evidence suggests about studies in promotion of the life quality.

• Martínez-Gregorio, S., Badenes-Ribera, L., and Oliver, A. (2021). Effect of entrepreneurship education on entrepreneurship intention and related outcomes in educational contexts: a meta-analysis. The International Journal of Management Education, 19, 100545. Doi: 10.1016/j.ijme.2021.100545. 
• Badenes-Ribera, L., Molla-Esparza, C., Longobardi, C., Sánchez-Meca, J., and Fabris, M. A. (2021). Homicide as a Source of Posttraumatic Stress?: A Meta-Analysis of the Prevalence of Posttraumatic Stress Disorder After Committing Homicide. Journal of Traumatic Stress, 34, 345-356. Doi: 10.1002/jts.22630. 
• Ventura, S., Badenes-Ribera, L., Herrero, R., Cebolla, A., Galiana, L., and Baños, R. M. (2020). Virtual Reality as a Medium to Elicit Empathy: A Meta-Analysis. Cyberpsychology Behavior and Social Networking. 23, 667-676. Doi: 10.1089/cyber.2019.0681.
• Rubio-Aparicio, M., Badenes-Ribera, L., Sánchez-Meca, J., Fabris, M., and Longobardi, C. (2020). A Reliability Generalization Meta-analysis of self-report measures of Muscle Dysmorphia. Clinical Psychology-Science and Practice, 27, e12303. 2020. Doi: 10.1111/cpsp.12303. 
• Longobardi, C., Badenes-Ribera, L., Fabris, M. A., Martinez, A., and McMahon, S. (2019). Prevalence of Student Violence Against Teachers: A Meta-Analysis. Psychology Of Violence, 9, 596-610. Doi: 10.1037/vio0000202.
• Longobardi, C., and Badenes-Ribera, L. (2019). The relationship between animal cruelty in children and adolescent and interpersonal violence: A systematic review. Aggression and Violent Behavior, 46, 201-211. Doi: 10.1016/j.avb.2018.09.001. 
• Badenes-Ribera, L., Sánchez-Meca, J., and Longobardi, C. (2019). The Relationship Between Internalized Homophobia and Intimate Partner Violence in Same-Sex Relationships: A Meta-Analysis. Trauma, Violence and Abuse, 20, 331-343. Doi: 10.1177/1524838017708781
• Badenes-Ribera, L., Rubio-Aparicio, M., Sánchez-Meca, J., Fabris, M. A., and Longobardi, C. (2019). The association between muscle dysmorphia and eating disorder symptomatology: A systematic review and meta-analysis. Journal of Behavioral Addictions, 8, 351-371. Doi: 10.1556/2006.8.2019.44.
• Badenes-Ribera, L., Fabris, M. A., and Longobardi, C. (2018). The relationship between internalized homonegativity and body image concerns in sexual minority men: a meta-analysis. Psychology and Sexuality, 9, 251-268. Doi: 10.1080/19419899.2018.1476905. 
• Longobardi, C., and Badenes-Ribera, L. (2017). Intimate Partner Violence in Same-Sex Relationships and The Role of Sexual Minority Stressors: A Systematic Review of the Past 10 Years. Journal of Child and Family Studies, 26, 2039-2049. Doi: 10.1007/s10826-017-0734-4. 
• Badenes-Ribera, L., Bonilla-Campos, A., Frias-Navarro, D., Pons-Salvador, G., and Monterde-i-Bort, H. (2016). Intimate Partner Violence in Self-Identified Lesbians: A Systematic Review of Its Prevalence and Correlates. Trauma, Violence and Abuse, 17, 284-297. Doi: 10.1177/1524838015584363.
• Badenes-Ribera, L., Frias-Navarro, D., Bonilla-Campos, A., Pons-Salvador, G., and Monterde-i-Bort, H. (2015). Intimate Partner Violence in Self-identified Lesbians: A Meta-analysis of its Prevalence. Sexuality Research and Social Policy, 12, 47-59. Doi: 10.1007/s13178-014-0164-7.

The following beams will be studied: 6 MV, 12 MV, Esteya, HDR & LDR brachytherapy source; the chambers of PTW: Soft X-Ray Chamber Type 23342, 23344 and 34013, Farmer Chamber Type 30010, 30011, 30012 and 30013, Semiflex Chamber Type 31010, 31013 and 31021, Roos Chamber Type 34001 and Advanced Markus Chamber Type 34045.

Development and characterisation of devices, based on the processing carried out by the visual system: colourimetric characterisation of image capture and display devices, image processing. Characterisation of optical devices.

Epidemiological study of teniasis / cisticercosis, with special reference to the third new parasitic tapeworm: Taenia asiatica. Ultrastructural studies of infective forms. Secretomics analysis of cisticercosis' infective forms (eggs) of the three human Taenia species.

Decision-making is a complex cognitive process that is influenced by emotions. In this line, we analyse these relationships applied to different experimental contexts and social settings.

The constructivist paradigm is gaining ground among qualitative researchers and new methodologies such as the narrative are opening up for research in local communities. Especially on problems that are not usually visible and that, through the recognition of the strategy of the citizens’ involvement in the solution of them, it is possible to plan processes of social change that recognize the need to generate public policies of community development.

Study of the geometric shape of the lumbar spine and its relationship with chronic non-specific low back pain.

We characterise the changes in immunophenotype and inflammation associated with the onset of MHE. We analyse the microRNA and protein content of exosomes and their usefulness for diagnosing MHE. We analysed alterations in neuronal connectivity by functional MRI. Funded by: ISCIII (PI18/00150). 

This line is related to the investigation of the ways in which teachers in initial teacher training construct meanings in relation to music. If these ways of meaning music are known, the processes of construction of musical knowledge (procedural and declarative) can also be known, and contributions can be made to the knowledge of initial and continuous teacher training, as well as to the training processes from pedagogy and didactics.

Our research activity focuses on studying mechanisms of pathogenesis and 
discovering potential drug therapies for diseases of genetic origin, in particular Myotonic Dystrophy (DM1 and DM2), Spinal Muscular Atrophy (SMA) and Limb-Girdle Muscular Dystrophy (LGMDD2).

The research and development topics are very broad and include studies of the travel habits or needs of users of a given territory or means of transport, user satisfaction, public transport, the impact of changes in supply, soft modes, freight, logistics, last mile, fares, accessibility, inclusiveness, gender, environment, electric mobility, etc.

Likewise, and even more so in the case of Road Safety, Intelligent Transport Systems (ITS) are the object of study and development, as well as other means of land transport, such as rail, tram and metro, as well as maritime and air transport.

We want to cross a strain of tumour-prone mice with our FN-syn mice and analyse the influence of this mutation on tumour development, migration and metastasis formation of tumour cells.

We are using several approaches to study human genetic diseases in Drosophila in order to dissect their pathogenesis pathways and identify biomarkers for diagnosis and/or progression, as well as to discover molecules with therapeutic potential.

To analyse the polyphenolic antioxidant capacity as protection against the development of retinopathies related to oxidative stress.

Monitoring natural and anthropogenic environments for disease surveillance, specially viral outbreaks. Detection of emerging viruses in natural environments and development of quantification techniques for population monitoring. Study of new transmission routes of emerging viruses.

The aim of this line of research is to deepen our knowledge, on the one hand, of vision disorders of organic, functional, psychogenic and transgeneric origin (among others) and, on the other hand, of resonance disorders derived to a large extent from velopharyngeal dysfunction.

From this perspective, Social Services are constituted as a cornerstone that catalyses the areas of quality of life. Social Services, Education, Justice, Employment, Housing, Health are structures that maintain quality levels in people; but also Social Services allow minimising the difficulties of globalised and neoliberal societies. GESinn is committed to investigating the current organisation of social services, the validity of their programmes and services, the revision and updating of intervention protocols and all those issues that result in reducing the imbalances between wealth and poverty.

Requirement to keep working time records, socio-labour implications, productivity, accidents, working time, prevention of occupational risks, flexibility, teleworking, etc.