The main objective of this line is to investigate the molecular mechanisms of drug hepatotoxicity. These studies are a very valuable aid in the preclinical stages of the development of new drugs, as well as to elucidate hepatic adverse reactions to drugs already on the market. They are also essential for finding new biomarkers (microRNAs, metabolites) to, for example, predict steatosis or cholestasis, which are two of the most frequent manifestations of drug-induced liver injury.

Hepatotoxicity, molecular mechanisms, necrosis, apoptosis, metabolic alterations, biomarkers, transcriptomics, metabolomics

• Gastroenterology and Hepatology