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Publicacions del grup d'investigació

 
  • Sagrado, S.; Pardo-Cortina, C.; Escuder-Gilabert, L.; Medina-Hernández, M.J.; Martín-Biosca, Y. Intelligent Recommendation Systems Powered by Consensus Neural Networks: The Ultimate Solution for Finding Suitable Chiral Chromatographic Systems?  Anal. Chem., 96 (2024) 12205−12212  https://doi.org/10.1021/acs.analchem.4c02656
  • M Pérez-Baeza, Y. Martín-Biosca; L. Escuder-Gilabert; M.J. Medina-Hernández; S. Sagrado. Artificial neural networks to model the enantioresolution of structurally unrelated neutral and basic compounds with cellulose tris(3,5-dimethylphenylcarbamate) chiral stationary phase and aqueous-acetonitrile mobile phases. J. Chromatogr. A, 1672 (2022) https://doi.org/10.1016/j.chroma.2022.463048
  • M Pérez-Baeza, L. Escuder-Gilabert; Y. Martín-Biosca; S. Sagrado; M.J. Medina-Hernández. Comparative study on retention behaviour and enantioresolution of basic and neutral structurally unrelated compounds with cellulose-based chiral stationary phases in reversed phase liquid chromatography-mass spectrometry conditions. J. Chromatogr. A, 1673 (2022) https://doi.org/10.1016/j.chroma.2022.463073
  • Martín-Biosca, L. Escuder-Gilabert, S. Sagrado, M.J. Medina-Hernández. Enantioselective Study on the Biodegradation of Verapamil and Cytalopram by Chiral Capillary Electrophoresis. Separations 8(3)(2021) 29. https://doi.org/10.3390/separations8030029
  • Perez-Baeza, L. Escuder-Gilabert, Y. Martín-Biosca, S. Sagrado, M.J. Medina-Hernández. Reversed phase liquid chromatography for the enantioseparation of local anaesthetics in polysaccharide-based stationary phases. Application to biodegradability studies. J. Chromatogr. A 1625‏ (2020) 461334. 10.1016/j.chroma.2020.461334
  • Pérez-Baeza, L. Escuder-Gilabert, Y. Martín-Biosca, S. Sagrado, M.J. Medina-Hernández. Comparative modelling study on enantioresolution of structurally unrelated compounds with amylose-based chiral stationary phases in reversed phase liquid chromatography-mass spectrometry conditions. J. Chromatogr. A, 1625 (2020) 461281. https://doi.org/10.1016/j.chroma.2020.461281
  • Martín-Biosca, L. Escuder-Gilabert, M.J. Medina-Hernández, S. Sagrado. Modelling the enantioresolution capability of cellulose tris(3,5-dichlorophenylcarbamate) stationary phase in reversed phase conditions for neutral and basic chiral compounds. J. Chromatogr. A 1567 (2018) 111-118. https://doi.org/10.1016/j.chroma.2018.06.0
  • Escuder-Gilabert, Y. Martín-Biosca, M. Perez-Baeza, S. Sagrado, M.J. Medina-Hernández. Direct chromatographic study of the enantioselective biodegradation of ibuprofen and ketoprofen by an activated sludge. J. Chromatogr. A 1568 (2018) 140-148. https://doi.org/10.1016/j.chroma.2018.07.034
  • Escuder-Gilabert, Y. Martín-Biosca, M. Perez-Baeza, S. Sagrado, M.J. Medina-Hernández. Trimeprazine is enantioselectively degraded by an activated sludge in ready biodegradability test conditions. Water Research 141 (2018) 57-64. https://doi.org/10.1016/j.watres.2018.05.008
  • Escuder-Gilabert, Y. Martín-Biosca, S. Sagrado, M.J. Medina-Hernández. Enantioresolution in electrokinetic chromatography-complete filling technique using sulfated gamma-cyclodextrin. Software-free topological anticipation. J. Chromatogr. A 1467 (2016) 391-399. https://doi.org/10.1016/j.chroma.2016.06.028
  • Escuder-Gilabert, Y. Martín-Biosca, S. Sagrado, M.J. Medina-Hernández. Fast-multivariate optimization of chiral separations in capillary electrophoresis: Anticipative strategies. J. Chromatogr. A 1363 (2014) 331-337. https://doi.org/10.1016/j.chroma.2014.06.095
  • Martín-Biosca; L. Escuder-Gilabert; S. Sagrado; M.J. Medina-Hernández. Electrophoretically mediated microanalysis for evaluation of enantioselective drug metabolism. Libro: Capillary Electrophoresis: Trends and Developments in Pharmaceutical Research Editorial: PAN STANFORD. ISBN:9789814774123. 2-21 (2016)
  • L-Escudert-Gilabert; Y. Martín-Biosca; S. Sagrado; M.J. Medina-Hernández. Enantioselective drug-plasma protein binding studies by capillary electrophoresis. Libro: Capillary Electrophoresis: Trends and Developments in Pharmaceutical Research Editorial: PAN STANFORD. ISBN:9789814774123 (2016) 1-21.
  • Asensi-Bernardi; Y. Martín-Biosca; L. Escuder-Gilabert; S. Sagrado; M.J. Medina-Hernández. Evaluation of the enantioselective binding of imazalil to human serum albumin by capillary electrophoresis. Biomed. Chromatogr. 29 (2015) 1637-1642. https://doi.org/10.1002/bmc.3472
  • Escuder-Gilabert; Y. Martín-Biosca; M.J. Medina-Hernández; S. Sagrado. Cyclodextrins in capillary electrophoresis: Recent developments and new trends. J. Chromatogr. A 1357 (2014) 2-23. https://doi.org/10.1016/j.chroma.2014.05.074Get rights and content
  • Asensi-Bernardi; L. Escuder-Gilabert; Y. Martín-Biosca; S. Sagrado; M.J. Medina-Hernández. Characterizing the interaction between enantiomers of eight psychoactive drugs and highly sulfated-β-cyclodextrin by counter-current capillary electrophoresis. Biomed. Chromatogr. 28 (2014) 120-126. https://doi.org/10.1002/bmc.2935
  • Asensi-Bernardi; Y. Martín-Biosca; L. Escuder-Gilabert; S. Sagrado; M.J. Medina-Hernández Modeling the chiral resolution ability of highly sulfated β-cyclodextrin for basic compounds in electrokinetic chromatography. J. Chromatogr. A 1308 (2013) 152-160. https://doi.org/10.1016/j.chroma.2013.08.003
  • Asensi-Bernardi; Y. Martín-Biosca; L. Escuder-Gilabert; S. Sagrado; M.J. Medina-Hernández. Fast evaluation of enantioselective drug metabolism by electrophoretically mediated microanalysis: application to fluoxetine metabolism by cytochrome P2D6. Electrophoresis 34 (2013) 3214- 3220. https://doi.org/10.1002/elps.201300267
  • Asensi-Bernardi; Y. Martín-Biosca; L. Escuder-Gilabert; S. Sagrado; M.J. Medina-Hernández In-line capillary electrophoretic evaluation of the enantioselective metabolism of verapamil by CYP3A4. J. Chromatogr. A 1298 (2013) 139-145. https://doi.org/10.1016/j.chroma.2013.05.038
  • Asensi-Bernardi; Y. Martín-Biosca; E. Fornet-Herrero; S. Sagrado M.J. Medina-Hernández Determination of fluoxetine enantiomers in pharmaceutical formulations by electrokinetic chromatography-counter current technique. Biomed. Chromatogr. 27 (2013) 377-381. https://doi.org/10.1002/bmc.2802
  • J. Gumede, P. Singh, M.I. Sabela, K. Bisetty, L. Escuder-Gilabert, M.J. Medina-Hernández, S. Sagrado. Experimental-like affinity constants and enantioselectivity estimates from flexible docking. Journal of Chemical Information and Modeling. 52 (2012) 2754-2759. https://doi.org/10.1021/ci300335m
  • Sabela, N. Gumede, L. Escuder-Gilabert, Y. Martin-Biosca, K. Bisetty, M.J Medina-Hernandez, S. Sagrado. Connecting simulated, bioanalytical and molecular docking data on the estereoselective binding of (±)-catechin to human serum albumin. Anal. Bioanal. Chem. 402 (2012) 1899-1909. DOI 10.1007/s00216-011-5636-5
  • A. Martínez-Gómez, L. Escuder-Gilabert, R.M. Villanueva-Camañas, S. Sagrado, M.J. Medina-Hernández. Evaluation of enantioselective binding of propanocaine to human serum albumin by ultrafiltration and electrokinetic chromatography under intermediate precision conditions J. Chromatogr. B- 889 (2012) 87-94. https://doi.org/10.1016/j.jchromb.2012.01.034
  • Asensi-Bernardi, Y. Martín-Biosca, S. Sagrado, M.J. Medina-Hernández: Electrokinetic chromatographic estimation of the enantioselective binding of nomifensine to human serum albumin and total plasma proteins. Biomed. Chromatogr. 26 (2012) 1357-1363. https://doi.org/10.1002/bmc.2704
  • Asensi-Bernardi, Y. Martín-Biosca, M.J. Medina-Hernández, S. Sagrado. On the zopiclone enantioselective binding to Human Albumin and plasma proteins. An electrokinetic chromatography approach. J. Chromatogr. A 1218 (2011) 3111-3117. https://doi.org/10.1016/j.chroma.2011.03.025
  • Asensi-Bernardi, Y. Martín-Biosca, R.M. Villanueva-Camañas, S. Sagrado, M.J. Medina-Hernández. Evaluation of Enantioselective Binding of Fluoxetine to Human Serum Albumin by Ultrafiltration and CE. Experimental Design and Quality considerations. Electrophoresis 31 (2010) 3268-3280. https://doi.org/10.1002/elps.201000250
  • Escuder-Gilabert, M.A. Martínez-Gómez, R.M. Villanueva-Camañas, S. Sagrado, M.J. Medina-Hernández. Microseparation techniques for the study of the enantioselectivity of drug-plasma protein binding. Biomed. Chromatogr. 23 (2009) 225-238. https://doi.org/10.1002/bmc.1134
  • A. Martínez-Gómez, L. Escuder-Gilabert, R.M. Villanueva-Camañas, S. Sagrado, M.J. Medina-Hernández. Enantioseparation of nuarimol by affinity electrokinetic chromatography-partial filling technique using human serum albumin as chiral selector. J. Sep. Sci. 31 (2008) 3265-3271. https://doi.org/10.1002/jssc.200800190
  • A. Martínez-Gómez, R.M. Villanueva-Camañas, S. Sagrado, M.J. Medina-Hernández. Evaluation of enantioselective binding of basic drugs to plasma by ACE. Electrophoresis 28 (2007) 3056-3063. https://doi.org/10.1002/elps.200700222
  • A. Martínez-Gómez, S. Sagrado, R.M. Villanueva-Camañas, M.J. Medina-Hernández. Enantiomeric quality control of antihistames in pharmaceuticals by affinity electrokinetic chromatography with human serum albumin as chiral selector. Anal. Chim. Acta 592 (2007) 202-209. https://doi.org/10.1016/j.aca.2007.04.029
  • A. Martínez-Gómez, R.M. Villanueva-Camañas, S. Sagrado, M.J. Medina-Hernández. Evaluation of enantioselective binding of antihistamines to human serum albumin by ACE. Electrophoresis 28 (2007) 2635-2643. https://doi.org/10.1002/elps.200600742
  • A. Martínez-Gómez, S. Sagrado, R.M. Villanueva-Camañas, M.J. Medina-Hernández. Enantioseparation of phenothiazines by affinity electrokinetic chromatography using human serum albumin as chiral selector. Aplication to enantiomeric quality control in pharmaceutical formulations. Anal. Chim. Acta 582 (2007) 223-228. https://doi.org/10.1016/j.aca.2006.09.036
  • A. Martínez-Gómez, R.M. Villanueva-Camañas, S. Sagrado, M.J. Medina-Hernández. Potential of human serum albumin as chiral selector of basic drugs in affinitty electrokinetic chromatography-partial filling technique. Electrophoresis 27 (2006) 1-11. https://doi.org/10.1002/elps.200600216
  • A. Martínez-Gómez, R.M. Villanueva-Camañas, S. Sagrado, M.J. Medina-Hernández. Multivariate optimization approach for chiral resolution of drugs using human serum albumin in affinity electrokinetic chromatography-partial filling technique. Electrophoresis 26 (2005) 4116-4126. https://doi.org/10.1002/elps.200500304
  • A. Martínez-Gómez, J.J. Martínez-Pla, S. Sagrado, R.M. Villanueva-Camañas, M.J. Medina-Hernández. Chiral separation of oxprenolol by affinity electrokinetic chromatography-partial filling technique using human serum albumin as chiral selector. J. Pharm. Biomed. Anal. 39 (2005) 76- 81. https://doi.org/10.1016/j.jpba.2005.03.028
  • J. Martínez-Pla, Y. Martín-Biosca, S. Sagrado, R.M. Villanueva-Camañas, M.J. Medina-Hernández. Chiral separation of bupivacaine enantiomers by capillary electrophoresis partial-filling technique with human serum albumin as chiral selector. J. Chromatogr. A 1048 (2004) 111-118. https://doi.org/10.1016/j.chroma.2004.07.024
  • J. Martínez-Pla, Y.Martín-Biosca, S. Sagrado, R.M. Villanueva-Camañas, M.J. Medina-Hernández. Fast enantiomeric separation of propranolol by affinity capillary electrophoresis using human serum albumin as chiral selector: application to quality control of pharmaceuticals. Anal. Chim. Acta 507 (2004) 171- 178. https://doi.org/10.1016/j.aca.2003.11.029Get rights and content