Our fundamental interest is to understand how cells respond to the signals they receive by modifying their gene expression. Our aim is to address changes in gene expression by studying its different stages, from the transcriptional activation of genes to the formation of messenger RNA molecules and their translation, paying attention not only to the factors involved and the mechanisms, but also to the connection or crosstalk that is established between them and makes gene expression not a linear process but one that is interconnected forwards and backwards, in time and space.
In addition, we pay special attention to some factors that appear to be key in the control of gene expression and that often act in a multidisciplinary way in several biological processes and different cellular compartments. One such factor is the eIF5A protein, highly conserved from yeast to humans and essential in eukaryotic cells. eIF5A is a translation elongation factor required in the synthesis of proteins containing amino acid motifs with consecutive proline or combinations of proline, glycine and charged amino acids.
Our interest is to understand the mechanism of translation regulation by eIF5A, determining which are the proteins whose synthesis requires this factor and how, directly or through its targets, eIF5A acts in pathological processes such as fibrosis, cancer or during ageing. In our group, we mainly use the yeast Saccharomyces cerevisiae as a model organism, since it is the best known eukaryote and a model for understanding evolutionarily conserved molecular processes at the cellular level. Furthermore, we have found that the conclusions of our research can be generalised to mammalian cells using mouse or human cell cultures.
- Objective 1: Generation of genome-scale techniques and their use in the investigation of the various stages and processes of gene expression.
- Objective 2: Study of the control of translation by the evolutionarily conserved factor eIF5A and its role in pathologies.
- Study of the control of translation by the evolutionarily conserved factor eIF5A and its role in pathologies
eIF5A is an elongation factor that binds to ribosomes when they get stuck during the synthesis of some proteins containing proline, glycine and charged amino acid motifs. Our group has determined that eIF5A is required for the synthesis of formins (yeast, fly and mouse), collagen (mouse and human) and human proteins that are prone to aggregation in aged cells. Our aim is to mechanistically determine the function of eIF5A, through the synthesis of its target proteins, in pathologies such as fibrosis, cancer or during ageing. Understanding these mechanisms will help in the development of specific therapies aimed at regulating eIF5A function.
- Genomic analysis of transcription in yeast
The complexity of the phenomenon of gene expression will be better understood if techniques for measuring transcription in vivo at the genomic level are improved and genetic and genomic approaches are used to clarify the functional connections that control transcription.
- PEREZ ORTIN, JOSE ENRIQUE
- PDI-Catedratic/a d'Universitat
- Coordinador/a de Programa de Doctorat
- Secretari/a d' Institut Universitari
- GARCIA MARTINEZ, JOSE
- PDI-Titular d'Universitat
- Director/a de Departament
- ContraerExpandirPEREZ ORTIN, JOSE ENRIQUEPDI-Catedratic/a d'UniversitatCoordinador/a de Programa de DoctoratSecretari/a d' Institut Universitari
Igual, J.C.; Matallana, E.; González-Bosch, C.; Franco, L.; Pérez-Ortín, J.E.(1991)A new glucose-repressible gene identified from the analysis of chromatin structure of deletion mutants of the yeast SUC2 locus.Yeast, 7, pp. 379 - 389. ISSN: 1097-0061
Matallana, E.; Franco, L. y Pérez-Ortín, J.E.(1992)Chromatin structure of the yeast SUC2 promoter in regulatory mutants.Molecular and General Genetics, 231, pp. 395 - 400. ISSN: 0026-8925
Igual, J.C.; González-Bosch, C; Dopazo, J.; Pérez-Ortín, J.E.(1992)Phylogenetic analysis of the thiolase family. Implications on the evolutionary origin of peroxisomes.Journal of Molecular Evolution, 35, pp. 147 - 155. ISSN: 0022-2844
Igual, J.C.; González-Bosch, C.; Franco, L.; Pérez-Ortín, J.E.(1992)The POT1 gene for the yeast peroxisomal thiolase is subjected to three different mechanisms of regulation.Molecular Microbiology, 6, pp. 1867 - 1875. ISSN: 0950-382X
Del Olmo M. y Pérez-Ortín, J.E.(1993)A natural A/T-rich sequence from the 3' end of yeast FBP1 gene exists as a cruciform in E. coli cells.Plasmid, 29, pp. 222 - 232. ISSN: 0147-619X
Tordera, V., Sendra, R. y Pérez-Ortín, J.E.(1993)The role of histones and their modifications in informative content of chromatin.Experientia, 49, pp. 780 - 788. ISSN: 0014-4754
Del Olmo, M.; Sogo, J.M.; Franco, L. y Pérez-Ortín, J.E.(1993)Chromatin structure of the yeast FBP1 gene: transcription-dependent changes in the regulatory and coding regions.Yeast, 9, pp. 1229 - 1240. ISSN: 1097-0061
Bargues, M.; Salom, D.; Gómez, A.; Paricio, N.; Pérez-Alonso, M. y Pérez-Ortín, J.E.(1996)Sequencing analysis of a 4.1 kb subtelomeric region from yeast chromosome IV identifies HXT15, a new member of the hexose transporter family.Yeast, 12, pp. 1005 - 1011. ISSN: 1097-0061
Puig, S.; Querol, A.; Ramón, D. y Pérez-Ortín, J.E.(1996)Evaluation of the use of late phase gene promoters for the expression of enological enzymes in an industrial wine yeast strain.Biotechnology Letters, 18, pp. 887 - 892. ISSN: 0141-5492
Jacq, C...Pérez-Ortín, J.E. et al.(1997)The complete nucleotide sequence of yeast chromosome IV.Nature, 387 (suplement), pp. 75 - 78. ISSN: 0028-0836
Aranda, A.; Pérez-Ortín, J.E.; Benham, C.J. y del Olmo, M.(1997)Analysis of the in vivo structure of a natural alternating d(TA)n sequence in yeast chromatin.Yeast, 13, pp. 313 - 326. ISSN: 1097-0061
Puig, S., Ramón D. y Pérez-Ortín, J. E.(1998)An optimized method to obtain stable food-safe recombinant wine yeast strains.Journal of Agricultural and Food Chemistry, 46, pp. 1689 - 1693. ISSN: 0021-8561
Aranda, A.; Pérez-Ortín, J.E.; Moore, C. y del Olmo, M.(1998)Transcription termination downstream of the Saccharomyces cerevisiae FBP1 poly(A) site does not depend on efficient 3' end processing.RNA-A Publication of the Rna Society, 4(3), pp. 303 - 318. ISSN: 1355-8382
Ruiz-García, A.B.; Sendra, R.; Galiana, M.; Pamblanco, M.; Pérez-Ortín, J.E. y Tordera., V.(1998)HAT1 and HAT2 proteins are componets of a yeast nuclear histone acetyltransferase enzyme specific for free histone H4.Journal of Biological Chemistry, 273, pp. 12599 - 12605. ISSN: 0021-9258
Aranda, A.; Pérez-Ortín, J.E.; Moore, C. y del Olmo, M.(1998)Research Group on Functional Genomics of YeastsNucleic Acids Research, 26(20), pp. 4588 - 4596. ISSN: 0305-1048
Gimeno-Alcañiz, J.; Pérez-Ortín, J.E. y Matallana, E.(1999)Differential patterns of threalose accumulation in wine yeast strains during microvinification process.Biotechnology Letters, 21, pp. 271 - 274. ISSN: 0141-5492
Ivorra, C.; Pérez-Ortín, J.E.y del Olmo, M.(1999)Reverse correlation of stress-resistance ability and stuck fermentations in wine yeasts. A molecular study.Biotechnology and Bioengineering, 64(6), pp. 698 - 708. ISSN: 0006-3592
Rodriguez-Navarro, S.; Estruch, F. y Pérez-Ortín, J.E.(1999)Functional analysis of twelve ORFs from Saccharomyces cerevisiae.Yeast, 15, pp. 913 - 919. ISSN: 1097-0061
Puig, S.; Matallana, E. y Pérez-Ortín, J.E(1999)Stochastical nucleosome positioning in a yeast chromatin region is not dependent on Histone H1.Current Microbiology, 39, pp. 168 - 172. ISSN: 0343-8651
Puig, S.; Pérez-Ortín, J.E y Matallana, E.(1999)Transcriptional and structural study of a region of two convergent overlapping yeast genes.Current Microbiology, 39, pp. 369 - 373. ISSN: 0343-8651
Puig, S.y Pérez-Ortín, J.E.(2000)Stress response and expression patterns in wine fermentation of yeast genes induced at the diauxic shift.Yeast, 16, pp. 139 - 148. ISSN: 1097-0061
van Helden, J.; Olmo Muñoz, Marcel·lí del; Pérez Ortín, José Enrique(2000)Research Group on Functional Genomics of YeastsNucleic Acids Research, 28(4), pp. 1000 - 1010. ISSN: 0305-1048
Puig Todolí, Sergi; Querol Simón, Amparo; Barrio Esparducer, Eladio; Pérez Ortín, José Enrique(2000)Research Group on Functional Genomics of YeastsApplied and Environmental Microbiology, 66(5), pp. 2057 - 2061. ISSN: 0099-2240
Puig, S. y Pérez-Ortín, J.E.(2000)Expression levels and pattern of glycolytic yeast genes during wine fermentation.Systematic and Applied Microbiology, 23, pp. 300 - 303. ISSN: 0723-2020
Hauser, N.C.; Fellenberg, K.; Gil, R., Bastuck, S.; Hoheisel, J.D.; Pérez Ortín, José Enrique(2001)Research Group on Functional Genomics of YeastsComparative And Functional Genomics, 2(2), pp. 69 - 79. ISSN: 1531-6912
PAMBLANCO, M.; POVEDA, A.; SENDRA, R.; RODRÍGUEZ-NAVARRO, S.; PÉREZ-ORTÍN, J. E.; TORDERA, V.(2001)Bromodomain factor 1 (Bdf1) protein interacts with histones.Febs Letters, 496, pp. 31 - 35. ISSN: 0014-5793
Rodríguez-Navarro, S.; Igual, J.C.; Pérez-Ortín, J.E.(2002)SRC1: an intron-containing yeast gene involved in sister chromatid segregation.Yeast, 19, pp. 43 - 54. ISSN: 1097-0061
Pérez-Ortín, J.E.; García-Martínez, J. and Alberola T. M.(2002)DNA chips for yeast biotechnology. The case of wine yeasts.Journal of Biotechnology, 98, pp. 227 - 241. ISSN: 0168-1656
Pérez-Torrado, R., Carrasco, P., Aranda, A., Gimeno-Alcañiz, J., Pérez-Ortín, J.E., Matallana, E, y Del Olmo, M.(2002)Study of the first hours of vinification by the use of osmotic stress-specific response genes as probes.Systematic and Applied Microbiology, 25(1), pp. 153 - 161. ISSN: 0723-2020
Rodríguez-Navarro, Susana; Llorente, B.; Rodríguez-Manzaneque, M.T.; Ramne, A.; Uber Garcia, Genoveva; Marchesan, D.; Dujon, B.; Herrero,E.; Sunnerhagen, P.; Pérez-Ortín, José Enrique(2002)Research Group on Functional Genomics of YeastsYeast, 19, pp. 1261 - 1276. ISSN: 1097-0061
Pérez Ortín, José Enrique; Querol Simón, Amparo; Puig Todolí, Sergi; Barrio Esparducer, Eladio(2002)Research Group on Functional Genomics of YeastsGenome Research, 12(10), pp. 1533 - 1539. ISSN: 1088-9051
Carrasco, P.; Pérez-Ortín, J.E. y del Olmo, M.(2003)Arginase Activity is a Useful Marker of Growth Nitrogen Limitation During Wine Fermentations.Systematic and Applied Microbiology, 26, pp. 471 - 479. ISSN: 0723-2020
Rodríguez-Navarro, Susana; Fischer, Tomás; Luo, Ming Juan; Antúnez, Oreto; Brettschneider, Susanne; Pérez Ortín, José Enrique; Reed, Robin; Hurt, Ed(2004)Research Group on Functional Genomics of YeastsCell, 116(1), pp. 75 - 86. ISSN: 0092-8674
Bellí, G.; Molina, M.M.; García Martínez, José; Pérez-Ortín, José Enrique; Herrero, Enrique(2004)Research Group on Functional Genomics of YeastsJournal of Biological Chemistry, 279(13), pp. 12386 - 12395. ISSN: 0021-9258
Alberola, T. M., García-Martínez, J., Antúnez, O., Viladevall, L., Barceló, A., Ariño, J. y Pérez-Ortín, J.E.(2004)Research Group on Functional Genomics of YeastsInternational Microbiology, 7(3), pp. 199 - 206. ISSN: 1139-6709
Pérez-Ortín, J.E.; del Olmo, M.; Matallana, E. y Tordera, V.(1997)Make your own gene library.Biochemical Education, 25, pp. 237 - 242. ISSN: 0307-4412
Del OLMO, M.; ARANDA, A.; TORDERA, V.; PÉREZ-ORTÍN, J.E.(1998)Detection of non-B-DNA secondary structures by S1 nuclease digestion.Journal of Chemical Education, 75, pp. 762 - 765. ISSN: 0021-9584
Pérez-Ortín, J.E. ; Moya, A. y Ramón, D.(1998)Els altres genomes.Mètode - Revista de la Universitat de València, 32, pp. 57 - 60. ISSN: 1133-3987
Carro, D.; García-Martínez, J; Pérez-Ortín, J.E. y Piña, B.(2003)Structural characterization of chromosome I size variants from a natural yeast strain.Yeast, 20, pp. 171 - 180. ISSN: 1097-0061
Güldener, U; Münsterkötter, M.; Kastenmüller, G; Strack1, N; van Helden, J.; Lemer, C.; Richelles, J.; Wodak, S.J.; García Martínez, José; Pérez Ortín, José E.; Michael, H.; Kaps, A.; Talla, E.; Dujon, B.; André, B.; Souciet, J.L.; De Montigny, J.; Bon, E.; Gaillardin, C. y Mewes, H.W(2005)Research Group on Functional Genomics of YeastsNucleic Acids Research, 33(suppl 1), pp. D364 - D368. ISSN: 0305-1048
Pérez-Ortín, J.E. y García-Martínez, J.(2004)Evaluation of transcription rates at the genomic level.Bioforum Europe, 8(5), pp. 46 - 48. ISSN: 1611-597X
Garcia Martinez, José; Aranda Fernández, Agustín; Pérez Ortín, José Enrique(2004)Research Group on Functional Genomics of YeastsMolecular Cell, 15(2), pp. 303 - 313. ISSN: 1097-2765
Rosaleny Peralvo, Lorena Estefania; Antúnez, O.; Ruiz Garcia, Ana Belén; Pérez Ortin, José Enriqu.; Tordera Donderis, Vicente(2005)Research Group on Functional Genomics of YeastsFebs Letters, 579(19), pp. 4063 - 4068. ISSN: 0014-5793
Solieri, L.; Gullo, M.; De Vero, L.; Antúnez, O.; Pérez Ortín, José Enrique; Giudici, P.(2005)Research Group on Functional Genomics of YeastsInternational Journal of Biotechnology & Biochemistry (IJBB), 1(1), pp. 11 - 21. ISSN: 0973-2691
Pelechano, Vicente José; García Martínez, José; Pérez Ortín, José Enrique(2006)Research Group on Functional Genomics of YeastsYeast, 23, pp. 689 - 699. ISSN: 1097-0061
Mendes-Ferreira A.; Olmo Muñoz, Marcel·lí del; García Martínez José; Jiménez Martí Elena; Mendes-Faia A.; Pérez Ortín, José Enrique; Leão C.(2007)Research Group on Functional Genomics of YeastsApplied and Environmental Microbiology, 73(9), pp. 3049 - 3060. ISSN: 0099-2240
Pérez Ortín, José Enrique; Alepuz Martínez, Paula; Moreno Mariño, Joaquín(2007)Research Group on Functional Genomics of YeastsTrends in Genetics, 23(5), pp. 250 - 257. ISSN: 0168-9525
Rosaleny Peralvo, Lorena Estefanía; Ruiz García, Ana Belén; García Martínez, José; Pérez Ortín, José Enrique; Tordera Donderis, Vicente(2007)Research Group on Functional Genomics of YeastsGenome biology, 8(6), p. R119. ISSN: 1474-7596
Mendes-Ferreira A.; Olmo Muñoz, Marcel·li del; García Martínez José; Jiménez Martí, Elena; Leão, C.; Mendes-Faia A, Pérez Ortín José E.(2007)Research Group on Functional Genomics of YeastsApplied and Environmental Microbiology, 73(16), pp. 5363 - 5369. ISSN: 0099-2240
Pelechano García, Vicente José; Pérez Ortín, José Enrique(2007)Research Group on Functional Genomics of YeastsYeast, 25(2), pp. 85 - 92. ISSN: 1097-0061
García Martínez, José; González Candelas, Fernando; Pérez Ortín, José Enrique(2007)Research Group on Functional Genomics of YeastsGenome biology, 8, p. R222. ISSN: 1474-7596
Pérez Ortín, José Enrique(2007)Research Group on Functional Genomics of YeastsBriefings in Functional Genomics & Proteomics, 6(4), pp. 282 - 291. ISSN: 1473-9550
Fernando Cardona, Purificación Carrasco, José Enrique Pérez-Ortín, Marcel.lí del Olmo*, Agustín Aranda (* corresponding author)(2007)Research Group on Functional Genomics of YeastsInternational Journal of Food Microbiology, 114(1), pp. 83 - 91. ISSN: 0168-1605
Molina-Navarro, M.M.; Castells-Roca, L.; Bellí, G.; García-Martínez, J.; Marín-Navarro, J.; Moreno, J. Pérez-Ortín, J.E. y Herrero, E.(2008)Comprehensive transcriptional analysis of the oxidative response in yeast.Journal of Biological Chemistry, 283, pp. 17908 - 17918. ISSN: 0021-9258
Solieri, L.; Antúnez, O.; Pérez-Ortín, J.E.; Barrio, E. y Giudici, P(2008)Research Group on Functional Genomics of YeastsYeast, 25(7), pp. 485 - 500. ISSN: 1097-0061
Grund, S.E.; Fischer, T.; Cabal, G.G.; Antúnez, O.; Pérez Ortín, José Enrique; Hurt, E.(2008)Research Group on Functional Genomics of YeastsJournal of Cell Biology, 182(5), pp. 897 - 910. ISSN: 0021-9525
Belloch, Carmela; Pérez Torrado, Roberto; González, Sara S.; Pérez Ortín, José Enrique; García Martínez, José; Querol Simón, Amparo; Barrio Esparducer, Eladio(2009)Research Group on Functional Genomics of YeastsApplied and Environmental Microbiology, 75(8), pp. 2534 - 2544. ISSN: 0099-2240
Pelechano García, Vicente José; Jimeno-González, Silvia; Rodríguez-Gil, Alfonso; García Martínez, José; Pérez Ortín, José Enrique; Chávez, Sebastián(2009)Research Group on Functional Genomics of YeastsPLOS genetics, 5(8), p. e1000614. ISSN: 1553-7390
Romero Santacreu, Lorena; Moreno Mariño, Joaquín; Pérez Ortín, José Enrique; Alepuz Martínez, Paula(2009)Research Group on Functional Genomics of YeastsRNA-A Publication of the Rna Society, 15(6), pp. 1110 - 1120. ISSN: 1355-8382
Pelechano García, Vicente José; Pérez Ortín, José Enrique(2010)Research Group on Functional Genomics of YeastsYeast, 27(7), pp. 413 - 422. ISSN: 1097-0061
Rodríguez-Gil, Alfonso; García Martínez, José; Pelechano García, Vicente José; Muñoz-Centeno, María de la Cruz; Geli, Vincent; Pérez Ortín, José Enrique; Chávez, Sebastián(2010)Research Group on Functional Genomics of YeastsNucleic Acids Research, 38(14), pp. 4651 - 4664. ISSN: 0305-1048
Bermúdez, Ignacio; García Martínez, José; Pérez Ortín, José Enrique; Roca, Joaquim(2010)Research Group on Functional Genomics of YeastsNucleic Acids Research, 38(19), p. e182. ISSN: 0305-1048
Pelechano García, Vicente José; Chávez, Sebastián; Pérez Ortín, José Enrique(2010)Research Group on Functional Genomics of YeastsPlos One, 5(11), p. e15442. ISSN: 1932-6203
Castells-Roca, L.; García-Martínez, J.; Moreno Mariño, Joaquín; Herrero, E.; Bellí, G. y Pérez Ortín, José Enrique(2011)Research Group on Functional Genomics of YeastsPlos One, 6(2), p. e17272. ISSN: 1932-6203
Pérez Ortín, José Enrique; Jordán Pla, Antonio; Pelechano García, Vicente José(2011)Research Group on Functional Genomics of YeastsComptes Rendus Biologies, 334(8-9), pp. 647 - 654. ISSN: 1631-0691
Vicente Tordera y José E. Pérez Ortín(2011)Hipótesis y dogmas.Investigación y Ciencia, 2011(Agosto), pp. 3 - 3. ISSN: 0210-136X
Pérez Ortín, José Enrique; Medina, Daniel A; Jordán Plá, Antonio(2011)Research Group on Functional Genomics of YeastsGenetics Research International, 2011(989303). ISSN: 2090-3154
M. Carmen García-López, Vicent Pelechano, M. Carmen Mirón-García, Ana I. Garrido-Godino,Alicia García, Olga Calvo, Michel Werner, José E. Pérez-Ortín, and Francisco Navarro(2011)The conserved foot domain of RNA Pol II associates with proteins involved in transcritpion initiation and/or early elongation.Genetics, 189, pp. 1235 - 1248. ISSN: 0016-6731
García Martínez, José; Ayala Gallego, Guillermo; Pelechano García, Vicente José; Chávez, S.; Herrero, E.; Pérez Ortín, José Enrique(2012)Research Group on Functional Genomics of YeastsTranscription, 3(1), pp. 39 - 44. ISSN: 2154-1264
Pérez Ortín, José Enrique; De Miguel-Jiménez, Lola; Chávez, Sebastián(2012)Research Group on Functional Genomics of YeastsBiochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1819(6), pp. 604 - 615. ISSN: 1874-9399
Alic, Andrei; Pérez Ortín, José Enrique; Moreno Mariño, Joaquín.; Arnau LLombart, Vicente(2013)Research Group on Functional Genomics of YeastsBioinformatics, 29, pp. 813 - 814. ISSN: 1367-4803
Garre García, Elena; Romero Santacreu Lorena; Barneo-Muñoz, Manuela; Miguel, Ana; Pérez Ortín, José Enrique; Alepuz Martínez, Paula(2013)Research Group on Functional Genomics of YeastsPlos One, 8(4), p. e61240. ISSN: 1932-6203
José E. Pérez-Ortín, Paula Alepuz, Sebastián Chávez and Mordechai Choder(2013)Research Group on Functional Genomics of YeastsJournal of Molecular Biology, S0022-2836(13), pp. 00131 - 00139. ISSN: 0022-2836
Haimovich, G.; Medina, D.A.; Causse, S.Z.; Garber, M.; Millán-Zambrano, G.; Barkai, O.; Chávez, S.; Pérez Ortín, José Enrique; Darzacq, X.; Choder, M.(2013)Research Group on Functional Genomics of YeastsCell, 153(5), pp. 1000 - 1011. ISSN: 0092-8674
Nikolaou, C.; Bermúdez, I.; Manichanh, C.; García-Martínez, José; Guigó, R.; Pérez-Ortín, José E.; Roca, J.(2013)Research Group on Functional Genomics of YeastsNucleic Acids Research, 41(20), pp. 9243 - 9256. ISSN: 0305-1048
Miguel, A.; Montón, F.; Li, T.; Gómez-Herreros, G.; Chávez, S.; Alepuz, P. y Pérez-Ortín, J.E.(2013)External conditions inversely change the RNA polymerase II elongation rate and density in yeast.Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1829, pp. 1248 - 1255. ISSN: 1874-9399
Pérez-Ortín, J.E., Alepuz, P.; Chávez, S. y Choder, M.(2013)Eukaryotic mRNA decay: methodologies, pathways, and links to other stages of gene expression.Journal of Molecular Biology, 425(20), pp. 3750 - 3775. ISSN: 0022-2836
José E. Pérez-Ortín, Daniel A. Medina, Sebastián Chavez y Joaquín Moreno(2013)What do you mean by transcription rate?.Bioessays, 35, pp. 1056 - 1062. ISSN: 0265-9247
Medina, DA; Jordán-Pla, A.; Millán-Zambrano, G.; Chávez, S.; Choder, M.; Pérez Ortín, José Enrique(2014)Research Group on Functional Genomics of YeastsFrontiers In Genetics, 5(1). ISSN: 1664-8021
Jordán-Pla, A.; Gupta, I.; de Miguel-Jiménez, L.; Steinmetz, L.M.; Chávez, S.; Pelechano V. y Pérez-Ortín, J.E.(2015)Research Group on Functional Genomics of YeastsNucleic Acids Research, 43(2), pp. 787 - 802. ISSN: 0305-1048
Barbosa C, García-Martínez J, Pérez-Ortín JE, Mendes-Ferreira A.(2015)Research Group on Functional Genomics of YeastsPlos One, 10(4), p. e0122709. ISSN: 1932-6203
Canadell D, García-Martínez J, Alepuz P, Pérez-Ortín JE, Ariño J.(2015)Impact of high pH stress on yeast gene expression: A comprehensive analysis of mRNA turnover during stress responses.Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1849(6), pp. 653 - 664. ISSN: 1874-9399
Juanes JM, Miguel A, Morales LJ, Pérez-Ortín JE, Arnau V(2015)Research Group on Functional Genomics of YeastsBioinformatics, 31(19), pp. 3228 - 3230. ISSN: 1367-4803
Natalia Gómez-Navarro, Antonio Jordán-Pla, Francisco Estruch y José E. Pérez-Ortín(2016)Research Group on Functional Genomics of YeastsBmc Genomics, 17, pp. 183-1 - 183-9. ISSN: 1471-2164
Tianlu Li; Nikki De Clercq; Daniel A. Medina; Elena Garre; Per Sunnerhagen; José E. Pérez-Ortín; Paula Alepuz(2016)The mRNA cap-binding protein Cbc1 is required for high and timely expression of genes by promoting the accumulation of gene-specific activators at promoters.Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1859, pp. 405 - 4119. ISSN: 1874-9399
García-Martínez, José; Delgado-Ramos, Lidia; Ayala, Guillermo; Pelechano, Vicent; Medina, Daniel A.; Carrasco, Fany; González, Ramón; Andrés-León, Eduardo; Steinmetz, Lars; Warringer, Jonas; Chávez, Sebastián; Pérez-Ortín, José E(2016)Research Group on Functional Genomics of YeastsNucleic Acids Research, 44, pp. 3643 - 3658. ISSN: 0305-1048
Garrido-Godino AI; García-López MC; García-Martínez J; Pelechano V; Medina DA; Pérez-Ortín JE; Navarro F.(2016)Research Group on Functional Genomics of YeastsBiochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1859(5), pp. 731 - 743. ISSN: 1874-9399
Sebastián Chávez; José García-Martínez;· Lidia Delgado-Ramos; José E. Pérez-Ortín(2016)Research Group on Functional Genomics of YeastsCurrent Genetics, 62(4), pp. 701 - 710. ISSN: 0172-8083
José García-Martínez; Kevin Troulé; Sebastián Chávez; José E. Pérez-Ortín(2016)Growth Rate controls mRNA turnover in steady and non-steady states.Rna Biology, 13(12), pp. 1175 - 1181. ISSN: 1547-6286
Benet M, Miguel A, Carrasco F, Li T, Planells J, Alepuz P, Tordera V, Pérez-Ortín JE.(2017)Research Group on Functional Genomics of YeastsBiochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1860, pp. 794 - 802. ISSN: 1874-9399
Adriana Mena, Daniel A. Medina, José García-Martínez, Victoria Begley, Abhyudai Singh, Sebastián Chávez, Mari C. Muñoz-Centeno, José E. Pérez-Ortín(2017)Research Group on Functional Genomics of YeastsNucleic Acids Research, 45(21), pp. 12401 - 12412. ISSN: 0305-1048
Gabriel Gutiérrez; Gonzalo Millán-Zambrano; Daniel A. Medina; Antonio Jordán-Pla; José E. Pérez-Ortín; Xenia Peñate; Sebastián Chávez(2017)Research Group on Functional Genomics of YeastsEpigenetics & Chromatin, 10(58), pp. 1 - 22. ISSN: 1756-8935
Varinia García‑Molinero, José García‑Martínez, Rohit Reja, Pedro Furió‑Tarí, Oreto Antúnez, Vinesh Vinayachandran, Ana Conesa, B. Franklin Pugh, José E. Pérez‑Ortín, Susana Rodríguez‑Navarro(2018)Research Group on Functional Genomics of YeastsEpigenetics & Chromatin, 11(13), pp. 1 - 12. ISSN: 1756-8935
Fernando Gómez-Herreros, Thanasis Margaritis, Olga Rodríguez-Galán, Vicent Pelechano, Victoria Begley, Gonzalo Millán-Zambrano, Macarena Morillo-Huesca, Mari Cruz Muñoz-Centeno, José E. Pérez-Ortín, Jesús de la Cruz, Frank C. P. Holstege y Sebastián Chávez.(2017)Research Group on Functional Genomics of YeastsNucleic Acids Research, 45(16), pp. 9302 - 9318. ISSN: 0305-1048
Blasco-Moreno B; de Campos-Mata L; Böttcher R; García-Martínez J; Jungfleisch J; Nedialkova DD; Chattopadhyay S; Gas ME; Oliva B; Pérez-Ortín JE; Leidel SA; Choder M; Díez J(2019)Research Group on Functional Genomics of YeastsNature Communications, 10, p. 1298. ISSN: 2041-1723
Paula Oliete-Calvo; Joan Serrano-Quílez; Carme Nuño-Cabanes; María E Pérez-Martínez; Luis M Soares; Bernhard Dichtl; Stephen Buratowski; José E Pérez-Ortín; Susana Rodríguez-Navarro(2018)Research Group on Functional Genomics of YeastsEmbo Reports, 19, p. e 45992. ISSN: 1469-221X
Antonio Jordán-Pla; Maria E. Pérez-Martínez; José E. Pérez-Ortín(2019)Research Group on Functional Genomics of YeastsMethods-A Companion to Methods in Enzymology, 159-160, pp. 177 - 182. ISSN: 1046-2023
Olga Calvo; Nathalie Grandin; Antonio Jordán-Pla; Esperanza Miñambres; Noelia González-Polo; José E. Pérez-Ortín; Michel Charbonneau(2019)Research Group on Functional Genomics of YeastsNucleic Acids Research, 47(12), pp. 6250 - 6268. ISSN: 0305-1048
Victoria Begley; Daniel Corzo; Antonio Jordán-Pla; Abel Cuevas-Bermúdez; Lola de Miguel-Jiménez; David Pérez-Aguado; Mercedes Machuca-Ostos; Francisco Navarro; María José Chávez; José E. Pérez-Ortín; Sebastián Chávez(2019)Research Group on Functional Genomics of YeastsNucleic Acids Research, 47(18), pp. 9524 - 9541. ISSN: 0305-1048
José E. Pérez-Ortín; Vicente Tordera; Sebastián Chávez(2019)Research Group on Functional Genomics of YeastsRna Biology, 16, pp. 1659 - 1666. ISSN: 1547-6286
Romero AM; Ramos-Alonso L; Montellá-Manuel S; García-Martínez J; de la Torre-Ruiz MÁ; Pérez-Ortín JE; Martínez-Pastor MT; Puig S(2019)Research Group on Functional Genomics of YeastsBiochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1862(9), p. 194414. ISSN: 1874-9399
A.I. Garrido-Godino; I. Gupta; F Gutiérrez-Santiago; A.B. Martínez-Padilla; A. Alekseenko; L.M. Steinmetz; J.E. Pérez-Ortín; V. Pelechano; F. Navarro(2021)Research Group on Functional Genomics of YeastsRna Biology, 18(8), pp. 1206 - 1220. ISSN: 1547-6286
Forés‐Martos, J.; Forte, A.; García‐Martínez, J; Pérez‐Ortín, J.E.(2021)Research Group on Functional Genomics of YeastsCells, 10(2), p. 334. ISSN: 2073-4409
Begley V; Jordán-Pla A; Peñate X; Garrido-Godino AI; Challal D; Cuevas-Bermúdez A; Mitjavila A; Barucco M; Gutiérrez G; Singh A; Alepuz P; Navarro F; Libri D; Pérez-Ortín JE; Chávez S.(2021)Research Group on Functional Genomics of YeastsRna Biology, 18(9), pp. 1310 - 1323. ISSN: 1547-6286
José García-Martínez; María E Pérez-Martínez; José E Pérez-Ortín; Paula Alepuz(2021)Research Group on Functional Genomics of YeastsRna Biology, 18(10), pp. 1458 - 1474. ISSN: 1547-6286
Pérez-Ortín JE; Mena A; Barba-Aliaga M; Singh A; Chávez S; García-Martínez J.(2021)Research Group on Functional Genomics of YeastsPlos Genetics, 17(4), p. e1009520. ISSN: 1553-7390
Barba-Aliaga M.; Alepuz P.; Pérez-Ortín J.E.(2021)Research Group on Functional Genomics of YeastsFrontiers In Molecular Biosciences, 8(663209). ISSN: 2296-889X
García-Martínez J; Medina DA; Bellvis P; Sun M; Cramer P; Chávez S; Pérez-Ortín JE(2021)Research Group on Functional Genomics of YeastsRNA-A Publication of the Rna Society, 27, pp. 1281 - 1290. ISSN: 1355-8382
Romero, A.M.; García-Martínez, J.; Pérez-Ortín, J.E.; Martínez-Pastor, M.T.; Puig, S.(2022)Changes in mRNA stability play an important role in the adaptation of yeast cells to iron deprivation.Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1865, p. 194800. ISSN: 1874-9399
Antonio Jordán-Pla; José E Pérez-Ortín(2022)Research Group on Functional Genomics of YeastsMethods in Molecular Biology, 2477, pp. 57 - 70. ISSN: 1064-3745
José E Pérez-Ortín; Sebastián Chávez(2022)Research Group on Functional Genomics of YeastsBiochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1865, p. 194849. ISSN: 1874-9399
Vicente Arnau; Marina Barba-Aliaga; Gaurav Singh; Javier Ferri; José García-Martínez; José E. Pérez-Ortín(2022)Research Group on Functional Genomics of YeastsPlos One, 17(9), p. e0272878. ISSN: 1932-6203
Shiladitya Chattopadhyay; Jose Garcia-Martinez; Gal Haimovich; Jonathan Fischer; Aya Khwaja; Oren Barkai; Silvia Gabriela Chuartzman; Maya Schuldiner; Ron Elran; Miriam I. Rosenberg; Shira Urim; Shubham Deshmukh; Katherine E. Bohnsack; Markus T. Bohnsack; Jose E. Perez-Ortin; Mordechai Choder(2022)Research Group on Functional Genomics of YeastsNature Communications, 13(7184), pp. 1 - 17. ISSN: 2041-1723
José García-Martínez; Abhyudai Singh; Daniel Medina; Sebastián Chávez; José E. Pérez-Ortín(2023)Research Group on Functional Genomics of YeastsBiochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1866, p. 194910. ISSN: 1874-9399
M. Kelbert; A. Jordan-Pla; L. de-Miguel-Jiménez; J García-Martínez; M. Selitrennik; A. Gutman; N Henig; S Granneman; J.E. Pérez-Ortín; S. Chávez; M. Choder(2023)Research Group on Functional Genomics of YeastsElife, 12(RP90766). ISSN: 2050-084X
José E. Pérez-Ortín; María J. García-Marcelo; Irene Delgado-Roman; María C. Muñoz- Centeno; Sebastián Chávez(2024)Research Group on Functional Genomics of YeastsBiochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1867(195008). ISSN: 1874-9399
José E. Pérez‐Ortín; Antonio Jordán‐Pla; Yujie Zhang; Jorge Moreno‐García; Claudio Bassot; Marina Barba‐Aliaga; Leire de Campos‐Mata; Mordechai Choder; Juana Díez; Ilaria Piazza; Vicent Pelechano; José García‐Martínez(2024)Research Group on Functional Genomics of YeastsYeast, 41, pp. 458 - 472. ISSN: 1097-0061
Pérez-Ortín, J.E; Jordán-Pla, A; Zhang, Y; Choder, M; Pelechano, V; García-Martínez, J; Forte, Anabel; Chattopadhyay, S(2025)Research Group on Functional Genomics of YeastsPlos One, 20(1), p. e0308195. ISSN: 1932-6203
Jordán-Pla, A.; Gupta, I.; de Miguel-Jiménez, L.; Steinmetz, L.M.; Chávez, S.; Pelechano V. y Pérez-Ortín, J.E.2015Research Group on Functional Genomics of YeastsNucleic Acids ResearchVolume 43. Number 2.
Barbosa C, García-Martínez J, Pérez-Ortín JE, Mendes-Ferreira A.2015Research Group on Functional Genomics of YeastsPlos OneVolume 10. Number 4.
Canadell D, García-Martínez J, Alepuz P, Pérez-Ortín JE, Ariño J.2015Impact of high pH stress on yeast gene expression: A comprehensive analysis of mRNA turnover during stress responsesBiochimica Et Biophysica Acta-Gene Regulatory MechanismsVolume 1849. Number 6.
Juanes JM, Miguel A, Morales LJ, Pérez-Ortín JE, Arnau V.2015Research Group on Functional Genomics of YeastsBioinformaticsVolume 31. Number 19.
Natalia Gómez-Navarro, Antonio Jordán-Pla, Francisco Estruch y José E. Pérez-Ortín.2016Research Group on Functional Genomics of YeastsBmc GenomicsVolume 17.
Tianlu Li; Nikki De Clercq; Daniel A. Medina; Elena Garre; Per Sunnerhagen; José E. Pérez-Ortín; Paula Alepuz.2016The mRNA cap-binding protein Cbc1 is required for high and timely expression of genes by promoting the accumulation of gene-specific activators at promotersBiochimica Et Biophysica Acta-Gene Regulatory MechanismsVolume 1859.
García-Martínez, José; Delgado-Ramos, Lidia; Ayala, Guillermo; Pelechano, Vicent; Medina, Daniel A.; Carrasco, Fany; González, Ramón; Andrés-León, Eduardo; Steinmetz, Lars; Warringer, Jonas; Chávez, Sebastián; Pérez-Ortín, José E.2016Research Group on Functional Genomics of YeastsNucleic Acids ResearchVolume 44.
Garrido-Godino AI; García-López MC; García-Martínez J; Pelechano V; Medina DA; Pérez-Ortín JE; Navarro F.2016Research Group on Functional Genomics of YeastsBiochimica Et Biophysica Acta-Gene Regulatory MechanismsVolume 1859. Number 5.
Sebastián Chávez; José García-Martínez;· Lidia Delgado-Ramos; José E. Pérez-Ortín.2016Research Group on Functional Genomics of YeastsCurrent GeneticsVolume 62. Number 4.
José García-Martínez; Kevin Troulé; Sebastián Chávez; José E. Pérez-Ortín.2016Growth Rate controls mRNA turnover in steady and non-steady statesRna BiologyVolume 13. Number 12.
Journal Publications
Pérez-Ortín, J.E.,(1997).Organización molecular del genoma de Saccharomyces cerevisiae.Organización y evolución del genoma eucariota. Marcadores moleculares. Colección Cursos, Congresos e Simposios... Volume. 30 . (pp. 99 - 114)..
Pérez-Ortín, J.E. y García Martínez, J,(2005).Genómica y proteómica de levaduras vínicas.Microbiología del vino. A.V. Carrascosa, R. González y R. Muñoz (eds)... (pp. 185 - 209)..
Tordera, V.; Del Olmo, M. Pérez-Ortín, J.E. y Matallana, E.,(2007).Qüestions en Biologia Molecular.Colección 'Educació. Laboratori de Materials'.. Volume. 10 . (pp. 1 - 259)..
Ji., S.; Chaovalitwongsea, W.A.; Fefferman, N.; Yoo, W. y Pérez-Ortín, J.E.,(2009).Mechanism-Based Clustering of Genome-Wide mRNA Levels: Roles of Transcription and Transcript-Degradation Rates.Clustering Challenges in Biological Networks.. (pp. 237 - 255)..
Pérez-Ortín, J.E., del Olmo, M., García-Martínez, J.,(2009).DNA arrays.Biology of microorganisms on grapes, in must and in wine.. (pp. 469 - 488)..
García Martínez, J, Pelechano, V. y Pérez-Ortín, J.E.,(2011).Genomic methods for evaluating transcription rates in yeast.Yeast Genetic Networks.. Volume. 734 . Number. part 1 . (pp. 25 - 44)..
Marín-Navarro, J., Jauhiainen, A., Moreno, J., Alepuz, P.M., Pérez-Ortín, P.M. y Sunnerhagen, P.,(2011).Global estimation of mRNA stability in yeast.Yeast Genetic Networks.. Volume. 734 . Number. part 1 . (pp. 3 - 23)..
Pérez-Ortín, J.E.; Alepuz, P.; García-Martínez, J.; Tordera, V. y Arnay, V.,(2014).Grupo Genómica Funcional de Levaduras... Number. 58 . (pp. 113 - 115)..
Jordán-Pla, A., Miguel, A.; Serna, E. Pelechano. V. y Pérez-Ortín, J.E.,(2016).Biotin-Genomic Run-On (Bio-GRO): A High-Resolution Method for the Analysis of Nascent Transcription in Yeast.Yeast Functional Genomics.. Volume. 1361 . (pp. 125 - 139)..
Ana Mendes-Ferreira, Marcel.lí del Olmo, José García-Martínez, José E. Pérez-Ortín,(2017).Functional Genomics in Wine Yeast: DNA Arrays and Next Generation Sequencing.Biology of Microorganisms on Grapes, in Must and in Wine. 2ª edición. Helmut König ¿ Gottfried Unden ¿ Jürgen Fröhlich, Editores.. (pp. 573 - 604)..
García-Marcelo, M.J.; Singh, G.; Chávez, S.; Pérez-Ortín, J.E.,(2025).Measurement of rRNA Synthesis Rate by 3H-Uracil Labeling in yeast.mRNA Decay: Methods and Protocols.. Volume. 2863 . (pp. 183 - 204)..
Other publications
- ContraerExpandirALEPUZ MARTINEZ, ELIA PAULAPDI-Catedratic/a d'Universitat
Alepuz, P.M.; Cunningham, K. W.; Estruch, F.(1997)Research Group on Functional Genomics of YeastsMolecular Microbiology, 26(1), pp. 91 - 99. ISSN: 0950-382X
de Alteriis, E., Alepuz, P.M., Estruch, F. and Parascandola, P(1997)Clues to the origin of high invertase activity in immobilized growing yeast: prolonged SUC2 transcription and less susceptibility of the enzyme to endogenous proteolysis. .Canadian Journal of Microbiology, 45(1), pp. 413 - 417. ISSN: 0008-4166
Alepuz, P. M., D. Matheos, K. Cunningham and F. Estruch(1999)The Saccharomyces cerevisiae RanGTP binding protein Msn5p is involved in different signal transduction pathways .Genetics, 153(3), pp. 1219 - 1231. ISSN: 0016-6731
Blondel, M., P. M. Alepuz, L. S. Huang, S. Shaham, G. Ammerer and M. Peter(1999)Nuclear export of Far1p in response to pheromones requires the export receptor Msn5p/Ste21p.Genes & Development, 13(17), pp. 2284 - 2300. ISSN: 0890-9369
Alepuz, P. M., Jovanovic, A., Reiser, V. and Ammerer, G(2001)Stress induced MAP kinase Hog1 is part of transcription activation complexes.Molecular Cell, 7(17), pp. 767 - 777. ISSN: 1097-2765
de Nadal, E., Alepuz, P. M., and Posas, F(2002)Dealing with osmo-stress through MAP kinase activation.Embo Reports, 3(8), pp. 735 - 740. ISSN: 1469-221X
Alepuz, P. M., de Nadal, E., Zapater, M., Ammerer, G. and Posas, F.,(2003)Osmostress induced transcription by Hot1 depends on a Hog1-mediated recruitment of the RNA polymerase II.Embo Journal, 22(10), pp. 2433 - 2442. ISSN: 0261-4189
de Nadal, E., Zapater, M., Alepuz, P. M., Sumoy, L., Mas, G. and Posas, F(2004)Regulation of gene expression by the Hog1 MAPK is mediated by the Rpd3 histone deacetylase.Nature, 427, pp. 271 - 274. ISSN: 0028-0836
Jimeno-González, S., Gómez-Herreros, F., Alepuz, P. M. and Chávez, S.,(2006)FACT requirement for transcription of yeast genes exhibiting nucleosomes positioned at the 5' end of their transcribed region. .Molecular and Cellular Biology, 26(23), pp. 8710 - 8721. ISSN: 0270-7306
Pérez-Ortín, J. E., Alepuz, P. M. and Moreno, J(2007)Genomics and gene transcription kinetics in yeast .Trends in Genetics, 23, pp. 250 - 257. ISSN: 0168-9525
Romero Santacreu, Lorena; Moreno Mariño, Joaquín; Pérez Ortín, José Enrique; Alepuz Martínez, Paula(2009)Research Group on Functional Genomics of YeastsRNA-A Publication of the Rna Society, 15(6), pp. 1110 - 1120. ISSN: 1355-8382
Romero-Santacreu, L., H. Orozco, E. Garre and P. Alepuz(2010)The bidirectional cytomegalovirus immediate/early promoter is regulated by Hog1 and the stress transcription factors Sko1 and Hot1 in yeast.Molecular Genetics and Genomics, 283(5), pp. 511 - 518. ISSN: 1617-4615
Garre, E.; Romero-Santacreu L; De Clercq, N.; Blasco-Angulo, N.; Sunnerhagen, P.; Alepuz P.(2012)Research Group on Functional Genomics of YeastsMolecular Biology of the Cell, 23(1), pp. 137 - 150. ISSN: 1059-1524
Garre García, Elena; Romero Santacreu Lorena; Barneo-Muñoz, Manuela; Miguel, Ana; Pérez Ortín, José Enrique; Alepuz Martínez, Paula(2013)Research Group on Functional Genomics of YeastsPlos One, 8(4), p. e61240. ISSN: 1932-6203
Miguel, A.; Montón, F.; Li, T.; Gómez-Herreros, G.; Chávez, S.; Alepuz, P. y Pérez-Ortín, J.E.(2013)External conditions inversely change the RNA polymerase II elongation rate and density in yeast.Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1829, pp. 1248 - 1255. ISSN: 1874-9399
Pérez-Ortín, J.E., Alepuz, P.; Chávez, S. y Choder, M.(2013)Eukaryotic mRNA decay: methodologies, pathways, and links to other stages of gene expression.Journal of Molecular Biology, 425(20), pp. 3750 - 3775. ISSN: 0022-2836
Mercè Gomar-Alba; Paula Alepuz; Marcel·lí del Olmo(2013)Research Group on Functional Genomics of YeastsBiochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1829, pp. 1111 - 1125. ISSN: 1874-9399
Li, T.; Belda-Palazón, B.; Ferrando, A.; Alepuz, P(2014)Research Group on Functional Genomics of YeastsGenetics, 197(4), pp. 1191 - 1200. ISSN: 0016-6731
Canadell D, García-Martínez J, Alepuz P, Pérez-Ortín JE, Ariño J.(2015)Impact of high pH stress on yeast gene expression: A comprehensive analysis of mRNA turnover during stress responses.Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1849(6), pp. 653 - 664. ISSN: 1874-9399
Aurora Zuzuarregui; Tianlu Li; Christina Friedmann; Gustav Ammerer; Paula Alepuz(2015)Research Group on Functional Genomics of YeastsBiochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1849(6), pp. 722 - 730. ISSN: 1874-9399
Tianlu Li; Nikki De Clercq; Daniel A. Medina; Elena Garre; Per Sunnerhagen; José E. Pérez-Ortín; Paula Alepuz(2016)The mRNA cap-binding protein Cbc1 is required for high and timely expression of genes by promoting the accumulation of gene-specific activators at promoters.Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1859, pp. 405 - 4119. ISSN: 1874-9399
van Wijlick L, Geissen R, Hilbig JS, Lagadec Q, Cantero PD, Pfeifer E, Juchimiuk M, Kluge S, Wickert S, Alepuz P, Ernst JF(2016)Research Group on Functional Genomics of YeastsPlos Genetics, 12(10), p. e1006395. ISSN: 1553-7390
Ballester-Tomás L; Prieto JA; Alepuz P; González A; Garre E; Randez-Gil F(2017)Research Group on Functional Genomics of YeastsBiochimica et Biophysica Acta-Molecular Cell Research, 1864(2), pp. 314 - 323. ISSN: 0167-4889
Benet M, Miguel A, Carrasco F, Li T, Planells J, Alepuz P, Tordera V, Pérez-Ortín JE.(2017)Research Group on Functional Genomics of YeastsBiochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1860, pp. 794 - 802. ISSN: 1874-9399
Pelechano V; Alepuz P(2017)Research Group on Functional Genomics of YeastsNucleic Acids Research, 45(12), pp. 7326 - 7338. ISSN: 0305-1048
MUÑOZ-SORIANO V.; LI T.; DOMINGO-MUELAS A.; GAMERO E.; BIZY A.; FARIÑAS I.; ALEPUZ P.; PARICIO N.(2017)Research Group on Functional Genomics of YeastsScientific Reports, 7(1), p. 9580. ISSN: 2045-2322
Ramos-Alonso L; Romero AM; Soler MÀ; Perea-García A; Alepuz P; Puig S; Martínez-Pastor MT.(2018)Research Group on Functional Genomics of YeastsPLOS genetics, 14(6), p. e1007476. ISSN: 1553-7390
Desai PR; Lengeler K; Kapitan M; Janßen SM; Alepuz P; Jacobsen ID; Ernst JF.(2018)Research Group on Functional Genomics of YeastsMsphere, 3(4), p. e00280-18. ISSN: 2379-5042
Garre E; Pelechano V; Sánchez Del Pino M; Alepuz P; Sunnerhagen P.(2018)Research Group on Functional Genomics of YeastsPlos Genetics, 14(7), p. e1007563. ISSN: 1553-7390
Quilis, I.; Taberner, F.J.; Martínez-Garay, C.A.; Alepuz, P.; Igual, J.C.(2019)Karyopherin Msn5 is involved in a novel mechanism controlling the cellular level of cell cycle regulators Cln2 and Swi5.Cell Cycle, 18(5), pp. 580 - 595. ISSN: 1538-4101
Pérez-Martínez ME, Benet M, Alepuz P, Tordera V.(2019)Research Group on Functional Genomics of YeastsEpigenetics, 15(3), pp. 251 - 271. ISSN: 1559-2294
Romero AM; Ramos-Alonso L; Alepuz P; Puig S; Martínez-Pastor MT(2020)Research Group on Functional Genomics of YeastsScientific Reports, 10(1), p. 233. ISSN: 2045-2322
Rosa-Téllez, S., Kanhonou R., Castellote-Bellés, C., Serrano, R., Alepuz, P., Ros, R.(2020)RNA-Binding Proteins as Targets to Improve Salt Stress Tolerance in Crops.Agronomy-Basel, 10(250). ISSN: 2073-4395
Barba-Aliaga M; Villarroel-Vicente C; Stanciu A; Corman A; Martínez-Pastor MT; Alepuz P.(2021)Research Group on Functional Genomics of YeastsInternational Journal Of Molecular Sciences, 22(219). ISSN: 1661-6596
José García-Martínez; María E Pérez-Martínez; José E Pérez-Ortín; Paula Alepuz(2021)Research Group on Functional Genomics of YeastsRna Biology, 18(10), pp. 1458 - 1474. ISSN: 1547-6286
Begley V; Jordán-Pla A; Peñate X; Garrido-Godino AI; Challal D; Cuevas-Bermúdez A; Mitjavila A; Barucco M; Gutiérrez G; Singh A; Alepuz P; Navarro F; Libri D; Pérez-Ortín JE; Chávez S.(2021)Research Group on Functional Genomics of YeastsRna Biology, 18(9), pp. 1310 - 1323. ISSN: 1547-6286
Barba-Aliaga M.; Alepuz P.; Pérez-Ortín J.E.(2021)Research Group on Functional Genomics of YeastsFrontiers In Molecular Biosciences, 8(663209). ISSN: 2296-889X
Barba-Aliaga M; Mena A; Espinoza V; Apostolova N; Costell M; Alepuz P.(2021)Research Group on Functional Genomics of YeastsJournal of Cell Science, 134(18), pp. jcs258643-1 - 21. ISSN: 0021-9533
Marina Barba-Aliaga; Paula Alepuz(2022)Research Group on Functional Genomics of YeastsInternational Journal Of Molecular Sciences, 23(3), p. 1284. ISSN: 1661-6596
Marina Barba-Aliaga M; Paula Alepuz(2022)Research Group on Functional Genomics of YeastsFebs Letters, 596((14)), pp. 1809 - 1818. ISSN: 0014-5793
Tania Jordá; Marina Barba-Aliaga; Nicolas Rozès; Paula Alepuz; María Teresa Martínez-Pastor; Sergi Puig(2022)Transcriptional regulation of Ergosterol biosynthesis genes in response to iron deficiency.Environmental Microbiology. ISSN: 1462-2912
Yu Xiao; Jia Li, Ruanlin Wang; Yajiao Fan; Xiaxia Han; Yuejun Fu; Paula Alepuz; Wei Wang; Aihua Liang(2023)eIF5A promotes +1 programmed ribosomal frameshifting in Euplotes octocarinatus.International Journal of Biological Macromolecules, 254, p. 127743. ISSN: 0141-8130
Rosa-Téllez, S., Alcántara-Enguídanos, A., Martínez-Seidel, F., Casatejada-Anchel, R., Saeheng, S., Bailes, C. L., Erban, A., Barbosa-Medeiros, D., Alepúz, Paula., Matus, J.T. Kopka, J., Muñoz-Bertomeu,J., Krueger, S., Roje, S., Fernie, A.R., Ros, R(2024)Research Group on Functional Genomics of YeastsPlant Cell, 36, pp. 404 - 426. ISSN: 1040-4651
Rocío Seoane; Tomás Lama‑Díaz; Antonia María Romero; Ahmed El Motiam; Arantxa Martínez‑Férriz; Santiago Vidal; Yanis H. Bouzaher; María Blanquer; Rocío M. Tolosa; Juan Castillo Mewa; Manuel S. Rodríguez; Adolfo García‑Sastre; Dimitris Xirodimas; James D. Sutherland; Rosa Barrio; Paula Alepuz; Miguel G. Blanco; Rosa Farràs; Carmen Rivas(2024)Research Group on Functional Genomics of YeastsCellular and Molecular Biology Letters, 29(1), p. 15. ISSN: 1689-1392
Marina Barba-Aliaga; Vanessa Bernal; Cynthia Rong; Madeleine Volfbeyn; Keguang Zhang; Brian Zid; Paula Alepuz(2024)Research Group on Functional Genomics of YeastsJournal of Cell Biology. ISSN: 0021-9525
Journal Publications
Elena Garre, Paula Alepuz, Per Sunnerhagen,(2018).Exploring how an RNA-binding protein affects stress-exposed cells... (pp. 1 - 3)..
Other publications
- ContraerExpandirGARCIA MARTINEZ, JOSEPDI-Titular d'UniversitatDirector/a de Departament
García-Martínez, J; Barrio, E; Raga, J.A. and Latorre, A(1995)Mitochondrial DNA variability of striped dolphin (Stenella coeruleoalba) in the Mediterranean Spanish waters.Marine Mammal Science, 11(2), pp. 183 - 199. ISSN: 0824-0469
Martínez-Izquierdo, J.A; García-Martínez, J. and Vicient, C.M.(1997)Research Group on Functional Genomics of YeastsGenetica, 100, pp. 15 - 28. ISSN: 0016-6707
García-Martínez, J; Castro, J.A; Ramón, M; Latorre, A. and Moya, A.(1998)Mitochondrial DNA haplotype frequencies in natural and experimental populations of Drosophila subobscura.Genetics, 149, pp. 1377 - 1382. ISSN: 0016-6731
García-Martínez, J; Raga, J.A. and Latorre, A(1999)Research Group on Functional Genomics of YeastsMolecular Ecology, 8(6), pp. 1069 - 1073. ISSN: 0962-1083
Pérez-Ortín, J.E.; García-Martínez, J. and Alberola T. M.(2002)DNA chips for yeast biotechnology. The case of wine yeasts.Journal of Biotechnology, 98, pp. 227 - 241. ISSN: 0168-1656
Carro, D.; García-Martínez, J; Pérez-Ortín, J.E. y Piña, B.(2003)Structural characterization of chromosome I size variants from a natural yeast strain.Yeast, 20, pp. 171 - 180. ISSN: 1097-0061
García-Martínez, J. and Martínez-Izquierdo, J.A.(2003)Research Group on Functional Genomics of YeastsMolecular Biology and Evolution, 20(5), pp. 831 - 841. ISSN: 0737-4038
Alberola, T. M., García-Martínez, J., Antúnez, O., Viladevall, L., Barceló, A., Ariño, J. y Pérez-Ortín, J.E.(2004)Research Group on Functional Genomics of YeastsInternational Microbiology, 7(3), pp. 199 - 206. ISSN: 1139-6709
Pérez-Ortín, J.E. y García-Martínez, J.(2004)Evaluation of transcription rates at the genomic level.Bioforum Europe, 8(5), pp. 46 - 48. ISSN: 1611-597X
Bellí, G.; Molina, M.M.; García Martínez, José; Pérez-Ortín, José Enrique; Herrero, Enrique(2004)Research Group on Functional Genomics of YeastsJournal of Biological Chemistry, 279(13), pp. 12386 - 12395. ISSN: 0021-9258
Garcia Martinez, José; Aranda Fernández, Agustín; Pérez Ortín, José Enrique(2004)Research Group on Functional Genomics of YeastsMolecular Cell, 15(2), pp. 303 - 313. ISSN: 1097-2765
Güldener, U; Münsterkötter, M.; Kastenmüller, G; Strack1, N; van Helden, J.; Lemer, C.; Richelles, J.; Wodak, S.J.; García Martínez, José; Pérez Ortín, José E.; Michael, H.; Kaps, A.; Talla, E.; Dujon, B.; André, B.; Souciet, J.L.; De Montigny, J.; Bon, E.; Gaillardin, C. y Mewes, H.W(2005)Research Group on Functional Genomics of YeastsNucleic Acids Research, 33(suppl 1), pp. D364 - D368. ISSN: 0305-1048
Pelechano, Vicente José; García Martínez, José; Pérez Ortín, José Enrique(2006)Research Group on Functional Genomics of YeastsYeast, 23, pp. 689 - 699. ISSN: 1097-0061
Castillo, L; Martínez, A.I; Garcerá, A; García-Martínez, J; Ruiz-Herrera, J; Valentín, E. and Sentandreu, R(2006)Research Group on Functional Genomics of YeastsFungal Genetics and Biology, 43, pp. 124 - 134. ISSN: 1087-1845
Mendes-Ferreira A.; Olmo Muñoz, Marcel·lí del; García Martínez José; Jiménez Martí Elena; Mendes-Faia A.; Pérez Ortín, José Enrique; Leão C.(2007)Research Group on Functional Genomics of YeastsApplied and Environmental Microbiology, 73(9), pp. 3049 - 3060. ISSN: 0099-2240
Rosaleny Peralvo, Lorena Estefanía; Ruiz García, Ana Belén; García Martínez, José; Pérez Ortín, José Enrique; Tordera Donderis, Vicente(2007)Research Group on Functional Genomics of YeastsGenome biology, 8(6), p. R119. ISSN: 1474-7596
Mendes-Ferreira A.; Olmo Muñoz, Marcel·li del; García Martínez José; Jiménez Martí, Elena; Leão, C.; Mendes-Faia A, Pérez Ortín José E.(2007)Research Group on Functional Genomics of YeastsApplied and Environmental Microbiology, 73(16), pp. 5363 - 5369. ISSN: 0099-2240
García Martínez, José; González Candelas, Fernando; Pérez Ortín, José Enrique(2007)Research Group on Functional Genomics of YeastsGenome biology, 8, p. R222. ISSN: 1474-7596
Molina-Navarro, M.M.; Castells-Roca, L.; Bellí, G.; García-Martínez, J.; Marín-Navarro, J.; Moreno, J. Pérez-Ortín, J.E. y Herrero, E.(2008)Comprehensive transcriptional analysis of the oxidative response in yeast.Journal of Biological Chemistry, 283, pp. 17908 - 17918. ISSN: 0021-9258
Campo, S; Manrique, S; García-Martínez, J. and San Segundo, B(2008)Research Group on Functional Genomics of YeastsPlant Biotechnology Journal, 6, pp. 585 - 608. ISSN: 1467-7644
Belloch, Carmela; Pérez Torrado, Roberto; González, Sara S.; Pérez Ortín, José Enrique; García Martínez, José; Querol Simón, Amparo; Barrio Esparducer, Eladio(2009)Research Group on Functional Genomics of YeastsApplied and Environmental Microbiology, 75(8), pp. 2534 - 2544. ISSN: 0099-2240
Pelechano García, Vicente José; Jimeno-González, Silvia; Rodríguez-Gil, Alfonso; García Martínez, José; Pérez Ortín, José Enrique; Chávez, Sebastián(2009)Research Group on Functional Genomics of YeastsPLOS genetics, 5(8), p. e1000614. ISSN: 1553-7390
Bermúdez, Ignacio; García Martínez, José; Pérez Ortín, José Enrique; Roca, Joaquim(2010)Research Group on Functional Genomics of YeastsNucleic Acids Research, 38(19), p. e182. ISSN: 0305-1048
Rodríguez-Gil, Alfonso; García Martínez, José; Pelechano García, Vicente José; Muñoz-Centeno, María de la Cruz; Geli, Vincent; Pérez Ortín, José Enrique; Chávez, Sebastián(2010)Research Group on Functional Genomics of YeastsNucleic Acids Research, 38(14), pp. 4651 - 4664. ISSN: 0305-1048
Castells-Roca, L.; García-Martínez, J.; Moreno Mariño, Joaquín; Herrero, E.; Bellí, G. y Pérez Ortín, José Enrique(2011)Research Group on Functional Genomics of YeastsPlos One, 6(2), p. e17272. ISSN: 1932-6203
García Martínez, José; Ayala Gallego, Guillermo; Pelechano García, Vicente José; Chávez, S.; Herrero, E.; Pérez Ortín, José Enrique(2012)Research Group on Functional Genomics of YeastsTranscription, 3(1), pp. 39 - 44. ISSN: 2154-1264
Campos-Soriano, L; García-Martínez, J. and San Segundo, B.(2012)Research Group on Functional Genomics of YeastsMolecular Plant Pathology, 13(6), pp. 579 - 592. ISSN: 1464-6722
Nikolaou, C.; Bermúdez, I.; Manichanh, C.; García-Martínez, José; Guigó, R.; Pérez-Ortín, José E.; Roca, J.(2013)Research Group on Functional Genomics of YeastsNucleic Acids Research, 41(20), pp. 9243 - 9256. ISSN: 0305-1048
Barbosa C, García-Martínez J, Pérez-Ortín JE, Mendes-Ferreira A.(2015)Research Group on Functional Genomics of YeastsPlos One, 10(4), p. e0122709. ISSN: 1932-6203
Canadell D, García-Martínez J, Alepuz P, Pérez-Ortín JE, Ariño J.(2015)Impact of high pH stress on yeast gene expression: A comprehensive analysis of mRNA turnover during stress responses.Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1849(6), pp. 653 - 664. ISSN: 1874-9399
García-Martínez, José; Delgado-Ramos, Lidia; Ayala, Guillermo; Pelechano, Vicent; Medina, Daniel A.; Carrasco, Fany; González, Ramón; Andrés-León, Eduardo; Steinmetz, Lars; Warringer, Jonas; Chávez, Sebastián; Pérez-Ortín, José E(2016)Research Group on Functional Genomics of YeastsNucleic Acids Research, 44, pp. 3643 - 3658. ISSN: 0305-1048
Garrido-Godino AI; García-López MC; García-Martínez J; Pelechano V; Medina DA; Pérez-Ortín JE; Navarro F.(2016)Research Group on Functional Genomics of YeastsBiochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1859(5), pp. 731 - 743. ISSN: 1874-9399
Sebastián Chávez; José García-Martínez;· Lidia Delgado-Ramos; José E. Pérez-Ortín(2016)Research Group on Functional Genomics of YeastsCurrent Genetics, 62(4), pp. 701 - 710. ISSN: 0172-8083
José García-Martínez; Kevin Troulé; Sebastián Chávez; José E. Pérez-Ortín(2016)Growth Rate controls mRNA turnover in steady and non-steady states.Rna Biology, 13(12), pp. 1175 - 1181. ISSN: 1547-6286
Adriana Mena, Daniel A. Medina, José García-Martínez, Victoria Begley, Abhyudai Singh, Sebastián Chávez, Mari C. Muñoz-Centeno, José E. Pérez-Ortín(2017)Research Group on Functional Genomics of YeastsNucleic Acids Research, 45(21), pp. 12401 - 12412. ISSN: 0305-1048
Varinia García‑Molinero, José García‑Martínez, Rohit Reja, Pedro Furió‑Tarí, Oreto Antúnez, Vinesh Vinayachandran, Ana Conesa, B. Franklin Pugh, José E. Pérez‑Ortín, Susana Rodríguez‑Navarro(2018)Research Group on Functional Genomics of YeastsEpigenetics & Chromatin, 11(13), pp. 1 - 12. ISSN: 1756-8935
Blasco-Moreno B; de Campos-Mata L; Böttcher R; García-Martínez J; Jungfleisch J; Nedialkova DD; Chattopadhyay S; Gas ME; Oliva B; Pérez-Ortín JE; Leidel SA; Choder M; Díez J(2019)Research Group on Functional Genomics of YeastsNature Communications, 10, p. 1298. ISSN: 2041-1723
Romero AM; Ramos-Alonso L; Montellá-Manuel S; García-Martínez J; de la Torre-Ruiz MÁ; Pérez-Ortín JE; Martínez-Pastor MT; Puig S(2019)Research Group on Functional Genomics of YeastsBiochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1862(9), p. 194414. ISSN: 1874-9399
Forés‐Martos, J.; Forte, A.; García‐Martínez, J; Pérez‐Ortín, J.E.(2021)Research Group on Functional Genomics of YeastsCells, 10(2), p. 334. ISSN: 2073-4409
Pérez-Ortín JE; Mena A; Barba-Aliaga M; Singh A; Chávez S; García-Martínez J.(2021)Research Group on Functional Genomics of YeastsPlos Genetics, 17(4), p. e1009520. ISSN: 1553-7390
García-Martínez J; Medina DA; Bellvis P; Sun M; Cramer P; Chávez S; Pérez-Ortín JE(2021)Research Group on Functional Genomics of YeastsRNA-A Publication of the Rna Society, 27, pp. 1281 - 1290. ISSN: 1355-8382
José García-Martínez; María E Pérez-Martínez; José E Pérez-Ortín; Paula Alepuz(2021)Research Group on Functional Genomics of YeastsRna Biology, 18(10), pp. 1458 - 1474. ISSN: 1547-6286
Romero, A.M.; García-Martínez, J.; Pérez-Ortín, J.E.; Martínez-Pastor, M.T.; Puig, S.(2022)Changes in mRNA stability play an important role in the adaptation of yeast cells to iron deprivation.Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1865, p. 194800. ISSN: 1874-9399
Vicente Arnau; Marina Barba-Aliaga; Gaurav Singh; Javier Ferri; José García-Martínez; José E. Pérez-Ortín(2022)Research Group on Functional Genomics of YeastsPlos One, 17(9), p. e0272878. ISSN: 1932-6203
Shiladitya Chattopadhyay; Jose Garcia-Martinez; Gal Haimovich; Jonathan Fischer; Aya Khwaja; Oren Barkai; Silvia Gabriela Chuartzman; Maya Schuldiner; Ron Elran; Miriam I. Rosenberg; Shira Urim; Shubham Deshmukh; Katherine E. Bohnsack; Markus T. Bohnsack; Jose E. Perez-Ortin; Mordechai Choder(2022)Research Group on Functional Genomics of YeastsNature Communications, 13(7184), pp. 1 - 17. ISSN: 2041-1723
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- PEREZ ORTIN, JOSE ENRIQUE
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