Pathophysiology, Prevention and Treatment of Eye Diseases Research Group

Description

Study of the cellular and molecular mechanisms that trigger retinal diseases such as diabetic retinopathy and age-related macular degeneration. Approaches for the prevention of the development of these pathologies, as well as therapeutic approaches to the development of advanced stages of the disease. To this end, we consider:

To study the role of redox regulation in the development of retinal diseases such as diabetic retinopathy of age-related macular degeneration.
Analysis of the protective role of natural antioxidants in the development of eye diseases related to oxidative stress.
Identification of markers in tears to determine and follow the evolution of diabetic retinopathy and age-related macular degeneration.
To study the physiopathology of uveal melanoma, search for new therapeutic approaches and biomarkers for its early detection.

Goals CT

To study the cellular and molecular mechanisms that trigger retinal diseases. Prevention and therapeutic approaches.

Research lines

Utility of natural polyphenols as preventive agents for the development of eye diseases
To analyse the polyphenolic antioxidant capacity as protection against the development of retinopathies related to oxidative stress.
Pathophysiology of uveal melanoma
Development of effective therapeutic approaches that enable both therapeutic avoidance and eradication of the disease before metastasis.
Pathophysiology, prevention and treatment of diabetic retinopathy and age-related macular degeneration
Evaluation of comparative lipidomic, metabolomic and epigenetic profiles between healthy and diseased patients.

Members

MENA MOLLA, SALVADOR
Alumn.-Servei de Formacio Permanent
Coordinador/a Curs

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NOGUERA SALVA, INMACULADA
PDI-Associat/Da Universitari/A
PAS-E.T.S. Veterinaria

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Collaborators

ASENSI MIRALLES, MIGUEL ANGEL
PDI-Catedratic/a d'Universitat

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Non-UV research staff

Contributors

María del Carmen Desco Esteban - Foundation for the Promotion of Health and Biomedical Research in the Comunitat Valenciana
Jorge Mataix Boronat - Foundation for the Promotion of Health and Biomedical Research in the Comunitat Valenciana
Iván Millán Yáñez - Universitat de València

Scientific production by UV researcher

MENA MOLLA, SALVADOR
Alumn.-Servei de Formacio PermanentCoordinador/a Curs
ContraerExpandir
- Benlloch M, Mena S, Ferrer P, Obrador E, Asensi M, Pellicer JA, Carretero J, Ortega A, Estrela JM.(2006)Bcl-2 and Mn-SOD Antisense Oligodeoxynucleotides and a Glutamine-enriched Diet Facilitate Elimination of Highly Resistant B16 Melanoma Cells by Tumor Necrosis Factor-{alpha} and Chemotherapy.Journal of Biological Chemistry, 281(1), pp. 69 - 79. ISSN: 0021-9258
- Mena S, Benlloch M, Ortega A, Carretero J, Obrador E, Asensi M, Petschen I, Brown BD, Estrela JM.(2007)Bcl-2 and glutathione depletion sensitizes B16 melanoma to combination therapy and eliminates metastatic disease.Clinical Cancer Research, 13(9), pp. 2658 - 2666. ISSN: 1078-0432
- Ferrer P, Asensi M, Priego S, Benlloch M, Mena S, Ortega A, Obrador E, Esteve JM, Estrela JM.(2007)Nitric oxide mediates natural polyphenol-induced Bcl-2 down-regulation and activation of cell death in metastatic B16 melanoma.Journal of Biological Chemistry, 282(5), pp. 2880 - 2890. ISSN: 0021-9258
- Mena S, Ortega A, Estrela JM.(2009)Oxidative stress in environmental-induced carcinogenesis.Mutation Research, 674(1-2), pp. 36 - 44. ISSN: 0921-8262
- Priego S, Feddi F, Ferrer P, Mena S, Benlloch M, Ortega A, Carretero J, Obrador E, Asensi M, Estrela JM.(2008)Natural polyphenols facilitate elimination of HT-29 colorectal cancer xenografts by chemoradiotherapy: a Bcl-2- and superoxide dismutase 2-dependent mechanism. .Molecular Cancer Therapeutics, 7(10), pp. 3330 - 3342. ISSN: 1535-7163
- Asensi M; Ortega A; Mena S; Feddi F; Estrela JM.(2011)Pathophysiology, Prevention and Treatment of Eye Diseases Research GroupCritical Reviews in Clinical Laboratory Sciences, 48(5-6), pp. 197 - 216. ISSN: 1040-8363
- Mena S; Rodriguez ML; Ortega A; Priego S; Obrador E; Asensi M; Petschen I; Cerdá M; Brown BD; Estrela JM.(2012)Pathophysiology, Prevention and Treatment of Eye Diseases Research GroupJournal Of Translational Medicine, 10(8). ISSN: 1479-5876
- Valles SL, Benlloch M, Rodriguez ML, Mena S, Pellicer JA, Asensi M, Obrador E, Estrela JM.(2013)Pathophysiology, Prevention and Treatment of Eye Diseases Research GroupJournal Of Translational Medicine. ISSN: 1479-5876
- Estrela JM; Ortega A; Mena S; Rodriguez ML; Asensi M.(2013)Pathophysiology, Prevention and Treatment of Eye Diseases Research GroupCritical Reviews in Clinical Laboratory Sciences, 50(3), pp. 65 - 78. ISSN: 1040-8363
- Mena S, Ortega A, Estrela JM(2009)Oxidative stress in environmental-induced carcinogenesis.Mutation Research, 674, pp. 36 - 44. ISSN: 0921-8262
- Ortega, A; Mena S; Estrela JM.(2011)Pathophysiology, Prevention and Treatment of Eye Diseases Research GroupCancers, 3(1), pp. 1285 - 1310. ISSN: 2072-6694
- García-Giménez JL; Sanchis-Gomar F; Lippi G; Mena S; Ivars D; Gomez-Cabrera MC; Viña J; Pallardó FV(2012)Pathophysiology, Prevention and Treatment of Eye Diseases Research GroupClinica Chimica Acta. ISSN: 0009-8981
- Mena, S; Rodríguez, ML; Ponsoda, X; Estrela, JM; Jäättela, M; Ortega, AL.(2012)Pterostilbene-induced tumor cytotoxicity: a lysosomal membrane permeabilization-dependent mechanism.Plos One, 413, pp. 1576 - 1582. ISSN: 1932-6203
- Weaver, Z; Difilippantonio, S; Carretero, J; Martin, PL; El Meskini, R; Iacovelli, AJ; Gumprecht, M; Kulaga, A; Guerin, T; Schlomer, J; Baran, M; Kozlov, S; MsCann, T; Mena, S; Al-Shahrour, F; Alexander, D; Wong, KK; Van Dyke, T.(2012)Temporal Molecular and Biological Assessment of an Erlotinib-Resistant Lung Adenocarcinoma Model Reveals Markers of Tumor Progression and Treatment Response.Cancer Research, 72, pp. 5921 - 5933. ISSN: 0008-5472
- Luis Antonio Tortajada-Genaro; Alejandro Rodrigo; Elizabeth Hevia; Salvador Mena; Regina Niñoles; Ángel Maquieira(2015)Microarray on digital versatile disc for identification and genotyping of Salmonella and Campylobacter in meat products.Analytical and Bioanalytical Chemistry, 407(24), pp. 7285 - 7294. ISSN: 1618-2642
- Sirerol JA; Feddi F;, Mena S; Rodriguez ML; Sirera P; Aupí M; Pérez S; Asensi M; Ortega A; Estrela JM(2015)Pathophysiology, Prevention and Treatment of Eye Diseases Research GroupFree Radical Biology and Medicine, 85, pp. 1 - 11. ISSN: 0891-5849
- Sirerol JA; Rodríguez ML; Mena S; Asensi MA; Estrela JM; Ortega AL.(2016)Pathophysiology, Prevention and Treatment of Eye Diseases Research GroupOxidative Medicine And Cellular Longevity. ISSN: 1942-0900
- Garcia-Giménez JL, Mena-Mollá S, Beltrán-García J, Sanchís-Gomar F(2017)Pathophysiology, Prevention and Treatment of Eye Diseases Research GroupClinical Chemistry and Laboratory Medicine, 55(10), pp. 1474 - 1477. ISSN: 1434-6621
- Tortajada-Genaro, Luis; Mena, Salvador; Niñoles, Regina; Puigmulé, Marta; Viladevall, Laia; Maquieira, Ángel(2016)Genotyping of single nucleotide polymorphisms related to attention deficit hyperactivity disorder.Analytical and Bioanalytical Chemistry, 408(9), pp. 2339 - 2345. ISSN: 1618-2642
- Salvador Mena; Pascual Cuadrado; José L. García-Giménez.(2016)Epigenética y envejecimiento. Claves para el desarrollo de una cosmética de nueva generación basada en la regulación de los mecanismos celulares del envejecimiento.Noticias de Cosmética y Perfumería, 348, pp. 5 - 13. ISSN: 0213-1579
- Salvador Mena; Pascual Cuadrado; José L. García-Giménez(2016)Epigenética y sus futuras aplicaciones en cosmética.Noticias de Cosmética y Perfumería, 347, pp. 5 - 9. ISSN: 0213-1579
- Salvador Mena Mollá; Pascual Cuadrado Escamilla; José Luis García-Giménez.(2016)Epigenética, contaminación, estilo de vida.Noticias de Cosmética y Perfumería(351). ISSN: 0213-1579
- Estrela JM; Ortega A; Mena S; Sirerol JA; Obrador E.(2016)Glutathione in metastases: From mechanisms to clinical applications.Critical Reviews in Clinical Laboratory Sciences. ISSN: 1040-8363
- García-Giménez JL, Pérez-Machado G, García-López E, González-Rodríguez D, Mena-Mollá S(2017)Challenges in the analysis of micro RNAs from liquid biopsy as epigenetic biomarkers in clinical samples.Journal of clinical epigenetics, 3(4). ISSN: 2472-1158
- Carme Perez-Quilis; Giuseppe Lippi; Salva Mena; Herbert Löllgen; José Luis García-Giménez; Fabian Sanchis-Gomar(2016)Pathophysiology, Prevention and Treatment of Eye Diseases Research GroupJournal of Laboratory and Precision Medicine, 1(8). ISSN: 2519-9005
- José M. Estrela; Salvador Mena; Elena Obrador; María Benlloch; Gloria Castellano; Rosario Salvador; Ryan W. Dellinger(2017)Pathophysiology, Prevention and Treatment of Eye Diseases Research GroupJournal of Medicinal Chemistry, 60, pp. 9413 - 9436. ISSN: 0022-2623
- Salvador Mena-Mollá; José Luis García-Giménez; Daymé González-Rodríguez; Pablo Soro-Barrio; Lidia Roselló; Pascual Cuadrado-Escamilla(2017)Key mechanisms for new era of personalised cosmetics.Personal care, April, pp. 77 - 81. ISSN: 2041-0441
- Garcia-Gimenez JL, Rubio Belmar PA, Peiró-Chova L, Hervas D, Gonzalez-Rodriguez D, Ibañez-Cabellos JS, Bas-Hermida P, Mena-Molla S, Garcia-Lopez E, Pallardo FV, Bas-Hermida T(2018)Pathophysiology, Prevention and Treatment of Eye Diseases Research GroupScientific Reports, 8. ISSN: 2045-2322
- David Ivars; Maria Teresa Orero; Karla Javier; Laura Díaz-Vico; José Luis García-Giménez; Salvador Mena; Carmen Tormos; Mercedes Egea; Pedro Luis Pérez; Beatriz Arrizabalaga; María Ángeles Ruiz; Nuria Yagüe; Mar Tormo; Reyes Sancho-Tello; Angela Gomes; Carmen Algueró; José Enrique O'Connor; Guillermo T. Sáez; Félix Carbonell; Rosa Collado(2017)Pathophysiology, Prevention and Treatment of Eye Diseases Research GroupClinical Biochemistry, 50, pp. 911 - 917. ISSN: 0009-9120
- Cardona-Monzonís, Alejandro ;Beltrán-García, Jesús ;Ibañez-Cabellos, José Santiago ;Pérez Machado, Giselle ;Sanchis-Gomar, Fabian; Mena-Mollá, Salvador; García Giménez, José Luis(2018)Epigenetic biomarkers in cardiovascular disease.Journal of Laboratory and Precision Medicine, 24. ISSN: 2519-9005
- García-Giménez, José Luis ;Pérez-Machado, Gisselle ;Beltrán-García, Jesús ;García-López, Eva María ;Berenguer, Ester ;Romá-Mateo, Carlos ;Mena-Mollá, Salvador(2018)Biomarcadores epigenéticos: hacia su implantación en la rutina clínica.Genética médica news. ISSN: 2386-5113
- Tortajada-Genaro LA; Niñoles R; Mena S; Maquieira Á(2019)Pathophysiology, Prevention and Treatment of Eye Diseases Research GroupAnalyst, 144(2), pp. 707 - 715. ISSN: 0003-2654
- María L. Rodríguez; Salvador Pérez; Salvador Mena-Mollá; M. Carmen Desco; Ángel Luis Ortega(2019)Oxidative Stress and microvascular alterations in diabetic retinopathy: Future therapies.Oxidative Medicine And Cellular Longevity. ISSN: 1942-0900
- Millán I, Desco MDC, Torres-Cuevas I, Pérez S, Pulido I, Mena-Mollá S, Mataix J, Asensi M, Ortega ÁL.(2019)Pathophysiology, Prevention and Treatment of Eye Diseases Research GroupNutrients, 12(1), p. pii: E82. ISSN: 2072-6643
- Beltrán-García J; Osca-Verdegal R; Mena-Mollá S; García-Giménez JL(2019)Pathophysiology, Prevention and Treatment of Eye Diseases Research GroupFrontiers In Genetics, 10(621). ISSN: 1664-8021
- Alejandro Cardona-Monzonís;José Luis García-Giménez;Salvador Mena-Mollá;Helios Pareja-Galeano;Fernando de la Guía-Galipienso;Giuseppe Lipp;iFederico V. Pallardó;Fabian Sanchis-Gomar(2020)Pathophysiology, Prevention and Treatment of Eye Diseases Research GroupAdvances in Experimental Medicine and Biology. ISSN: 0065-2598
- Pérez-Machado G.; Berenguer-Pascuala E.; Bovea-Marco M.; Rubio-Belmar P.A.;García-López E.; Garzón M.J.; Mena-Mollá S.; Pallardó FV.; Bas T.; Viña J.R.; García-Giménez J.L.(2020)From genetics to epigenetics to unravel the etiology of adolescent idiopathic scoliosis.Bone, 140, p. 115563. ISSN: 8756-3282
- Morales-Roselló J, García-Giménez JL, Martinez Priego L, González-Rodríguez D, Mena-Mollá S, Maquieira Catalá A, Loscalzo G, Buongiorno S, Jakaite V, Cañada Martínez AJ, Perales Marín A.(2020)MicroRNA-148b-3p and MicroRNA-25-3p Are Overexpressed in Fetuses with Late-Onset Fetal Growth Restriction.Fetal Diagnosis and Therapy, 47(9), pp. 665 - 674. ISSN: 1015-3837
- García-Giménez JL; Mena-Molla S; Tarazona-Santabalbina FJ; Viña J; Gomez-Cabrera MC; Pallardó FV.(2021)Pathophysiology, Prevention and Treatment of Eye Diseases Research GroupInternational Journal Of Environmental Research And Public Health, 18(4), p. 1883. ISSN: 1661-7827
- Lorente-Pozo S, Navarrete P, Garzón MJ, Lara-Cantón I, Beltrán-García J, Osca-Verdegal R, Mena-Mollá S, García-López E, Vento M, Pallardó FV, García-Giménez JL.(2021)DNA Methylation Analysis to Unravel Altered Genetic Pathways Underlying Early Onset and Late Onset Neonatal Sepsis. A Pilot Study.Frontiers in Immunology, 12, p. 622599. ISSN: 1664-3224
- Loscalzo G, Scheel J; Ibañez-Cabellos JS; García-Lopez E; Gupta S; García-Gimenez JL; Mena-Mollá S; Perales-Marín A; Morales-Roselló J(2021)Pathophysiology, Prevention and Treatment of Eye Diseases Research GroupInternational Journal Of Molecular Sciences, 23(1), p. 293. ISSN: 1661-6596
- Wiam Saadi; Ahlam Fatmi; Federico V. Pallardó; José Luis García-Giménez; Salvador Mena-Mollá(2022)Pathophysiology, Prevention and Treatment of Eye Diseases Research GroupCancers, 15(1), p. 184. ISSN: 2072-6694

CNAE

Investigation activities

Associated structure

Physiology

www.uv.es/fisiologia

dep.fisiologia@uv.es

Contact group details

Research Group on Physiopathology, Prevention and Treatment of Eye Diseases (FIPTEO)

Blasco Ibáñez Campus

Av. Blasco Ibáñez, 15

46010 València (Valencia)

+34 963 543 817

Geolocation

angel.ortega@uv.es

Pathophysiology, Prevention and Treatment of Eye Diseases Research Group - FIPTEO