The formation of reactive oxygen species (ROS) and oxidative stress represent a mechanism of action that underlies the aetiopathogenesis of various pathophysiological processes, including different types of metabolic disorders, cardiovascular diseases and cancer. The Oxidative Pathology Unit (UPOX) has the experimental objective of describing the redox changes that establish the balance between the levels of activity and expression of antioxidant systems and the formation of ROS in human pathology. Special attention is devoted to oxidative modifications of organic macromolecules such as proteins, lipids and nucleic acids. The oxidation of genetic material (DNA) is analysed by choice techniques in order to establish the role of 8-oxo-7,8-2'-dihydro-guanosine (8-oxo-dG) and repair systems (hOGG1, MUTYH, MTH1 RAD51) as mediators of degenerative and neoplastic diseases. Experimental strategies for the identification and validation of new markers in clinical pathology are among the milestones proposed.
The impact of oxidative stress on the development of metabolic diseases such as diabetes mellitus, metabolic syndrome and obesity, as well as other cardiovascular risk factors, is currently being studied in different cohorts of affected subjects. The role of the mutagenic base 8-oxo-7,8-2'-dihydro-guanosine (8-oxo-dG) in human carcinogenesis is investigated by analysing this metabolite in different biological media. The identification and assessment of 8-oxo-dG in serum and urine allows us to know the degree of DNA oxidation and its mutagenic potential in the evolution of human tumours, such as colorectal, gastric and prostate carcinoma, together with other blood neoplasms. This line is in line with the possible validation of this oxidative modification product as a tumour marker.
In parallel, different ROS-regulated signalling pathways and oxidative changes induced in different cell lines in culture and circulating mononuclear cells from patients with diseases that are the focus of our biomedical research are identified and described.
During the last few years we have described different types of alterations in redox metabolism in different pathophysiological processes of cardiovascular evolution. Initially, we identified reduced levels of antioxidant enzymes and high concentrations of lipid oxidation products (MDA) in nucleated cells of hypertensive patients, and for the first time high levels of the mutagenic base 8-oxo-dG in both nuclear and mitochondrial DNA that are reduced back to the values of the healthy population after normalisation of blood pressure either by pharmacological or dietary treatment.
In this regard, our contribution to the multicentre project of the PREDIMED Network stands out, where we first demonstrated the increase in oxidative stress and damage to genetic material in a large population at high cardiovascular risk and then the remission of this oxidative phenomenon through dietary intervention based on a Mediterranean diet supplemented with olive oil or nuts. As a result of these collaborations, novel results have been published in relation to dietary intervention rich in antioxidants and the modulation of different oxidative parameters.
In the field of experimental and human carcinogenesis, different mechanisms of action have been identified that are regulated by certain free radical species that act as inducers of the expression of transcriptional factors involved in the differentiation and apoptosis of tumour cells. The antitumour effect of various agents is mediated by and is dependent on the reduction of antioxidants such as reduced glutathione (GSH) and increased DNA oxidation, as a step prior to the activation of signalling pathways.
- Biochemical-molecular characterisation of oxidative stress in the physiopathology of cardiovascular diseases and tumour processes.
- Identification of new clinical markers.
Role of free radicals and oxidative stress as a pathophysiological mechanism of disease.
Basic translational research on biochemical and molecular mechanisms related to free radical formation and oxidative stress in metabolic, cardiovascular and tumour diseases. Molecular signalling pathways in DNA damage and repair.
- SAEZ TORMO, GUILLERMO
- PDI-Catedratic/a d'Universitat
- Coordinador/a de Mobilitat
- Vicedega/Vicedegana / Vicedirector/a Ets
Partners
- Ana Bediaga Collado - Consorcio Hospital General Universitario de Valencia
- ContraerExpandirSAEZ TORMO, GUILLERMOPDI-Catedratic/a d'UniversitatCoordinador/a de MobilitatVicedega/Vicedegana / Vicedirector/a Ets
Tomás-Simó P; D'Marco L; Romero-Parra M; Tormos-Muñoz MC; Sáez G; Torregrosa I; Estañ-Capell N; Miguel A; Gorriz JL; Puchades MJ.(2021)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitInternational Journal Of Environmental Research And Public Health, 18(15), pp. 7806 - 6198. ISSN: 1661-7827
Alcala M; Bolado VE; Sánchez-Vera I; Clapés S; Dasí F; Sáez G; Carrera E; Alvarez-Gallego F; Loeken MR; Viana M.(2021)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitAntioxidants, 10(8), p. 1173. ISSN: 2076-3921
Delia Acevedo-León; Lidia Monzó-Beltrán; Segundo A Gómez-Abril; Nuria Estañ-Capell; Natalia Camarasa-Lillo; Marisa Luisa Pérez-Ebri; Jorge Escandón-Álvarez; Eulalia Alonso-Iglesias; Marisa Santaolaria-Ayora; Araceli Carbonell-Moncho; Josep Ventura-Gayete; Luis Pla; M Carmen Martínez-Bisbal; Ramón Martínez-Máñez; Leticia Bagán-Debón; Aurora Viña-Almunia; M. Amparo Martínez-Santamaría; María Ruiz-Luque; Jorge Alonso-Fernandez; Celia Bañuls; Guillermo Sáez(2021)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitInternational Journal Of Molecular Sciences. ISSN: 1661-6596
Paz-Graniel I; Babio N; Becerra-Tomás N; Toledo E; Camacho-Barcia L; Corella D; Castañer-Niño O; Romaguera D; Vioque J; Alonso-Gómez ÁM; Wärnberg J; Martínez JA; Serra-Majem L; Estruch R; Tinahones FJ; Fernandez-Aranda F; Lapetra J; Pintó X; Tur JA; García-Rios A; Bueno-Cavanillas A; Gaforio JJ; Matía-Martín P; Daimiel L; Sánchez VM; Vidal J; Prieto-Sanchez L; Ros E; Razquin C; Mestres C; Sorli JV; Cuenca-Royo AM; Rios A; Torres-Collado L; Vaquero-Luna J; Pérez-Farinós N; Zulet MA; Sanchez-Villegas A; Casas R; Bernal-Lopez MR; Santos-Lozano JM; Corbella X; Mateos D; Buil-Cosiales P; Jiménez-Murcia S; Fernandez-Carrion R; Forcano-Gamazo L; López M; Sempere-Pascual MÁ; Moreno-Rodriguez A; Gea A; de la Torre-Fornell R; Salas-Salvadó J; PREDIMED-Plus Investigators (¿G Sáez Tormo, N Estañ-Capell, A Iradi Casal, L Monzó Beltrán, C Bañuls Morant, E Alonso Iglesias¿)(2020)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitEuropean Journal of Nutrition, 60(5), pp. 2381 - 2396. ISSN: 1436-6207
M Amparo Martínez-Santamaría; Delia Acevedo-León; Celia Bañuls-Morant; Lidia Monzó-Beltrán; Nuria Estañ-Capell; María Ruiz-Luque; Segundo Ángel Gómez-Abril; Marisa Pérez-Ebri; Jorge Escandón-Álvarez; Eulalia Alonso-Iglesias; Marisa Santaolaria-Ayora; Araceli Carbonell-Moncho; María José Vila-Planells; Pablo Blas-Blasco; Carmen Martínez-Bisbal; Leticia Bagán-Debón; Ramón Martínez-Mañez; Guillermo Sáez Tormo(2021)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitFree Radical Biology and Medicine, 165, p. 53. ISSN: 0891-5849
Becerra-Tomás N; Mena-Sánchez G: Díaz-López A; Martínez-González MÁ; Babio N; Corella D; Freixer G; Romaguera D; Vioque J; Alonso-Gómez ÁM; Wärnberg J; Martínez JA; Serra-Majem L; Estruch R; Fernández-García JC; Lapetra J; Pintó X: Tur JA; López-Miranda J; Bueno-Cavanillas A; Gaforio JJ; Matía-Martín P; Daimiel L; Martín-Sánchez V; Vidal J; Vázquez C; Ros E; Razquin C; Abellán Cano I; Sorlí JV; Torres L; Morey M; Navarrete-Muñoz EM; Tojal Sierra L; Crespo-Oliva E; Zulet MÁ; Sanchez-Villegas A; Casas R; Bernal-Lopez MR; Santos-Lozano JM; Corbella E; Del Mar Bibiloni M; Ruiz-Canela M; Fernández-Carrión R; Quifer M; Prieto RM; Fernandez-Brufal N; Salaverria Lete I; Cenoz JC; Llimona R; Salas-Salvadó J;- (Sáez G; Tormo; Estañ-Capell N; Iradi Casal A; Monzó Beltrán N, Fandos Sánchez M ;Alonso Iglesias E.)(2020)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitEuropean Journal of Nutrition, 59(5), pp. 2195 - 2206. ISSN: 1436-6207
Josep Redón, Maria R.Oliva,Carmen Tormos, Vicente Giner, Javier Chaves, Antonio Iradi, Guillermo T. Sáez.(2003)Antioxidant activities and oxidative stress byproducts in human hypertension.Hypertension, 41, pp. 1096 - 1101. ISSN: 0194-911X
Martínez-González MA, Buil-Cosiales P, Corella D, Bulló M, Fitó M, Vioque J, Romaguera D, Martínez JA, Wärnberg J, López-Miranda J, Estruch R, Bueno-Cavanillas A, Arós F, Tur JA, Tinahones F, Serra-Majem L, Martín V, Lapetra J, Vázquez C, Pintó X, Vidal J, Daimiel L, Delgado-Rodríguez M, Matía P, Ros E, Fernández-Aranda F, Botella C, Portillo MP, Lamuela-Raventós RM, Marcos A, Sáez G, Gómez-Gracia E, Ruiz-Canela M, Toledo E, Alvarez-Alvarez I, Díez-Espino J, Sorlí JV, Basora J, Castañer O, Schröder H, Navarrete-Muñoz EM, Zulet MA, García-Rios A, Salas-Salvadó J.(2019)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitInternational Journal of Epidemiology, 48(2), pp. 387 - 388 o. ISSN: 0300-5771
Garcia-Arellano A, Martínez-González MA, Ramallal R, Salas-Salvadó J, Hébert JR, Corella D, Shivappa N, Forga L, Schröder H, Muñoz-Bravo C, Estruch R, Fiol M, Lapetra J, Serra-Majem L, Ros E, Rekondo J, Toledo E, Razquin C, Ruiz-Canela M; SUN and PREDIMED Study Investigators(2019)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitClinical Nutrition, 38(3), pp. 1221 - 1231. ISSN: 0261-5614
Pintó X; Fanlo-Maresma M; Corbella E; Corbella X; Mitjavila MT; Moreno JJ; Casas R; Estruch R; Corella D; Bulló M; Ruiz-Canela M; Castañer O; Martinez JA; Ros E(2019)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitJournal of Nutrition, 149(11), pp. 1920 - 1929. ISSN: 0022-3166
Salas-Salvadó J; Díaz-López A; Ruiz-Canela M, Basora J; Fitó M, Corella D; Serra-Majem L; Wärnberg J, Romaguera D, Estruch R, Vidal J, Martínez JA, Arós F, Vázquez C, Ros E, Vioque J, López-Miranda J, Bueno-Cavanillas A, Tur JA, Tinahones FJ, Martín V, Lapetra J, Pintó X, Daimiel L, Delgado-Rodríguez M,Matía P, Gómez-Gracia E, Díez-Espino J, Babio N, Castañer O, Sorlí JV, Fiol M, Zulet MÁ, Bulló M, Goday A, Martínez-González MA; PREDIMED-Plus investigators-(Monzó Beltrán, M. Fandos Sánchez, E. Alonso Iglesias, D. Acevedo León, A. Hernando Espinilla, A. Mora Herranz, C. Cerdá Micó C, Estáñ Capell N, Iradi Casal A, Fandos Sánchez M, Sáez G)(2019)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitDiabetes Care, 42(5), pp. 777 - 788. ISSN: 0149-5992
Sayón-Orea C, Razquin C, Bulló M, Corella D, Fitó M, Romaguera D, Vioque J, Alonso-Gómez ÁM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Tinahones FJ, Lapetra J, Pintó X, Tur JA, López-Miranda J, Bueno-Cavanillas A, Delgado-Rodríguez M, Matía-Martín P, Daimiel L, Sánchez VM, Vidal J, Vázquez C, Ros E, Ruiz-Canela M, Sorlí JV, Castañer O, Fiol M, Navarrete-Muñoz EM, Arós F, Gómez-Gracia E, Zulet MA, Sánchez-Villegas A, Casas R, Bernal-López R, Santos-Lozano JM, Corbella E, Bouzas C, García-Arellano A, Basora J, Asensio EM, Schröder H, Moñino M, García de la Hera M, Tojal-Sierra L, Toledo E, Díaz-López A, Goday A, Salas-Salvadó J, Martínez-González MA -Predimed Plus Study Investigators-(Sáez G.)(2019)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitJAMA - Journal of the American Medical Association, 322(15), pp. 1486 - 1499. ISSN: 0098-7484
Gargallo P; Colado JC; Juesas A; Hernando-Espinilla A; Estañ-Capell N; Monzó-Beltran L; García-Pérez P; Cauli O; Sáez GT.(2018)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitBiological Research For Nursing, 20(2), pp. 205 - 217. ISSN: 1099-8004
Carratala A; Martinez-Hervas S; Rodriguez-Borja E; Benito E; Real JT; Saez GT; Carmena R; Ascaso JF(2018)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitJournal of Investigative Medicine, 66(1), pp. 17 - 21. ISSN: 1081-5589
Olivares D; Perez-Hernandez J; Forner MJ; Perez-Soriano C; Tormos MC; Saez GT; Chaves FJ; Redon J; Cortes R.(2018)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitClinical Science, 132(5), pp. 569 - 579. ISSN: 0143-5221
Corella D, Ramírez-Sabio JB, Coltell O, Ortega-Azorín C, Estruch R, Martínez-González MA, Salas-Salvadó J, Sorlí JV, Castañer O, Arós F, Garcia-Corte FJ, Serra-Majem L, Gómez-Gracia E, Fiol M, Pintó X, Saez GT, Toledo E, Basora J, Fitó M, Cofán M, Ros E, Ordovas JM.(2018)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitJournal Of The Academy Of Nutrition And Dietetics, 118(4), pp. 589 - 605. ISSN: 2212-2672
Sáez GT(2018)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitInternational Journal Of Molecular Sciences, 19(7), pp. 1 - 4. ISSN: 1661-6596
Estruch R, Ros E, Salas-Salvadó J, Covas MI, Corella D, Arós F, Gómez-Gracia E, Ruiz-Gutiérrez V, Fiol M, Lapetra J, Lamuela-Raventos RM, Serra-Majem L, Pintó X, Basora J, Muñoz MA, Sorlí JV, Martínez JA, Fitó M, Gea A, Hernán MA, Martínez-González MA; PREDIMED Study Investigators- (University of Valencia, Spain: P. Carrasco, R. Osma, M. Guillén, P. Guillem-Saiz, O. Portolés, V. Pascual, C. Riera, J. Valderrama, A. Serrano, E. Lázaro, A. Sanmartín, A. Girbés, V. Santamaría, C. Sánchez, Z. Plá, E. Sánchez, C. Ortega-Azorín, J.I. González, C. Saiz, O. Coltell and E.M. Asensio, G. Sáez).(2018)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitNew England Journal of Medicine, 378(25), p. e34. ISSN: 0028-4793
Guillermo Sáez Tormo(2017)DNA Damage and Repair in Degenerative Diseases 2016.International Journal Of Molecular Sciences, 18(166), pp. 1 - 5. ISSN: 1661-6596
Storniolo CE, Casillas R, Bulló M, Castañer O, Ros E, Sáez GT, Toledo E, Estruch R, Ruiz-Gutiérrez V, Fitó M, Martínez-González MA, Salas-Salvadó J, Mitjavila MT, Moreno JJ.(2017)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitEuropean Journal of Nutrition, 56(1):89-97((1)), pp. 89 - 97. ISSN: 1436-6207
David Ivars; Maria Teresa Orero; Karla Javier; Laura Díaz-Vico; José Luis García-Giménez; Salvador Mena; Carmen Tormos; Mercedes Egea; Pedro Luis Pérez; Beatriz Arrizabalaga; María Ángeles Ruiz; Nuria Yagüe; Mar Tormo; Reyes Sancho-Tello; Angela Gomes; Carmen Algueró; José Enrique O'Connor; Guillermo T. Sáez; Félix Carbonell; Rosa Collado(2017)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitClinical Biochemistry, 50, pp. 911 - 917. ISSN: 0009-9120
Amor AJ, Serra-Mir M, Martínez-González MA, Corella D, Salas-Salvadó J, Fitó M, Estruch R, Serra-Majem L, Arós F, Babio N, Ros E, Ortega E; PREDIMED Investigators(2017)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitJournal Of The American Heart Association, 6(3), p. e004803. ISSN: 2047-9980
Lidia Monzo-Beltran; Antonio Vazquez-Tarragon; Concha Cerda; Paula García-Perez; Antonio Iradi: Carlos Sánchez; Benjamin Climent; Carmen Tormos; Antonio Vazquez-Prado; Javier Girbés; Nuria Estañ; Sebastián Blesa; Raquel Cortés; Felipe J. Chaves; Guillermo T. Saez(2017)One-year follow-up of clinical, metabolic and oxidative stress profile of morbid obese patients after laparoscopic sleeve gastrectomy. 8-oxo-dG as a clinical marker.Redox Biology, 12, pp. 389 - 402. ISSN: 2213-2317
Sandra Martín‑Peláez;Olga Castañer; Valentini Konstantinidou;· Isaac Subirana;Daniel Muñoz‑Aguayo; Gemma Blanchart;Sonia Gaixas; · Rafael de la Torre;· Magí Farré5; · Guillermo T Sáez; · Kristina Nyyssonen; Hans Joachim Zunft;· Maria Isabel Covas; · Montse Fitó;(2017)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitEuropean Journal of Nutrition, 56(2), pp. 663 - 670. ISSN: 1436-6207
Benlloch M; Obrador E; Valles S; Rodriguez ML; Sirerol JA; Alcácer J; Pellicer JA; Salvador R; Cerdá C; Saez G; Estrela JM(2016)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitAntioxidants & Redox Signaling, 24(17), pp. 974 - 990. ISSN: 1523-0864
Viña J; Saez GT; Gambini J; Gomez-Cabrera MC; Borrás C.(2016)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitArchives of Biochemistry and Biophysics, 595 , pp. 176 - 180. ISSN: 0003-9861
Martinez-Hervas S, Artero A, Martinez-Ibañez J, Tormos MC, Gonzalez-Navarro H, Priego A, Martinez-Valls JF, Saez GT, Real JT, Carmena R, Ascaso JF(2016)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitEuropean Journal of Clinical Investigation, 6(7), pp. 636 - 642. ISSN: 0014-2972
Sala-Vila A, Guasch-Ferré M, Hu FB, Sánchez-Tainta A, Bulló M, Serra-Mir M, López-Sabater C, Sorlí JV, Arós F, Fiol M, Muñoz MA, Serra-Majem L, Martínez JA, Corella D, Fitó M, Salas-Salvadó J, Martínez-González MA, Estruch R, Ros E, PREDIMED Investigators, (Nodo de Valencia: Sorli JV, Carrasco P, Ortega-Azorín C, Asensio EM, Osma R, Barragán R, Francés F, Guillén M, González JI, Saiz C, Portolés O, Giménez FJ, Coltell O, Guillem-Saiz P.)(2016)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitJournal Of The American Heart Association, 5(1), p. e002543. ISSN: 2047-9980
Rangel-Zuñiga OA, Haro C, Tormos C, Perez-Martinez P, Delgado-Lista J, Marin C, Quintana-Navarro GM, Cerdá C, Sáez GT, Lopez-Segura F, Lopez-Miranda J, Perez-Jimenez F, Camargo A.(2016)Frying oils with high natural or added antioxidants content, which protect against postprandial oxidative stress, also protect against DNA oxidation damage. Eur J Nutr. 2016 Mar 25. [Epub ahead of print] PMID: 27015911 Similar articles.European Journal of Nutrition. ISSN: 1436-6207
Bagan L, Sáez GT, Tormos MC, Labaig-Rueda C, Murillo-Cortes J, Bagan JV.(2016)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitClinical Oral Investigations, 20(4), pp. 737 - 743. ISSN: 1432-6981
Rogers NL; Juesas A; Fritz N; Gargallo P; Munoz V; Saez G; Hernando A; Colado JC.(2016)Effects Of Drinking Seawater During A Resistance Training Program On Kidney, Performance And Cardiovascular Health. Med Sci Sports Exerc. 05/2016.European Journal of Nutrition. ISSN: 1436-6207
Sala-Vila A; Guasch-Ferré M; Hu FB; Sánchez-Tainta A; Bulló M; Serra-Mir M. Dietary α-Linolenic Acid, Marine(2016)ω-3 Fatty Acids, and Mortality in a Population With High Fish Consumption.Journal Of The American Heart Association. ISSN: 2047-9980
Medina-Remón A, Tresserra-Rimbau A, Pons A, Tur JA, Martorell M, Ros E, Buil-Cosiales P, Sacanella E, Covas MI, Corella D, Salas-Salvadó J, Gómez-Gracia E, Ruiz-Gutiérrez V, Ortega-Calvo M, García-Valdueza M, Arós F, Saez GT, Serra-Majem L, Pinto X, Vinyoles E, Estruch R, Lamuela-Raventos RM; PREDIMED Study Investigators.(2015)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitNutrition Metabolism and Cardiovascular Diseases, 25(1), pp. 60 - 67. ISSN: 0939-4753
Martín-Peláez S, Castañer O, Konstantinidou V, Subirana I, Muñoz-Aguayo D, Blanchart G, Gaixas S, de la Torre R, Farré M, Sáez GT, Nyyssönen K, Zunft HJ, Covas MI, Fitó M.(2015)Effect of olive oil phenolic compounds on the expression of blood pressure-related genes in healthy individuals.European Journal of Nutrition. ISSN: 1436-6207
Storniolo CE, Casillas R, Bulló M, Castañer O, Ros E, Sáez GT, Toledo E, Estruch R, Ruiz-Gutiérrez V, Fitó M, Martínez-González MA, Salas-Salvadó J, Mitjavila MT, Moreno JJ.(2015)A Mediterranean diet supplemented with extra virgin olive oil or nuts improves endothelial markers involved in blood pressure control in hypertensive women. Eur J Nutr.European Journal of Nutrition. ISSN: 1436-6207
Eguaras S, Toledo E, Buil-Cosiales P, Salas-Salvadó J, Corella D, Gutierrez-Bedmar M, Santos-Lozano JM, Arós F, Fiol M, Fitó M, Ros E, Serra-Majem L, Pintó X, Martínez JA, Sorlí JV, Muñoz MA, Basora J, Estruch R, Martínez-González MA.(2015)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitNutrition Metabolism and Cardiovascular Diseases, 25(6), pp. 569 - 574. ISSN: 0939-4753
Martínez-González MA, Zazpe I, Razquin C, Sánchez-Tainta A, Corella D, Salas-Salvadó J, Toledo E, Ros E, Muñoz MA, Recondo J, Gómez-Gracia E, Fiol M, Lapetra J, Buil-Cosiales P, Serra-Majem L, Pinto X, Schröder H, Tur JA, Sorli JV, Lamuela-Raventós RM, Estruch R(2015)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitClinical Nutrition, 34(5), pp. 859 - 867. ISSN: 0261-5614
Concha Cerdá , Carlos Sánchez , Benjamín Climent , Antonio Vázquez , Antonio Iradi , Fátima El Amrani , Ana Bediaga , and Guillermo T. Sáez(2014)Oxidative stress and DNA damage in obesity-related tumorigenesis.Advances in Experimental Medicine and Biology, 824, pp. 5 - 17. ISSN: 0065-2598
Flores-Mateo G, Elosua R, Rodriguez-Blanco T, Basora-Gallisà J, Bulló M, Salas-Salvadó J, Martínez-González MÁ, Estruch R, Corella D, Fitó M, Fiol M, Arós F, Gómez-Gracia E, Subirana I, Lapetra J, Ruiz-Gutiérrez V, Sáez GT, Covas MI; PREDIMED Study Investigators.(2014)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitPlos One, 9(9), p. e105881. ISSN: 1932-6203
Cortes R, Martinez-Hervas S, Ivorra C, De Marco G, Gonzalez-Albert V, Rojo-Martínez G, Saez G, Carmena R, Ascaso JF, Real JT, Chaves FJ.(2014)Enhanced reduction in oxidative stress and altered glutathione and thioredoxin system response to unsaturated fatty acid load in familial hypercholesterolemia.Clin Biochem Contemp, 47(18), pp. 291 - 297
Collado R, Ivars D, Oliver I, Tormos C, Egea M, Miguel A, Sáez GT, Carbonell F.(2014)Increased oxidative damage associated with unfavorable cytogenetic subgroups in chronic lymphocytic leukemia.Biomed Research International. ISSN: 2314-6133
Galan-Chilet I, Tellez-Plaza M, Guallar E, De Marco G, Lopez-Izquierdo R, Gonzalez-Manzano I, Carmen Tormos M, Martin-Nuñez GM, Rojo-Martinez G, Saez GT, Martín-Escudero JC, Redon J, Javier Chaves F.(2014)Plasma selenium levels and oxidative stress biomarkers: a gene-environment interaction population-based study.Free Radical Biology and Medicine. ISSN: 0891-5849
Corella D, Sorlí JV, Estruch R, Coltell O, Ortega-Azorín C, Portolés O, Martínez-González MA, Bulló M, Fitó M, Arós F, Lapetra J, Asensio EM, Sáez GT, Serra-Majem L, Muñoz-Bravo C, Ruiz-Gutiérrez V, Fiol M, Vinyoles E, Pintó X, Richardson K, Ros E, Ordovás JM(2014)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitAmerican Journal of Clinical Nutrition, 100(2), pp. 719 - 731. ISSN: 0002-9165
Martínez-González MÁ, Toledo E, Arós F, Fiol M, Corella D, Salas-Salvadó J, Ros E, Covas MI, Fernández-Crehuet J, Lapetra J, Muñoz MA, Fitó M, Serra-Majem L, Pintó X, Lamuela-Raventós RM, Sorlí JV, Babio N, Buil-Cosiales P, Ruiz-Gutierrez V, Estruch R, Alonso A; PREDIMED Investigators.(2014)Extravirgin olive oil consumption reduces risk of atrial fibrillation: the PREDIMED (Prevención con Dieta Mediterránea) trial.Circulation, 1(130), pp. 18 - 26. ISSN: 0009-7322
Fitó M, Estruch R, Salas-Salvadó J, Martínez-Gonzalez MA, Arós F, Vila J, Corella D, Díaz O, Sáez G, de la Torre R, Mitjavila MT, Muñoz MA, Lamuela-Raventós RM, Ruiz-Gutierrez V, Fiol M, Gómez-Gracia E, Lapetra J, Ros E, Serra-Majem L, Covas MI; PREDIMED Study Investigators.(2014)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitEuropean Journal of Heart Failure, 16(5), pp. 543 - 550. ISSN: 1388-9842
Tresserra-Rimbau A, Rimm EB, Medina-Remón A, Martínez-González MA, de la Torre R, Corella D, Salas-Salvadó J, Gómez-Gracia E, Lapetra J, Arós F, Fiol M, Ros E, Serra-Majem L, Pintó X, Saez GT, Basora J, Sorlí JV, Martínez JA, Vinyoles E, Ruiz-Gutiérrez V, Estruch R, Lamuela-Raventós RM(2014)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitNutrition Metabolism and Cardiovascular Diseases, 24(6), pp. 639 - 647. ISSN: 0939-4753
Bagan J, Sáez GT, Tormos MC, Gavalda-Esteve C, Bagan L, Leopoldo-Rodado M, Calvo J, Camps C.(2014)Oxidative stress in bisphosphonate-related osteonecrosis of the jaws. J Oral Pathol Med. 2014 May;43(5):371-7.Journal of Oral Pathology & Medicine, 43(5), pp. 371 - 377. ISSN: 0904-2512
Bagan J, Saez G, Tormos C, Gavalda C, Sanchis JM, Bagan L, Scully C.(2014)Oxidative stress and recurrent aphthous stomatitis.Clinical Oral Investigations, 218(8), pp. 1919 - 1923. ISSN: 1432-6981
Rumià J, Marmol F, Sanchez J, Giménez-Crouseilles J, Carreño M, Bargalló N, Boget T, Pintor L, Setoain X, Donaire A, Saez GT, Ribalta T, Ferrer E, Puig-Parellada P(2013)Oxidative stress markers in the neocortex of drug-resistant epilepsy patients submitted to epilepsy surgery.Epilepsy Research, 107(1-2), pp. 75 - 85. ISSN: 0920-1211
Alfredo Gea1, Juan J Beunza2, Ramón Estruch3,4, Almudena Sánchez-Villegas3,5, Jordi Salas-Salvadó3,6, Pilar Buil-Cosiales7, Enrique Gómez-Gracia3,8, María-Isabel Covas3,9, Dolores Corella3,10, Miquel Fiol3,11, Fernando Arós3,12, José Lapetra3,13, Rosa-María Lamuela-Raventós3,14, Julia Wärnberg3,8, Xavier Pintó3,15, Lluis Serra-Majem3,5 and Miguel A Martínez-González1,3*, for the PREDIMED GROUP(2013)Alcohol intake, wine consumption and the development of depression: the PREDIMED study.Bmc Medicine, 11(192), pp. 1 - 10. ISSN: 1741-7015
Silvia Borrego 1,2, Antonio Vazquez 3, Francisco Dasí 4, Concha Cerdá 1,2, Antonio Iradi 5, Carmen Tormos 6, Julia M. Sánchez 6, Leticia Bagán 6, Javier Boix 7, Cristóbal Zaragoza 3, Jordi Camps 8 and Guillermo Sáez 1,2,6,*(2013)Oxidative Stress and DNA Damage in Human Gastric Carcinoma: 8-Oxo-7'8-dihydro-2'-deoxyguanosine (8-oxo-dG) as a Possible Tumor Marker.International Journal Of Molecular Sciences, 14, pp. 3467 - 3486. ISSN: 1661-6596
TERESA PEDRO, SERGIO MARTINEZ-HERVAS, CARMEN TORMO, ANA BARBARA GARCIA-GARCIA, GUILLERMO SAEZ-TORMO, JUAN F. ASCASO, F. JAVIER CHAVES, RAFAEL CARMENA, and JOSE T. REAL(2013)Oxidative stress and antioxidant enzyme values in lymphomonocytes after an oral unsaturated fat load test in familial hypercholesterolemic subjects.Translational Research, pp. 50 - 56. ISSN: 1931-5244
Leonardo De Tursi Ríspoli1, Antonio Vázquez Tarragón2, Antonio Vázquez Prado1,Guillermo Sáez Tormo (CIBEROBN)3, Ali Mahmoud Ismail1 y Verónica Gumbau Puchol1(2013)Estrés oxidativo; estudio comparativo entre un grupo de población normal y un grupo de población obesa mórbida.Nutricion Hospitalaria, 28(3), pp. 671 - 675. ISSN: 0212-1611
Aristotelis Kotronoulasa, Nieves Pizarroa,b, Aida Serrac, Patricia Robledoa,d, Jesús Joglare,Laura Rubióc, Álvaro Hernaézg, Carmen Tormosf,i, MaJosé Motilvac, Montserrat Fitóg,i,Maria-Isabel Covasg,i, Rosa Solàh, Magí Farréa,b, Guillermo Saezf,i, Rafael de la Torrea,d,i,∗(2013)Dose-dependent metabolic disposition of hydroxytyrosol andformation of mercapturates in rats.Pharmacological Research, 77, pp. 47 - 56. ISSN: 1043-6618
Estefania Toledo1,2,3, Frank B Hu2,4, Ramon Estruch3,5, Pilar Buil-Cosiales1,3, Dolores Corella3,6, Jordi Salas-Salvadó3,7, M Isabel Covas3,8, Fernando Arós3,9, Enrique Gómez-Gracia3,10, Miquel Fiol3,11, Jose Lapetra3,12, Luis Serra-Majem3,13, Xavier Pinto3,14, Rosa M Lamuela-Raventós3,15, Guillermo Saez3,16,17, Mònica Bulló3,7, Valentina Ruiz-Gutiérrez3,18, Emilio Ros3,19, José V Sorli3,6,20 and Miguel Angel Martinez-Gonzalez1,3*(2013)Effect of the Mediterranean diet on blood pressure in the PREDIMED trial: results from a randomized controlled trial 11:207 1741-7015/11/207.Bmc Medicine, 11(207). ISSN: 1741-7015
Lars Barregard,1 Peter Møller,2 Trine Henriksen,3 Vilas Mistry,4 Gudrun Koppen,5 Pavel Rossner, Jr.,6 Radim J. Sram,6 Allan Weimann,3 Henrik E. Poulsen,3 Robert Nataf,7 Roberta Andreoli,8,9 Paola Manini,8 Tim Marczylo,4 Patricia Lam,4 Mark D. Evans,4 Hiroshi Kasai,10 Kazuaki Kawai,10 Yun-Shan Li,10 Kazuo Sakai,11 Rajinder Singh,12 Friederike Teichert,12 Peter B. Farmer,12 Rafal Rozalski,13 Daniel Gackowski,13 Agnieszka Siomek,13 Guillermo T. Saez,14 Concha Cerda,14 Karin Broberg,15,16 Christian Lindh,15 Mohammad Bakhtiar Hossain,15,16 Siamak Haghdoost,17 Chiung-Wen Hu,18 Mu-Rong Chao,18 Kuen-Yuh Wu,19 Hilmi Orhan,20 Nilufer Senduran,20 Raymond J. Smith,21 Regina M. Santella,22 Yali Su,23 Czarina Cortez,23 Susan Yeh,23 Ryszard Olinski,13 Steffen Loft,2 and Marcus S. Cooke4,24(2013)Human and Methodological Sources of Variability in the Measurement of Urinary 8-Oxo-7, 8-dihydro-2¢-deoxyguanosine.Antioxidants & Redox Signaling, 18, pp. 2377 - 2391. ISSN: 1523-0864
Ramón Estruch, M.D., Ph.D., Emilio Ros, M.D., Ph.D., Jordi Salas-Salvadó, M.D., Ph.D., Maria-Isabel Covas, D.Pharm., Ph.D., Dolores Corella, D.Pharm., Ph.D., Fernando Arós, M.D., Ph.D., Enrique Gómez-Gracia, M.D., Ph.D., Valentina Ruiz-Gutiérrez, Ph.D., Miquel Fiol, M.D., Ph.D., José Lapetra, M.D., Ph.D., Rosa Maria Lamuela-Raventos, D.Pharm., Ph.D., Lluís Serra-Majem, M.D., Ph.D., Xavier Pintó, M.D., Ph.D., Josep Basora, M.D., Ph.D., Miguel Angel Muñoz, M.D., Ph.D., José V. Sorlí, M.D., Ph.D., José Alfredo Martínez, D.Pharm, M.D., Ph.D., and Miguel Angel Martínez-González, M.D., Ph.D., for the PREDIMED Study Investigators*(2013)Primary Prevention of Cardiovascular Disease with a Mediterranean Diet.New England Journal of Medicine, 38(14), pp. 1279 - 1290. ISSN: 0028-4793
Anabel García-Heredia,¿ Elizabeth Kensicki,¿ Robert P. Mohney,¿ Anna Rull,¿ Iris Triguero,¿ Judit Marsillach,§ Carmen Tormos,∥ Bharti Mackness,¿ Michael Mackness,¿ Diana M. Shih,⊥ Juan Pedro-Botet,¶ Jorge Joven,¿ Guillermo Sáez,∥ and Jordi Camps*,¿(2013)Paraoxonase‑1 Deficiency Is Associated with Severe Liver Steatosis in Mice Fed a High-fat High-cholesterol Diet: A Metabolomic Approach.Journal of Proteome Research. ISSN: 1535-3893
Puchades MJ, Saez G, Muñoz MC, Gonzalez M, Torregrosa I, Juan I, Miguel A.(2013)Study of oxidative stress in patients with advanced renal disease and undergoing either hemodialysis or peritoneal dialysis. Puchades MJ, Saez G, Muñoz MC, Gonzalez M, Torregrosa I, Juan I, Miguel A. Clin Nephrol.Clinical Nephrology, 80(3), pp. 177 - 186. ISSN: 0301-0430
Leonardo De Tursi Ríspoli1, Antonio Vázquez Tarragón2, Antonio Vázquez Prado1,Guillermo Sáez Tormo (CIBEROBN)3, Ali Ismail Mahmoud1, Marcos Bruna Esteban1,Claudia Mulas Fernandez1 y Verónica Gumbau Puchol1(2013)Relación del estrés oxidativo y la pérdida de peso obtenida en pacientes obesos mórbidos mediante cirugía bariátrica con la técnica del cruce duodenal.Nutricion Hospitalaria, 28(3), pp. 1085 - 1092. ISSN: 0212-1611
Mitjavila MT, Fandos M, Salas-Salvadó J, Covas MI, Borrego S, Estruch R, Lamuela-Raventós R, Corella D, Martínez-Gonzalez MÁ, Sánchez JM, Bulló M, Fitó M, Tormos C, Cerdá C, Casillas R, Moreno JJ, Iradi A, Zaragoza C, Chaves J, Sáez GT.(2013)The Mediterranean diet improves the systemic lipid and DNA oxidative damage in metabolic syndrome individuals. A randomized, controlled, trial.Clinical Nutrition, 32(2), pp. 172 - 178. ISSN: 0261-5614
Collado R, Oliver I, Tormos C, Egea M, Miguel A, Cerdá C, Ivars D, Borrego S, Carbonell F, Sáez GT.(2012)Early ROS-mediated DNA damage and oxidative stress biomarkers in Monoclonal B Lymphocytosis.Cancer Letters, 28(317(2)), pp. 144 - 149. ISSN: 0304-3835
Martínez-González MÁ, Corella D, Salas-Salvadó J, Ros E, Covas MI, Fiol M, Wärnberg J, Arós F, Ruíz-Gutiérrez V, Lamuela-Raventós RM, Lapetra J, Muñoz MÁ, Martínez JA, Sáez G, Serra-Majem L, Pintó X, Mitjavila MT, Tur JA, Portillo MP, Estruch R; PREDIMED Study Investigators.(2012)Cohort profile: design and methods of the PREDIMED study. Int J Epidemiol. 41(2):377-85.International Journal of Epidemiology, 41(2), pp. 377 - 385. ISSN: 0300-5771
Ortega-Azorín C, Sorlí JV, Asensio EM, Coltell O, Martínez-González MÁ, Salas-Salvadó J, Covas MI, Arós F, Lapetra J, Serra-Majem L, Gómez-Gracia E, Fiol M, Sáez-Tormo G, Pintó X, Muñoz MA, Ros E, Ordovás JM, Estruch R, Corella D.(2012)Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low. Cardiovasc Diabetol. 6;11:137.Cardiovascular Diabetology, 6(11), p. 137. ISSN: 1475-2840
Mansego ML, Solar Gde M, Alonso MP, Martínez F, Sáez GT, Escudero JC, Redón J, Chaves FJ.(2011)Polymorphisms of antioxidant enzymes, blood pressure and risk of hypertension.Journal of Hypertension, Mar 29(3), pp. 492 - 500. ISSN: 0263-6352
Dalli E, Colomer E, Tormos MC, Cosín-Sales J, Milara J, Esteban E, Sáez G.(2011)Crataegus laevigata decreases neutrophil elastase and has hypolipidemic effect: A randomized, double-blind, placebo-controlled trial.Phytomedicine, 18(8-9), pp. 769 - 775. ISSN: 0944-7113
Castañer O, Fitó M, López-Sabater MC, Poulsen HE, Nyyssönen K, Schröder H, Salonen JT, De la Torre-Carbot K, Zunft HF, De la Torre R, Bäumler H, Gaddi AV, Saez GT, Tomás M, Covas MI; EUROLIVE Study Group.(2011)The effect of olive oil polyphenols on antibodies against oxidized LDL. A randomized clinical trial.Clinical Nutrition, 30(4), pp. 490 - 493. ISSN: 0261-5614
Mansego ML, Redon J, Martinez-Hervas S, Real JT, Martinez F, Blesa S, Gonzalez-Albert V, Saez GT, Carmena R, Chaves FJ.(2011)Different impacts of cardiovascular risk factors on oxidative stress.International Journal Of Molecular Sciences, 12(9), pp. 6146 - 6163. ISSN: 1661-6596
Medina-Remón A, Zamora-Ros R, Rotchés-Ribalta M, Andres-Lacueva C, Martínez-González MA, Covas MI, Corella D, Salas-Salvadó J, Gómez-Gracia E, Ruiz-Gutiérrez V, García de la Corte FJ, Fiol M, Pena MA, Saez GT, Ros E, Serra-Majem L, Pinto X, Warnberg J, Estruch R, Lamuela-Raventos RM, PREDIMED Study Investigators.(2011)Total polyphenol excretion and blood pressure in subjects at high cardiovascular risk.Nutr Metab Cardiovasc Dis. 2011 May ;21(5):323-31.Nutrition Metabolism and Cardiovascular Diseases, 21(5), pp. 323 - 331. ISSN: 0939-4753
Martínez-González MA, Corella D, Salas-Salvadó J, Ros E, Covas MI, Fiol M, Wärnberg J, Aros F, Ruíz-Gutiérrez V, Lamuela-Raventós RM, Lapetra J, Muñoz MA, Martínez JA, Sáez G, Serra-Majem L, Pintó X, Mitjavila MT, Tur JA, Portillo MD, Estruch R; for the PREDIMED Study Investigators.(2010)Cohort Profile: design and methods of the PREDIMED study.International Journal of Epidemiology, 2010, pp. 1 - 9. ISSN: 0300-5771
Konstantinidou V, Covas MI, Muñoz-Aguayo D, Khymenets O, de la Torre R, Saez G, Tormos Mdel C, Toledo E, Marti A, Ruiz-Gutiérrez V, Ruiz Mendez MV, Fito M.(2010)In vivo nutrigenomic effects of virgin olive oil polyphenols within the frame of the Mediterranean diet: a randomized controlled trial..Faseb Journal, 24(jul 2010), pp. 2546 - 2557. ISSN: 0892-6638
López-Fontal R, Zeini M, Través PG, Gómez-Ferrería M, Aranda A, Sáez GT, Cerdá C, Martín-Sanz P, Hortelano S, Boscá L.(2010)Mice lacking thyroid hormone receptor Beta show enhanced apoptosis and delayed liver commitment for proliferation after partial hepatectomy.Plos One, 5, pp. 1 - 5. ISSN: 1932-6203
López-Uriarte P, Nogués R, Saez G, Bulló M, Romeu M, Masana L, Tormos C, Casas-Agustench P, Salas-Salvadó J.(2010)10. Effect of nut consumption on oxidative stress and the endothelial function in metabolic syndrome. .Clinical Nutrition, 29, pp. 373 - 380. ISSN: 0261-5614
European Standards Committee on Urinary (DNA) Lesion Analysis, Evans MD, Olinski R, Loft S, Cooke MS.(2010)Toward consensus in the analysis of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine as a noninvasive biomarker of oxidative stress.Faseb Journal, 24(4), pp. 1249 - 1260. ISSN: 0892-6638
Beltrán B, Nos P, Dasí F, Iborra M, Bastida G, Martínez M, O'Connor JE, Sáez G, Moret I, Ponce J.(2010)16. Mitochondrial dysfunction, persistent oxidative damage, and catalase inhibition in immune cells of naïve and treated Crohn's disease. .Inflammatory Bowel Diseases. ISSN: 1078-0998
Real JT, Martínez-Hervás S, Tormos MC, Domenech E, Pallardó FV, Sáez-Tormo G, Redon J, Carmena R, Chaves FJ, Ascaso JF, García-García AB.(2010)Increased oxidative stress levels and normal antioxidant enzyme activity in circulating mononuclear cells from patients of familial hypercholesterolemia.Metabolism-Clinical and Experimental, 59, pp. 293 - 298. ISSN: 0026-0495
Fandos M, Corella D, Guillén M, Portolés O, Carrasco P, Iradi A, Martínez-González MA, Estruch R, Covas MI, Lamuela-Raventós RM, Michavilla MT, Cerdá C, Torregrosa R, Redón J, Chaves FF, Tormos MC, Ocete D, Sáez GT.(2009)Impact of cardiovascular risk factors on oxidative stress and DNA damage in a high risk Mediterranean population.Free Radical Research, 43(12), pp. 1179 - 86. ISSN: 1071-5762
Schröder H, de la Torre R, Estruch R, Corella D, Martínez-González MA, Salas-Salvadó J, Ros E, Arós F, Flores G, Civit E, Farré M, Fiol M, Vila J, Fernandez-Crehuet J, Ruiz-Gutiérrez V, Lapetra J, Sáez G, Covas MI; PREDIMED Study Investigators.(2009)Alcohol consumption is associated with high concentrations of urinary hydroxytyrosol. Am J Clin Nutr. .American Journal of Clinical Nutrition, 90(5), pp. 1329 - 1335. ISSN: 0002-9165
Estruch R, Martínez-González MA, Corella D, Basora-Gallisá J, Ruiz-Gutiérrez V, Covas MI, Fiol M, Gómez-Gracia E, López-Sabater MC, Escoda R, Pena MA, Diez-Espino J, Lahoz C, Lapetra J, Sáez G, Ros E; PREDIMED Study Investigators.(2009)Effects of dietary fibre intake on risk factors for cardiovascular disease in subjects at high risk.Journal of Epidemiology and Community Health, 63(7), pp. 582 - 588. ISSN: 0143-005X
Corella D, González JI, Bulló M, Carrasco P, Portolés O, Díez-Espino J, Covas MI, Ruíz-Gutierrez V, Gómez-Gracia E, Arós F, Fiol M, Herrera MC, Santos JM, Sáez G, Lamuela R, Lahoz C, Vinyoles E, Ros E, Estruch R.(2009)Polymorphisms cyclooxygenase-2 -765G>C and interleukin-6 -174G>C are associated with serum inflammation markers in a high cardiovascular risk population and do not modify the response to a Mediterranean diet supplemented with virgin olive oil or nuts. 139(1):128-34. Epub 2008 Dec 3 .Journal of the American College of Nutrition, 139(1), pp. 128 - 134. ISSN: 0731-5724
Toledo E, Delgado-Rodríguez M, Estruch R, Salas-Salvadó J, Corella D, Gomez-Gracia E, Fiol M, Lamuela-Raventós RM, Schröder H, Arós F, Ros E, Ruíz-Gutiérrez V, Lapetra J, Conde-Herrera M, Sáez G, Vinyoles E, Martínez-González MA(2009)Low-fat dairy products and blood pressure: follow-up of 2290 older persons at high cardiovascular risk participating in the PREDIMED study. Br J Nutr. Jan;101(1):59-67 .British Journal of Nutrition, 101(1), pp. 59 - 67. ISSN: 0007-1145
Medina-Remón A, Zamora-Ros R, Rotchés-Ribalta M, Andres-Lacueva C, Martínez-González MA, Covas MI, Corella D, Salas-Salvadó J, Gómez-Gracia E, Ruiz-Gutiérrez V, García de la Corte FJ, Fiol M, Pena MA, Saez GT, Ros E, Serra-Majem L, Pinto X, Warnberg J, Estruch R, Lamuela-Raventos RM; on behalf of the PREDIMED Study Investigators.(2009)Total polyphenol excretion and blood pressure in subjects at high cardiovascular risk. Nutr Metab Cardiovasc Dis. 2010 Feb 16. .Nutrition Metabolism and Cardiovascular Diseases, xxx, pp. 1 - 9. ISSN: 0939-4753
Sánchez-Taínta A, Estruch R, Bulló M, Corella D, Gómez-Gracia E, Fiol M, Algorta J, Covas MI, Lapetra J, Zazpe I, Ruiz-Gutiérrez V, Ros E, Martínez-González MA; PREDIMED group.(2008)Adherence to a Mediterranean-type diet and reduced prevalence of clustered cardiovascular risk factors in a cohort of 3,204 high-risk patients.European Journal Of Cardiovascular Prevention & Rehabilitation, 5(15), pp. 589 - 593. ISSN: 1741-8267
Ferri J, Martínez-Hervás S, Espinosa O, Fandos M, Pedro T, Real JT, Chaves FJ, Cerdá C, Sáez G, Ascaso JF(2008)[8-oxo-7,8-dihydro-2'-deoxyguanosine as a marker of DNA oxidative stress in individuals with combined familiar hyperlipidemia] .Medicina Clínica, 131 (1)(Jun 7), pp. 1 - 4. ISSN: 0025-7753
Martinez-Hervas S, Fandos M, Real JT, Espinosa O, Chaves FJ, Saez GT, Salvador A, Cerdá C, Carmena R, Ascaso JF.(2008)Insulin resistance and oxidative stress in familial combined hyperlipidemia. .Atherosclerosis, 199, pp. 384 - 389. ISSN: 0021-9150
Chaves FJ,Carella D,Blesa S, Mansego ML,Marín P, Portoles O, Sorlí JV,González-Albert V, Tormos MC, Garcia-Garcia AB, Sáez G,Redón J(2007)Xanthine oxidoreductase polymorphisms: influence in blood pressure and oxidative stress levels.Pharmacogenetics And Genomics, Aug 17(8)(2), pp. 589 - 596. ISSN: 1744-6872
Fito M, Guxens M,Carella D,Sáez G,Estruch R, de la Torre R, Frances F,Cabezas C, lópez-Sabater M del C, Marrugat J, García-Arellano A,Arós F,Ruiz-Gutierrez V, Ros E, Salas-Salvadó J, Fiol M, Solá R, Covas MI.(2007)Effect of a traditional Mediterranean diet on lipoprotein oxidation:a randomized controlled trial.Archives of Internal Medicine, Jun 11 167(11), pp. 1195 - 1203. ISSN: 0003-9926
Mansego ML, Blesa S, Gonzalez-Albert V, Tormos MC, Saez G,Redon J, Chaves FJ.(2007)Discordant response of glutathione and thioredoxin systems in human hypertension?.Antioxidants & Redox Signaling, Apr 9(4), pp. 507 - 514. ISSN: 1523-0864
N Abdilla, MC Tormos, MJ Fabia, FJ Chaves, G Sáez J Redón.(2007)Impact of the components of metabolic syndrome on oxidative stress and enzymatic antioxidant activity in essential hypertension.Journal of Human Hypertension, 21, pp. 68 - 75. ISSN: 0950-9240
Felipe J. Chaves, Maria l. Mansego, Sebastian Blesa, Veronica Gonzalez-Albert, Jorge Jimenez,Maria C Tormos, Olga Espinosa, Vicente Giner, Antonio Iradi, Guillermo Sáez and Josep Redon.(2007)Inadequate Cytoplasmic Antixidant Enzymes Response Contributes to the Oxidative Stress in HUman Hypertension.American Journal of Hypertension, 20, pp. 62 - 69. ISSN: 0895-7061
Olga Espinosa,Jorge Jimenez,Felipe J. Chaves, Maria C Tormos, Sonia Clapes, Antonio Iradi,Amparo Salvador, Marta Fandos,Josep Redon and Guillermo Sáez .(2007)Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG),a reliable oxidative stress marker in hypertension.Free Radical Research, 41(5), pp. 546 - 554. ISSN: 1071-5762
Sergio Martinez-Hervas,Marta Fandos,Jose T. Real, Olga Espinosa,Felipe J. Chaves,Guillermo Sáez, Amparo Salvador, Concha Cerdá, Rafael Carmena, Juan F. Ascaso.(2007)Insulin resistance and oxidative stress in familial combined hyperlipidemia.Atherosclerosis. ISSN: 0021-9150
María Sanchez, Jose Vicente Torres, Carmen Tormos, Antonio Iradi, Pilar Muñiz, Olga Espinosa, Amparo Salvador, Juana Rodriguiez-Delgado, Marta Fandos, Guillermo T.Sáez(2006)Impairment of antioxidant enzymes, lipid peroxidation and 8-oxo-2'deoxiiiyguanosine in advanced epithelial ovarian carcinoma of Spanish community.Cancer Letters, 233, pp. 28 - 35. ISSN: 0304-3835
Ramón Estruch,Miguel A Martínez-González,D. Corella,J Salas,V Rúiz Guitérrez, MI Covas, Miguel Fiol,Enrique Gómez Gracia, M C López Sabater, E Vinyoles, F Arós Manuel Conde, C Lahoz, J Lapetra, G Sáez, E Ros.(2006).- Effects of a Mediterranean-Style Diet on Classical and Nobel RisK Factors for Coronary Heart Disease. THE PREDIMED Study, a Randomized Controlled Feeding Trial. Annals of Internal Medicine (I.F.12).Annals of Internal Medicine, Jul 4;(145(1)), pp. 1 - 11. ISSN: 0003-4819
Sánchez, M., Torres, J.V., Tormos, C., Iradi, A., Oliva, M.R., Muñiz, P. Espinosa O, Salvador A, Rodriguez-Delgado J, Fandos M, and Sáez, G.T.(2006)Impairment of antioxidant enzymes, lipid peroxidation and 8-oxo-2'-deoxyguanosine in advanced epithelial ovarian carcinoma of a spanish community.Cancer Letters, Feb 20(233(1)), pp. 28 - 35. ISSN: 0304-3835
Sánchez, M., Torres, J.V., Tormos, C., Iradi, A., Oliva, M.R., Muñiz, P. Espinosa O, Salvador A, Rodriguez-Delgado J, Fandos M, and Sáez, G.T.(2006)Impairment of antioxidant enzymes, lipid peroxidation and 8-oxo-2'-deoxyguanosine in advanced epithelial ovarian carcinoma of a spanish community.Cancer Letters, Feb 20(233(1)), pp. 28 - 35. ISSN: 0304-3835
Amparo Salvador, Salvador Donderis, Carmen Olivares, Marcos Guaita, Olga Espinosa, Juana Rodríguez, Marta Fondos y Guillermo T.Sáez.(2006)El estrés oxidativo en la patología degenerativa. Mecanismos de acción y marcadores de lesión molecular.Química Clínica, 25(2), pp. 49 - 57. ISSN: 1139-2436
González-Santiago, L., Suárez, Y., Zarich, N., Martínez, T., Alonso, J.L., Goya, L., Sáez Tormo, G., Rojas, J.M. and Muñoz, A.(2006)Aplidin,TM alters glutathione homeostasis causing oxidative stress, Rac and Rho activation, MKP-1 phosphatase down-regulation and JNK-dependent apoptosis in human breast cancer cells.Cell Death and Differentiation, Mar 17. ISSN: 1350-9047
Gonzalez Rico M, Puchades MJ, Garcia Ramon R, Sáez G, Tormos MC, Miguel A.(2006)Effect of oxidative stress in patients with chronic renal failure.Nefrologia, 26(2), pp. 218 - 225. ISSN: 0211-6995
Ramón Estruch,Miguel A Martínez-González,D. Corella,J Salas,V Rúiz Guitérrez, MI Covas, Miguel Fiol,Enrique Gómez Gracia, M C López Sabater, E Vinyoles, F Arós Manuel Conde, C Lahoz, J Lapetra, G Sáez, E Ros.(2005).- Effects of a Mediterranean-Style Diet on Classical and Nobel RisK Factors for Coronary Heart Disease. THE PREDIMED Study, a Randomized Controlled Feeding Trial. Annals of Internal Medicine (I.F.12).Annals of Internal Medicine. ISSN: 0003-4819
Amparo Salvador, Salvador Donderis, Carmen Olivares, Marcos Guaita, Olga Espinosa, Juana Rodríguez, Marta Fondos y Guillermo T.Sáez.(2005)El estrés oxidativo en la patología degenerativa. Mecanismos de acción y marcadores de lesión molecular.Química Clínica. ISSN: 1139-2436
González-Santiago, L., Suárez, Y., Zarich, N., Martínez, T., Alonso, J.L., Goya, L., Sáez Tormo, G., Rojas, J.M. and Muñoz, A.(2005)Aplidin,TM alters glutathione homeostasis causing oxidative stress, Rac and Rho activation, MKP-1 phosphatase down-regulation and JNK-dependent apoptosis in human breast cancer cells.Cell Death and Differentiation. ISSN: 1350-9047
Miguel, A., González-Rico, M., García, R., Tormos, C., Iradi, A., Oliva, M.R., Gil, D., Espinosa, O., Jimenez, J., Guaita, M. and Sáez, G.T.(2005)A comparative study of oxidative stress in renal failure patients undergoing peritoneal dialysis versus haemoldialysis treatment.Free Radical Biology and Medicine. ISSN: 0891-5849
Olga Espinosa,* Jorge Jimenez, Felipe J. Chaves, Carmen Tormos, Sonia Clapes, Antonio Iradi, Amparo Salvador, Marta Fandos, Josep Redon and Guillermo T. Sáez.(2005)Urinary 8-oxo-deoxyguanosine a reliable oxidative stress marker in hypertension.Free Radical Research. ISSN: 1071-5762
Tanja Weinbrenner, Montserrat Fito, Rafael de la Torre, Guillermo Sáez, Philip Rijken, Carmen Tormos,Stefan Coolen, Magí Farré Albadejo,Sergio Abadanes, Helmut Schroder, Jaume Marrugat, and Maria-Isabel Covas.(2004)Olive Oils High in Phenolic Compounds Modulate Oxidative/Antioxidative Status in Men.Journal of Nutrition, 134(9), pp. 2314 - 2321. ISSN: 0022-3166
Weinbrenner t, Fito M, Farre Albaladejo M, Saez GT, Rijiken P, Tormos C, Coolen S, De LA Torre R, Covas MI.(2004)Bioavailability of phenolic compounds from olive oil and oxidative/antixidant status at postprandial state in healty humans.Drugs Under Experimental and Clinical Research, 30(5-6), pp. 207 - 212. ISSN: 0378-6501
V. Giner, C. Tormos, F.J. Chaves, G. Sáez, J.Redón.(2004)Microalbuminuria and Oxidative stress in essential hypertension.Journal of Internal Medicine, 255, pp. 588 - 594. ISSN: 0954-6820
Saez GT, Tormos C, Giner V, Chaves J, Lozano JV, Iradi A, Redón J.(2004)Factors Related to the Impact of Anthypertensive treatment in antioxidant activities and oxidative stress by-products in human hypertension.American Journal of Hypertension, 17, pp. 809 - 816. ISSN: 0895-7061
Guillermo T.Sáez and Josep Redón(2003)Oxidative Stress in Hypertension.Iberoamerican Journal Hypertension., 10(4), pp. 139 - 248. ISSN: 1136-5943
V.Valls, M.Goicochea, P.Muñiz, G.T:Sáez, J:R:Cabo(2003)Effect of corn oil and vitamin E on the oxidative status of adipose tissues and liver in rat.Food Chemistry, 81, pp. 281 - 286. ISSN: 0308-8146
Josep Redón, Maria R.Oliva,Carmen Tormos, Vicente Giner, Javier Chaves, Antonio Iradi, Guillermo T. Sáez.(2003)Antioxidant activities and oxidative stress byproducts in human hypertension.Hypertension, 41, pp. 1096 - 1101. ISSN: 0194-911X
Delia Acevedo-León; Lidia Monzó-Beltrán; Laura Pérez-Sánchez; Eva Naranjo-Morillo; Segundo Ángel Gómez-Abril; Nuria Estañ-Capell; Celia Bañuls; Guillermo Sáez(2022)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitInternational Journal Of Molecular Sciences, 23(19), p. 11664. ISSN: 1661-6596
Gargallo P; Colado JC; Juesas A; Hernando-Espinilla A; Estañ-Capell N; Monzó-Beltran L; García-Pérez P; Cauli O; Sáez GT.(2018)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitBiological Research For Nursing, 20(2), pp. 205 - 217. ISSN: 1099-8004
Nerea Becerra-Tom as; Andr es Díaz-L opez; Núria Rosique-Esteban; Emilio Ros; Pilar Buil-Cosiales; Dolores Corella;Ramon Estruch; Montserrat Fit o; Lluís Serra-Majem; Fernando Ar os; Rosa Maria Lamuela-Ravent os; Miquel Fiol; Jos e Manuel Santos-Lozano;Javier Díez-Espino; Olga Portoles; Jordi Salas-Salvad o; PREDIMED Study Investigators (Guillermo T. Sáez)(2018)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitClinical Nutrition, 37(3)(3), pp. 906 - 912. ISSN: 0261-5614
Sandra Martín‑Peláez;Olga Castañer; Valentini Konstantinidou;· Isaac Subirana;Daniel Muñoz‑Aguayo; Gemma Blanchart;Sonia Gaixas; · Rafael de la Torre;· Magí Farré5; · Guillermo T Sáez; · Kristina Nyyssonen; Hans Joachim Zunft;· Maria Isabel Covas; · Montse Fitó;(2017)Oxidative imbalance in low/intermediate-1-risk myelodysplastic syndrome patients: The influence of iron overload.European Journal of Nutrition, 56(2), pp. 663 - 670. ISSN: 1436-6207
Dualde P; León N; Sanchis Y; Corpas-Burgos F; Fernández SF; Hernández CS; Saez G; Pérez-Zafra E; Mora-Herranz A; Pardo O; Coscollà C; López A; Yusà V; On Behalf Of The Bioval Task Force(2021)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitInternational Journal Of Environmental Research And Public Health, 18(17), p. 8909. ISSN: 1661-7827
Delia Acevedo-León; Segundo Ángel Gómez-Abril; Lidia Monzó-Beltrán; Nuria Estañ-Capell; Rafael Arroyo-Montañés; Celia Bañuls; Jordi Salas-Salvadó; Guillermo Sáez(2022)Adherence to the Mediterranean diet has a protective role against metabolic and DNA damage markers in colorectal cancer patients.Antioxidants. ISSN: 2076-3921
Delia Acevedo-León; Lidia Monzó-Beltrán; Laura Pérez-Sánchez; Eva Naranjo-Morillo; Segundo Ángel Gómez-Abril; Nuria Estañ-Capell; Celia Bañuls; Guillermo Sáez(2022)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitInternational Journal Of Molecular Sciences, 23(19)(11664). ISSN: 1661-6596
Acevedo-León D; Gómez-Abril SÁ; Sanz-García P; Estañ-Capell N; Bañuls C; Sáez G.(2023)Research Group on Free Radicals and Oxidative Stress. Oxidative Pathology UnitRedox Biology, 62(102662). ISSN: 2213-2317
Journal Publications
Burjassot/Paterna Campus
C/ Doctor Moliner, 50
46100 Burjassot (Valencia)
- SAEZ TORMO, GUILLERMO
- PDI-Catedratic/a d'Universitat
- Coordinador/a de Mobilitat
- Vicedega/Vicedegana / Vicedirector/a Ets
