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Description

Chirality is a property related to the three-dimensional shape of molecules. Chiral molecules can exist in two forms (enantiomers) that are mirror images of each other. This subtle difference has tremendously important implications in chemistry, as two enantiomers can exhibit completely different or even opposite biological or pharmacological properties. Similarly, the mechanical, magnetic or electrical properties of many materials can vary completely depending on whether they are made up of a single enantiomer or mixtures of enantiomers.

As a consequence of all this, there is a real need at both laboratory and industrial level for synthetic procedures that allow chiral compounds to be obtained selectively in a defined enantiomeric form. Among the different methodologies available for this purpose, those using chiral catalysts are the most suitable, as they allow minimising the consumption of chiral starting materials and reducing waste production, contributing to more efficient, more economical and more environmentally friendly chemical processes.

In this context, the asymmetric catalysis group investigates the development of new chiral catalysts based on both metal complexes and organocatalysts and their application in various enantioselective C-C bond formation reactions aimed at the synthesis of enantiomerically enriched chiral organic compounds of pharmacological interest. These reactions include functionalisation reactions of aromatic and heteroaromatic compounds (Friedel-Crafts reactions), carbanion addition reactions (aldol reactions, Henry reactions), addition reactions of organometallic reagents (alkylation and alkynylation) or cycloaddition reactions (Diels-Alder reactions, 1,3-dipolar addition) etc.

We have recently incorporated the use of photoredox catalysis in C-C bond formation reactions.

Goals CT
  • Development of new methodologies for the formation of C-C bonds by means of asymmetric catalysis.
  • Development of new chiral catalysts based on metal complexes and organocatalysts.
  • Enantioselective synthesis of compounds of pharmacological and agrochemical interest using enantioselective catalysis.
  • Development of new methodologies for the formation of C-C bonds using photoredox catalysis.
Research lines
Management
  • BLAY LLINARES, GONZALO
  • PDI-Catedratic/a d'Universitat
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Members
  • PEDRO LLINARES, JOSE RAMON
  • PDI-Emerit/a Universitat
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  • FERNANDEZ PICOT, ISABEL
  • PDI-Catedratic/a d'Universitat
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  • VILA DESCALS, CARLOS
  • Alumn.-Servei de Formacio Permanent
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  • MONLEON VENTURA, ALICIA
  • Alumn.-Servei de Formacio Permanent
  • Coordinador/a Curs
  • Responsables de Gestio Academica
  • Coordinador/a Practiques Ext Centre
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  • SANZ MARCO, AMPARO
  • Alumn.-Servei de Formacio Permanent
  • Coordinador/a Curs
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Collaborators
  • SANZ MARCO, AMPARO
  • Alumn.-Servei de Formacio Permanent
  • Coordinador/a Curs
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Scientific production by UV researcher
Associated structure
Contact group details
Research Group on Asymmetric Catalysis with Metal Complexes and Organocatalysts (AsymCat)

Burjassot/Paterna Campus

Faculty of Chemistry
Organic Chemistry Department
F - 5th floor
C/ Dr. Moliner, 50

46100 Burjassot (Valencia)

+34 963 544 329

+34 963 544 336

Geolocation

www.uv.es/asymcat

jose.r.pedro@uv.es

gonzalo.blay@uv.es

Contact people
  • PEDRO LLINARES, JOSE RAMON
  • PDI-Emerit/a Universitat
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