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Description

La seua activitat se centra en les àrees de neurociència i investigació cardiovascular, sent els seus objectius principals l'estudi de la fisiologia de la circulació cerebral, la prevenció, fisiopatologia i tractament de l'ictus isquèmic, i la fisiopatologia de la vasculopatia diabètica, com a factor de risc cerebrovascular. Es realitza tant investigació preclínica (models animals d'ictus i diabetis) com a clínica (pacients de d'ictus).

Goals CT
  • Physiology of cerebral circulation.
  • Pathophysiology of cerebral ischaemia.
  • Acute ischaemic stroke.
  • Neuroprotection and neuroreparation.
  • Diabetes and vascular damage.
Research lines
  • Analysis of thrombus obtained by mechanical thrombectomy in patients with ischaemic stroke due to large vessel occlusion

    In patients with large vessel ischaemic stroke, the use of thrombectomy devices makes it possible to retrieve the occluding thrombus and make it available for analysis. The thrombus can be studied fresh, frozen or fixed for preservation and subsequent analysis. The aim is to subject thrombi to different types of analysis to obtain information on their characteristics, structure and composition, and to establish associations between the nature of the thrombus and clinical-radiological variables relating to the diagnosis, treatment and prognosis of stroke. It will also help to explain the behaviour of the thrombus during fibrinolysis and/or thrombectomy, enabling research and development of more effective thrombolytic treatments and thromectomy devices.

  • Cellular senescence as a biomaker and therapeutic target in ischaemic stroke

    Brain cell senescence remains unexplored as a target for neuroprotection in stroke. The aim is to characterise brain cell senescence associated with ageing and stroke in a rat model, and to reposition a senolytic drug, Navitoclax, as an effective neuroprotectant for use as an adjunct to endovascular treatment in ischaemic stroke. The influence of gender will also be analysed.

Management
  • MIRANDA ALONSO, FRANCISCO JAVIER
  • PDI-Catedratic/a d'Universitat
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Members
  • CENTENO GUIL, JOSE MARIA
  • PDI-Titular d'Universitat
  • Coordinador/a Curs
  • Secretari/a de Facultat/Secretari/a Ets
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  • JOVER MENGUAL, TERESA
  • PDI-Titular d'Universitat
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  • SALOM SANVALERO, JUAN BAUTISTA
  • PDI-Associat/Da Universitari/A
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Non-UV research staff

Contributor/s

  • Alicia Aliena Valero - Universitat de València 
  • María Jorques González - Universitat de València 
  • Mikahela López Morales - Universitat de València 
  • Luis Miranda Gómez - Universitat de València 
Scientific production by UV researcher
  • CENTENO GUIL, JOSE MARIA
    PDI-Titular d'UniversitatCoordinador/a CursSecretari/a de Facultat/Secretari/a Ets
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  • JOVER MENGUAL, TERESA
    PDI-Titular d'Universitat
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Associated structure
Contact group details
Joint Unit for Cerebrovascular Research, La Fe Health Research Institute - University of Valencia (UMIC)

Blasco Ibáñez Campus

Av. Blasco Ibáñez, 15

46010 València (Valencia)

+34 963 543 814

Geolocation

francisco.j.miranda@uv.es

Contact people
  • MIRANDA ALONSO, FRANCISCO JAVIER
  • PDI-Catedratic/a d'Universitat
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