Description
- Genetic analysis in solid tumours in children. At European level, we participate in the establishment of a uniform nomenclature, a standard operating procedure and quality validation studies, essential to obtain and maintain a high quality of the results of fluorescent in situ hybridisation, single nucleotide polymorphism and sequencing (FISH, SNPs and NGS) used for therapeutic stratification in neuroblastoma.
- Identification of new genetic factors and digital microscopic analysis with prognostic value in low prevalence tumours (rare tumours).
- Obtaining and characterising cell lines derived from fresh tumours of neuroblastic and skeletogenic tumours in children.
- Establishment and characterisation of in vivo models (2D and 3D) of neuroblastic tumours.
- Marker expression studies in paediatric solid tumours and colorectal carcinoma.
- Digital pathology studies of the tumour microenvironment.
Goals CT
Digital Pathology Studies. Identification and validation of diagnostic, prognostic and follow-up biomarkers in histological and peripheral blood samples from patients with low prevalence neoplasms and in designed artificial related tumours.
Research lines
- Analysis of genetic prognostic factors in neuroblastoma (NB)
Detection of genomic changes. Identification and characterisation of unusual cases.
- Analysis of experimental tumours in animal models
Validation of clinically useful tests.
- Development of hihg-throughput pangenomic techniques for sarcomas
Use and improvement of tools for genetic diagnosis of tumours.
- Digital microscopy analysis in histopathology
Detection. Quantification and objective topology of biological parameters in histological samples.
- Analysis of histopathological prognostic factors in neuroblastoma (NB)
Histological category determination and neuroblastic differentiation. Expression studies.
Management
- NOGUERA SALVA, ROSA
- PDI-Catedratic/a d'Universitat
Members
- NAVARRO FOS, SAMUEL
- PDI-Catedratic/a d'Universitat
Non-UV research staff
Contributor/s
- Maite Blanquer Maceiras - Clinic Hospital Research Foundation of the Comunitat Valenciana
- Rebeca Brugos Panadero - Clinic Hospital Research Foundation of the Comunitat Valenciana
- María Amparo López Carrasco - Centre for Networked Biomedical Research - Cancer Area (Madrid)
- Ezequiel Monferrer Garzarán - Universitat de València
Associated structure
Contact group details
Translational Research Group on Pediatric Solid Tumors (ResPediaTu)
Blasco Ibáñez Campus
Av. Blasco Ibáñez, 15
46010 València (Valencia)
Contact people
- NOGUERA SALVA, ROSA
- PDI-Catedratic/a d'Universitat
