At the beginning, our group was dedicated to the study and characterisation of gastrointestinal disorders related to acid production and motility, becoming an international reference group in this field due to the large number of high-level publications in the area of basic or experimental pharmacology.
New applications for the study of drug effects, such as genetics or molecular biology, have led to a broadening of the topics to be studied.
The most important characteristic of our group from a research point of view is the desire for our different lines of research to be focused on the study of physiological and pathological processes with a broad clinical impact. That is why our lines of research address diseases of particular relevance in today's society: Crohn's disease, NSAID gastroenteropathy, AIDS, diabetes and obesity. Since its foundation in 2007, our group has been part of the Centro de Investigación Biomédica en Red: Liver and Digestive Diseases (CIBERehd), whose function is to promote research of excellence at both clinical and basic levels. In addition, we have been recognised by the Valencian Government as a group of excellence within the PROMETEO 2010 call.
Our group has published more than 200 articles and reviews in international journals including, among others, Gastroenterology, Hepatology, PNAS, Circulation, Immunity, Circulation Research, British Journal of Pharmacology and Trends in Pharmacological Sciences.
- Clarify the physiopathological mechanisms of the aforementioned chronic diseases and to optimise their treatment.
- Modulation of epithelial autophagy by macrophages: relevance to Crohn's disease and NSAID gastroenteropathy
We study the mechanisms that regulate gastrointestinal mucosal recovery in chronic inflammatory pathologies (e.g. IBD), in particular how macrophages, cells of the innate immune system that accumulate in the mucosa of patients with this pathology, modulate these mechanisms.
- Mitochondrial-endothelial dysfunction, reticulum stress and autophagy in type 2 diabetes: pathophysiological and therapeutic implications
We studied type 2 diabetes and mitochondrial dysfunction, having shown that it correlates with the development of silent ischaemic heart disease. We have also shown that high levels of myeloperoxidase correlate with the development of diabetic nephropathy in type 2 diabetes.
- Characterising cellular mechanisms of antiretroviral-induced toxicity
We study the mechanisms responsible for the toxicity of antiretroviral therapy in different organs and tissues, with special emphasis on three of the main adverse effects associated with this treatment: liver toxicity, metabolic alterations and neurotoxicity.
- Study of the cellular and molecular mechanisms mediating antiretroviral therapy-induced vascular toxicity
We study the mechanisms responsible for the vascular toxicity described for some antiretroviral drugs. We have analysed the effect of the most commonly used antiretroviral drugs on leukocyte-endothelium interaction as a first step in the development of vascular pathologies.
- ESPLUGUES MOTA, JUAN VICENTE
- PDI-Catedratic/a d'Universitat
- MARTI CABRERA, MIGUEL
- PDI-Catedratic/a d'Universitat
- Coordinador/a de Programa de Doctorat
- Secretari/a de Facultat/Secretari/a Ets
- APOSTOLOVA ATANASOVSKA, NADEZDA
- PDI-Titular d'Universitat
- GALINDO PUERTO, MARIA JOSE
- PDI-Associat/Da Assistencial Ciencies Salut
- RIOS NAVARRO, CESAR
- Alumn.
- Alumn.-Servei de Formacio Permanent
- VICTOR GONZALEZ, VICTOR MANUEL
- PDI-Titular d'Universitat
Contributors
- Rafael Alos Company - Manises Hospital (Valencia)
- Dulce Carolina Macias Cejar - Universitat de València
- Marta Montero Alonso - Hospital Universitari i Politècnic La Fe (Valencia)
- Nicole Roupain - Foundation for the Promotion of Health and Biomedical Research of Valencia Region
Burjassot/Paterna Campus
Avda. Blasco Ibáñez, 15
46010 València (Valencia)
- ESPLUGUES MOTA, JUAN VICENTE
- PDI-Catedratic/a d'Universitat
