The characterisation of drug release, absorption, distribution, metabolism and excretion processes has a major impact on medicine design and provides rational criteria for selecting the most appropriate dosage form, route and method of administration. These aspects are particularly important for drugs with bioavailability problems and/or high pharmacokinetic variability.
The research group is dedicated to pre-formulation studies of medicine (and cosmetics), characterisation of drug release and/or absorption processes from the medicine containing them and evaluation of the pharmacokinetic profile after its administration to the organism.
The group is formed by a group of professors belonging to the area of knowledge of Stomatology and Physiology of the Faculty of Medicine and Dentistry of the Universitat de València. Within the area of Stomatology knowledge, to the Teaching Unit of Orthodontics, a branch of Dentistry responsible for the supervision, care and correction of the dentofacial structures (in growth or in a definitive state) including those conditions that require dental movement or correction of related bone malformations.
Its centre is located in the Dental Clinic of the Fundació Lluís Alcanyís of the Universitat de València, establishing points of contact with other Spanish and European Universities in order to promote and establish exchanges and unify criteria between the different fields of research.
Radiopharmaceuticals for therapeutic and diagnostic use: study of drug labelling conditions and stability of the complexes formed.
Radioimmunoanalytical techniques: obtaining a kinetic model for some reactions used in the assessment of different hormones, antigenic substances or antibodies, used in human clinical practice, by developing speed equations for the overall process. establishing the possible reaction mechanism.
Study of the influence of different variables such as temperature, viscosity, dielectric constant or ionic strength of the medium.
Application of topological methods to the design of new structures with pharmacological activity, using artificial neural networks as methods of discrimination and prediction of properties, allowing the best candidates to be selected for subsequent in vitro experimental trials.
