Based on the prior research experience of María Celia García Álvarez-Coque, the activity of the FUSCHROM group began under her lead in 1992, in the Micellar liquid chromatography field, applied to drug analysis in biological fluids and to the improvement of the characteristics of chromatographic peaks in basic compounds. As a result of these researches, the group specialised in fundamental studies and chemometric developments, aimed at extracting the potential information contained in chromatographic signals and improving separations, extending its application field to other chromatographic modes. In particular, new optimisation strategies, peak models, purity tests, deconvolution methods and quantitative structure-retention relationships have been developed. In addition, numerous analytical methods for the analysis of pharmaceutical, clinical and food samples have been published. The group is currently involved in the use of secondary equilibria in liquid chromatography, development of clean analytical methods, rapid chromatography, chromatographic column characterisation, column coupling and two-dimensional separations.

The members of the group have jointly published more than 400 scientific articles, approximately half of them in journals belonging to the first quartile of the ISI Web of Knowledge, with more than 110 articles in Journal of Chromatography A. In addition, they have published 40 review articles, 25 book chapters, and three books (Micellar liquid chromatography, Chemometrics and Ionic Liquids in Analytical Chemistry: New Insights and Recent Developments, published by Marcel Dekker, Síntesis and Elsevier, respectively). The group director is part of the editorial board of the Journal of Chromatography A, Analytica Chimica Acta and Separation and Purification Reviews.

For its researches, the group has received continuous funding from several Ministries for more than 30 years. Under the direction of group members, 30 students from different countries have received their PhDs. Of these students, 8 have been awarded doctoral prizes, 3 have received Marie Curie grants from the European Community, 3 have been awarded Ramón y Cajal contracts, and 12 have been professors at various universities.

It is noteworthy the collaborations with Alain Berthod (Université de Lyon, France), Desiré Massart (Vrije Universeit Brussel, Belgium), Michael Abraham (University College London, UK), Daniel Armstrong (University of Texas, Arlington, USA), Peter Schoenmakers (van't Hoff Institute of Molecular Sciences, University of Amsterdam, The Netherlands), Elisabeth Bosch and Martí Rosés (University of Barcelona), and Benjamín Monrabal and Alberto Ortín (manufacturing company of scientific instrumentation for polyolefin characterisation, Polymer Char, Valencia).