Research Group on Digestive and Inflammatory Pharmacology Unit

Description

At the beginning, our group was dedicated to the study and characterisation of gastrointestinal disorders related to acid production and motility, becoming an international reference group in this field due to the large number of high-level publications in the area of basic or experimental pharmacology.

New applications for the study of drug effects, such as genetics or molecular biology, have led to a broadening of the topics to be studied.

The most important characteristic of our group from a research point of view is the desire for our different lines of research to be focused on the study of physiological and pathological processes with a broad clinical impact. That is why our lines of research address diseases of particular relevance in today's society: Crohn's disease, NSAID gastroenteropathy, AIDS, diabetes and obesity. Since its foundation in 2007, our group has been part of the Centro de Investigación Biomédica en Red: Liver and Digestive Diseases (CIBERehd), whose function is to promote research of excellence at both clinical and basic levels. In addition, we have been recognised by the Valencian Government as a group of excellence within the PROMETEO 2010 call.

Our group has published more than 200 articles and reviews in international journals including, among others, Gastroenterology, Hepatology, PNAS, Circulation, Immunity, Circulation Research, British Journal of Pharmacology and Trends in Pharmacological Sciences.

Goals CT

Clarify the physiopathological mechanisms of the aforementioned chronic diseases and to optimise their treatment.

Research lines

Modulation of epithelial autophagy by macrophages: relevance to Crohn's disease and NSAID gastroenteropathy
We study the mechanisms that regulate gastrointestinal mucosal recovery in chronic inflammatory pathologies (e.g. IBD), in particular how macrophages, cells of the innate immune system that accumulate in the mucosa of patients with this pathology, modulate these mechanisms.
Mitochondrial-endothelial dysfunction, reticulum stress and autophagy in type 2 diabetes: pathophysiological and therapeutic implications
We studied type 2 diabetes and mitochondrial dysfunction, having shown that it correlates with the development of silent ischaemic heart disease. We have also shown that high levels of myeloperoxidase correlate with the development of diabetic nephropathy in type 2 diabetes.
Characterising cellular mechanisms of antiretroviral-induced toxicity
We study the mechanisms responsible for the toxicity of antiretroviral therapy in different organs and tissues, with special emphasis on three of the main adverse effects associated with this treatment: liver toxicity, metabolic alterations and neurotoxicity.
Study of the cellular and molecular mechanisms mediating antiretroviral therapy-induced vascular toxicity
We study the mechanisms responsible for the vascular toxicity described for some antiretroviral drugs. We have analysed the effect of the most commonly used antiretroviral drugs on leukocyte-endothelium interaction as a first step in the development of vascular pathologies.

Management

ESPLUGUES MOTA, JUAN VICENTE
PDI-Catedratic/a d'Universitat

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Members

MARTI CABRERA, MIGUEL
PDI-Catedratic/a d'Universitat
Coordinador/a de Programa de Doctorat
Secretari/a de Facultat/Secretari/a Ets

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ORTIZ MASIA, M. DOLORES
Alumn.

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Collaborators

APOSTOLOVA ATANASOVSKA, NADEZDA
PDI-Catedratic/a d'Universitat

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GALINDO PUERTO, MARIA JOSE
PDI-Associat/Da Assistencial Ciencies Salut

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VICTOR GONZALEZ, VICTOR MANUEL
PDI-Catedratic/a d'Universitat

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Non-UV research staff

Contributors

Rafael Alos Company - Manises Hospital (Valencia)
Dulce Carolina Macias Cejar - Universitat de València
Marta Montero Alonso - Hospital Universitari i Politècnic La Fe (Valencia)
Nicole Roupain - Foundation for the Promotion of Health and Biomedical Research of Valencia Region

Scientific production by UV researcher

ORTIZ MASIA, M. DOLORES
Alumn.
ContraerExpandir
- Ortiz-Zapater, E.; Soriano-Ortega, E.; Marcote, M.J.; Ortiz-Masiá, D.; Aniento, F.2006Research Group on Digestive and Inflammatory Pharmacology UnitPlant JournalVolume 48. Number 5.
- Ortiz-Masia, D., Perez-Amador, M.A., Carbonell, J. and Marcote, M.J.2007Research Group on Digestive and Inflammatory Pharmacology UnitFebs LettersVolume 581. Number 9.
- Ortiz-Masiá, D.; Pérez-Amador, M.A., Carbonell, P.; Aniento, F.; Carbonell, J.; Marcote, M.J.2008Research Group on Digestive and Inflammatory Pharmacology UnitPlantaVolume 227. Number 6.
- Hernandez, C; Santamatlde, E; McCreath, K; Cervera, AM, Diez, I; Ortiz-Masia, D; Martinez, N; Calatayud, S; Esplugues, JV; Barrachina, MD.2009Research Group on Digestive and Inflammatory Pharmacology UnitBritish Journal of PharmacologyVolume 156. Number 2.
- Ortiz-Masia, D; Hernandez, C, Quintana, E; Velazquez, M; Cebrian, S; Riaño, A; Calatayud, S; Esplugues, JV, Barrachina, MD.2010Research Group on Digestive and Inflammatory Pharmacology UnitFaseb JournalVolume 24. Number 1.
- Riaño, A; Ortiz-Masia, D; Velaquez, M; Calatayud, S; Esplugues, JV; Barrachina, MD.2011Research Group on Digestive and Inflammatory Pharmacology UnitJournal of GastroenterologyVolume 46. Number 5.
- D Ortiz-Masià,I Díez, S. Calatayud, C. Hernandez, J. Cosin, J V Esplugues and MD Barrachina.2012Research Group on Digestive and Inflammatory Pharmacology UnitPlos OneVolume 7. Number 10.
- Cosín-Roger J; Ortiz-Masiá D; Calatayud S; Hernández C; Alvarez A; Hinojosa J; Esplugues JV; Barrachina MD.2013Research Group on Digestive and Inflammatory Pharmacology UnitPlos OneVolume 8. Number 10.
- Ortiz-Masia,D; Cosin-Roger, J; Calatayud, S; Hernandez, C; Alos, R; Hinojosa, J; Apostolova, N; Alvarez, A; Barrachina MD.2014Research Group on Digestive and Inflammatory Pharmacology UnitMucosal ImmunologyVolume 7. Number 4.
- HERNANDEZ C, BARRACHINA MD, COSIN-ROGER J, ORTIZ-MASIA D, ALVAREZ A, TERRADEZ L, NICOLAU MJ, ALOS R, ESPLUGUES JV, CALATAYUD S.2014Research Group on Digestive and Inflammatory Pharmacology UnitPlos OneVolume 9. Number 6.
- Danquah A, de Zélicourt A, Boudsocq M, Neubauer J, Frei Dit Frey N, Leonhardt N, Pateyron S, Gwinner F, Tamby JP, Ortiz-Masia D, Marcote MJ, Hirt H, Colcombet J.2015Research Group on Digestive and Inflammatory Pharmacology UnitPlant JournalVolume 82. Number 2.
- Cosin-Roger J; Ortiz-Masià D; Calatayud S; Hernandez C; Esplugues JV; Barrachina MD.2016Research Group on Digestive and Inflammatory Pharmacology UnitMucosal ImmunologyVolume 9. Number 4.
- Ortiz-Masiá D; Cosín-Roger J; Calatayud S; Hernández C; Alós R; Hinojosa J; Esplugues J; Barrachina MD.2016Research Group on Digestive and Inflammatory Pharmacology UnitJournal Of Crohns & Colitis
- Macias-Ceja DC; Cosín-Roger J; Ortiz-Masiá D; Salvador P; Hernández C; Calatayud S; Esplugues JV; Barrachina MD.2016Research Group on Digestive and Inflammatory Pharmacology UnitClinical NutritionVolume 35. Number 6.
- Hernández C; Barrachina MD; Vallecillo-Hernández J; Álvarez Á; Ortiz-Masiá D; Cosín-Roger J; Esplugues JV; Calatayud S.2016Research Group on Digestive and Inflammatory Pharmacology UnitJournal of GastroenterologyVolume 5. Number 7.
- Macias-Ceja DC, Cosín-Roger J, Ortiz-Masiá D, Salvador P, Hernández C, Esplugues JV, Calatayud S, Barrachina MD.2017Research Group on Digestive and Inflammatory Pharmacology UnitBritish Journal of PharmacologyVolume 174. Number (15).
- Salvador P; Macias-Ceja DC; Gisbert-Ferrándiz L; Hernández C; Bernardo D; Alos R; Navarro-Vicente F; Esplugues JV; Ortiz-Masiá D; Barrachina MD; Calatayud S.2018Research Group on Digestive and Inflammatory Pharmacology UnitJournal Of Crohns & ColitisVolume 12. Number 5.
- Vallecillo-Hernández J, Barrachina MD, Ortiz-Masiá D, Coll S, Esplugues JV, Calatayud S, Hernández C.2018Research Group on Digestive and Inflammatory Pharmacology UnitScientific ReportsVolume 8. Number Art. 3593.
- Gisbert-Ferrándiz L; Salvador P; Ortiz-Masiá D; Macías-Ceja DC; Orden S; Esplugues JV; Calatayud S; Hinojosa J; Barrachina MD; Hernández C.2018Research Group on Digestive and Inflammatory Pharmacology UnitInflammatory Bowel DiseasesVolume 24. Number 7.
- Macias-Ceja DC; Ortiz-Masiá D; Salvador P; Gisbert-Ferrándiz L; Hernández C; Hausmann M; Rogler G; Esplugues JV; Hinojosa J; Alós; Navarro F; Cosin-Roger J; Calatayud S; Barrachina MD.2019Research Group on Digestive and Inflammatory Pharmacology UnitMucosal ImmunologyVolume 12. Number 1.
- Cosin-Roger J; Canet F; Macias-Ceja DC; Gisbert-Ferrándiz L; Ortiz-Masiá D; Esplugues JV; Alós R; Navarro F; Barrachina MD; Calatayud S.2019Research Group on Digestive and Inflammatory Pharmacology UnitCellsVolume 8. Number 9.
- Cosin-Roger J; Ortiz-Masiá D; Barrachina MD.2019Research Group on Digestive and Inflammatory Pharmacology UnitFrontiers in ImmunologyVolume 10.
- Ortiz-Masià D; Salvador P; Macias-Ceja DC; Gisbert-Ferrándiz L; Esplugues JV; Manyé J; Alós R; Navarro-Vicente F; Mamie C; Scharl M; Cosin-Roger J; Calatayud S; Barrachina MD.2020Research Group on Digestive and Inflammatory Pharmacology UnitJournal Of Crohns & ColitisVolume 14. Number 2.
- Gisbert-Ferrándiz L; Cosin-Roger J; Hernández ; Macias-Ceja DC; Ortiz-Masiá D; Salvador P; Wildenberg ME; Esplugues JV; Alós R; Navarro F; Calatayud S; Barrachina MD.2020Research Group on Digestive and Inflammatory Pharmacology UnitJournal of Steroid Biochemistry and Molecular BiologyVolume 202. Number Art. 105720.
- Cosín-Roger J; Ortiz-Masia D; Barrachina MD; Calatayud S.2020Research Group on Digestive and Inflammatory Pharmacology UnitCellsVolume 9. Number 11.
- Ortiz-Masiá D, Gisbert-Ferrándiz L, Bauset C, Coll S, Mamie C, Scharl M, Esplugues JV, Alós R, Navarro F, Cosín-Roger J, Barrachina MD, Calatayud S.2020Research Group on Digestive and Inflammatory Pharmacology UnitCellsVolume 9. Number (5).
- Gisbert-Ferrándiz L, Cosín-Roger J, Hernández C, Macias-Ceja DC, Ortiz-Masiá D, Salvador P, Esplugues JV, Hinojosa J, Navarro F, Calatayud S, Barrachina MD.2020Research Group on Digestive and Inflammatory Pharmacology UnitNutrientsVolume 12 . Number 4.
- Alegre F; Martí-Rodrigo A; Polo M; Ortiz-Masiá D; Bañuls C; Pinti M; Álvarez Á; Apostolova N; Esplugues JV; Blas-García A.2022Research Group on Digestive and Inflammatory Pharmacology UnitBiomedicinesVolume 10. Number 1.
- Cristina Bauset; Lluis Lis-Lopez; Sandra Coll; Laura Gisbert-Ferrándiz; Dulce C. Macias-Ceja; Marta Seco-Cervera; Francisco Navarro; Juan V. Esplugues; Sara Calatayud; Dolores Ortiz-Masia*; Maria D. Barrachina; Jesús Cosín-Roger.2022Research Group on Digestive and Inflammatory Pharmacology UnitBiomedicinesVolume 10. Number 3.
- Dulce C. Macias-Ceja; Sandra Coll; Cristina Bauset; Marta Seco-Cervera; Laura Gisbert-Ferrándiz; Francisco Navarro; Jesus Cosin-Roger; Sara Calatayud; María D. Barrachina; Dolores Ortiz-Masia.2022Research Group on Digestive and Inflammatory Pharmacology UnitBiomedicinesVolume 10. Number 5.
- Dulce Carolina Macias-Ceja, M Dolores Barrachina y Dolores Ortiz-Masia.2023Research Group on Digestive and Inflammatory Pharmacology UnitFrontiers In PharmacologyVolume 14. Number Art. 1170436.
- Lluis Lis-López, Cristina Bauset, Marta Seco-Cervera, Dulce Macias-Ceja, Francisco Navarro, Ángeles Álvarez, Juan Vicente Esplugues, Sara Calatayud, Maria Dolores Barrachina, Dolores Ortiz-Masià, Jesús Cosín-Roger.2023Research Group on Digestive and Inflammatory Pharmacology UnitInternational Journal Of Molecular Sciences
- Dulce Carolina Macias-Ceja, Maria Teresa Mendoza-Ballesteros, María Ortega-Albiach, Maria Dolores Barrachina and Dolores Ortiz-Masia.2023Research Group on Digestive and Inflammatory Pharmacology UnitFrontiers In Cell And Developmental BiologyVolume 11.
- M. Seco-Cervera; D. Ortiz-Masiá; D.C. Macias-Ceja; S. Coll; L. Gisbert-Ferrándiz; J. Cosín-Roger; C. Bauset; M. Ortega; B. Heras-Morán; F. Navarro-Vicente; M. Millán; J.V. Esplugues; S. Calatayud; M.D. Barrachina.2024Research Group on Digestive and Inflammatory Pharmacology UnitBiochimica et Biophysica Acta-Molecular Basis of DiseaseVolume 1870. Number 2.
- Bauset C; Carda-Diéguez M; Cejudo-Garcés A; Buetas E; Seco-Cervera M; Macias-Ceja DC; Navarro-Vicente F; Esplugues JV; Calatayud S; Mira Á;, Ortiz-Masiá D; Barrachina MD; Cosín-Roger J.2024Research Group on Digestive and Inflammatory Pharmacology UnitBiochimica et Biophysica Acta-Molecular Basis of DiseaseVolume 1870. Number 8.
- Gisbert-Ferrándiz L, Llau J, Ortiz-Masia D, Cosín-Roger J, Macias-Ceja DC, Hinojosa J, Calatayud S, Barrachina MD.2024Research Group on Digestive and Inflammatory Pharmacology UnitNutrientsVolume 16. Number 20.
- Andrea Cejudo-Garcés, Miguel Carda-Diéguez, Francisco Navarro-Vicente, Sara Calatayud, Dolores Ortiz-Masiá, Álex Mira, María Dolores Barrachina, Jesús Cosín-Roger.2025Research Group on Digestive and Inflammatory Pharmacology UnitInflammatory Bowel Disease Monitor
- Marta Seco-Cervera, Laura Gisbert-Ferrándiz, Dulce C Macias-Ceja, Dolores Ortiz-Masiá3, Jesús Cosín-Roger, Cristina Bauset, Begoña Heras-Moran, Francisco Navarro-Vicente, Maria Civera-Barrachina, José Santiago Ibáñez-Cabellos, Sara Calatayud, María D Barrachina.2025Research Group on Digestive and Inflammatory Pharmacology UnitPlos One
- Dolores Ortiz-Masià.,2020.Biological therapy in the prevention of complications of Crohn..Biological Therapy for Inflammatory Bowel Disease...
- Clemente Tomás, Claudia Pilar; Ortiz Masià, María Dolores.,2021.La música como herramienta en la dislexia..La música como herramienta en la dislexia...
- Teresa Pérez Gil, Claudia Lahiguera Lujan, Mª José Bautista Pérez, Soraya Triguero Tarazona, Sheila Baguena Mancebo, Dolores Ortiz-Masià.,2018.Aplicación de la metodología ApS en alumnos del Grado de Logopedia: intervención con personas de la tercera edad..IN-RED 2018...
- Teresa Pérez Gil, Nadia Martínez Gilbert, Vera Soler Molina, Sara Puchades Díaz, Esther Giménez Martínez, Cristina Hurtado Vizcaíno, Dolores Ortiz-Masià.,2019.La utilización de la metodología ApS refuerza la adquisición de competencias a largo plazo..IN-RED 2019...
- Teresa Pérez Gil, Nadia Martínez Gilbert, Vera Soler Molina, Sara Puchades Díaz, Esther Giménez Martínez, Cristina Hurtado Vizcaíno, Dolores Ortiz-Masià.,2019.La metodología ApS refuerza la adquisición de competencias generales y específicas..IN-RED 2019...
- Teresa Perez Gil, Claudia Lahiguera Lujan, Mª Jose Bautista Pérez, Soraya Triguero Tarazona, Sheila Baguena Mancebo, Dolores Ortiz-Masià.,2019.Aplicación de la metodología ApS en alumnos del Grado de Logopedia: intervención con personas de la tercera edad..JORNADES D'INNOVACIÓ DOCENT EN L'EDUCACIÓ SUPERIOR 2018...
- Dolores Ortiz-Masià.,2019.Service-learning methodology reinforces long-term Skills adquisition..EDULEARN19 Proceedings...
- Dolores Ortiz-Masià.,2019.Service learning methodology reinforces the acquisition of general and specific skills..EDULEARN19 Proceedings...
- T. Civera, M.D. Barrachina, S. Calatayud, S. Martínez-Hervás, A. Álvarez, Dolores Ortiz-Masià.,2020.Continuous, participatory and progressive evaluation in Medical teaching: experience with the University of Valencia's virtual classroom questionnaire..EDULEARN20 Proceedings...
- T. Civera, M.D. Barrachina, S. Calatayud, S. Martínez-Hervás, A. Álvarez, Dolores Ortiz-Masià.,2020.Service-learning as a methodology to achieve sustainable Development goals: experience with the clinical neurology subject in the degree of speech therapy..EDULEARN20 Proceedings...
- Dolores Ortiz-Masià.,2020.Influencia del proceso de evaluación continua en la calificación final de la asignatura Neurología Clínica Aplicada a la Logopedia del Grado de Logopedia..EDUNOVATIC2020 Proceedings...
- Dolores Ortiz-Masià.,2020.Aprendizaje-Servicio como metodología para alcanzar los objetivos de desarrollo sostenible: experiencia en el departamento de Medicina de la Universitat de València..EDUNOVATIC2020 Proceedings...
- Dolores Ortiz-Masià.,2021.Análisis de la docencia en línea en el proceso enseñanza-aprendizaje: efectos colaterales del SARS-COV2 en la asignatura Fundamentos Médicos del Máster Ingeniería Biomédica..INRED 2021...
- S. Martinez-Hervas, D. Ortiz Masia, J.F. Martinez-Valls, J.F. Merino Torres, C. Sanchez Juan, J.T. Real.,2022.Guided clinical case as a methodology for learning: experience in the subject of endocrinology and nutrition in the Medical degree..EDULEARN22 Proceedings...
- Dolores Ortiz-Masià.,2022.El elearning y el aprendizaje por problemas como metodologías docentes..EDULEARN22 Proceedings...
- Mar Edo, Sergio Martinez-Hervas, Ana Blas-García, Dolores Ortiz Masià.,2022.Flipped classroom: la experiencia en patología nutricional del Grado de Nutrición humana y dietética..VIII Jornades d'Innovació docente 2022: La transferencia en la innovación educativa: opotunitat per a generar aprenentatges i consolidar el curriculum....
- Sergio Martínez-Hervás, Dolores Ortiz Masiá, José Francisco Martínez Valls, Juan Francisco Merino Torres, Carlos Sánchez Juan, José Tomás Real.,2022.El caso clínico guiado como metodología de aprendizafe: la experiencia en la asignatura de endocrinología y nutrición en la carrera de medicina..VIII Jornades d'Innovació docente 2022: La transferencia en la innovación educativa: opotunitat per a generar aprenentatges i consolidar el curriculum....
- Dolores Ortiz Masiá.,2022.El e-learning y el aprendizaje por problemas como metodologías docentes: experiencia en el Grado de Nutrición humana y dietética..Tendencias educativas emergentes en Ciencias de la Salud y Enfermería...
- M. M. Edo, S. Martínez-Hervas, y Dolores Ortiz-Masià.,2022.The inverted class favors the use of class time and participation: experience in Human Nutrition and Dietetics' degree..Hitos en educación: lecciones de la pandemia, modalidades docentes y ODS...
- Juan F Ascaso Gimilio, F. Javier Ampudia Blasco, Miguel Civera Andrés, Sergio Martínez Hervás, Juan Francisco Merino Torres, Joaquín Ortega Serrano, M. Dolores Ortiz Masía, José T Real Collado, Carlos Sánchez Juan.,2023.Endocrinología y Nutrición..Endocrinología y Nutrición...
- S. Martinez-Hervas, D. Ortiz Masiá, H. Gonzalez-Navarro, F.J. Ampudia-Blasco, J.F. Merino Torres, C. Sánchez Juan, J.T. Real.,2023.Usefulness of the guided clinical case to improve student motivation and learning in the subject of Endocrinology and Nutrition in the Medical degree. Two years experience..EDULEARN23 Proceedings...
- Dolores Ortiz Masiá.,2025.Aprendizaje basado en problemas en el Grado de Nutrición Humana y Dietética. Evaluación del rendimiento y desarrollo de competencias..Acercando el futuro a los estudiantes de ciencias de la salud...
- Dolores Ortiz Masiá.,2025.Análisis de la evaluación continua y final en el rendimiento académico. Impacto en la asignatura Neurología Clínica del Grado de Logopedia..Acercando el futuro a los estudiantes de ciencias de la salud...

CNAE

Other research and experimental development on natural sciences and engineering

Associated structure

Pharmacology

www.uv.es/farmacologia

dep.farmacologia@uv.es

Contact group details

Digestive and Inflammatory Diseases Research Unit (UFDI)

Burjassot/Paterna Campus

Avda. Blasco Ibáñez, 15

46010 València (Valencia)

+34 963 864 624

Geolocation

www.farmacologiavalencia.es

farmacologiavalencia@uv.es

Contact people

ESPLUGUES MOTA, JUAN VICENTE
PDI-Catedratic/a d'Universitat

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Research Group on Digestive and Inflammatory Pharmacology Unit - UFDI