Research Group on Systems Biology in yeasts of biotechnological interest

Description

Industrial yeasts, responsible for biotechnological processes, are highly specialised organisms that have evolved under restrictive environmental conditions in different environments manipulated by humans. Our group is interested in understanding the mechanisms involved in their adaptation, which have shaped the yeast genome conferring them properties of biotechnological interest. Different "omics" approaches and evolutionary analysis are used to understand the mechanisms of adaptation to environmental and nutritional changes (temperature, availability of nitrogen and iron, etc.) of yeasts of industrial interest. This research is applicable to the selection and genetic improvement of new yeast strains of interest in industrial fermentations (wine, beer, cider, etc.) and the production of dietary supplements, by different techniques such as adaptive evolution, hybridisation, or the development of GMOs.

Our working group is interested in understanding the molecular mechanisms involved in the adaptive processes that have shaped the yeast genome, giving them such peculiar properties of biotechnological interest.

The results of our research are applicable to the following topics of interest to industry:

Application of molecular techniques for the identification and characterisation of yeasts in fermentation processes (mainly wine and beer).
Selection of starter cultures for use in alcoholic fermentations.
Yeast breeding by non-GMO techniques such as directed evolution, intra- and inter-specific hybridisation, as well as breeding by genetic engineering (GMOs). These techniques are being applied to wine and brewing yeast breeding to increase glycerol production, to decrease ethanol yield, to improve tolerance to low temperatures, to improve growth under nitrogen limiting conditions, to improve fermentative aroma production and varietal aroma release.

Goals CT

Metabolic and gene expression regulation studies related to the molecular mechanisms of stress response in wine yeasts.
Study of yeasts present in food as potential emerging pathogens: molecular basis of pathogenicity.
Use of global analysis techniques (genomics, transcriptomics, proteomics, metabolomics, etc.) to understand the interaction of genomes.
Study of interactions between yeasts during industrial fermentations using global analysis techniques.
Acquisition of new gene functions of adaptive value by gene or genomic duplication or horizontal transfer.

Research lines

Genetics and genomics of yeasts of biotechnological interest

Analysis of molecular mechanisms involved in the adaptive processes that have shaped the yeast genome, giving them such peculiar properties of biotechnological interest.

Management

BARRIO ESPARDUCER, ELADIO
PDI-Catedratic/a d'Universitat
Director/a de Servei General

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Non-UV research staff

Partners

Javier Alonso del Real Arias - Consejo Superior de Investigaciones Científicas (Madrid)
Roberto Pérez Torrado - Consejo Superior de Investigaciones Científicas (Madrid)

Scientific production by UV researcher

BARRIO ESPARDUCER, ELADIO
PDI-Catedratic/a d'UniversitatDirector/a de Servei General
ContraerExpandir
- F. Badotti; S. Torres-Vilaça; A. Arias; C.A. Rosa; E. Barrio(2014)Research Group on Systems Biology in yeasts of biotechnological interestFems Yeast Research, 14(2), pp. 289 - 301. ISSN: 1567-1356
- C. Ibáñez; R. Pérez-Torrado; R. Chiva; J.M. Guillamón; E. Barrio; A. Querol(2014)Research Group on Systems Biology in yeasts of biotechnological interestInternational Journal of Food Microbiology, 171, pp. 129 - 135. ISSN: 0168-1605
- Oliveira, Bruno M.; Barrio Esparducer, Eladio; Querol Simón, Amparo; Pérez Torrado, Roberto(2014)Research Group on Systems Biology in yeasts of biotechnological interestPlos One, 9(1), p. e87290. ISSN: 1932-6203
- Pérez Través, Laura; Lopes, Christian A.; Querol Simón, Amparo; Barrio Esparducer, Eladio(2014)Research Group on Systems Biology in yeasts of biotechnological interestPlos One, 9(4), p. e93729. ISSN: 1932-6203
- Rodríguez, M. Eugenia; Pérez-Través, Laura; Sangorrín, Marcela P.; Barrio, Eladio; Lopes, Christian A.;(2014)Research Group on Systems Biology in yeasts of biotechnological interestFems Yeast Research, 14(6), pp. 948 - 965. ISSN: 1567-1356
- Pérez-Través L.; Lopes C.A.; Barrio E.; Querol A.(2014)Research Group on Systems Biology in yeasts of biotechnological interestInternational Microbiology, 17(4), pp. 213 - 224. ISSN: 1139-6709
- Marsit, S.; Mena, A.; Bigey, F.; Sauvage, F.X.; Couloux, A.; Guy, J.; Legras, J.L.; Barrio, E.; Dequin, S.; Galeote, V.;(2015)Research Group on Systems Biology in yeasts of biotechnological interestMolecular Biology and Evolution, 32(7), pp. 1695 - 1707. ISSN: 0737-4038
- Pérez-Torrado, R.; González, S.S.; Combina, M.; Barrio, E.; Querol, A.;(2015)Research Group on Systems Biology in yeasts of biotechnological interestInternational Journal of Food Microbiology, 204, pp. 101 - 110. ISSN: 0168-1605
- Pérez-Través, L.; Lopes, C.A.; González, R.; Barrio, E.; Querol A.;(2015)Research Group on Systems Biology in yeasts of biotechnological interestInternational Journal of Food Microbiology, 205, pp. 30 - 40. ISSN: 0168-1605
- Rodríguez, M.E.; Pérez-Través, L.; Sangorrín, M.P.; Barrio, E.; Querol, A.; Lopes, C.A.(2017)Research Group on Systems Biology in yeasts of biotechnological interestFems Yeast Research, 14(6), pp. 948 - 965. ISSN: 1567-1356
- Fasoli, G.; Barrio, E.; Tofalo, R.; Suzzi, G.; Belloch, C.(2016)Research Group on Systems Biology in yeasts of biotechnological interestInternational Journal of Food Microbiology, 233, pp. 1 - 10. ISSN: 0168-1605
- Peris, D.; Arias, A.; Orlić, S.; Belloch, C.; Pérez-Través, L.; Querol, A.; Barrio, E.(2017)Research Group on Systems Biology in yeasts of biotechnological interestMolecular Phylogenetics and Evolution, 108, pp. 49 - 60. ISSN: 1055-7903
- Alonso-Del-Real, J.; Lairón-Peris, M.; Barrio, E.; Querol, A.(2017)Research Group on Systems Biology in yeasts of biotechnological interestFrontiers In Microbiology, 8, p. 150. ISSN: 1664-302X
- Alonso-Del-Real, J.; Contreras-Ruiz, A.; Castiglioni, G.L.; Barrio, E.; Querol, A.(2017)Research Group on Systems Biology in yeasts of biotechnological interestFrontiers In Microbiology, 8, p. 2087. ISSN: 1664-302X
- Guillamón, J.M.; Barrio, E.(2017)Research Group on Systems Biology in yeasts of biotechnological interestFrontiers In Microbiology, 8, p. 806. ISSN: 1664-302X
- Pérez-Torrado, R.; Barrio, E.; Querol, A.(2018)Research Group on Systems Biology in yeasts of biotechnological interestCritical Reviews in Food Science and Nutrition, 58(11), pp. 1780 - 1790. ISSN: 1040-8398
- Ibáñez, C.;Pérez-Torrado, R.; Morard, M.; Toft, C.; Barrio, E.; Querol, A.(2017)Research Group on Systems Biology in yeasts of biotechnological interestInternational Journal of Food Microbiology, 257, pp. 262 - 270. ISSN: 0168-1605
- Peris, D.; Pérez-Torrado, R.; Hittinger, C.T.; Barrio, E.; Querol, A.(2018)Research Group on Systems Biology in yeasts of biotechnological interestYeast, 35(1), pp. 51 - 69. ISSN: 1097-0061
- Ortiz-Tovar, G.; Pérez-Torrado, R.; Adam, A.C.; Barrio, E.; Querol, A.(2018)Research Group on Systems Biology in yeasts of biotechnological interestInternational Journal of Food Microbiology, 274, pp. 12 - 19. ISSN: 0168-1605
- Ortiz-Tovar, G.; Minebois, R.; Barrio, E.; Querol, A.; Pérez-Torrado, R.;(2019)Research Group on Systems Biology in yeasts of biotechnological interestInternational Journal of Food Microbiology, 297, pp. 51 - 59. ISSN: 0168-1605
- Macías, L.G.; Morard, M.; Toft, C.; Barrio, E.(2019)Research Group on Systems Biology in yeasts of biotechnological interestFrontiers In Genetics, 10, p. 187. ISSN: 1664-8021
- Morard, M.; Macías, L.G.; Adam, A.C., Lairón-Peris, M., Pérez-Torrado, R., Toft, C.; Barrio, E.(2019)Research Group on Systems Biology in yeasts of biotechnological interestFrontiers In Genetics, 10, p. 82. ISSN: 1664-8021
- J. Alonso-del-Real; R. Pérez-Torrado; A. Querol; E. Barrio(2019)Research Group on Systems Biology in yeasts of biotechnological interestEnvironmental Microbiology, 21(5), pp. 1627 - 1644. ISSN: 1462-2912
- E. García-Ríos; M. Nuévalos; E. Barrio; S. Puig; J.M. Guillamón(2019)Research Group on Systems Biology in yeasts of biotechnological interestEnvironmental Microbiology, 21(5), pp. 1771 - 1781. ISSN: 1462-2912
- Morard, M.; Benavent-Gil, Y.; Ortiz-Tovar, G., Pérez-Través, L.; Querol, A.; Toft, C.; Barrio, E.(2020)Research Group on Systems Biology in yeasts of biotechnological interestMicrobial Genomics, 6(3), pp. 1 - 15. ISSN: 2057-5858
- Lairón-Peris, M.; Pérez-Través, L.; Muñiz-Calvo, S.; Guillamón, J.M.; Heras, J.M.; Barrio, E., Querol, A.(2020)Research Group on Systems Biology in yeasts of biotechnological interestFrontiers In Bioengineering And Biotechnology, 8, p. 129. ISSN: 2296-4185
- Matos, T.T.S.; Teixeira, J.F.; Macías, L.G.; Santos, A.R.O.; Suh, S.O.; Barrio, E.; Lachance, M.A.; Rosa, C.A.(2020)Research Group on Systems Biology in yeasts of biotechnological interestInternational Journal of Systematic and Evolutionary Microbiology, 70(5), pp. 3374 - 3378. ISSN: 1466-5026
- Morard, M.; Ibáñez, C.; Adam, A.C., Querol, A.; Barrio, E.; Toft, C.(2020)Research Group on Systems Biology in yeasts of biotechnological interestMicrobial Genomics, 6(10), p. mgen000448. ISSN: 2057-5858
- Macías, L.G.; Barrio, E.; Toft, C.(2020)Research Group on Systems Biology in yeasts of biotechnological interestG3-Genes Genomes Genetics, 10(12), pp. 4369 - 4372. ISSN: 2160-1836
- Gonzalez-Flores, M.; Rodríguez, M.E.; Peris, D.; Querol, A.; Barrio, E.; Lopes, C.A.(2020)Research Group on Systems Biology in yeasts of biotechnological interestFungal Ecology, 48, p. 100990. ISSN: 1754-5048
- Lairón-Peris, M.; Routledge, S.J.; Linney, J.A.; Alonso-del-Real, J.; Spickett, C.M.; Pitt, A.R.; Guillamón, J.M.; Barrio, E.; Goddard, A.D.; Querol, A.;(2021)Research Group on Systems Biology in yeasts of biotechnological interestApplied and Environmental Microbiology, 87(12), p. e0044021. ISSN: 0099-2240
- R. Minebois; M. Lairón-Peris; E. Barrio; R. Pérez-Torrado; A. Querol;(2021)Research Group on Systems Biology in yeasts of biotechnological interestEnvironmental Microbiology, 23(6), pp. 3059 - 3076. ISSN: 1462-2912
- María Lairón-Peris; Gabriel L. Castiglioni; Sarah J Routledge; Javier Alonso del Real; John A. Linney; Andrew R. Pitt; Josef Melcr; Alan D. Goddard; Eladio Barrio; Amparo Querol;(2021)Research Group on Systems Biology in yeasts of biotechnological interestMicrobial Genomics, 7(8), p. 000628. ISSN: 2057-5858
- David Henriques; Romain Minebois; Sebastián Mendonza; Laura G. Macías; Roberto Pérez-Torrado; Eladio Barrio; Bas Teusink; Amparo Querol; Eva Balsa-Canto(2021)A multi-phase multi-objective dynamic genome-scale model shows different redox balancing among yeast species in fermentation.Msystems, 6(4), p. e00260-21. ISSN: 2379-5077
- Laura G. Macías; Melisa González-Flores; Ana C. Adam; María E. Rodríguez; Amparo Querol; Eladio Barrio; Christian A. Lopes; Roberto Pérez-Torrado.(2021)Research Group on Systems Biology in yeasts of biotechnological interestPLOS genetics, 17(11), p. e1009872. ISSN: 1553-7390
- Sebastián M. Tapia; Roberto Pérez-Torrado; Ana C. Adam; Laura G. Macías; Eladio Barrio; Amparo Querol;(2022)Research Group on Systems Biology in yeasts of biotechnological interestMicrobial Biotechnology, 15(8), pp. 2281 - 2291. ISSN: 1751-7915
- Sebastián M. Tapia; Roberto Pérez-Torrado; Ana C. Adam; Laura G. Macías; Eladio Barrio; Amparo Querol;(2022)Research Group on Systems Biology in yeasts of biotechnological interestMicrobial Biotechnology, 15, pp. 2958 - 2969. ISSN: 1751-7915
- Sebastián M. Tapia; Laura G. Macías; Roberto Pérez-Torrado; Noemi Daroqui; Paloma Manzanares; Amparo Querol; Eladio Barrio;(2023)Research Group on Systems Biology in yeasts of biotechnological interestBmc Biology, 21, p. 102. ISSN: 1741-7007
- Sonia Albillos-Arenal; Romain Minebois; Amparo Querol; Eladio Barrio(2023)Research Group on Systems Biology in yeasts of biotechnological interestMicrobial Biotechnology, 16(9), pp. 1858 - 1871. ISSN: 1751-7915
- Alba Contreras-Ruiz; Javier Alonso-del-Real; Eladio Barrio; Amparo Querol;(2023)Research Group on Systems Biology in yeasts of biotechnological interestFood Microbiology, 114, p. 104276. ISSN: 0740-0020
- David Henriques; Romain Minebois; David Santos; Eladio Barrio; Amparo Querol; Eva Balsa-Canto(2023)Research Group on Systems Biology in yeasts of biotechnological interestMicrobiology Spectrum, 11(3), p. e03519-22. ISSN: 2165-0497
- Querol, Amparo; Pérez-Torrado, Roberto; Alonso-del-Real, Javier; Minebois, Romain; Stribny, Jiri; Oliveira, Bruno M.; Barrio, Eladio,(2018).Chapter 5. New trends in the uses of yeasts in oenology.Advances in Food and Nutrition Research.. Volume. 85 . (pp. 177 - 202)..

CNAE

Research and experimental development on biotechnology

Associated structure

Genetics

www.uv.es/genetica

dep.genetica@uv.es

Contact group details

Systems Biology in Yeasts of Biotechnological Interest (SBYBI)

Burjassot/Paterna Campus

Science Park
C/ Catedrático José Beltrán, 2

46980 Paterna (Valencia)

+34 963 544 180

Geolocation

eladio.barrio@uv.es

Contact people

BARRIO ESPARDUCER, ELADIO
PDI-Catedratic/a d'Universitat
Director/a de Servei General

View details

Research Group on Systems Biology in yeasts of biotechnological interest - SBYBI