It is a research group dedicated to the study of tumours of the central nervous system, addressing clinical, neuropathological, genetic, molecular and metabolomic aspects. These studies are carried out in both "in vivo" tumours and "in vitro" experimental models, with a translational orientation with the aim of biopathological characterisation towards the identification of molecular targets with application to diagnosis, prognosis and therapeutics.
- The general objective of this work is the clinical, histopathological and genetic characterisation of CNS tumours.
- To define the genetic and molecular profile to establish diagnostic and prognostic criteria and to propose effective therapeutic actions.
- To analyse the epigenetic mechanisms linked to the processes of initiation and progression through analysis of the changes in gene methylation that have a prognostic value.
- Analysis of microRNAs involved in gene modulation of oncogenic cellular functions (MET, cell migration, angiogenesis, apoptosis, cell cycle).
- Development and analysis of experimental models in vitro and in vivo (xenotransplants) with the aim of defining significant molecular targets in oncogenic processes that can be used as diagnostic, prognostic and therapeutic values.
- Primary GBM. EGFR amplification status and angiogenic/infiltrative phenotypes. Molecular networks responsible for the modulation processes of these patterns
The aim of this work is to define the phenotypic and genetic characteristics of glioblastoma multiforme (GBM). To analyse the angiogenic and infiltrative characteristics of the nodular and diffuse pattern of GBM, the genetic profiles and the molecular networks responsible for these GBM patterns in relation to the EGFR receptor amplification profiles.
- Metabolomic and microvascular environment characterisation of aggressive human glioma by DCE-MRI and genetic study of biopsies
The aims of this work are to characterise the microvascular environment of gliomas and to study the infiltration, migration and invasiveness of these neoplasms using DCE-MRI.
- Role of microRNAs in gene regulation of EGFR-dependent signalling pathways. MicroRNA expression patterns in GBM. MicroRNA expression profile in the angiogenic and infiltrative patterns of GBM. Prognostic value
The aims of this work are to study the expression of miRNAs in high-grade gliomas, such as primary glioblastoma multiforme, secondary glioblastomas and high-grade astrocytomas.
- Development of a model in cell cultures and xeno-transplants for the analysis of the processes of modulation of gene activity by microRNA in the processes of emigration (infiltration), angiogenesis, hypoxia, apoptosis and cell cycle.
The aim of this work is to generate experimental models to study the modulation of gene activity by transfection methods (inhibition and overexpression) of miRNAs in primary cell cultures and established Glioblastoma multiforme cell lines.
- Development of a model for population analysis and spatial distribution in these neoplasms
This line of work is aimed at establishing models of tumour growth in GBM through the analysis of cell populations in mitosis/cell cycle and their distribution in the tumour, establishing intercellular and intratumoural spatial patterns.
- Clinical, histo-pathological and genetic characterisation in recurrent meningioma
The aims of this work are to establish morphological and genetic profiles of recurrent meningioma with a diagnostic and prognostic objective.
- SAN MIGUEL DIEZ, TERESA CONSUELO
- Alumn.-Servei de Formacio Permanent
- CALABUIG FARIÑAS, SILVIA
- Alumn.-Servei de Formacio Permanent
- MONLEON SALVADO, DANIEL
- PDI-Catedratic/a d'Universitat
- Director/a de Departament
- MORALES TATAY, JOSE MANUEL
- Alumn.-Servei de Formacio Permanent
Blasco Ibáñez Campus
Av. Blasco Ibáñez, 15
46010 València (Valencia)
