In patients with large vessel ischaemic stroke, the use of thrombectomy devices makes it possible to retrieve the occluding thrombus and make it available for analysis. The thrombus can be studied fresh, frozen or fixed for preservation and subsequent analysis. The aim is to subject thrombi to different types of analysis to obtain information on their characteristics, structure and composition, and to establish associations between the nature of the thrombus and clinical-radiological variables relating to the diagnosis, treatment and prognosis of stroke. It will also help to explain the behaviour of the thrombus during fibrinolysis and/or thrombectomy, enabling research and development of more effective thrombolytic treatments and thromectomy devices.
Brain cell senescence remains unexplored as a target for neuroprotection in stroke. The aim is to characterise brain cell senescence associated with ageing and stroke in a rat model, and to reposition a senolytic drug, Navitoclax, as an effective neuroprotectant for use as an adjunct to endovascular treatment in ischaemic stroke. The influence of gender will also be analysed.
We are better characterising the early neurological and brain alterations associated with MHE and the mechanisms that produce them in order to identify and evaluate new, earlier and more sensitive diagnostic procedures for MHE. Line funded by the ISCIII (PI18/00150).
Dental pathology: epidemiology, clinical manifestations, diagnosis and treatment. Quality of care and user satisfaction.
Identification of genes and molecules involved in the ocular complications of diabetes mellitus. Oxidative stress. Cellular bases of retinopathies.
Endodontic materials. Irrigation techniques. Root canal preparation and obturation procedures. Material/dental tissue interface studies. Pathology of the dentin-pulp complex and its periapical complications.
We are evaluating the usefulness of eye movement abnormalities for early diagnosis of MHE. This is being addressed in collaboration with AURA Innovative Robotics, which has developed sensitive equipment for fine analysis of various parameters of eye movements.
We are evaluating the effects of treatment of patients with MHE with rifaximin on neurological, cerebral, immunological, metabolic and exosome alterations. Line funded by the ISCIII (PI18/00150).
Analysis of health-related psychosocial factors that have an impact on people's quality of life. Prevention and treatment protocol for chronic patients. Especially in the areas of oncology, infertility and ageing.
We are characterising inflammatory processes in detail to create a bioinformatic model of molecular, cellular and intercellular communication events associated with the development of MHE. We will evaluate its usefulness in predicting the onset of MHE. Funded by the Ramón Areces Foundation.
Design of tools based on ICT in the teaching, welfare and healthcare fields.
Study of macular pathology and its impact on visual acuity and quality of life.
Chemical synthesis of new multi-diane compounds, in particular peroxisome proliferator-activated receptors and liver X receptors, which are regulators of lipid metabolism, glucose and cholesterol homeostasis, as well as of the inflammatory process.
Study of Retinoic Acid Related Receptors (RORs) involved in the regulation of glucose metabolism, inflammation and angiogenesis in endothelial dysfunction and angiogenesis associated with obesity and abdominal aortic aneurysm.
Study of nutrition and eating disorders on the visual system. Nutrition, vitamins, antioxidants, eye diseases and eating disorders (obesity and anorexia nervosa).
Biomechanics of intraradicular pins. Materials and techniques for dental restoration. Tooth reconstruction with root canal treatment.
In this line of research, studies are carried out to quantify the habitual physical activity of groups of people with some special situation, usually a pathology that affects the musculoskeletal system. In this way, the aim is to establish the effect of the practice of physical activity on parameters related to the health and functionality of these people.
Glaucoma research. Identification of genes and molecules involved in glaucoma. Cellular bases of glaucomatous disease. Application of omic sciences to the study of glaucoma.
Identification of genes and molecules involved in the development of the eyeball and optic nerve. Effect of pre- and postnatal exposure to alcohol and drugs on the development of the visual system.
We are studying whether patients with fatty liver disease present neurological, cerebral and biochemical alterations, in order to characterise them and look for biomarkers of cerebral alterations in steatohepatitis. Funded by: Agencia Valenciana de la Innovación (Valencian Government).
Study of the population affected by or at risk of osteoporosis and its improvement and prevention through physical exercise using a working system with elastic bands that is easy to handle and applicable to home treatment.
Study of tendon pathologies in general and tendon injuries in sports in particular, and their recovery using a work methodology with physical activity.
The aim of this study is to search for biomarkers of cognitive impairment associated with liver disease by characterising the salivary and faecal microbiota in cirrhotic patients and in patients with non-alcoholic steatohepatitis.
The socio-technical processes applied to the sustainability of integrated social and health systems are investigated, based on the principles of user satisfaction and system efficiency.
Study of systemic inflammation induced by different risk factors for atherosclerosis: angiotensin-II, menopause, cigarette smoke, metabolic syndrome, insulin resistance or familial hypercholesterolemia. Search for biomarkers of cardiovascular pahtology.
This is a pioneering work with international collaboration and the first in the world to study the influence of the genetic factor on tendinopathies in the shoulder in different populations where we will study sportsmen, haemophiliacs, disabled people in wheelchairs and the general population.
We characterise the changes in immunophenotype and inflammation associated with the onset of MHE. We analyse the microRNA and protein content of exosomes and their usefulness for diagnosing MHE. We analysed alterations in neuronal connectivity by functional MRI. Funded by: ISCIII (PI18/00150).
Diagnosis and treatment of dental colour pathology. Colorimetry. In vivo and in vitro studies on bleaching agents and procedures.
Study of molecular mechanisms potentially linking type 2 diabetes (T2DM) and cardiovascular disease (CVD), as well as the study of new therapeutic pathways.
