Molecular characterisation of colorectal cancer by liquid biopsy based on the analysis of ctDNA and CTCs. Application of radiomics in prognostic assessment. Study of the mechanisms of resistance to standard and targeted therapy and identification of new therapeutic targets. Development of clinical trials with drugs directed against potentially targetable alterations.
Use of Oxidative stress as a biomarker for embryo viability in human IVF and its use as an additional marker to the existing morphokinetic algorithms provided by time-lapse.
Our study must be considered an initial attempt to create an in vitro model for the direct conversion of somatic cells from patients with gamete-alterations production into germ cells in vitro, opening the field to discover new cell therapies to treat them in the future.
