Isolation and characterisation of extracellular vesicles (EVs) in different helminth parasites. Identification of molecules present in EVs. Analysis for the usefulness of EVs in helminthiasis control and other diseases (diagnosis, vaccination and treatment).
... in emergency myelopoiesis during candidiasis and reveal the mechanisms involved in trained innate immunity during fungal infections.
The hypothesis we are currently working on is that HSPCs can directly detect microorganisms and contribute to protection against infection by different mechanisms, including their ability to differentiate into myeloid cells with an enhanced (trained) phenotype to face the pathogen and initiate the immune response.
Translated with www.DeepL.com/Translator (free version)
Host- and parasite-dependent factors that determine resistance to intestinal helminths or the development of chronic infections are discussed.
Study of molecular interactions between helminth parasites and their hosts. Tools destined to the control of said parasitosis (proteins and recombinant peptides along with polyclonal antibodies) stem from identified molecules.
