Quantification of the main vasoactive compounds and study of the regulatory pathways involved.
Ventricular stretch, a pathophysiological condition present in situations involving pressure or volume overload of the cardiac chambers, generates proarrhythmogenic electrophysiological alterations. Search for and identification of pharmacological agents that counteract these effects.
Study of the protective electrophysiological effects of chronic physical exercise: influence of the autonomic nervous system and mitochondrial oxidative stress. Analysis of the effects on electrophysiological changes induced by myocardial ischaemia in relation to IKATP current.
To advance methods of diagnosis and prevention of myocardial damage after acute myocardial infarction. The group will conduct an experimental analysis of the relationship between the characteristics of ischaemia-reperfusion injury and the inducibility and maintenance of ventricular arrhythmias.
This line focuses on the analysis of the physical conditions and human movement for the development of tools for the assessment and diagnose as well as for the design of interventions programs.
Development of an animal model (New Zealand White rabbits) of metabolic syndrome and study of the impact of the combination of the different manifestations of the disease on cardiac electrical remodelling and its potential arrhythmogenic mechanisms.
Development, updating and integration of tools for the recording, processing and analysis of cardiac electrophysiological signals based on multi-electrode devices and optical mapping systems (voltage and calcium signal analysis).
Ischaemia/reperfusion damage promotes pro-arrhythmogenic ventricular remodelling. The effects of histone deacetylase (DHA) enzyme inhibition on this process and its impact on electrophysiological properties and arrhythmogenesis will be discussed.
Study of oxidative stress and DNA repair mechanisms in different progeroid syndromes and genodermatoses.
Analysis of the electrophysiological properties affecting the processes involved in the onset, perpetuation and cessation of VF, an arrhythmia responsible for about 80% of all sudden cardiac deaths, the underlying mechanisms of which remain incompletely understood.
Pathophysiology of Fanconi anaemia and Friedreich's ataxia.
Analysis of the effects of alterations in calcium homeostasis on arrhythmogenesis. Search for and study of the electrophysiological effects of drugs that act on intracellular calcium dynamics.
Study of oxidative stress and DNA repair mechanisms in different progeroid syndromes and genodermatoses.
