Airway tissue engineering. We work on designing tissue engineered substitutes for tracheal and bronchial prostheses including PCL constructs, hyaluronic acid, combined PLA scaffolds and alginate/agarose hydrogels and decellularised tissue matrices. This line of research is funded by the Carlos III through grant PI16/01315.
Ventricular stretch, a pathophysiological condition present in situations involving pressure or volume overload of the cardiac chambers, generates proarrhythmogenic electrophysiological alterations. Search for and identification of pharmacological agents that counteract these effects.
Study of the protective electrophysiological effects of chronic physical exercise: influence of the autonomic nervous system and mitochondrial oxidative stress. Analysis of the effects on electrophysiological changes induced by myocardial ischaemia in relation to IKATP current.
To advance methods of diagnosis and prevention of myocardial damage after acute myocardial infarction. The group will conduct an experimental analysis of the relationship between the characteristics of ischaemia-reperfusion injury and the inducibility and maintenance of ventricular arrhythmias.
Development of an animal model (New Zealand White rabbits) of metabolic syndrome and study of the impact of the combination of the different manifestations of the disease on cardiac electrical remodelling and its potential arrhythmogenic mechanisms.
Development, updating and integration of tools for the recording, processing and analysis of cardiac electrophysiological signals based on multi-electrode devices and optical mapping systems (voltage and calcium signal analysis).
Ischaemia/reperfusion damage promotes pro-arrhythmogenic ventricular remodelling. The effects of histone deacetylase (DHA) enzyme inhibition on this process and its impact on electrophysiological properties and arrhythmogenesis will be discussed.
Analysis of the electrophysiological properties affecting the processes involved in the onset, perpetuation and cessation of VF, an arrhythmia responsible for about 80% of all sudden cardiac deaths, the underlying mechanisms of which remain incompletely understood.
To assess the effect of therapeutic exercise and physiotherapy on cardiocirculatory function in adults and older adults with cardiovascular disease, as well as to study the effectiveness of strategies to improve adherence to a physically active lifestyle in these subjects.
Analysis of the effects of alterations in calcium homeostasis on arrhythmogenesis. Search for and study of the electrophysiological effects of drugs that act on intracellular calcium dynamics.
Study of the extent of myocardial infarction and its determining factors. In this line, we work on the histopathological evaluation of myocardial infarction from a morphometric approach, assessing distortion at the level of cellular and conjunctive elements of the cardiac wall.
