Cilia and ciliopathies. We evaluate the ultrastructure of the ciliary apparatus in patients diagnosed with CPD and other ciliopathies by combining diagnostic support techniques such as high-definition video capture and molecular biology marker analysis. This line has been funded by the Carlos III through different grants (PI06/60726, PI16/01315).
Functional genomics of lung cancer. Identification of new markers and molecular targets for the treatment of lung cancer using omics technologies (transcriptomics, proteomics, metabolomics). Study of the mechanisms of innate and acquired resistance to tyrosine kinase inhibitors based on the epithelial-mesenchymal transition (EMT) and the cancer stem cell (CSC) phenotype. Regulation of tumour metabolism by oncogenes and suppressor genes in lung cancer.
Identification of new markers and molecular targets for the treatment of pulmonary fibrosis. Identification of molecular determinants of fibroblast-myofibroblast transition using omics technologies. Role of inflammation and stroma in the tumour microenvironment and lung cancer progression.
Physiotherapy from a global perspective can improve the health of patients with respiratory problems. This line of research aims to develop new tools and implement interventions to assess the prognosis and improve the functional capacity of these patients.
