Study of the kinetic and thermodynamic properties of membrane-active complexes. Description of the structure of active complexes and their formation mechanisms.
Methodology: Infrared, UV-Vis, DC and fluorescence spectroscopies. Fluorescence microscopy. AFM nanoscopy. Langmuir monocaps. Molecular simulations. Theoretical diffusion models. Statistical analysis.
Design of new polypeptide sequences with membrane activity from native proteins and peptides.
Methodologies: Computational analysis of polypeptide structures at various levels. Chemical synthesis of peptides.
Cooperative phenomena and variability in information processing with bio-inspired nanostructures.
Theoretical and experimental study of polymeric nanopores, functionalised on their surface with molecules of specific properties, with applications to Micro and Nanofluidics.
