Analysis of FNdeltaRGD mice
We want to find out what are the implications of removing the RGD sequence located in the 10th repeat of type III: 1) can a5ß1 integrins and av class bind to other regions of the FN or are they totally dependent on this sequence? can FN fibrillogenesis occur in the absence of this?
Study of basic developmental processes in Drosophila relevant to human health
Genetic and cellular study of developmental processes in Drosophila, such as embryonic dorsal closure and the establishment of epithelial planar polarity, used as models of processes relevant to human health such as wound healing or cell migration processes.
