Clinical, histo-pathological and genetic characterisation in recurrent meningioma
The aims of this work are to establish morphological and genetic profiles of recurrent meningioma with a diagnostic and prognostic objective.
Development of a model in cell cultures and xeno-transplants for the analysis of the processes of modulation of gene activity by microRNA in the processes of emigration (infiltration), angiogenesis, hypoxia, apoptosis and cell cycle.
The aim of this work is to generate experimental models to study the modulation of gene activity by transfection methods (inhibition and overexpression) of miRNAs in primary cell cultures and established Glioblastoma multiforme cell lines.
Role of microRNAs in gene regulation of EGFR-dependent signalling pathways. MicroRNA expression patterns in GBM. MicroRNA expression profile in the angiogenic and infiltrative patterns of GBM. Prognostic value
The aims of this work are to study the expression of miRNAs in high-grade gliomas, such as primary glioblastoma multiforme, secondary glioblastomas and high-grade astrocytomas.
