Fitxa persona

JUAN NACHER ROSELLO
PDI-Catedratic/a d'Universitat

juan.nacher@uv.es
http://www.uv.es/nacher
http://nacher.blogs.uv.es

Área de conocimiento: BIOLOGIA CELULAR
Departamento: Biología Celular, Biología Funcional y Antropología Física

(9635) 43241

Asignaturas impartidas y modalidades docentes

33067 - Neurobiología - Grado en Biología	Teoría, Tutorías
33159 - Trabajo Final de Grado en Bioquímica y Ciencias Biomédicas - Grado en Bioquímica y Ciencias Biomédicas	Trabajo fin de estudios
33824 - Trabajo Final de Grado en Biología - Grado en Biología	Trabajo fin de estudios
36350 - Neurobiología y neuropatología molecular - Grado en Bioquímica y Ciencias Biomédicas	Teoría
40142 - Neurobiología celular y molecular - Máster Universitario en Neurociencias Básicas y Aplicadas	Teoría
40145 - Neurobiología experimental - Máster Universitario en Neurociencias Básicas y Aplicadas	Teoría
40148 - Trabajo de fin de máster - Máster Universitario en Neurociencias Básicas y Aplicadas	Trabajo fin de estudios

Tutorías

Anual

Martes de 10:00 a 11:30. DESPATX 2.12.P4.018, EDIF. B, FAC. BIOLÓGIQUES. 4ª PLANTA. PREVIA CONFIRMACIÓ CORREU ELECTRÒNIC

Anual

Jueves de 10:00 a 11:30. DESPATX 2.12.P4.018, EDIF. B, FAC. BIOLÓGIQUES. 4ª PLANTA. PREVIA CONFIRMACIÓ CORREU ELECTRÒNIC

Observaciones

Participa en el programa de tutorías electrónicas de la Universitat de València.

Publicaciones en revistas

Ballestín R; Blasco-Ibáñez JM; Crespo C; Nacher J; López-Hidalgo R; Gilabert-Juan J; Moltó D; Varea E. (2014) Astrocytes of the murine model for Down Syndrome Ts65Dn display reduced intracellular ionic zinc. Neurochemistry International, 75, pp. 48 - 53 . ISSN: 0197-0186
Guirado R; Perez-Rando M; Sanchez-Matarredona D; Castrén E; Nacher J. (2014) Chronic fluoxetine treatment alters the structure, connectivity and plasticity of cortical interneurons. International Journal of Neuropsychopharmacology, 30, pp. 1 - 12 . ISSN: 1461-1457
Tzanoulinou S; García-Mompó C; Castillo-Gómez E; Veenit V; Nacher J; Sandi C. (2014) Long-term behavioral programming induced by peripuberty stress in rats is accompanied by GABAergic-related alterations in the Amygdala. Plos One, 9(4), p. e94666 . ISSN: 1932-6203
van der Kooij MA; Fantin M; Kraev I; Korshunova I; Grosse J; Zanoletti O; Guirado R; Garcia-Mompó C; Nacher J; Stewart MG; Berezin V; Sandi C. (2014) Impaired hippocampal neuroligin-2 function by chronic stress or synthetic peptide treatment is linked to social deficits and increased aggression. Neuropsychopharmacology, 39(5), pp. 1148 - 1158 . ISSN: 0893-133X
Guirado R; Perez-Rando M; Sanchez-Matarredona D; Castillo-Gómez E; Liberia T; Rovira-Esteban L; Varea E; Crespo C; Blasco-Ibáñez JM; Nacher J. (2014) The Dendritic Spines of Interneurons Are Dynamic Structures Influenced by PSA-NCAM Expression. Cerebral Cortex, 24, pp. 3014 - 3024 . ISSN: 1047-3211
Liberia T; Blasco-Ibáñez JM; Nácher J; Varea E; Lanciego JL; Crespo C. (2015) Synaptic connectivity of the cholinergic axons in the olfactory bulb of the cynomolgus monkey. Frontiers In Neuroanatomy. ISSN: 1662-5129
Lopez-Campos G; Gilabert-Juan J; Sebastia-Ortega N; Gonzalez-Martinez R; Nacher J; Sanjuan J; Molto MD. (2015) Using gene expression and systems biology to interrogate auditory hallucinations in schizophrenic patients. Studies in health technology and informatics, 210, p. 950 . ISSN: 0926-9630
Nacher J; Bonfanti L. (2015) New neurons from old beliefs in the adult piriform cortex? A Commentary on: 'Occurrence of new neurons in the piriform cortex'. Frontiers In Neuroanatomy. ISSN: 1662-5129
Rubio A; Belles M; Belenguer G; Vidueira S; Fariñas I; Nacher J (2015) Characterization and isolation of immature neurons of the adult mouse piriform cortex. Developmental Neurobiology, 229(3), pp. 850 - 857 . ISSN: 1932-8451
Gilabert-Juan J, Sáez AR, Lopez-Campos G, Sebastiá-Ortega N, González-Martínez R, Costa J, Haro JM, Callado LF, Meana JJ, Nacher J, Sanjuán J, Moltó MD. (2015) Semaphorin and plexin gene expression is altered in the prefrontal cortex of schizophrenia patients with and without auditory hallucinations. Psychiatry Research, 229(3), pp. 850 - 857 . ISSN: 0165-1781
Castillo-Gomez E; Coviello S; Perez-Rando M; Curto Y; Carceller H; Salvador A; Nacher J. (2015) Streptozotocin diabetic mice display depressive-like behavior and alterations in the structure, neurotransmission and plasticity of medial prefrontal cortex interneurons. Brain Research Bulletin, 116, pp. 45 - 56 . ISSN: 0361-9230
Hernández-González S; Ballestín R; López-Hidalgo R; Gilabert-Juan J; Blasco-Ibáñez JM; Crespo C; Nácher J; Varea E. (2015) Altered distribution of hippocampal interneurons in the murine Down Syndrome model Ts65Dn. Neurochemical Research, 40(1), pp. 151 - 164 . ISSN: 0364-3190
Tzanoulinou S; García-Mompó C; Riccio O; Grosse J; Zanoletti O; Dedousis P; Nacher J; Sandi C (2016) Neuroligin-2 Expression in the Prefrontal Cortex is Involved in Attention Deficits Induced by Peripubertal Stress. Neuropsychopharmacology, 41(3), pp. 751 - 761 . ISSN: 0893-133X
Castillo-Gómez E; Varea E; Blasco-Ibáñez JM; Crespo C; Nacher J. (2016) Effects of Chronic Dopamine D2R Agonist Treatment and Polysialic Acid Depletion on Dendritic Spine Density and Excitatory Neurotransmission in the mPFC of Adult Rats. Neural Plasticity, 2016, p. 1615363 . ISSN: 0792-8483
López-Hidalgo R; Ballestín R; Vega J; Blasco-Ibáñez JM; Crespo C; Gilabert-Juan J; Nácher J; Varea E. (2016) Hypocellularity in the Murine Model for Down Syndrome Ts65Dn Is Not Affected by Adult Neurogenesis. Frontiers In Neuroscience. ISSN: 1662-453X
Javier Gilabert-Juan; Clara Bueno-Fernandez; Esther Castillo-Gomez; Juan Nacher (2016) Reduced interneuronal dendritic arborization in CA1 but not in CA3 region of mice subjected to chronic mild stress. Brain And Behavior. ISSN: 2162-3279
Castillo-Gómez E; Pérez-Rando M; Vidueira S; Nacher J (2016) Polysialic Acid Acute Depletion Induces Structural Plasticity in Interneurons and Impairs the Excitation/Inhibition Balance in Medial Prefrontal Cortex Organotypic Cultures. Frontiers In Cellular Neuroscience, 10, p. 170 . ISSN: 1662-5102
König R; Benedetti B; Rotheneichner P; O' Sullivan A; Kreutzer C; Belles M; Nacher J; Weiger TM; Aigner L; Couillard-Després S (2016) Distribution and fate of DCX/PSA-NCAM expressing cells in the adult mammalian cortex: A local reservoir for adult cortical neuroplasticity?. Frontiers of Biology in China. ISSN: 1673-3509
Carceller H; Rovira-Esteban L; Nacher J; Castren E; Guirado R. (2016) Neurochemical phenotype of Reelin immunoreactive cells in the piriform cortex layer II. Frontiers In Cellular Neuroscience, 10, pp. 1 - 11 . ISSN: 1662-5102
Guirado R; La Terra D; Bourguignon M; Carceller H; Umemori J; Sipilä P; Nacher J; Castrén E. (2016) Efects of PSA removal from NCAM on the critical period plasticity triggered by the antidepressant fluoxetine in the visual cortex. Frontiers In Cellular Neuroscience, 10(22), pp. 1 - 9 . ISSN: 1662-5102
Esther Castillo-Gómez; Marta Pérez-Rando; María Bellés; Javier Gilabert-Juan, Jose Vicente Llorens; Héctor Carceller; Clara Bueno-Fernández; Clara García-Mompó; Beatriz Ripoll-Martínez; Yasmina Curto; Noelia Sebastiá-Ortega; María Dolores Moltó; Julio Sanjuan; Juan Nacher (2017) Early Social isolation stress and perinatal nmda receptor antagonist treatment induce changes in the structure and neurochemistry of inhibitory neurons of the adult amygdala and prefrontal cortex. Eneuro, 4(2), pp. 1 - 23 . ISSN: 2373-2822
Perez-Rando M; Castillo-Gómez E; Guirado R; Blasco-Ibañez JM; Crespo C; Varea E; Nacher J (2017) NMDA Receptors Regulate the Structural Plasticity of Spines and Axonal Boutons in Hippocampal Interneurons. Frontiers In Cellular Neuroscience, 11(166) . ISSN: 1662-5102
Perez-Rando M; Castillo-Gómez E; Bellés M; Carceller H; Nacher J (2017) The activation of NMDA receptors alters the structural dynamics of the spines of hippocampal interneurons. Neuroscience Letters, 658, pp. 79 - 84 . ISSN: 0304-3940
Mulet M; Blasco-Ibañez JM; Crespo C; Nacher J; Varea E (2017) Early increased density of COX-2 immunoreactive neurons in Down Syndrome. Folia Neuropathologica, 55(2), pp. 1 - 7 . ISSN: 1641-4640
Villarroya O; Ballestín R; López-Hidalgo R; Mulet M; Blasco-Ibánez JM; Crespo C; Nácher J; Gilabert-Juan J; Varea E (2018) Morphological alterations in the hippocampus of the Ts65Dn mouse model for Down Syndrome correlate with structural plasticity markers. Histology and Histopathology, 33(1), pp. 101 - 115 . ISSN: 0213-3911
Nacher, J. (2018) Plasticity Molecule Reveals Interneuronal Alterations in Alzheimer's Disease. Neuroscience, 372, pp. 304 - 305 . ISSN: 0306-4522
Perez-Rando M; Castillo-Gomez E; Bueno-Fernandez C; Nacher J. (2018) The TrkB agonist 7,8-dihydroxyflavone changes the structural dynamics of neocortical pyramidal neurons and improves object recognition in mice. Brain Structure & Function, 223(5), pp. 2393 - 2408 . ISSN: 1863-2653
Guirado R; Carceller H; Castillo-Gómez E; Castrén E; Nacher J (2018) Automated analysis of images for molecular quantification in immunohistochemistry. Heliyon, 4(6), pp. 1 - 16 . ISSN: 2405-8440
Carceller H; Perez-Rando M; Castren E; Nacher J; Guirado R. (2018) Effects of the antidepressant fluoxetine on the somatostatin interneurons in the basolateral amygdala. Neuroscience, 386(21 August 2018), pp. 205 - 213 . ISSN: 0306-4522
Rotheneichner P; Belles M; Benedetti B: König R; Dannehl D; Kreutzer C; Zaunmair P; Engelhardt M; Aigner L; Nacher J; Couillard-Despres S. (2018) Cellular Plasticity in the Adult Murine Piriform Cortex: Continuous Maturation of Dormant Precursors Into Excitatory Neurons. Cerebral Cortex, 28(7), pp. 2610 - 2621 . ISSN: 1047-3211
Crespo C; Liberia T; Blasco-Ibáñez JM; Nácher J; Varea E. (2019) Cranial Pair I: The Olfactory Nerve. The Anatomical Record, 302(3), pp. 405 - 427 . ISSN: 0003-276X
Curto Y; Alcaide J; Röckle I; Hildebrandt H; Nacher J. (2019) Effects of the genetic depletion of polysialyltransferases on the structure and connectivity of interneurons in the adult prefrontal cortex. Frontiers In Neuroanatomy, 13(6) . ISSN: 1662-5129
Bellés M; Carbonell J; Blasco-Ibáñez JM; Crespo C; Nácher J; Varea E (2019) Alterations in reelin and reelin receptors in Down syndrome. Neuroreport. ISSN: 0959-4965
Elena Martínez-Rodríguez; Ana Martín-Sánchez; Simona Coviello; Cristina Foiani; Emre Kul; Oliver Stork; Fernando Martínez-García; Juan Nacher; Enrique Lanuza; Mónica Santos; Carmen Agustín-Pavón (2019) Lack of MeCP2 leads to region-specific increase of doublecortin in the olfactory system. Brain Structure & Function, 224(4), pp. 1647 - 1658 . ISSN: 1863-2653
Di Forti M; Quattrone D; Moltó MD; Nacher J; Olmeda MS; et al. (2019) The Contibution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study. Lancet Psychiatry, 6(5), pp. 427 - 436 . ISSN: 2215-0374
Pesarico AP; Bueno-Fernandez C; Guirado R; Gómez-Climent MÁ; Curto Y; Carceller H; Nacher J. (2019) Chronic Stress Modulates Interneuronal Plasticity: Effects on PSA-NCAM and Perineuronal Nets in Cortical and Extracortical Regions. Frontiers In Cellular Neuroscience, 13(197) . ISSN: 1662-5102
Alcaide J; Guirado; Crespo C; Blasco-Ibáñez JM; Varea E; Sanjuan J; Nacher J. (2019) Alterations of perineuronal nets in the dorsolateral prefrontal cortex of neuropsychiatric patients. International Journal Of Bipolar Disorders, 7(1), p. 24 . ISSN: 2194-7511
Mas S; Gassó P; Rodríguez N; Cabrera B; Mezquida G; Lobo A; González-Pinto A; Parellada M; Corripio I; Vieta E; Castro-Fornieles J; Bobes J; Usall J; Saiz-Ruiz J; Contreras F; Parellada E; Bernardo M; PEPs group. (2019) Personalized medicine begins with the phenotype: identifying antipsychotic response phenotypes in a first-episode psychosis cohort. Acta Psychiatrica Scandinavica. ISSN: 0001-690X
Carceller H; Guirado R; Nacher J. (2020) Dark exposure affects plasticity-related molecules and interneurons throughout the visual system during adulthood. Journal of Comparative Neurology, 528(8), pp. 1349 - 1366 . ISSN: 0021-9967
Rovira-Esteban L; Hájos N; Nagy GA; Crespo C; Nacher J; Varea E; Blasco-Ibáñez JM. (2020) Semilunar granule cells are the primary source of the perisomatic excitatory innervation onto parvalbumin-expressing interneurons in the dentate gyrus. Eneuro, ENEURO.0323-19. . ISSN: 2373-2822
Garcia-Mompo C; Curto Y; Carceller H; Gilabert-Juan J; Rodriguez-Flores E; Guirado R; Nacher J. (2020) Δ-9-Tetrahydrocannabinol treatment during adolescence and alterations in the inhibitory networks of the adult prefrontal cortex in mice subjected to perinatal NMDA receptor antagonist injection and to postweaning social isolation. Translational Psychiatry, 10(1), p. 177 . ISSN: 2158-3188
Carceller H; Guirado R; Ripolles-Campos E; Teruel-Marti V; Nacher J. (2020) Perineuronal nets regulate the inhibitory perisomatic input onto parvalbumin interneurons and γ activity in the prefrontal cortex. Journal of Neuroscience, 40(26), pp. 5008 - 5018 . ISSN: 0270-6474
Wakhloo D; Scharkowski F; Curto Y; Javed Butt U; Bansal V; Steixner-Kumar AA; Wüstefeld L; Rajput A; Arinrad S; Zillmann MR; Seelbach A; Hassouna I; Schneider K; Qadir Ibrahim A; Werner HB; Martens H; Miskowiak K; Wojcik SM; Bonn S; Nacher J; Nave KA; Ehrenreich H. (2020) Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin. Nature Communications, 11(1), p. 1313 . ISSN: 2041-1723
Coviello S; Gramuntell Y; Castillo-Gomez E; Nacher J (2020) Effects of Dopamine on the Immature Neurons of the Adult Rat Piriform Cortex. Frontiers In Neuroscience. ISSN: 1662-453X
Guirado R; Perez-Rando M; Ferragud A; Gutierrez-Castellanos N; Umemori J; Carceller H; Nacher J; Castillo-Gómez E (2020) A critical period for prefrontal network configurations underlying psyquiatric disorders and addiction. Frontiers In Behavioral Neuroscience, 14(51) . ISSN: 1662-5153
Carbonell J; Blasco-Ibáñez JM; Crespo C; Nácher J; Varea E (2020) Piriform cortex alterations in the Ts65Dn model for down syndrome. Brain Research. ISSN: 0006-8993
La Rosa C; Cavallo F; Pecora A; Chincarini M; Ala U; Faulkes CG; Nacher J; Cozzi B; Sherwood CC; Amrein I; Bonfanti L (2020) Phylogenetic variation in cortical layer II immature neuron reservoir of mammals. Elife. ISSN: 2050-084X
Mulet M; Blasco-Ibáñez JM; Kirstein M; Crespo C; Nacher J; Varea E. (2020) Phenotypic characterization of MCP-1 expressing neurons in the rat cerebral cortex. Journal of Chemical Neuroanatomy, 106, p. 101785 . ISSN: 0891-0618
Perez-Rando M; Guirado R; Tellez-Merlo G; Carceller H; Nacher J. (2021) Estradiol regulates PSA-NCAM expression and connectivity of O-LM interneurons in the hippocampus of adult female mice. Neuroendocrinology. ISSN: 0028-3835
Vallejo, L; Zapater-Fajarí, M; Montoliu, T; Puig-Perez, S; Nacher, J; Hidalgo, V; Salvador, A (2021) No effects of acute psychosocial stress on working memory in older people with type 2 diabetes. Frontiers In Psychology, 11:596584 . ISSN: 1664-1078
Etxeandia-Pradera JI; Martinez-Uribe D; Bellver-Pradas F; Gonzalez-Piqueras JC; Nacher J; Aguilar EJ. (2021) Training psychiatry residents in descriptive psychopathology: A systematic review. Psychopathology. ISSN: 0254-4962
Pesarico AP; Chagas PM; Nacher J. (2021) Editorial: Animal models of stress - Current knowledge and potential directions. Frontiers In Behavioral Neuroscience, 15, p. 655214 . ISSN: 1662-5153
Casquero-Veiga M; Bueno-Fernandez C; Romero-Miguel D; Lamanna-Rama N; Nacher J; Desco M; Soto-Montenegro ML. (2021) Exploratory study of the long-term footprint of deep brain stimulation on brain metabolism and neuroplasticity in an animal model of obesity. Scientific Reports, 11(1), p. 5580 . ISSN: 2045-2322
Clara Bueno-Fernandez; Marta Perez-Rando; Julia Alcaide; Simona Coviello; Carmen Sandi; Esther Castillo-Gómez; Juan Nacher (2021) Long term effects of peripubertal stress on excitatory and inhibitory circuits in the prefrontal cortex of male and female mice. Neurobiology Of Stress(14) . ISSN: 2352-2895
Coviello S; Benedetti B; Jakubecova D; Belles M; Klimczak P; Gramuntell Y; Couillard-Despres S; Nacher J. (2021) PSA depletion induces the differentiation of immature neurons in the piriform cortex of adult mice. International Journal Of Molecular Sciences. ISSN: 1661-6596
Fernandez Garcia-Agudo L; Steixner-Kumar AA; Curto Y; Barnkothe N; Hassouna I; Jähne S; Butt UJ; Grewe K; Weber MS; Green K; Rizzoli S; Nacher J; Nave KA; Ehrenreich H. (2021) Brain erythropoietin fine-tunes a counterbalance between neurodifferentiation and microglia in the adult hippocampus. Cell Reports, 36(8), p. 109548 . ISSN: 2211-1247
Perez-Caballero L; Carceller H; Nacher J; Teruel-Marti V; Pujades E; Casañ-Pastor N; Berrocoso E (2021) Modulation of wireless effects in implanted electrodes. Effects of implanting insulated electrodes on an animal test to screen antidepressant activity. Journal Of Clinical Medicine, 10(17), p. 4003 . ISSN: 2077-0383
Klimczak P; Rizzo A; Castillo-Gómez E; Perez-Rando M; Gramuntell Y; Beltran M; Nacher J (2021) Parvalbumin interneurons and perineuronal nets in the hippocampus and retrosplenial cortex of adult male mice after early social isolation stress and perinatal NMDA receptor antagonist treatment. Frontiers In Synaptic Neuroscience, 13, p. 733989 . ISSN: 1663-3563
Guirado R; La Terra D; Bourguignon M; Carceller H; Umemori J; Sipilä P; Nacher J; Castrén E. (2016) Effects of PSA Removal from NCAM on the Critical Period Plasticity Triggered by the Antidepressant Fluoxetine in the Visual Cortex. Frontiers In Cellular Neuroscience, 10, p. 22 . ISSN: 1662-5102
Curto Y; Garcia-Mompo C; Bueno-Fernandez C; Nacher J. (2016) Chronic benzodiazepine treatment decreases spine density in cortical pyramidal neurons. Neuroscience Letters, 613, pp. 41 - 46 . ISSN: 0304-3940
Rubio A; Belles M; Belenguer G; Vidueira S; Fariñas I; Nacher J (2016) Characterization and isolation of immature neurons of the adult mouse piriform cortex. Developmental Neurobiology, 76(7), pp. 748 - 763 . ISSN: 1932-8451
Gassó P; Rodríguez N; Martínez-Pinteño A; Mezquida G; Ribeiro M; González-Peñas J; Zorrilla I; Martínez-Sadurni L; Rodriguez-Jimenez R; Corripio I; Sarró S; Ibáñez A; Usall J; Lobo A; Moren C; Cuesta MJ; Parellada M; González-Pinto A; Berrocoso E; Bernardo M; Mas S; 2EPs Group. (2021) A longitudinal study of gene expression in first-episode schizophrenia; exploring relapse mechanisms by co-expression analysis in peripheral blood. Translational Psychiatry, 11(1), p. 539 . ISSN: 2158-3188
Gramuntell Y; Klimczak P; Coviello S; Perez-Rando M; Nacher J. (2021) Effects of Aging on the Structure and Expression of NMDA Receptors of Somatostatin Expressing Neurons in the Mouse Hippocampus. Frontiers In Aging Neuroscience, 13, p. 782737 . ISSN: 1663-4365
Pesarico AP; Carceller H; Guirado R; Coviello S; Nacher J (2022) Long term effects of 24-h-restraint stress on the connectivity and structure of interneurons in the basolateral amygdala. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 115, p. 110512 . ISSN: 0278-5846
Martínez-Pinteño A; Mezquida G; Bioque M; López-Ilundain JM; Andreu-Bernabeu Á; Zorrilla I; Mané A; Rodríguez-Jiménez R; Corripio I; Sarró S; Ibáñez Á; Usall J; Rivero O; Gassó P, Leza JC; Cuesta MJ; Parellada M; González-Pinto A; Berrocoso E; Mas S; Bernardo M; 2EPs Group. (2022) The role of BDNF and NGF plasma levels in first-episode schizophrenia: A longitudinal study. European Neuropsychopharmacology, 57, pp. 105 - 117 . ISSN: 0924-977X
Pina-Camacho L; Martinez K; Diaz-Caneja CM; Mezquida G; Cuesta MJ; Moreno C; Amoretti S; González-Pinto A; Arango C; Vieta E; Castro-Fornieles J; Lobo A; Fraguas D; Bernardo M; Janssen J; Parellada M; PEPs Group. (2022) Cortical thinning over two years after first-episode psychosis depends on age of onset. Npj Schizophrenia, 8(1), p. 20 . ISSN: 2334-265X
Coviello S; Gramuntell Y; Klimczak P; Varea E; Blasco-Ibañez JM; Crespo C; Gutierrez A; Nacher J. (2022) Phenotype and Distribution of Immature Neurons in the Human Cerebral Cortex Layer II. Frontiers In Neuroanatomy, 16, p. 851432 . ISSN: 1662-5129
Perez-Rando M; Elvira UKA; García-Martí G; Gadea M; Aguilar EJ; Escarti MJ; Ahulló-Fuster MA; Grasa E; Corripio I; Sanjuan J; Nacher J (2022) Alterations in the volume of thalamic nuclei in patients with schizophrenia and persistent auditory hallucinations. Neuroimage-Clinical, 35, p. 103070 . ISSN: 2213-1582
Al-Soufi L; Martorell L; Moltó MD; González-Peñas J; García-Portilla MP; Arrojo M; Rivero O; Gutiérrez-Zotes A; Nácher J; Muntané G; Paz E; Páramo M; Bobes J; Arango C; Sanjuan J; Vilella E, Costas J. (2022) A polygenic approach to the association between smoking and schizophrenia. Addiction Biology, 27(1) . ISSN: 1355-6215
Mónica Alba Ahulló-Fuster; Tomás Ortiz; Enrique Varela-Donoso; Juan Nacher; M Luz Sánchez-Sánchez (2022) The Parietal Lobe in Alzheimer's Disease and Blindness. Journal Of Alzheimers Disease, 89(4), pp. 1193 - 1202 . ISSN: 1387-2877
Perez-Rando M; Carceller H; Castillo-Gomez E; Bueno-Fernandez C; García-Mompó C; Gilabert-Juan J; Guirado R; Pesarico AP; Nacher J (2022) Impact of stress on inhibitory neuronal circuits, our tribute to Bruce McEwen. Neurobiology Of Stress, 13(19), p. 100460 . ISSN: 2352-2895
Julio Sanjuán;Xochitl Helga Castro-Martínez; Gracián García-Martí; Javier González-Fernández;Roberto Sanz-Requena;Josep María Haro;J. Javier Meana; Luis Martí Bonmatí;Juan Nacher;Noelia Sebastiá-Ortega;Javier Gilabert-Juan;María Dolores Moltó. (2020) FOXP2 expression and gray matter density in the male brains of patients with schizophrenia. Brain Imaging And Behavior. ISSN: 1931-7557
Andreu-Bernabeu Á; Díaz-Caneja CM; Costas J; De Hoyos L; Stella C; Gurriarán ;, Alloza C; Fañanás L; Bobes J; González-Pinto A; Crespo-Facorro B; Martorell L; Vilella E; Muntané G; Nacher J; Molto MD; Aguilar EJ; Parellada M; Arango C; González-Peñas J. (2022) Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia. Nature Communications, 13(1), p. 51 . ISSN: 2041-1723
Browne CA; Conant K; Lasek AW; Nacher J (2022) Editorial: Perineuronal Nets as Therapeutic Targets for the Treatment of Neuropsychiatric Disorders. Frontiers In Synaptic Neuroscience, 14, p. 889800 . ISSN: 1663-3563
Rodríguez N; Gassó P; Martínez-Pinteño A; Segura ÀG; Mezquida G; Moreno-Izco L; González-Peñas J; Zorrilla I; Martin M; Rodriguez-Jimenez R; Corripio I; Sarró S; Ibáñez A; Butjosa A; Contreras F; Bioque M; Cuesta MJ; Parellada M; González-Pinto A; Berrocoso E; Bernardo M; Mas S; 2EPS group (2022) Gene co-expression architecture in peripheral blood in a cohort of remitted first-episode schizophrenia patients. Npj Schizophrenia, 8(1), p. 45 . ISSN: 2334-265X
Serra-Navarro M, Amoretti S, Verdolini N, Forte MF, Sánchez-Torres AM, Vieta E, Clougher D, Lobo A, González-Pinto A, Panadero R, Roldán A, Carvalho AF, de la Serna E, Toll A, Ramos-Quiroga JA, Torrent C, Cuesta MJ, Bernardo M; PEPs Group. (2022) Influence of clinical and neurocognitive factors in psychosocial functioning after a first episode non-affective psychosis: Differences between males and females. Frontiers In Psychiatry, 13(982583) . ISSN: 1664-0640
Carceller H; Gramuntell Y; Klimczak P; Nacher J (2022) Perineuronal Nets: Subtle Structures with Large Implications. Neuroscientist, 23, p. 107385842211063 . ISSN: 1073-8584
Bravo L; Mariscal P; Llorca-Torralba M; López-Cepero JM; Nacher J; Berrocoso E (2022) Altered expression of vesicular glutamate transporter-2 and cleaved caspase-3 in the locus coeruleus of nerve-injured rats. Frontiers In Molecular Neuroscience, 15, p. 918321 . ISSN: 1662-5099
González-Vivas C; Valdés-Florido MJ; García-Martí G; Soldevila-Matías P; Martí-Bonmatí L; Nacher J; Sanjuan J. (2022) How voices change the brain. Two fMRI follow-up case reports. Schizophrenia Research, 248, pp. 329 - 330 . ISSN: 0920-9964
Valli I, Segura AG, Verdolini N, Garcia-Rizo C, Berge D, Baeza I, Cuesta MJ, Gonzalez-Pinto A, Lobo A, Martinez-Aran A, Mezquida G, Pina-Camacho L, Bejarano AR, Mas S, McGuire P, Bernardo M, Vieta E; PEPs group; Amoretti S, Aina AP, Balanzá-Martínez V, Borras R, Butjosa A, Castro-Fornirles J, De-la-Cámara C, De la Serna E, Etxeandia-Pradera JI, Forte MF, García-Portilla P, González JM, González-Blanco L, Gonzalez-Ortega I, Ibañez A, Madero S, Martínez-Sadurni L, Nacher J, Panadero R, Edith PC, Fatjó-Vilas M, Rodriguez-Jimenez R, Ruiz P, Sanchez-Pastor L, Rafael SE, Sánchez-Torres AM, Judith SG, Trabsa A, Urbiola E, Usall J, Arantzazu ZR, Zorrilla I. (2023) Obstetric complications and genetic risk for schizophrenia: differential role of antenatal and perinatal events in first episode psychosis. Acta Psychiatrica Scandinavica, 148(1), pp. 81 - 90 . ISSN: 0001-690X
Saiz-Masvidal C; Contreras F; Soriano-Mas C; Mezquida G; Díaz-Caneja CM; Vieta E; Amoretti S; Lobo A; González-Pinto A; Janssen J; Sagué-Vilavella M; Castro-Fornieles J; Bergé D; Bioque M; Lois NG; Parellada M; Bernardo M; PEPs Group. (2023) Structural covariance predictors of clinical improvement at 2-year follow-up in first-episode psychosis. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 120(110645) . ISSN: 0278-5846
Olivas-Cano I; Rodriguez-Andreu JM; Blasco-Ibañez JM; Crespo C; Nácher J; Varea E (2023) Fluoxetine increased adult neurogenesis is mediated by 5-HT3 receptor. Neuroscience Letters, 795, p. 137027 . ISSN: 0304-3940
Perez-Rando M; Penades-Gomiz C; Martinez-Marin P; García-Martí G; Aguilar EJ; Escarti MJ; Grasa E; Corripio I; Sanjuan J; Nacher J. (2023) Volume alterations of the hippocampus and amygdala in patients with schizophrenia and persistent auditory hallucinations. Revista de Psiquiatria y Salud Mental. ISSN: 1888-9891
Casquero-Veiga M; Lamanna-Rama N; Romero-Miguel D; Rojas-Marquez H; Alcaide J; Beltran M; Nacher J; Desco M; Soto-Montenegro ML (2023) The Poly I:C maternal immune stimulation model shows unique patterns of brain metabolism, morphometry, and plasticity in female rats. Frontiers In Behavioral Neuroscience, 16, p. 1022622 . ISSN: 1662-5153
Sideli L; Aas M; Quattrone D; La Barbera D; La Cascia C; Ferraro L; Alameda L; Velthorst E; Trotta G; Tripoli G; Schimmenti A; Fontana A; Gayer-Anderson C; Stilo S; Seminerio F; Sartorio C; Marrazzo G; Lasalvia A; Tosato S; Tarricone I; Berardi D; D'Andrea G; EU-GEI WP2 Group; Arango C; Arrojo M; Bernardo M; Bobes J; Sanjuán J; Santos JL; Menezes PR; Del-Ben CM; Jongsma HE; Jones PB; Kirkbride JB; Llorca PM; Tortelli A; Pignon B; de Haan L; Selten JP; Van Os J; Rutten BP; Bentall R; Di Forti M; Murray RM; Morgan C; Fisher HL (2023) The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study. Social Psychiatry and Psychiatric Epidemiology, 58(10), pp. 1573 - 1580 . ISSN: 0933-7954
Costas-Carrera A; Verdolini N; Garcia-Rizo C; Mezquida G; Janssen J; Valli I; Corripio I; Sanchez-Torres AM; Bioque M; Lobo A; Gonzalez-Pinto A; Rapado-Castro M; Vieta E; De la Serna H; Mane A; Roldan A; Crossley N; Penades R; Cuesta MJ; Parellada M; Bernardo M; PEPs group. (2023) Difficulties during delivery, brain ventricle enlargement and cognitive impairment in first episode psychosis. Psychological Medicine, 54(7), pp. 1339 - 1349 . ISSN: 0033-2917
López-Hidalgo, R.; Ballestín, R.; Lorenzo, L.; Sánchez-Martí, S.; Blasco-Ibánez, J.M.; Crespo, C.; Nacher, J.; Varea, E. (2024) Early chronic fasudil treatment rescues hippocampal alterations in the Ts65Dn model for down syndrome. Neurochemistry International, 174(March 2024), p. 105679 . ISSN: 0197-0186
Garcia-Marti G; Escarti MJ; Nacher J; Perez-Rando M; Mane A; Usall J; Berrocoso E; Pomarol-Clotet E; Lopez-Ilundain JM; Cuesta MJ; Rodriguez-Jimenez R; Gonzalez-Pinto A; Mar L; Ibañez A; Roldan A; Janssen J; Parellada M; Amoretti S; Bernardo M; Sanjuan J; Aguilar EJ; 2EP Group. (2023) Progressive loss of cortical gray matter in first episode psychosis patients with auditory hallucinations. Schizophrenia Research, S0920-9964(23), p. 00423-1 . ISSN: 0920-9964
Perez-Rando M; García-Martí G; Escarti MJ; Salgado-Pineda P; McKenna PJ; Pomarol-Clotet E; Grasa E; Postiguillo A; Corripio I; Nacher J (2024) Alterations in the volume and shape of the basal ganglia and thalamus in schizophrenia with auditory hallucinations. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 131, p. 110960 . ISSN: 0278-5846
Curto Y; Carceller H; Klimczak P; Perez-Rando M; Wang Q; Grewe K; Kawaguchi R; Rizzoli S; Geschwind D; Nave KA; Teruel-Marti V; Singh M; Ehrenreich H; Nacher J (2024) Erythropoietin restrains the inhibitory potential of interneurons in the mouse hippocampus. Molecular Psychiatry. ISSN: 1359-4184

Textos del currículum

Resumen de la trayectoria científica. El objetivo principal de mi investigación es el estudio de la plasticidad estructural neuronal en el sistema nervioso central adulto, que incluye remodelación sináptica y de neuritas y neurogénesis adulta. Estamos particularmente interesados en cómo esta plasticidad estructural está involucrada en la etiología de diferentes trastornos psiquiátricos y su tratamiento. Nuestros focos principales son los circuitos inhibidores corticales y la forma polisializada de la molécula de adhesión celular neural (PSA-NCAM) como modulador de su plasticidad. Nuestro grupo descubrió que la expresión de PSA-NCAM en la corteza prefrontal medial está regulada por serotonina (a través de receptores 5HT3) y dopamina (a través de receptores D2), dos monoaminas profundamente implicadas en la etiología y el tratamiento de la esquizofrenia y la depresión y cambios en la expresión de moléculas relacionadas con la neurotransmisión inhibidora También describimos la distribución de las células que expresan PSA-NCAM en la amígdala, la corteza prefrontal medial y otras regiones corticales durante la vida adulta y el envejecimiento y encontramos que la mayoría de estas células eran interneuronas maduras polisializadas exclusivamente por la polisialiltransferasa St8SiaIV. Recientemente descubrimos que la expresión de PSA-NCAM es un regulador crítico de la estructura y conectividad de las interneuronas corticales, especialmente en la inhibición perisomática de las células piramidales.
RESUMEN DEL CV. Catedrático de Biología Celular en la Unidad de Neurobiología del Instituto de Biotecnología y Biomedicina de la Universitat de València (www.uv.es/biotecmed/neuro), IP G23 CIBERSAM, IP Unidad de Investigación en Enfermedades Psiquiátricas y Neurodegenerativas INCLIVA. Doctora en Neurobiología Universitat de València, trabajo postdoctoral en el Laboratorio de Neuroendocrinología de la Universidad Rockefeller (Nueva York). Líneas de investigación sobre la plasticidad del sistema nervioso central del adulto y su implicación en la etiología y tratamiento de los trastornos psiquiátricos. Particularmente interesado en las alteraciones de los circuitos inhibidores y la influencia de las experiencias adversas tempranas. 152 artículos en revistas internacionales JCR, índice h: 48. Vicepresidente y secretario Sociedad Española de Neurociencia (SENC) (2013-17). Director del Programa de Postgrado en Neurociencias de la Universidad de València (2005-10). Director del Máster en Neurociencias Básicas y Aplicadas de la Universidad de València (2012-14). IP 7 proyectos de I+D del gobierno español y varios proyectos de gobiernos locales y fundaciones privadas. IP Socio local proyecto ERA-NET Neuron. 11 tesis dirigidas, todos los estudiantes trabajan ahora en investigación/academia. Organizador de diferentes eventos de divulgación pública de la neurociencia: Pinta de ciencia, Brainshake, Neuromascletá, semana de concientización del cerebro, @neuronacher en twitter, autor del libro 'Neuroregeneración' (RBA/National Geographic). Traducción: Una molécula alejada de la locura 'Sara M. Peskin' (Publicacions UV).