Research lines of the group “Gene Expression in Eukaryotes: from DNA to Proteins – EGE-DtoP”

Research in this group is based on the idea that only a model organism offers the possibility of sufficiently in-depth investigation of the molecular mechanisms that control the functioning of a cell. We have chosen Saccharomyces cerevisiae (baker’s yeast) as our model organism because it is the best-known eukaryote. The availability of genetic tools and techniques makes it the most flexible organism for carrying out experiments on gene and protein functions involved in virtually all fundamental processes of eukaryotic cells. Moreover, this yeast was the first eukaryote to have its genome sequenced, and also the first in which a functional genomics project was initiated, making it the “standard” for various global-scale techniques. Our group has been involved in these projects since their inception.

In recent years, S. cerevisiae has also become a model for studying genetic diseases, fungal pathogen infections, and drug testing.

Additionally, S. cerevisiae is of great biotechnological interest, as it is responsible for traditional fermentations in wine, beer, and bread, as well as for newer applications such as bioethanol production, recombinant vaccines, and dietary supplements.

Thus, working with this organism combines the potential for both basic research and applied work in Biotechnology and Biomedicine.

1. Genomic analysis of transcription in yeast

Development of genome-wide techniques for studying the various stages and processes involved in the expression of eukaryotic genes.

2. Study of the response to osmotic stress

General objective: Determine the mechanisms involved in the cellular response to osmotic stress.