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Ocular Surface & Dry Eye

Research into tear-film dysfunction, ocular surface disease, inflammation, Meibomian gland dysfunction, non-invasive biomarkers and emerging therapeutic strategies.

  • Dry eye
  • Tear film
  • Meibomian gland dysfunction
  • Ocular inflammation
  • Neuropathic ocular pain
  • Non-invasive biomarkers
  • Diagnostic technologies
  • Emerging therapies

The question

How can tear-film and ocular surface dysfunction be characterised objectively, and which measurable signals predict symptoms, disease progression and response to treatment?

Why it matters

Ocular surface disease is among the most frequent reasons for an eye-care consultation, yet signs and symptoms are often poorly correlated. Better biomarkers mean earlier diagnosis and more targeted treatment.

Our approach

We combine non-invasive imaging of the tear film and Meibomian glands, clinical phenotyping, quantitative image analysis and prospective clinical studies in university and hospital settings.

Translational impact

Objective, reproducible endpoints for clinical practice and for the evaluation of new diagnostic and therapeutic technologies.

Technologies & methods

  • Ocular Surface

    Non-invasive tear-film analysis

    Interferometric and video-based assessment of tear-film stability and dynamics.

  • Ocular Surface

    Meibography & ocular surface imaging

    Infrared imaging of Meibomian gland structure with quantitative grading.

  • Ocular Surface

    Tear osmolarity

    Point-of-care measurement of tear osmolarity as a diagnostic marker.

  • Computational Methods

    Quantitative image analysis

    Reproducible measurement pipelines for imaging data, with automated segmentation and metrics.

People in this area

Projects

  • Completed

    European Dry Eye Network (EDEN)

    European doctoral training network advancing the understanding of Dry Eye Disease through structural and physiological characterisation, improved diagnostics and therapy, and multidisciplinary training of early-stage researchers.

Selected publications

[PLACEHOLDER] Selected publications for this research area will be listed here from the shared publications database. No references have been invented.