This study examined the effects of weightlifting (WTG) and plyometric (PTG) training on ankle mobility, strength, power, and running performance in highly trained adolescent basketball players. Participants (male, n = 23; female, n = 35) were randomly assigned to WTG or PTG, training three times weekly for four weeks. Assessments included ankle dorsiflexion, hip strength (ABD-ADD ratio and asymmetry), handgrip strength, lower limb power (Counter Movement Jump -CMJ- and Broad Jump), and running performance. Both interventions significantly improved ankle dorsiflexion (left: p < .001, d = 1.10; right: p < .001, d = 1.50) and hip strength (left adduction: p = .001, d = 0.93; right abduction: F[1,54] = 6.65, p = .013, d = 0.71). The WTG improved right handgrip strength (m.d. 1.76 kg, p = .028, d = 0.23) and CMJ (m.d. 1.81 cm, p = .004, d = 0.30). Both groups improved Broad Jump performance (WTG: m.d. 0.13 m, p = .002, d = 0.46; PTG: m.d. 0.13 m, p = .007, d = 0.47). The PTG showed significant improvement in the Compass Drill (p = .003, d = 0.42). Both interventions have the potential to enhance physical performance, with no clear superiority for one type of training over the other.