Our research group is made up of two researchers of the staff of the Universitat de València. Marcel·lí del Olmo Muñoz is University Professor and carries out his academic and research activity in the Department of Biochemistry and Molecular Biology. He has obtained 4 tranches of evaluation of research activity to date. His research has been mainly linked to the yeast S. cerevisiae, covering aspects such as DNA and chromatin structure, regulation of gene expression, polyadenylation and transcription termination, as well as applications of this microorganism in biotechnological processes such as wine and bioethanol production or biocatalysis. He has carried out research stays at the Institut für Zellbiologie (ETH-Hönggerberg, Zurich) and at Tufts University (Boston).
Cecilia Andreu Masiá is Associate Professor in the Department of Organic Chemistry at UVEG. She did her postdoctoral stay at the Department of Chemistry of the Massachusetts Institute of Technology. Her research activity has been developed in several fields: asymmetric synthesis with enzymes in organic solvents, supramolecular chemistry studies of reaction mechanisms, biological chemistry (synthesis of peptides and their applications as therapeutic agents and in organocatalysis processes, as well as in the use of yeasts as biocatalysts in stereoselective synthesis). She has obtained four tranches of research activity evaluation.
Over the last few years, the research of both researchers has progressively converged so that they now form an independent research group whose main objective is the development of biotechnological applications of yeasts in different fields. Specifically, we have worked together on projects of different nature: characterisation of peptides with antimicrobial activity; use of yeast for the generation of chiral synthons precursors of compounds of pharmaceutical and industrial interest and development and improvement of the "Yeast Surface Display" methodology for the exposure of certain peptides and proteins on the cell surface and analysis of the biotechnological relevance of this technique. All this work has resulted in 12 publications in mainly 1st quartile international journals since 2010. At present, the research group continues to deepen these lines of work.
- To analyse the capacity of certain yeasts to develop biocatalytic processes to generate chiral synthons of pharmaceutical interest.
- To develop the Yeast Surface Display methodology on Saccharomyces and non-Saccharomyces yeasts and explore biotechnological potential.
- Use of yeasts in biocatalysis processes
The aim is to analyse the capacity of different yeasts species and strains to carry out the synthesis of chiral synthons of pharmaceutical and industrial interest. The possibility of genetic manipulations leading to an improvement of their capacity in this aspect is also contemplated.
- Development of the "Yeast surface display" methodology and its applications in biotechnology
The development of the Yeast Surface Display methodology is addressed, not only in Sacchomyces cerevisiae but also in other non-Saccharomyces years. In addition, the aim is to develop applications in biocatalysis, bioremediation and health through the exposure of specific proteins and peptides.
- OLMO MUÑOZ, MARCEL LI DEL
- PDI-Catedratic/a d'Universitat
- Responsables de Gestio Academica
- Coordinador/a Titulacio de Grau
- ANDREU MASIA, CECILIA
- PDI-Titular d'Universitat
- ExpandirOLMO MUÑOZ, MARCEL LI DELPDI-Catedratic/a d'UniversitatResponsables de Gestio AcademicaCoordinador/a Titulacio de Grau
Burjassot/Paterna Campus
C/ Doctor Moliner, 50
46100 Burjassot (Valencia)
- OLMO MUÑOZ, MARCEL LI DEL
- PDI-Catedratic/a d'Universitat
- Responsables de Gestio Academica
- Coordinador/a Titulacio de Grau
