University of Valencia logo Logo Scientific Technological Offer Logo del portal

Description

Our research activity focuses on studying mechanisms of pathogenesis and discovering potential drug therapies for rare diseases of genetic origin, in particular Myotonic Dystrophy (DM1 and DM2), Spinal Muscular Atrophy (SMA) and Limb-Girdle Muscular Dystrophy (LGMDD2). To this end, we used Drosophila as an initial experimental model, whose genome we manipulated to create suitable models for our studies. We apply the results obtained in cell cultures, murine models or human samples. One of our main objectives is to identify and develop drugs from both repositioning strategies and RNA oligonucleotide-based drugs.

Goals CT
  • Identification and validation of new molecular pathways involved in the onset and progression of muscle atrophy in DM1.
  • Discovery and development of therapeutic gene modulators based on RNA oligonucleotides in DM1.
  • Development of the first disease models for LGMDD2 in Drosophila melanogaster and mouse.
  • Drug discovery and development for Myotonic Dystrophy type 1 (DM1), Spinal Muscular Atrophy (SMA) and Limb-Girdle Muscular Dystrophy (LGMDD2), using Drosophila and mouse models, through the design of next-generation therapies and drug repurposing.
  • Study of the molecular basis of the cardiac phenotype of DM1
Research lines

Translational Genomics

Our research activity focuses on studying mechanisms of pathogenesis and 
discovering potential drug therapies for diseases of genetic origin, in particular Myotonic Dystrophy (DM1 and DM2), Spinal Muscular Atrophy (SMA) and Limb-Girdle Muscular Dystrophy (LGMDD2).

Management
  • ARTERO ALLEPUZ, RUBEN DARIO
  • PDI-Catedratic/a d'Universitat
View details
Members
  • GONZALEZ MARTINEZ, IRENE
  • Doctorand.
View details
  • MORENO CERVERA, NEREA
  • Doctorand.
View details
  • PEREZ ALONSO, MANUEL
  • PDI-Catedratic/a d'Universitat
View details
Non-UV research staff

Partners

  • Nicolás Charlet Berguerand - Institut Génétique Biologie Moléculaire Cellulaire (Francia) 
  • Geneviève Gourdon - Institut National de la Sante et de la Recherche Medicale (Francia) 
  • Adolfo López de Munain - Hopital Donostia-Biodonostia (San Sebastian) 
  • Javier Ramón Azcón - Institució Catalana Recerca i Estudis Avançats (Barcelona) 
  • Matthew Wood - Oxford University (UK) 
Scientific production by UV researcher
  • ARTERO ALLEPUZ, RUBEN DARIO
    PDI-Catedratic/a d'Universitat
    Expandir
  • PEREZ ALONSO, MANUEL
    PDI-Catedratic/a d'Universitat
    Expandir
  • LOPEZ CASTEL, ARTURO
    PDI-Ajudant Doctor/A
    Expandir
Associated structure
Institute of Biotechnology and Biomedicine (BIOTECMED)
Contact group details
Human Translational Genomics (GT)

Burjassot/Paterna Campus

C/ Doctor Moliner, 50

46100 Burjassot (Valencia)

+34 961 625 580

Geolocation

www.uv.es/gt

arlocas@uv.es

Contact people
  • ARTERO ALLEPUZ, RUBEN DARIO
  • PDI-Catedratic/a d'Universitat
View details