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Development of a model for population analysis and spatial distribution in these neoplasms

This line of work is aimed at establishing models of tumour growth in GBM through the analysis of cell populations in mitosis/cell cycle and their distribution in the tumour, establishing intercellular and intratumoural spatial patterns.

Metabolomic and microvascular environment characterisation of aggressive human glioma by DCE-MRI and genetic study of biopsies

The aims of this work are to characterise the microvascular environment of gliomas and to study the infiltration, migration and invasiveness of these neoplasms using DCE-MRI.

Primary GBM. EGFR amplification status and angiogenic/infiltrative phenotypes. Molecular networks responsible for the modulation processes of these patterns

The aim of this work is to define the phenotypic and genetic characteristics of glioblastoma multiforme (GBM). To analyse the angiogenic and infiltrative characteristics of the nodular and diffuse pattern of GBM, the genetic profiles and the molecular networks responsible for these GBM patterns in relation to the EGFR receptor amplification profiles.