Small molecule structure elucidation: elucidation of connectivity, stereochemical configuration and conformation.
- Small molecule structure elucidation: elucidation of connectivity, stereochemical configuration and conformation.
- Structural characterisation of nanoparticles and their interactions with substrates.
- Mobility studies and molecular dynamics.
- Monitoring of chemical processes: kinetics.
- Determination of association and molecular interaction processes.
- Studies at variable temperatures.
- Observation of a wide variety of magnetic cores: 19F, 195Pt, 133Cs, 11B, 31P, 6Li, 29Si, etc.
Structural characterisation of solid materials and immobilised substances on solids.
It enables the analysis of very diverse materials:
- Soil, wood, cellulose
- Ceramic materials
- Polymers
- Polymorphs, glass, metal and alloys
- Porous materials such as zeolites and aluminosilicates
- Nanoparticles
- Studies on solid organometallic complexes.
Small molecule structure elucidation: elucidation of connectivity, stereochemical configuration and conformation.
Structural characterisation of nanoparticles and their interactions with substrates.
Mobility studies and molecular dynamics.
Monitoring of chemical processes: kinetics.
Determination of association and molecular interaction processes.
Studies at variable temperatures.
Mixture analysis, component quantification and determination.
Studies on molecular dissemination, size and mobility.
Studies on chemical reaction mechanisms, characterisation of reaction intermediates, acquisition of kinetic and thermodynamic reaction parameters.
Studies on molecular interactions, association processes determination and host-guest affinity molecular interaction, enzyme-substrate molecular recognition.
Autoclave steam steriliser, 890 litres, double door, for the deactivation of biological waste as well as the substrate fumigation prior to its use. The sterilisation is done with pressure saturated water steam, functioning according to the process of fractionated vacuum.
Low-flow anaesthesia machine for rat and mouse.
Equipment of the Experimental Aquarium Plant Laboratory.
Nine water filtration and recirculation systems for the preservation of aquatic organisms.
Equipment that determines the lowest temperature at which sufficient vapour is emitted to form a flammable mixture in air at standard atmospheric pressure.
Equipment designed to perform Barnes maze experiments in rodents (rat and mouse).
We work with laboratories that require borosilicate glass instruments:
- Table-top torch.
- Hand torch.
- Lathe.
The equipment allows DNA sequencing by the Sanger method and fragment size determination.
Cell Culture laboratory of Biological Containment Level 2 (BCL2). It has several rooms: Cell Lines Room, Primary Cultures Room, Hypoxia Room and Viral Vectors Room (BCL2+), with 10 biosafety cabinets, 6 incubators and all the necessary equipment to work with eukaryotic cell cultures.
Prepared and controlled by technicians so the user just focuses on his experiment.
Cell Separator equipped with 6 lasers, biosafety cabinet and aerosol extraction. It allows, firstly, the rapid measurement of morphological and functional parameters of a large number of individual cells suspended in liquid medium. For this, cells are initially labelled with fluorochrome-conjugated antibodies, or fluorescent probes that bind to proteins located on the cell surface or inside the cell. The scattered light and fluorescence emitted by the markers as the cells are passed one by one through the different lasers allows simultaneous measurement of structural features and various parameters in each of these cells.
In addition, after analysis, it is possible to separate and collect subpopulations of interest from the sample for further studies.
Equipment that allows the induction and maintenance of rodents under anaesthesia for the performance of surgical procedures. Anaesthesia should always be complemented with an adequate analgesic protocol.
Climatic chamber with 12 glass aquariums for pathology tests with aquatic organisms.
Fibre optic light sources.
Cryopreservation room belonging to the Cell Culture laboratory for the storage and management of frozen samples from users and the section's cell bank.
Fully equipped laboratory for sample preparation, acquisition, separation and analysis by flow cytometry.
Equipment that performs analysis of carbon, hydrogen, nitrogen, sulphur and oxygen.
Equipment designed for the slaughter of rodents belonging to experimental procedures approved by the approved or surplus body.
Confocal microscope mounted on a motorised inverted IX81 which includes the following lenses: 10x, 20x, 40x (oil), 60x (oil), 60x (water). This equipment’s excitation lines are: 405nm, 488nm, 515nm, 559nm, 594nm y 635nm. Moreover, the equipment has an incubation system, which makes it the appropriate equipment for live-cell work.
Multiphoton confocal microscope mounted on a motorised BX61WI upright microscope equipped with a XPLN25xWMP water immersion lens exclusive to multiphoton microscopy, with a numerical aperture of 1.05 and a working distance of 2mm. It has a Mai-Tai HP DeepSee pulsed tunable laser (Spectra Physics) in the 690 to 1040nm range with an average power of 2.0 W. The infrared element of this laser allows for further penetration in the sample and causes less cell damage. The signal is picked up by four detectors covering the whole visible range (420-500/515-580/590-650/660-740).
Fully motorised standard confocal equipment allowing for programmed acquisitions on several predefined areas. It has a dry 10x (NA 0,4) lens and a 60x (NA 1,2) water immersion one. The excitation lines are: 405nm, 473nm, 559nm y 635nm. This equipment is suited for live-cell experiments as it includes an incubator with temperature control.
Scanning electron microscope with field emission gun (FEG) and a resolution of 1.4 nm to 1 kV.
Open cultivation chamber for the growth and development of plants, completely shut off from the exterior and with precise control over the temperature, humidity, CO2 and radiation (max 300 μmoles/m2s per level) with the latest generation of white light LED tubes, with a focused spectrum for plant cultivation, AR 12.
Its internal dimensions are 2040 x 2010 x 3210 mm (height x width x depth).
Open cultivation chamber for the growth and development of plants, completely shut off from the exterior and with precise control over the temperature, humidity, CO2 and radiation (max 600 μmoles/m2s per level) with the latest generation of white light LED tubes, with a focused spectrum for plant cultivation, AR 12.
Its internal dimensions are 2040 x 2010 x 3210 mm (height x width x depth).
Equipment for the analysis of metals and inorganic elements.
A 5-laser analysing cytometer for rapid measurement of morphological and functional parameters of large numbers of single cells suspended in a liquid medium. For this purpose, cells are initially labelled with fluorochrome-conjugated antibodies or fluorescent probes that bind to proteins located on the cell surface or inside the cell. The scattered light and fluorescence emitted by the markers as the cells are passed one by one through the different lasers allows simultaneous measurement of structural features and various parameters in each of these cells.
A three-laser analysing cytometer for rapid measurement of morphological and functional parameters of large numbers of single cells suspended in liquid medium. For this purpose, cells are initially labelled with fluorochrome-conjugated antibodies or fluorescent probes that bind to proteins located on the cell surface or inside the cell. The scattered light and fluorescence emitted by the markers as the cells are passed one by one through the different lasers allows simultaneous measurement of structural features and various parameters in each of these cells.
Equipment that determines the fluorescence of a substance or material that is capable of absorbing energy in the form of electromagnetic radiation and then emitting part of that energy in the form of electromagnetic radiation of a different wavelength.
Gas chromatographer with single quadrupole mass spectrometry detector, GC-MS, applying volatile compound analysis.
Platform to carry out transcriptomic studies in the single cell field, allowing the study of transcriptomic and phenotypic variability among thousands of cells based on single cell RNA.
Venlo greenhouse cabin with biological containment level 1 (NCB1), with control of temperature, relative humidity, CO₂, lighting and irrigation through the Ridder Multima system for regulation, and climate and irrigation control.
Venlo greenhouse cabin with biological containment level 1 (NCB1), with control of temperature, relative humidity, CO₂, lighting and irrigation through the Ridder Multima system for regulation, and climate and irrigation control.
200kV field emission transmission electron microscope (FEG) with a resolution (Point Resolution) of 0.24nm. It’s equipped with a CCD GATAN camera and “Digital Micrograph”, a Software for image acquisition and treatment. This equipment allows to make HRTEM images, electron diffraction patterns and spectroscopic techniques such as EDS and Mapping. It also includes a “Double-Tilt” sample holder, which allows for a complete sample orientation.
Equipment designed to perform analgesia measurements using the plantar test of the Hargreaves method. The hind leg of rodents is stimulated with radiant heat, through a glass pane, using the plantar part as the surface to be irradiated.
High content screening analysis equipment via automatic image capture for the study of live or fixed cell cultures, in plates or slides. It includes four long-distance lens: 4x, 10x, 20x y 40x. It also includes an incubator with temperature control and an automatic reagent dispenser.
X-ray diffraction system multi-purpose diffractometer and Pre-FIX system has the unique ability to measure, with a single instrument, any type of sample: from powders to thin films and from nanomaterials to solid objects.
The ORION NanoFab is an ion microscope designed for the fabrication of nanostructures less than 10 nm using a helium beam. The neon beam allows for an increased the rate of nanostructure formation, thus improving efficiency and performance. The ORION is also capable of acquiring images with a resolution of up to 0.5 nm.
This steriliser provides a safe, effective and convenient method of sterilising your valuable surgical instruments prior to surgery. Without using potentially hazardous gases, flames or chemicals, you can ensure that your instruments are free of pathogens and microbial contaminants.
Room located inside the Cell Culture laboratory (BCL2) composed of a closed Hypoxia Station and necessary equipment for the maintenance of the cultures. The closed station allows a precise control of the percentage of hypoxia and/or hyperoxia, even at extreme values, keeping the culture conditions constant at all times, both during its handling and within the incubators. All of this ensures reproducible data.
Equipment for the analysis of metals and inorganic elements at trace level.
Mass spectrometer with TQ Detector triple quadrupole analyser. Metabolite quantification.
Equipment designed to perform Y-maze experiments.
High resolution hybrid mass spectrometer and quadrupole time-of-flight analyser TRIPLETOF 6600+ and UHPLC (QTOF6600+).
Mass spectrometer with ESI ionisation source and hybrid, double quadrupole time-of-flight analyser.
High-throughput sequencing equipment that allows obtaining short sequences of up to 300 bp.
High-throughput sequencing equipment that allows obtaining sequences with an average length of more than 30 kb.
Microdialysis is a unique technique for monitoring the chemistry of the extracellular space in living tissue. In basic research it is mainly used to determine in vivo changes in endogenous compounds, drug delivery, PK/PD, bioavailability and bioequivalence.
Ultracentrifuge for small volumes with 3 rotors: S55A2, S50A and swing-out rotor S52ST.
Equipment designed to perform social interaction tests on mice.
Equipment that performs analysis of metals and inorganic elements.
Rodent monitor: for monitoring electrocardiogram, respiratory rate.
Room located inside the Cell Culture laboratory (NCB2), with its own equipment and higher level work protocols. Designed to work with viral vectors, GMOs or level 2 biological agents that require greater security.
Equipment designed for open field experiments.
Optogenetic stimulation system.
Equipment designed to handle liquids by generating a flow with controlled velocity.
The IVIS Lumina X5 combines a high-performance fluorescence and bioluminescence imaging system with a high-resolution 2D X-ray system.
Equipment designed to perform automated assessment of conditioned place preference and aversion in rodents.
A more sensitive and selective piece of equipment, faster in carrying out analysis and a solid service improver for the analysis of trace-level samples (pico-nanograms levels) of a great metabolite number in complex matrices such as biofluids and tissues, in an automated and relatively fast manner, generating a profile by multivariate statistical techniques, etc.
Mass spectrometer with ESI ionisation source and hybrid triple quadrupole analyser.
Este equip permet el manteniment del peix zebra o altres espècies de xicoteta grandària en condicions controlades.
Equipment that performs determinations of materials by Raman Spectrophotometry coupled to a confocal microscope.
Equipment for the realisation of quantitative PCR tests.
Equipment for the realisation of digital quantitative PCR tests.
Equipment designed to perform Rota Rod experiments on rodents (rat and mouse).
Bruker N8 HORIZON X-ray diffraction system is a compact, specific and dedicated laboratory equipment for the analysis of Small Angle X-ray Scattering (SAXS) and Grazing Incidence Small Angle X-ray Scattering (GISAXS).
Small angle X-ray diffraction analysis allows to obtain values of particle size and distribution, distance between particles, as well as their arrangement. Establishing volume fractions and degree of crystallinity in materials, calculating porosity, shape and dimensions of nanoparticles.
The D8 Venture Diffractometer is a 3-D single crystal structure determination system. The system covers all typical single crystal applications in organic and inorganic chemistry, solid-state and organo-metallic chemistry, as well as mineralogy and pharmacy. It can be configured for electron density investigations at room or low temperatures, phase transition investigations or high-pressure studies. It also allows all these studies to be carried out with two radiations; Mo or Cu. Obtained through two microsources and their associated optics. The PHOTON 100 detector with CMOS technology, cold light illumination and HD video-microscope.
Standard greenhouse cabin type "venlo", with control of temperature, relative humidity, CO₂, lighting and irrigation through the Ridder Multima system for regulation, and climate and irrigation control.
The UV Statistics Unit works with experts in the use of computer equipment and specific software. The main software used for data analysis is the free R Software.
Surgical microscopes are useful for microsurgery. The optical unit provides an enlarged and sharply focused image of the surgical field.
Super-resolution confocal microscope LCS 980 has the following objectives: 10x, 20x, 25x (oil), 40x (water) and 63x (oil), 60x. The excitation lines present in this equipment are: 405nm, 488nm, 561nm and 639nm. This equipment also has an incubation system, which makes it suitable for working with live cells. This equipment incorporates the Airyscan 2 and Elyra 7 super-resolution systems.
Surgical microscopes are useful for microsurgery. The optical unit provides an enlarged and sharply focused image of the surgical field.
High-contrast 120Kv transmission electron microscope with 20 Mpx CMOS EMSIS XAROSA digital camera.
High contrast 100 Kv transmission electron microscope with 8 Mpx AMT digital camera.
The Field Emission Scanning Electron Microscope with focused ion beam (FIB). Counts with the EDX microanalysis, cryo option for the observation of frozen samples and variable pressure.
Mass spectrometer with ESI ionisation source and QTOF hybrid analyser with trapped ion mobility.
UV-Vis spectroscopy equipment based on the process of absorption of ultraviolet-visible radiation (radiation with a wavelength between 160 and 780 nm) by a molecule, which allows us to identify the functional groups present in a molecule.
El Voltímetre Millicell® ERS 3.0 és un dispositiu dissenyat per a mesurar de manera precisa la resistència elèctrica transepitelial (TEER), el potencial de membrana en cultius cel·lulars d'epitelis i endotelis i depotencial elèctric a través de monocapas cel·lulars en insercions de cultiu. Estos mesuraments són fonamentals per a avaluar la integritat i la confluència de les monocapas cel·lulars en models de barrera, com els de l'intestí, pulmó o barrera hematoencefàlica.
Bruker D8 ADVANCE A25 X-ray diffraction system capable of measuring crystalline phases on powder samples, thin films and small heterogeneous solid samples.
Bruker D8 ADVANCE A25 X-ray diffraction system capable of measuring crystalline phases on powder samples, thin films and small heterogeneous solid samples.
